Jane Ramberg - Academia.edu (original) (raw)

Papers by Jane Ramberg

Background: Recent research on the consumption of Ambrotose ® complex, a mixture of polysaccharid... more Background: Recent research on the consumption of Ambrotose ® complex, a mixture of polysaccharides from aloe vera, Larch and various gums, has demonstrated improvements in cognitive function and mood in healthy adults. While the immunomodulatory functions of specific oral polysaccharides are fairly well-established (1), their ability to affect brain function is a relatively novel concept. A comprehensive collection of the available literature on this subject would be a useful tool for researchers interested in the cognitive and mood effects of dietary polysaccharides.

Interactions between intercellular adhesion molecule 1 (ICAM-1, CD54) and leukocyte func- tion-as... more Interactions between intercellular adhesion molecule 1 (ICAM-1, CD54) and leukocyte func- tion-associated antigen 1 (LFA-1, CD11aICD18) play a critical role in T cell-B cell collaboration. The current cx- periments were carried out to determine the expression and distribution of these adhesion molecules on human peripheral T cells and B cells during T cell-B cell collabo- ration. Resting CD4� T cells

Nutrition Journal, 2010

Background: A large body of literature suggests that certain polysaccharides affect immune system... more Background: A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides.

Pullulan standards (5,000; 0,000; and 800,000 MW) were added to deionized water (about mg/ml) and... more Pullulan standards (5,000; 0,000; and 800,000 MW) were added to deionized water (about mg/ml) and analyzed by HPLC £ to confirm that EP dialysis had eliminated the

Nutritional Neuroscience, 2012

Objectives: Current research efforts are centered on delineating the novel health benefits of nat... more Objectives: Current research efforts are centered on delineating the novel health benefits of naturally derived saccharides, including growing interest in their abilities to influence neurologic health. We performed a comprehensive review of the literature to consolidate all controlled studies assessing various roles of exogenous saccharide compounds and polysaccharide-rich extracts from plants, fungi, and other natural sources on brain function, with a significant focus on benefits derived from oral intake. Methods: Studies were identified by conducting electronic searches on PubMed and Google Scholar. Reference lists of articles were also reviewed for additional relevant studies. Only articles published in English were included in this review. Results: Six randomized, double-blind, placebo-controlled clinical studies were identified in which consumption of a blend of plant-derived polysaccharides showed positive effects on cognitive function and mood in healthy adults. A separate controlled clinical study observed improvements in well-being with ingestion of a yeast beta-glucan. Numerous animal and in vitro studies have demonstrated the ability of individual saccharide compounds and polysaccharide-rich extracts to modify behavior, enhance synaptic plasticity, and provide neuroprotective effects. Discussion: Although the mechanisms by which exogenous saccharides can influence brain function are not well understood at this time, the literature suggests that certain naturally occurring compounds and polysaccharide-rich extracts show promise, when taken orally, in supporting neurologic health and function. Additional well-controlled clinical studies on larger populations are necessary, however, before specific recommendations can be made.

Neuropsychopharmacology, 1999

The question of whether schizophrenic-like disorders are neurodevelopmental or degenerative in or... more The question of whether schizophrenic-like disorders are neurodevelopmental or degenerative in origin has been argued since the time of Kraepelin. The authors provide evidence for the existence of two etiologically distinct endophenotypes of the psychoses contained within the rubric of familial non-affective psychosis (schizophrenia), one atrophic and the other neurodevelopmental. The atrophic psychosis, identified by progressive ventricular enlargement throughout adult illness, evidences progressive impairment of interests, relationships, and withdrawal from latency through adolescence, with emergence of trait-like negative symptoms which are only marginally responsive to conventional neuroleptics. This psychosis also exhibits delayed response of positive symptoms during neuroleptic treatment, and may also proceed to a praecox dementia in later life. In contrast, a putative neurodevelopmental psychosis, associated with static ventricles during the course of adult illness, also demonstrates preadolescent impairments, but impairments which do not progress to marked negative symptoms. Conventional neuroleptics appear to have little effect (except sedation) on positive symptoms, but appear to induce negative symptomatology and partial disengagement from the burden of persistent psychotic thought processes in such static ventricle psychoses. Thus, separate patterns of illnesses with different prodromal features, different treatment response patterns, and different patterns of residual (negative) symptoms appear to characterize patients with psychosis who have expanding as opposed to stable cerebral-ventricles at doses of neuroleptic at 10 mg haloperidol equivalents/day.

