Jan Novák - Academia.edu (original) (raw)

Papers by Jan Novák

Children

Changes in lifestyle can be significantly reflected in growth and development. Adaptations to red... more Changes in lifestyle can be significantly reflected in growth and development. Adaptations to reduced levels of physical activity, together with non-corresponding nutritional intakes, can result in body build and body composition changes at an early age. The present cross-sectional study aimed to evaluate the secular trend of modifications of body composition and body mass index (BMI) in Czech preschoolers over the last two to three decades. Boys and girls (386 boys and 372 girls) aged 4 to 6 years in 2014–2019 were measured. Outcome data were compared with the reference sample of preschoolers from 1990: 911 boys and 896 girls. Body height, BMI, and percentage of body fat, muscle, and bone mass were evaluated. Height and BMI have not changed. Body fat increased in both genders (p < 0.01), and contrarily, a significant reduction of muscle and skeletal mass was revealed (p < 0.001). Significant changes in body composition and unchanged BMI indicate the development of latent obes...

Beverages

Bottle conditioning refers to a method of adding fermenting wort or yeast suspension in sugar sol... more Bottle conditioning refers to a method of adding fermenting wort or yeast suspension in sugar solution into beer in its final package. Additionally denoted as bottle refermentation, this technique has been originally developed to assure beer carbonation, and has further significance related to formation of distinctive sensory attributes and enhancement of sensory stability, which are the phenomena associated with ongoing yeast metabolic activities in the final package. This review covers historical development of the method, describes metabolic pathways applied during refermentation, and explains practical aspects of the refermentation process management. Furthermore, an overview of the traditional and novel approaches of bottle conditioning with mixed yeast bacterial cultures and its impact on the properties of final beer is provided.

Vegetation History and Archaeobotany

Interní medicína pro praxi

PŘEHLEDOVÉ ČLÁNKY Flow mediated dilation-její úloha a význam ve screeningu rizika kardiovaskulárn... more PŘEHLEDOVÉ ČLÁNKY Flow mediated dilation-její úloha a význam ve screeningu rizika kardiovaskulárních chorob

Urologie pro praxi

Autoři shrnují farmakologické a klinické poznatky o topické léčbě poruchy erekce alprostadilem v ... more Autoři shrnují farmakologické a klinické poznatky o topické léčbě poruchy erekce alprostadilem v krému.

Journal of Clinical Oncology

PURPOSE Nucleophosmin 1 ( NPM1) mutations are associated with a favorable prognosis in acute myel... more PURPOSE Nucleophosmin 1 ( NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene ( FLT3) is absent ( FLT3-ITDneg) or present with a low allelic ratio ( FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We investigated the validity of this assumption. METHODS We analyzed associations between karyotype and outcome in intensively treated patients with NPM1mut/ FLT3-ITDneg/low AML who were prospectively enrolled in registry databases from nine international study groups or treatment centers. RESULTS Among 2,426 patients with NPM1mut/ FLT3-ITDneg/low AML, 2,000 (82.4%) had a normal and 426 (17.6%) had an abnormal karyotype, including 329 patients (13.6%) with intermediate and 83 patients (3.4%) with adverse-risk chromosomal abnormalities. In patients with NPM1mut/ FLT3-ITDneg/low AML, adverse ...

Transactions on Transport Sciences

The goal of this work was to analyze the behavior of drivers on third class roads with and withou... more The goal of this work was to analyze the behavior of drivers on third class roads with and without horizontal lane marking. The roads have low traffic volume, and therefore a conventional short-term study would not be able to provide enough data. We used recording devices for long-term (weeks) recording of the traffic and designed a system for analyzing the trajectories of the vehicles by means of computer vision. We collected a dataset at 6 distinct locations, containing 1 010 hours of daytime video. In this dataset, we tracked over 12 000 cars and analyzed their trajectories. The results show that the selected approach is functional and provides information that would be difficult to mine otherwise. After application of the horizontal markings, the drivers slowed down and shifted slightly towards the outer side of the curve.

