Jarmo Pystynen - Academia.edu (original) (raw)

Papers by Jarmo Pystynen

Research paper thumbnail of Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of 2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of Catechol derivatives, methods for their manufacture and their use as medicinal substances

Research paper thumbnail of Catechol derivatives, processes for their preparation and their use as medicaments

Research paper thumbnail of A process for the preparation of the pharmacologically active heterocyclic compounds

Research paper thumbnail of Derives de la naphthalene presentant une activite d'inhibition de l'enzyme comt

L'invention concerne les composes de la formule (I'). Dans cette derniere A, R1 a R3 et t... more L'invention concerne les composes de la formule (I'). Dans cette derniere A, R1 a R3 et t sont tels que definis dans les revendications. Ces composes presentent une activite inhibant l'enzyme COMT de telle sorte qu'ils consitutent des inhibiteurs de l'enzyme COMT tres utiles.

Research paper thumbnail of inhibiting the COMT enzyme activity are coumarin derivatives

Research paper thumbnail of Foerfarande Foer framstaellning of the substituted-b-diketoner

Research paper thumbnail of Pyridazinone Derivatives and Their Preparation Processes

Novel heterocyclic compounds of formula I HET IN WHICH ONE OF THE MEANS following groups: wherein... more Novel heterocyclic compounds of formula I HET IN WHICH ONE OF THE MEANS following groups: wherein R11, R13 and R14 independently of HYDROGEN GROUP hydroxymethyl or lower alkyl, Z is S, O, NH; A MEAN VALENCIA LIAISON GROUP -CH = CH-, -CH2-CH2- O GROUP; R1 and R2 independently nitrogen, cyano, amino, CARBOXILOAMIDO, aryl, aroyl, pyridyl, ALCOXILOCARBONILO, acyl or ONE of the following groups: wherein R6 is hydrogen or lower alkyl group, R8 is lower alkyl, R7 is cyano O COOR10, wherein R10 is hydrogen or lower alkyl or R1 and R2 together form a 5- or 6-membered substituted or unsubstituted, containing 1 or 2 heteroatoms of N; R3, R4 and R5 are independently hydrogen, hydroxyl or lower alkyl group; Y is CH NO. COMPOUNDS MAY BE USED IN THE TREATMENT OF HEART FAILURE Congestive OF.

Research paper thumbnail of inhibiting the COMT enzyme naphthalene

Research paper thumbnail of Composition pharmaceutique pour le traitement de la maladie de parkinson

Research paper thumbnail of Nya farmakologiskt aktiva foereningar, industry innehaollande The compositions samt foerfarande Science mellanprodukter Foer anvaendning at framstaellning of the year

Research paper thumbnail of Heterocyclic ring compound and its preparation

NEW MATERIAL: A compound of formula I [wherein Het is a group of formula II, a group of formula I... more NEW MATERIAL: A compound of formula I [wherein Het is a group of formula II, a group of formula III (wherein R 11 , R 13 , R 14 are each H, a lower alkyl; Z is S, O, NH), etc.; A is a direct bond or -CH=CH-, -CH 2 -CH 2 -; R 1 , R 2 are each NO 2 , CN, a halogen, carboxamido, pyridyl, etc., or R 1 and R 2 join to form a ring; R 3 -R 5 are each H, OH a lower alkyl; Y is N, CH]. EXAMPLE: 6-[4-(1,1-Dicyanomethylidenehydrazino)phenyl]-4,5-dihydro-5- methylpyridazin-3(2H)-one. USE: A cardiotonic, an antihypertensive, a vasodilator. PREPARATION: A compound of formula IV and a compound of formula V are reacted under an acidic condition of pH 3-6 at 0-5°C to obtain the compound of formula I, etc. COPYRIGHT: (C)1990,JPO

Research paper thumbnail of Entsyymiõ COMT inhibiting activity are coumarin derivatives

Research paper thumbnail of Substituted beta-diketone and inflammatory intestinal disease treating agent consisting of the same as effective component

