Jane Trinca - Academia.edu (original) (raw)

Papers by Jane Trinca

Pain and therapy, Dec 18, 2021

Introduction: This phase I open-label study examined pharmacokinetics, safety, and tolerability o... more Introduction: This phase I open-label study examined pharmacokinetics, safety, and tolerability of escalating doses of a novel combination cannabinoid medication (1:1 tetrahydrocannabinol [THC]/cannabidiol [CBD]) in patients with chronic non-cancer pain (CNCP) on high dose opioid analgesia. Methods: Nine people with CNCP and oral morphine equivalent daily dose of 60 mg or higher were recruited. Blood concentrations of THC, 11-hydroxytetrahydrocannabinol (OH-THC), 11-nor-9-carboxy-tetrahydrocannabinol (COOH-THC), and CBD were assayed weekly. Concentrations were measured after a single dose of 2.5 mg THC/2.5 mg CBD on day 1, and daily escalating doses up to a single dose of 12.5 mg THC/12.5 mg CBD on day 29. Followup was on day 36 after a 7-day washout. Secondary outcome data encompassed pain, mood, and sleep parameters. Results: The parent compounds THC, and CBD, and metabolites OH-THC and COOH-THC were detected at most time points. In general, the concentration of all analytes increased until 2 h post-administration,

Anaesthesia and Intensive Care, Aug 1, 2001

Most universities in the Middle East and North America are relying on implementing various techno... more Most universities in the Middle East and North America are relying on implementing various technological tools in the math curriculum. This research is a unique attempt that compares students attitudes towards technology use in math classes in two private universities, Middle Eastern and North American. The Acceptance Technology Model (TAM) has been widely used by researchers to test user's acceptance of technology. In this study, we integrate TAM and user satisfaction. A sample of 400 students participated in this study that test students' acceptance of MathXL as a technological tool in their math classes. Structural equation melding which included various constructs was used based on the integration of TAM and user satisfaction. In the two groups of students, the results support the theoretical model showing the importance of user satisfaction on perceived ease of use and subjective norm on behavioral intention.

Administration of analgesic medicines

Analgesic medicines can be administered by a number of different routes, either relying on a syst... more Analgesic medicines can be administered by a number of different routes, either relying on a systemic or local effect or a combination of both. The choice of route may be determined by various factors, including the aetiology, severity, location and type of pain, the patient's overall condition and the characteristics of the chosen administration technique. Additional factors to consider with any route of administration are ease of use, accessibility, speed of analgesic onset, reliability of effect, duration of action, patient acceptability and cost.

Knowledge of and willingness to try acupuncture for postoperative nausea and vomiting: an Australian survey of surgical patients

Acupuncture in medicine : journal of the British Medical Acupuncture Society, Jan 27, 2017

Level 1 evidence supports the use of acupuncture as a safe and effective treatment for postoperat... more Level 1 evidence supports the use of acupuncture as a safe and effective treatment for postoperative nausea and vomiting (PONV). However, to date, very few hospitals in Western countries have incorporated this technique into their management strategies. To conduct a survey to establish patientsâ€™ knowledge and opinions of acupuncture as a treatment option for the management of PONV in a large Western teaching hospital that did not offer acupuncture. Over a 4-week period, a self-completed, anonymous questionnaire survey was distributed to 171 consecutive patients attending the preadmission clinic pending surgery. Overall, 161 participants met the selection criteria and completed the survey (100%). The majority of them had a European background (88.8%) and were over 40 years old (87.6%). Seventy-eight participants (48%) had a history of nausea and vomiting and 39 (24%) had suffered from PONV. One hundred and four (65%) and 110 (68%) patients, respectively, stated that they would be w...

Medical Journal of Australia, 2016

Length of stay after open radical retropubic prostatectomy with intravenous lignocaine followed by a 24-hour subcutaneous infusion: blinded placebo controlled multicentre trial

Anaesthesia and intensive care

An adherent transversus abdominis plane catheter

Anaesthesia and intensive care, 2011

Pain Medicine, 2012

Objectives. Temporomandibular disorders and orofacial pain are common presenting conditions to de... more Objectives. Temporomandibular disorders and orofacial pain are common presenting conditions to dentists. There has been a call for improvement in teaching about these conditions in the international literature since the 1970s. Design. This study evaluates the current state of knowledge about basic pain mechanisms and management in dental students and dentists in Victoria, Australia, using a pain knowledge test adapted for dentists. Results. The results show that overall 47% of fourth year dental students and 58% of final year dental students scored correctly on the pain knowledge test compared with 48% of a convenience sample of practicing dentists on the same test. Conclusions. This pilot study indicates that levels of knowledge about pain are consistently low among dental students. There does appear to be improvement in knowledge after exposure to teaching in advanced training years in this dental school. There is some evidence that graduate dentists as a group may also have low levels of knowledge about basic pain mechanisms and evidenced-based treatment principles. This study highlights the need for improved training of dentists and dental students with regard to pain and orofacial pain.

Other specific patient groups

Pregnant women with pain that is severe enough to warrant pharmacological treatment (self-adminis... more Pregnant women with pain that is severe enough to warrant pharmacological treatment (self-administered or prescribed by attendants) represent a challenging group as medicines given to them almost always cross the placenta. While most medicines are safe, there are particular times of concern, notably the period of organogenesis (wk 4-10) and just before birth. Where possible, nonpharmacological treatment options should be considered before analgesic medications are used. Ongoing analgesic use requires close liaison between the health professional managing the pregnancy and the health professional managing the pain.

Pharmacokinetics, safety, and tolerability of a THC:CBD oil formulation in patients with chronic non-cancer pain on long term high dose opioid analgesia

Aim This Phase I open label study examined pharmacokinetics, safety, and tolerability of escalati... more Aim This Phase I open label study examined pharmacokinetics, safety, and tolerability of escalating doses of a combination cannabinoid medication (1:1 ratio THC:CBD) in patients with chronic non-cancer pain (CNCP) on high dose opioid analgesia. Methods Nine people with CNCP and oral morphine equivalent daily dose of ≥60mg were recruited. Blood concentrations of THC, 11-hydroxytetrahydrocannabinol (OH-THC), 11-nor-9-carboxy-tetrahydrocannabinol (COOH-THC) and CBD were assayed weekly. Concentrations were measured after a single dose of 2.5mg THC/2.5mg CBD up to 12.5mg THC/12.5mg CBD on Day 29. Follow-up was on Day 36 after 7 day washout. Secondary outcome data encompassed pain, mood, and sleep parameters. Results The parent THC, CBD, OH-THC, COOH-THC were detected at most time points. In general, the concentration of all analytes increased until 2 hours post-administration, decreasing to approximately pre-dose concentrations by 8 hrs. There was considerable inter- and intra-individual...

Abdominal aortic aneurysm repair and coronary artery grafting as a combined procedure on cardiopulmonary bypass

Journal of Cardiothoracic Anesthesia, 1989

Pain Medicine, 2007

The National Prescribing Service (NPS) in collaboration with State DUE Groups is undertaking a qu... more The National Prescribing Service (NPS) in collaboration with State DUE Groups is undertaking a quality improvement initiative aimed at improving Acute PostOperative Pain management (the APOP project) in 63 Australian hospitals. Following discussions between NPS and ANZCA, it was decided to undertake a national survey of key acute pain service (APS) contacts to aid development of educational messages for the APOP project. The ANZCA Trials Group research co-ordinator and NPS supported survey development and processing.Purpose of the study: To gain an understanding of what expert acute pain service clinicians see as common prescribing errors and poor pain management practice in the postoperative patient, and to investigate the degree of consensus which exists for specific aspects of basic analgesic prescribing, monitoring and documentation.Methods: A postal questionnaire consisting of an open question regarding prescribing errors and 27 opinion statements was sent to 144 key APS contacts across Australia. This group included medical and nursing co-ordinators and a small group of clinical pharmacists with expertise in acute pain management. Opinion statements covered a range of topics including prescribing of opioids, tramadol, NSAIDs, and paracetamol, patient monitoring, and discharge medications.Results: A response rate of 74% was achieved, with extensive use of the open question and comments space. Common areas of concern included both under- and overdosing of opioids, use of multiple opioids via multiple routes, inappropriate dose intervals and under-use of paracetamol. There were high levels of agreement regarding several opinion statements, particularly the inappropriate use of pethidine, but divergent views on others, such as the maximum daily dose of tramadol.Conclusions: The survey provided information to the APOP project by identifying areas of educational need, highlighting specific analgesic prescribing practices judged to be correct by most experts as well as highlighting those where there is a lack of consensus.

Journal of Advanced Nursing, 2003

0 0 3 ) ( 2 0 0 3 ) Journal of Advanced Nursing 41 , 99-108 A study to evaluate the pain knowledg... more 0 0 3 ) ( 2 0 0 3 ) Journal of Advanced Nursing 41 , 99-108 A study to evaluate the pain knowledge of two sub-populations of final year nursing students: Australia and Philippines Background. Pain management is an essential and important aspect of nursing care. Deficits in pain knowledge and attitudes continue to be reported despite a growth of educational programmes. A lack of basic knowledge of pain at an undergraduate level may limit nurses from effectively developing their knowledge after graduation. Aim of the study. To assess the type and level of knowledge of basic aspects of pain mechanisms and treatment principles in complete classes of final year nurses, at three nursing schools. Method. Data were collected in 1999, from 150 students (81 Australian and 69 Philippine) via a 23-item pain knowledge test questionnaire, previously used to assess undergraduate health professionals including nurses. Results. The mean score of concordant answers for all students was 38AE6%, scores ranged from 0% to 70%, 95% Confidence Interval of the mean was 36-41%. There were few significant differences between the groups for individual questions and no significant difference in overall mean scores. Common questions answered poorly included those related to complex regional pain syndrome, pharmacology and central sensitization.