Archaeological and Anthropological Sciences

The number of species of crop plants in Central Europe increased constantly during the Bronze Age... more The number of species of crop plants in Central Europe increased constantly during the Bronze Age. The structure of the composition of cultivated plants was probably connected to the cultural contacts of human populations. During the Bronze Age (2300/2000–800 BC), the region of South Bohemia (Czech Republic) increasingly became the focus of long-distance trade and exchange networks with regions to the east and many other regions (the Eastern Alps, the Alpine Foreland, the central lowlands of the Czech Republic, Hungary and Western Slovakia). The aim of the paper is to examine archaeobotanical assemblages of charred plant remains to see if these changes within Bronze Age societies, and their spheres of interaction, are also recorded within their agricultural practices. In particular, the importance of specific individual crop species can be reflected in the study region in comparison with other individual regions of Central Europe. Humans in the region of South Bohemia had more connections with the Eastern Alps and the Alpine Foreland region during the Early and Middle Bronze Ages. Regarding the structure of crop species, the composition of sub/dominant crops in South Bohemia and the Eastern Alps and the Alpine Foreland had many similarities. The cultural trajectory of the human populations of the South Bohemian region changed substantially in the Late and Final Bronze Ages: intensive contacts are documented, primarily with the region of Central Bohemia. This is reflected in the composition of the sub/dominant crops in South Bohemia, which shows many similarities to the other regions of the Czech Republic. Changes in migration and exchange networks—in particular those that involvedmore formalised trade—are associated with a large number of innovations and specific goods and led to much wider levels of cultural and social integration within Bronze Age Europe than had been previously seen.

Palaeogeography, Palaeoclimatology, Palaeoecology

Journal of Physics: Conference Series

Construction of a model of Quantum Gravity, which will be one day in concordance with experiments... more Construction of a model of Quantum Gravity, which will be one day in concordance with experiments, is one of the most fascinating tasks which we have in modern theoretical physics. There are common phenomenons for all of the approaches to quantum gravity, which were developed so far. We mention the non-locality, dark energy and dimensional reduction. Then we introduce the concept of nonlinear graviton and we suggest the mathematical apparatus for Quantum Gravity. We discuss further the problematics of Feynman path integral. We end with a possible experimental evidence for our approach and we pose a list of open questions.

Central European Journal of Public Health

We would like to submit the following correction to our recently published paper due to an error ... more We would like to submit the following correction to our recently published paper due to an error in the Table 2. The corrected table is given below.

Textile Research Journal

This study presents an investigation into the sound absorption behavior and compression propertie... more This study presents an investigation into the sound absorption behavior and compression properties of perpendicular-laid nonwovens. Seven types of perpendicular-laid nonwovens produced by vibrating and rotating perpendicular lappers were selected. Nonwovens with varying thickness and areal density were prepared by the heat-pressing method to investigate the effect of structural parameters such as thickness and areal density on sound absorption ability. Measurements of sound absorption properties were carried out with a Brüel and Kjær measuring instrument. The effect of manufacturing techniques on sound absorption performance and compression properties was investigated. The effect of porosity on sound absorption ability was studied. The influence of density and fiber orientation angle on compression properties was analyzed. The results show that samples prepared by vibrating perpendicular lapper exhibit better compression properties, whereas there is no significant influence of two m...

Kvasny Prumysl

II. Buněčný cyklus tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPT... more II. Buněčný cyklus tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE AND CELL CYCLE OF BREWING YEAST II. Cell cycle of three brewing yeast strains during pilot plant fermentation

Kvasny Prumysl

sacharidů tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE ... more sacharidů tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE AND CELL CYCLE OF BREWING YEAST I. Wort sugars metabolism of three brewing yeast strains during pilot plant fermentation

International journal of molecular sciences, Jan 19, 2018

Cytokinin is a multifaceted plant hormone that plays major roles not only in diverse plant growth... more Cytokinin is a multifaceted plant hormone that plays major roles not only in diverse plant growth and development processes, but also stress responses. We summarize knowledge of the roles of its metabolism, transport, and signalling in responses to changes in levels of both macronutrients (nitrogen, phosphorus, potassium, sulphur) and micronutrients (boron, iron, silicon, selenium). We comment on cytokinin's effects on plants' xenobiotic resistance, and its interactions with light, temperature, drought, and salinity signals. Further, we have compiled a list of abiotic stress-related genes and demonstrate that their expression patterns overlap with those of cytokinin metabolism and signalling genes.

Acta parasitologica, Jan 20, 2017

The study was focused on the dynamics of humoral response to Toxocara canis excretory-secretory a... more The study was focused on the dynamics of humoral response to Toxocara canis excretory-secretory antigens (TES antigens) in mice experimentally infected by T. canis L3 larvae in different ways. In particular, we compared the effect of infection with two doses of 1000 larvae vs. repeated infections with a low number of larvae (daily infection with 10 larvae and weekly infection with 100 larvae in the course of 22 weeks). In ELISA, all infections, including both schemes with lower larval doses, elicited significant antibody response. Elevated levels of total IgE and TES-antigen-specific IgM were detected on day 12 after the first infection, followed by IgG and IgG1, and later by IgG3, IgG2a and IgG2b; specific IgE response was not detected. It seems that the high levels of IgM and IgG1 represent the best markers of infection. In addition, gradual increase of IgG2a and IgG2b could help in determination of the infection course. As a byproduct of our work, a new method of infection by rep...

Clinical lymphoma, myeloma & leukemia, Feb 7, 2017

We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-... more We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-risk cytogenetics in first complete remission (CR1) to evaluate the usage and efficacy of various types of postremission therapy. Cox regression with time-dependent covariates, landmark analysis, and competing risk models were used to estimate the outcomes and effects of treatment and patient- and disease-related risk factors. The early relapse rate and early nonrelapse mortality (NRM) were 12.8% and 4.4%, respectively. In our study, 77.2% of patients completed postremission therapy: 44% received allogeneic hematopoietic cell transplantation (HCT), 20% completed treatment with high-dose cytarabine (HIDAC), and 13% completed treatment with intermediate-dose cytarabine. The 3-year overall survival rate was 67.5% for patients treated with HIDAC and 63.4% after HCT (P = .5876). The NRM and relapse rate at 3 years were 0% and 58.9% after HIDAC and 21.9% and 29.3% after HCT, respectively. HCT ...

ACM Transactions on Graphics

Children

Changes in lifestyle can be significantly reflected in growth and development. Adaptations to red... more Changes in lifestyle can be significantly reflected in growth and development. Adaptations to reduced levels of physical activity, together with non-corresponding nutritional intakes, can result in body build and body composition changes at an early age. The present cross-sectional study aimed to evaluate the secular trend of modifications of body composition and body mass index (BMI) in Czech preschoolers over the last two to three decades. Boys and girls (386 boys and 372 girls) aged 4 to 6 years in 2014–2019 were measured. Outcome data were compared with the reference sample of preschoolers from 1990: 911 boys and 896 girls. Body height, BMI, and percentage of body fat, muscle, and bone mass were evaluated. Height and BMI have not changed. Body fat increased in both genders (p < 0.01), and contrarily, a significant reduction of muscle and skeletal mass was revealed (p < 0.001). Significant changes in body composition and unchanged BMI indicate the development of latent obes...

Beverages

Bottle conditioning refers to a method of adding fermenting wort or yeast suspension in sugar sol... more Bottle conditioning refers to a method of adding fermenting wort or yeast suspension in sugar solution into beer in its final package. Additionally denoted as bottle refermentation, this technique has been originally developed to assure beer carbonation, and has further significance related to formation of distinctive sensory attributes and enhancement of sensory stability, which are the phenomena associated with ongoing yeast metabolic activities in the final package. This review covers historical development of the method, describes metabolic pathways applied during refermentation, and explains practical aspects of the refermentation process management. Furthermore, an overview of the traditional and novel approaches of bottle conditioning with mixed yeast bacterial cultures and its impact on the properties of final beer is provided.

Vegetation History and Archaeobotany

Interní medicína pro praxi

PŘEHLEDOVÉ ČLÁNKY Flow mediated dilation-její úloha a význam ve screeningu rizika kardiovaskulárn... more PŘEHLEDOVÉ ČLÁNKY Flow mediated dilation-její úloha a význam ve screeningu rizika kardiovaskulárních chorob

Urologie pro praxi

Autoři shrnují farmakologické a klinické poznatky o topické léčbě poruchy erekce alprostadilem v ... more Autoři shrnují farmakologické a klinické poznatky o topické léčbě poruchy erekce alprostadilem v krému.

Journal of Clinical Oncology

PURPOSE Nucleophosmin 1 ( NPM1) mutations are associated with a favorable prognosis in acute myel... more PURPOSE Nucleophosmin 1 ( NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene ( FLT3) is absent ( FLT3-ITDneg) or present with a low allelic ratio ( FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We investigated the validity of this assumption. METHODS We analyzed associations between karyotype and outcome in intensively treated patients with NPM1mut/ FLT3-ITDneg/low AML who were prospectively enrolled in registry databases from nine international study groups or treatment centers. RESULTS Among 2,426 patients with NPM1mut/ FLT3-ITDneg/low AML, 2,000 (82.4%) had a normal and 426 (17.6%) had an abnormal karyotype, including 329 patients (13.6%) with intermediate and 83 patients (3.4%) with adverse-risk chromosomal abnormalities. In patients with NPM1mut/ FLT3-ITDneg/low AML, adverse ...

Transactions on Transport Sciences

The goal of this work was to analyze the behavior of drivers on third class roads with and withou... more The goal of this work was to analyze the behavior of drivers on third class roads with and without horizontal lane marking. The roads have low traffic volume, and therefore a conventional short-term study would not be able to provide enough data. We used recording devices for long-term (weeks) recording of the traffic and designed a system for analyzing the trajectories of the vehicles by means of computer vision. We collected a dataset at 6 distinct locations, containing 1 010 hours of daytime video. In this dataset, we tracked over 12 000 cars and analyzed their trajectories. The results show that the selected approach is functional and provides information that would be difficult to mine otherwise. After application of the horizontal markings, the drivers slowed down and shifted slightly towards the outer side of the curve.

Archaeological and Anthropological Sciences

The number of species of crop plants in Central Europe increased constantly during the Bronze Age... more The number of species of crop plants in Central Europe increased constantly during the Bronze Age. The structure of the composition of cultivated plants was probably connected to the cultural contacts of human populations. During the Bronze Age (2300/2000–800 BC), the region of South Bohemia (Czech Republic) increasingly became the focus of long-distance trade and exchange networks with regions to the east and many other regions (the Eastern Alps, the Alpine Foreland, the central lowlands of the Czech Republic, Hungary and Western Slovakia). The aim of the paper is to examine archaeobotanical assemblages of charred plant remains to see if these changes within Bronze Age societies, and their spheres of interaction, are also recorded within their agricultural practices. In particular, the importance of specific individual crop species can be reflected in the study region in comparison with other individual regions of Central Europe. Humans in the region of South Bohemia had more connections with the Eastern Alps and the Alpine Foreland region during the Early and Middle Bronze Ages. Regarding the structure of crop species, the composition of sub/dominant crops in South Bohemia and the Eastern Alps and the Alpine Foreland had many similarities. The cultural trajectory of the human populations of the South Bohemian region changed substantially in the Late and Final Bronze Ages: intensive contacts are documented, primarily with the region of Central Bohemia. This is reflected in the composition of the sub/dominant crops in South Bohemia, which shows many similarities to the other regions of the Czech Republic. Changes in migration and exchange networks—in particular those that involvedmore formalised trade—are associated with a large number of innovations and specific goods and led to much wider levels of cultural and social integration within Bronze Age Europe than had been previously seen.

Palaeogeography, Palaeoclimatology, Palaeoecology

Journal of Physics: Conference Series

Construction of a model of Quantum Gravity, which will be one day in concordance with experiments... more Construction of a model of Quantum Gravity, which will be one day in concordance with experiments, is one of the most fascinating tasks which we have in modern theoretical physics. There are common phenomenons for all of the approaches to quantum gravity, which were developed so far. We mention the non-locality, dark energy and dimensional reduction. Then we introduce the concept of nonlinear graviton and we suggest the mathematical apparatus for Quantum Gravity. We discuss further the problematics of Feynman path integral. We end with a possible experimental evidence for our approach and we pose a list of open questions.