PURPOSE: To provide an extremely excellent inflammatory intestinal disease treating agent consist... more PURPOSE: To provide an extremely excellent inflammatory intestinal disease treating agent consisting of partly novel and specific substd. β-diketone or its pharmacologically permissible salts or ester as an effective component. CONSTITUTION: This inflammatory intestinal disease treating agent is prepd. by using the substd. β-diketone of formula I [n is 0, 1; R 1 , R 2 are methyl, ethyl, cyclopropyl; R is formula II (X 1 is H, alkoxy; X 2 , X 3 are H, nitro, cyano, halogen, CF 3 , etc.), formula III (R 4 is H, nitro, halogen), formula IV] or its pharmacologically permissible salts or ester; for example, novel 2-[4- acetoamidphenyl)methylene]-1,3-dicyclopropyl-1,3 propanedione, etc., as the effective components. The compd. of formula VI (R 4 is formula II; R 5 is methyl, ethyl, cyclopropyl; R 6 is ethyl, cyclopropyl or R 5 , R 6 are methyl, R 4 is formula II) of the compd. the formula I, the salt and the ester are novel. COPYRIGHT: (C)1992,JPO

Research paper thumbnail of Catechol derivatives to processes for their preparation and their Verwending as medicaments

Research paper thumbnail of Pharmaceutical preparation, and catechol derivatives for the manufacture thereof

Research paper thumbnail of Laegemiddelpraeparat and catechol derivatives for the manufacture thereof

Research paper thumbnail of Process for preparing new derivatives of pharmacologically active catechol

NEW PROCESS FOR PREPARING catechol derivatives pharmacologically active formula (I) where differe... more NEW PROCESS FOR PREPARING catechol derivatives pharmacologically active formula (I) where different radicals have the meanings given in the description. SYNTHESIS AMONG OTHERS, the method comprises condensing a compound of formula (II) in the presence of an acid catalyst or base, with a compound of formula (III). The compounds (I) are pharmacologically active and may be applied AS DRUG FOR TREATING PARKINSON'S DISEASE OF STATES AND BUGS DEPRESSIVE CARDIAC.

Research paper thumbnail of An Ontology for Insider Threat Indicators Development and Applications

We describe our ongoing development of an insider threat indicator ontology. Our ontology is inte... more We describe our ongoing development of an insider threat indicator ontology. Our ontology is intended to serve as a standardized expression method for potential indicators of malicious insider activity, as well as a formalization of much of our team's research on insider threat detection, prevention, and mitigation. This ontology bridges the gap between natural language descriptions of malicious insiders, malicious insider activity, and machine-generated data that analysts and investigators use to detect behavioral and technical observables of insider activity. The ontology provides a mechanism for sharing and testing indicators of insider threat across multiple participants without compromising organization-sensitive data, thereby enhancing the data fusion and information sharing capabilities of the insider threat detection domain.

Research paper thumbnail of Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of 2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of Catechol derivatives, methods for their manufacture and their use as medicinal substances

Research paper thumbnail of Catechol derivatives, processes for their preparation and their use as medicaments

Research paper thumbnail of A process for the preparation of the pharmacologically active heterocyclic compounds

Research paper thumbnail of Derives de la naphthalene presentant une activite d'inhibition de l'enzyme comt

L'invention concerne les composes de la formule (I'). Dans cette derniere A, R1 a R3 et t... more L'invention concerne les composes de la formule (I'). Dans cette derniere A, R1 a R3 et t sont tels que definis dans les revendications. Ces composes presentent une activite inhibant l'enzyme COMT de telle sorte qu'ils consitutent des inhibiteurs de l'enzyme COMT tres utiles.

Research paper thumbnail of inhibiting the COMT enzyme activity are coumarin derivatives

Research paper thumbnail of Foerfarande Foer framstaellning of the substituted-b-diketoner

Research paper thumbnail of Pyridazinone Derivatives and Their Preparation Processes

Novel heterocyclic compounds of formula I HET IN WHICH ONE OF THE MEANS following groups: wherein... more Novel heterocyclic compounds of formula I HET IN WHICH ONE OF THE MEANS following groups: wherein R11, R13 and R14 independently of HYDROGEN GROUP hydroxymethyl or lower alkyl, Z is S, O, NH; A MEAN VALENCIA LIAISON GROUP -CH = CH-, -CH2-CH2- O GROUP; R1 and R2 independently nitrogen, cyano, amino, CARBOXILOAMIDO, aryl, aroyl, pyridyl, ALCOXILOCARBONILO, acyl or ONE of the following groups: wherein R6 is hydrogen or lower alkyl group, R8 is lower alkyl, R7 is cyano O COOR10, wherein R10 is hydrogen or lower alkyl or R1 and R2 together form a 5- or 6-membered substituted or unsubstituted, containing 1 or 2 heteroatoms of N; R3, R4 and R5 are independently hydrogen, hydroxyl or lower alkyl group; Y is CH NO. COMPOUNDS MAY BE USED IN THE TREATMENT OF HEART FAILURE Congestive OF.

Research paper thumbnail of inhibiting the COMT enzyme naphthalene

Research paper thumbnail of Composition pharmaceutique pour le traitement de la maladie de parkinson

Research paper thumbnail of Nya farmakologiskt aktiva foereningar, industry innehaollande The compositions samt foerfarande Science mellanprodukter Foer anvaendning at framstaellning of the year

Research paper thumbnail of Heterocyclic ring compound and its preparation

NEW MATERIAL: A compound of formula I [wherein Het is a group of formula II, a group of formula I... more NEW MATERIAL: A compound of formula I [wherein Het is a group of formula II, a group of formula III (wherein R 11 , R 13 , R 14 are each H, a lower alkyl; Z is S, O, NH), etc.; A is a direct bond or -CH=CH-, -CH 2 -CH 2 -; R 1 , R 2 are each NO 2 , CN, a halogen, carboxamido, pyridyl, etc., or R 1 and R 2 join to form a ring; R 3 -R 5 are each H, OH a lower alkyl; Y is N, CH]. EXAMPLE: 6-[4-(1,1-Dicyanomethylidenehydrazino)phenyl]-4,5-dihydro-5- methylpyridazin-3(2H)-one. USE: A cardiotonic, an antihypertensive, a vasodilator. PREPARATION: A compound of formula IV and a compound of formula V are reacted under an acidic condition of pH 3-6 at 0-5°C to obtain the compound of formula I, etc. COPYRIGHT: (C)1990,JPO

Research paper thumbnail of Entsyymiõ COMT inhibiting activity are coumarin derivatives

Research paper thumbnail of Substituted beta-diketone and inflammatory intestinal disease treating agent consisting of the same as effective component

PURPOSE: To provide an extremely excellent inflammatory intestinal disease treating agent consist... more PURPOSE: To provide an extremely excellent inflammatory intestinal disease treating agent consisting of partly novel and specific substd. β-diketone or its pharmacologically permissible salts or ester as an effective component. CONSTITUTION: This inflammatory intestinal disease treating agent is prepd. by using the substd. β-diketone of formula I [n is 0, 1; R 1 , R 2 are methyl, ethyl, cyclopropyl; R is formula II (X 1 is H, alkoxy; X 2 , X 3 are H, nitro, cyano, halogen, CF 3 , etc.), formula III (R 4 is H, nitro, halogen), formula IV] or its pharmacologically permissible salts or ester; for example, novel 2-[4- acetoamidphenyl)methylene]-1,3-dicyclopropyl-1,3 propanedione, etc., as the effective components. The compd. of formula VI (R 4 is formula II; R 5 is methyl, ethyl, cyclopropyl; R 6 is ethyl, cyclopropyl or R 5 , R 6 are methyl, R 4 is formula II) of the compd. the formula I, the salt and the ester are novel. COPYRIGHT: (C)1992,JPO

Research paper thumbnail of Catechol derivatives to processes for their preparation and their Verwending as medicaments

Research paper thumbnail of Pharmaceutical preparation, and catechol derivatives for the manufacture thereof

Research paper thumbnail of Laegemiddelpraeparat and catechol derivatives for the manufacture thereof

Research paper thumbnail of Process for preparing new derivatives of pharmacologically active catechol

NEW PROCESS FOR PREPARING catechol derivatives pharmacologically active formula (I) where differe... more NEW PROCESS FOR PREPARING catechol derivatives pharmacologically active formula (I) where different radicals have the meanings given in the description. SYNTHESIS AMONG OTHERS, the method comprises condensing a compound of formula (II) in the presence of an acid catalyst or base, with a compound of formula (III). The compounds (I) are pharmacologically active and may be applied AS DRUG FOR TREATING PARKINSON'S DISEASE OF STATES AND BUGS DEPRESSIVE CARDIAC.

Research paper thumbnail of An Ontology for Insider Threat Indicators Development and Applications

We describe our ongoing development of an insider threat indicator ontology. Our ontology is inte... more We describe our ongoing development of an insider threat indicator ontology. Our ontology is intended to serve as a standardized expression method for potential indicators of malicious insider activity, as well as a formalization of much of our team's research on insider threat detection, prevention, and mitigation. This ontology bridges the gap between natural language descriptions of malicious insiders, malicious insider activity, and machine-generated data that analysts and investigators use to detect behavioral and technical observables of insider activity. The ontology provides a mechanism for sharing and testing indicators of insider threat across multiple participants without compromising organization-sensitive data, thereby enhancing the data fusion and information sharing capabilities of the insider threat detection domain.