Jasmi Patel - Academia.edu (original) (raw)
Papers by Jasmi Patel
The problem of environmental pollution is one of the most burning topics and has been on the chec... more The problem of environmental pollution is one of the most burning topics and has been on the checklist of almost all the nations. Among these environmental pollutants, heavy metals such as lead, mercury, arsenic, chromium and cadmium have received special attention worldwide as they are widely distributed in nature and leads to widespread occurrence of specific toxicological problems (Patra and Swarup, 2000). Chromium is a naturally occurring element found in volcanic dust, rocks, soil, plants, and animals. The most common forms of chromium in the environment are hexavalent (Cr 6+) or chromate, and trivalent (Cr 3+) or chromites. Cr 6+ are widely used in industrial and chemical processes, such as leather tanning, printing, in hair dyes, steel manufacturing, and wood preservative production. In some regions, waste disposal of chromium compounds to the environment contributes to increase its presence and potential toxicity. Chromium induces dermatotoxicity, immunotoxicity, neurotoxicity, genotoxicity, and carcinogenicity (Bagchi et al., 2002). Chromium compounds induce oxidative stress leading to tissue damage (Stohs et al., 2001). Kawanishi et al., (1986) demonstrated that reactive oxygen species (ROS) including superoxide anion, singlet oxygen and hydroxyl radicals are generated during reduction process might be responsible for Cr (VI) toxicity. The present work was carried out to study biochemical and histopathological alterations induced by potassium dichromate toxicity. Materials and methods Experimental animals The study was conducted on fifty colony bred Albino Wistar strain rats of both sexes, which were procured from Cadilla Pharmaceuticals, Dholka,
Indian Journal of Veterinary Pathology, 2017
In present study subacute oral toxicity of thioglycolic acid was evaluated in rats. Forty Wistar ... more In present study subacute oral toxicity of thioglycolic acid was evaluated in rats. Forty Wistar rats of either sex were divided into four groups. Group I rats received only distilled water as a control, while Group II, III and IV were given thioglycolic acid dissolved in distilled water dosedat the rate of 6, 12 and 24 mg/kg b.wt., respectively, by oral gavage daily for 28 days. Clinically, Group IV (high dose) rats showed lethargy and decreased activity after 21day of experiment. There was significant increase in haemoglobin level in Group II female rats and increase in TEC in Group II and III female rats as compared to control rats. Significantly decrease in ALP infemale rats of Group II, III and IV as compared to control rats. Significantly decrease in creatinine level in Group II, III and IV male rats. The male rats of Group III revealed a significant increase in calcium level. Triglyceride level was significantly (p<0.05) decreased and increased in female rats of Group II and III respectively as compared to control rats. There was significant decrease in absolute and relative adrenal weight in Group II, III and IV female rats as compared to control. Mild pathomorphological changes were seen in lung, liver and spleen. Microscopically, in Group IV rats, lungs showed perivascular mononuclear cell infiltration, minimal alveolar histiocytic infiltration, congestion and emphysema; liverevincedcongestion and perivascular leukocytic infiltration; kidney showed mineralization in tubules; and spleen revealed yellowish intracellular pigmentation. In conclusion, thioglycolic acid did not produce any significant pathology in Wistar rats at dose rates of 6, 12 and 24 mg/kg b.wt.
Veterinarski Arhiv, 2021
1Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Sardarkrushi... more 1Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India 2Livestock Research Station, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India 3Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India
Indian Journal of Veterinary Pathology
The problem of environmental pollution is one of the most burning topics and has been on the chec... more The problem of environmental pollution is one of the most burning topics and has been on the checklist of almost all the nations. Among these environmental pollutants, heavy metals such as lead, mercury, arsenic, chromium and cadmium have received special attention worldwide as they are widely distributed in nature and leads to widespread occurrence of specific toxicological problems (Patra and Swarup, 2000). Chromium is a naturally occurring element found in volcanic dust, rocks, soil, plants, and animals. The most common forms of chromium in the environment are hexavalent (Cr 6+) or chromate, and trivalent (Cr 3+) or chromites. Cr 6+ are widely used in industrial and chemical processes, such as leather tanning, printing, in hair dyes, steel manufacturing, and wood preservative production. In some regions, waste disposal of chromium compounds to the environment contributes to increase its presence and potential toxicity. Chromium induces dermatotoxicity, immunotoxicity, neurotoxicity, genotoxicity, and carcinogenicity (Bagchi et al., 2002). Chromium compounds induce oxidative stress leading to tissue damage (Stohs et al., 2001). Kawanishi et al., (1986) demonstrated that reactive oxygen species (ROS) including superoxide anion, singlet oxygen and hydroxyl radicals are generated during reduction process might be responsible for Cr (VI) toxicity. The present work was carried out to study biochemical and histopathological alterations induced by potassium dichromate toxicity. Materials and methods Experimental animals The study was conducted on fifty colony bred Albino Wistar strain rats of both sexes, which were procured from Cadilla Pharmaceuticals, Dholka,
Indian Journal of Veterinary Pathology, 2017
In present study subacute oral toxicity of thioglycolic acid was evaluated in rats. Forty Wistar ... more In present study subacute oral toxicity of thioglycolic acid was evaluated in rats. Forty Wistar rats of either sex were divided into four groups. Group I rats received only distilled water as a control, while Group II, III and IV were given thioglycolic acid dissolved in distilled water dosedat the rate of 6, 12 and 24 mg/kg b.wt., respectively, by oral gavage daily for 28 days. Clinically, Group IV (high dose) rats showed lethargy and decreased activity after 21day of experiment. There was significant increase in haemoglobin level in Group II female rats and increase in TEC in Group II and III female rats as compared to control rats. Significantly decrease in ALP infemale rats of Group II, III and IV as compared to control rats. Significantly decrease in creatinine level in Group II, III and IV male rats. The male rats of Group III revealed a significant increase in calcium level. Triglyceride level was significantly (p<0.05) decreased and increased in female rats of Group II and III respectively as compared to control rats. There was significant decrease in absolute and relative adrenal weight in Group II, III and IV female rats as compared to control. Mild pathomorphological changes were seen in lung, liver and spleen. Microscopically, in Group IV rats, lungs showed perivascular mononuclear cell infiltration, minimal alveolar histiocytic infiltration, congestion and emphysema; liverevincedcongestion and perivascular leukocytic infiltration; kidney showed mineralization in tubules; and spleen revealed yellowish intracellular pigmentation. In conclusion, thioglycolic acid did not produce any significant pathology in Wistar rats at dose rates of 6, 12 and 24 mg/kg b.wt.
Veterinarski Arhiv, 2021
1Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Sardarkrushi... more 1Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India 2Livestock Research Station, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India 3Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India
Indian Journal of Veterinary Pathology