Central European Journal of Public Health

We would like to submit the following correction to our recently published paper due to an error ... more We would like to submit the following correction to our recently published paper due to an error in the Table 2. The corrected table is given below.

Textile Research Journal

This study presents an investigation into the sound absorption behavior and compression propertie... more This study presents an investigation into the sound absorption behavior and compression properties of perpendicular-laid nonwovens. Seven types of perpendicular-laid nonwovens produced by vibrating and rotating perpendicular lappers were selected. Nonwovens with varying thickness and areal density were prepared by the heat-pressing method to investigate the effect of structural parameters such as thickness and areal density on sound absorption ability. Measurements of sound absorption properties were carried out with a Brüel and Kjær measuring instrument. The effect of manufacturing techniques on sound absorption performance and compression properties was investigated. The effect of porosity on sound absorption ability was studied. The influence of density and fiber orientation angle on compression properties was analyzed. The results show that samples prepared by vibrating perpendicular lapper exhibit better compression properties, whereas there is no significant influence of two m...

Kvasny Prumysl

II. Buněčný cyklus tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPT... more II. Buněčný cyklus tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE AND CELL CYCLE OF BREWING YEAST II. Cell cycle of three brewing yeast strains during pilot plant fermentation

Kvasny Prumysl

sacharidů tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE ... more sacharidů tří kmenů pivovarských kvasinek za podmínek modelového kvašení WORT SUGARS UPTAKE RATE AND CELL CYCLE OF BREWING YEAST I. Wort sugars metabolism of three brewing yeast strains during pilot plant fermentation

International journal of molecular sciences, Jan 19, 2018

Cytokinin is a multifaceted plant hormone that plays major roles not only in diverse plant growth... more Cytokinin is a multifaceted plant hormone that plays major roles not only in diverse plant growth and development processes, but also stress responses. We summarize knowledge of the roles of its metabolism, transport, and signalling in responses to changes in levels of both macronutrients (nitrogen, phosphorus, potassium, sulphur) and micronutrients (boron, iron, silicon, selenium). We comment on cytokinin's effects on plants' xenobiotic resistance, and its interactions with light, temperature, drought, and salinity signals. Further, we have compiled a list of abiotic stress-related genes and demonstrate that their expression patterns overlap with those of cytokinin metabolism and signalling genes.

Acta parasitologica, Jan 20, 2017

The study was focused on the dynamics of humoral response to Toxocara canis excretory-secretory a... more The study was focused on the dynamics of humoral response to Toxocara canis excretory-secretory antigens (TES antigens) in mice experimentally infected by T. canis L3 larvae in different ways. In particular, we compared the effect of infection with two doses of 1000 larvae vs. repeated infections with a low number of larvae (daily infection with 10 larvae and weekly infection with 100 larvae in the course of 22 weeks). In ELISA, all infections, including both schemes with lower larval doses, elicited significant antibody response. Elevated levels of total IgE and TES-antigen-specific IgM were detected on day 12 after the first infection, followed by IgG and IgG1, and later by IgG3, IgG2a and IgG2b; specific IgE response was not detected. It seems that the high levels of IgM and IgG1 represent the best markers of infection. In addition, gradual increase of IgG2a and IgG2b could help in determination of the infection course. As a byproduct of our work, a new method of infection by rep...

Clinical lymphoma, myeloma & leukemia, Feb 7, 2017

We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-... more We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-risk cytogenetics in first complete remission (CR1) to evaluate the usage and efficacy of various types of postremission therapy. Cox regression with time-dependent covariates, landmark analysis, and competing risk models were used to estimate the outcomes and effects of treatment and patient- and disease-related risk factors. The early relapse rate and early nonrelapse mortality (NRM) were 12.8% and 4.4%, respectively. In our study, 77.2% of patients completed postremission therapy: 44% received allogeneic hematopoietic cell transplantation (HCT), 20% completed treatment with high-dose cytarabine (HIDAC), and 13% completed treatment with intermediate-dose cytarabine. The 3-year overall survival rate was 67.5% for patients treated with HIDAC and 63.4% after HCT (P = .5876). The NRM and relapse rate at 3 years were 0% and 58.9% after HIDAC and 21.9% and 29.3% after HCT, respectively. HCT ...

ACM Transactions on Graphics