Annals of the Rheumatic Diseases, 2007

Schizophrenia Bulletin, 1998

Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly propo... more Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative

Background: Recent research on the consumption of Ambrotose ® complex, a mixture of polysaccharid... more Background: Recent research on the consumption of Ambrotose ® complex, a mixture of polysaccharides from aloe vera, Larch and various gums, has demonstrated improvements in cognitive function and mood in healthy adults. While the immunomodulatory functions of specific oral polysaccharides are fairly well-established (1), their ability to affect brain function is a relatively novel concept. A comprehensive collection of the available literature on this subject would be a useful tool for researchers interested in the cognitive and mood effects of dietary polysaccharides.

Interactions between intercellular adhesion molecule 1 (ICAM-1, CD54) and leukocyte func- tion-as... more Interactions between intercellular adhesion molecule 1 (ICAM-1, CD54) and leukocyte func- tion-associated antigen 1 (LFA-1, CD11aICD18) play a critical role in T cell-B cell collaboration. The current cx- periments were carried out to determine the expression and distribution of these adhesion molecules on human peripheral T cells and B cells during T cell-B cell collabo- ration. Resting CD4� T cells

Nutrition Journal, 2010

Background: A large body of literature suggests that certain polysaccharides affect immune system... more Background: A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides.

Pullulan standards (5,000; 0,000; and 800,000 MW) were added to deionized water (about mg/ml) and... more Pullulan standards (5,000; 0,000; and 800,000 MW) were added to deionized water (about mg/ml) and analyzed by HPLC £ to confirm that EP dialysis had eliminated the

Nutritional Neuroscience, 2012

Objectives: Current research efforts are centered on delineating the novel health benefits of nat... more Objectives: Current research efforts are centered on delineating the novel health benefits of naturally derived saccharides, including growing interest in their abilities to influence neurologic health. We performed a comprehensive review of the literature to consolidate all controlled studies assessing various roles of exogenous saccharide compounds and polysaccharide-rich extracts from plants, fungi, and other natural sources on brain function, with a significant focus on benefits derived from oral intake. Methods: Studies were identified by conducting electronic searches on PubMed and Google Scholar. Reference lists of articles were also reviewed for additional relevant studies. Only articles published in English were included in this review. Results: Six randomized, double-blind, placebo-controlled clinical studies were identified in which consumption of a blend of plant-derived polysaccharides showed positive effects on cognitive function and mood in healthy adults. A separate controlled clinical study observed improvements in well-being with ingestion of a yeast beta-glucan. Numerous animal and in vitro studies have demonstrated the ability of individual saccharide compounds and polysaccharide-rich extracts to modify behavior, enhance synaptic plasticity, and provide neuroprotective effects. Discussion: Although the mechanisms by which exogenous saccharides can influence brain function are not well understood at this time, the literature suggests that certain naturally occurring compounds and polysaccharide-rich extracts show promise, when taken orally, in supporting neurologic health and function. Additional well-controlled clinical studies on larger populations are necessary, however, before specific recommendations can be made.

Neuropsychopharmacology, 1999

The question of whether schizophrenic-like disorders are neurodevelopmental or degenerative in or... more The question of whether schizophrenic-like disorders are neurodevelopmental or degenerative in origin has been argued since the time of Kraepelin. The authors provide evidence for the existence of two etiologically distinct endophenotypes of the psychoses contained within the rubric of familial non-affective psychosis (schizophrenia), one atrophic and the other neurodevelopmental. The atrophic psychosis, identified by progressive ventricular enlargement throughout adult illness, evidences progressive impairment of interests, relationships, and withdrawal from latency through adolescence, with emergence of trait-like negative symptoms which are only marginally responsive to conventional neuroleptics. This psychosis also exhibits delayed response of positive symptoms during neuroleptic treatment, and may also proceed to a praecox dementia in later life. In contrast, a putative neurodevelopmental psychosis, associated with static ventricles during the course of adult illness, also demonstrates preadolescent impairments, but impairments which do not progress to marked negative symptoms. Conventional neuroleptics appear to have little effect (except sedation) on positive symptoms, but appear to induce negative symptomatology and partial disengagement from the burden of persistent psychotic thought processes in such static ventricle psychoses. Thus, separate patterns of illnesses with different prodromal features, different treatment response patterns, and different patterns of residual (negative) symptoms appear to characterize patients with psychosis who have expanding as opposed to stable cerebral-ventricles at doses of neuroleptic at 10 mg haloperidol equivalents/day.

Annals of the Rheumatic Diseases, 2007

Schizophrenia Bulletin, 1998

Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly propo... more Whereas etiological heterogeneity of the various types of schizophrenia has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of schizophrenia, we demonstrate that currently available data on schizophrenia patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative