Jasmine Micklem - Academia.edu (original) (raw)

Papers by Jasmine Micklem

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, Apr 1, 2008

The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepa... more The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepatotoxic when administered orally to mice, and cytotoxic and genotoxic to human cell lines. To determine the effects of CYN on primary human IVF-derived granulosa cells, 0-1 g/ml CYN was added to cells for 2, 4 or 6 h ± hCG (n = 6), or for 24, 48 and 72 h (n = 6). Cytotoxicity was evaluated by MTT assay, and secreted progesterone or estrogen quantified by radioimmunoassay. 24 h exposure to 1 g/ml CYN was cytotoxic (p < 0.05), whereas 0.0625 g/ml CYN did not cause cytotoxicity or affect estrogen production, but did inhibit basal progesterone production (p < 0.01). Similarly, 6 h exposure to 1 g/ml CYN did not affect cytotoxicity or hCG-stimulated estrogen production, but did inhibit hCG-stimulated progesterone production (p < 0.01). In this in vitro assay, CYN inhibited progesterone production and therefore has the potential to be an endocrine disrupter by changing the progesterone:estrogen ratio in women.

Research paper thumbnail of Health-related quality of life after head and neck cancer: Aboriginal patients’ experiences in South and Central Australia

Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islan... more Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islander XIII Aims and objectives of study XIV Abbreviations and acronyms XV Chapter 1. Introduction and background 2

Research paper thumbnail of A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma

Journal of Laryngology and Otology, May 8, 2017

The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with t... more The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes. This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour-node-metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated. Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group. This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with primary surgery compared with primary chemoradiotherapy. This reflects overall lower tumour stage and higher human papillomavirus status in this group.

Research paper thumbnail of Self-reported health-related quality-of-life issues for Aboriginal and Torres Strait Islander patients with experience of cancer in Australia

International Journal of Evidence-based Healthcare, Dec 1, 2015

Background: Aboriginal peoples and Torres Strait Islander peoples (who comprise the indigenous pe... more Background: Aboriginal peoples and Torres Strait Islander peoples (who comprise the indigenous people or the original inhabitants of Australia before colonization) are more likely to experience cancers with poorer prognoses, are more likely to be diagnosed with cancer at a later stage of disease progression, are less likely to receive adequate cancer treatment and are more likely to pass away due to cancer, compared with other Australians. Cancer and biomedical therapies for cancer often have significant, ongoing effects on patient health-related quality of life (HRQL). Therefore, consideration of HRQL for Aboriginal and Torres Strait Islander peoples with experience of cancer in Australia is imperative. This article examines the literature for HRQL issues self-reported by Aboriginal and/or Torres Strait Islander people with experience of cancer in Australia. Methods: A search of peer-reviewed journal articles, government reports, and other literature was undertaken using electronic databases and citation snowballing. Self-reports from Aboriginal and/or Torres Strait Islander people with experience of cancer were examined. HRQL issues were determined utilizing the Australian Psycho-Oncology Cooperative Research Group's definition of HRQL. Results: Fifty-two documents were found with original data from Aboriginal and/or Torres Strait Islander people who self-reported their experiences of cancer. No published reports were found that specifically examined selfreports from Aboriginal and/or Torres Strait Islander people on the impact of cancer and biomedical treatment on their HRQL. Conclusion: Previous literature suggests that there is urgency for improved communication and cultural competency in cancer care for Aboriginal and Torres Strait Islander patients in Australia, with a stronger focus on meeting patient needs and improving HRQL. This review has provided insight into HRQL issues for Aboriginal and Torres Strait Islander patients with cancer in Australia. Further work using patient-reported outcomes measures would provide greater insight into the impact of cancer and biomedical treatments on Aboriginal and Torres Strait Islander patients' HRQL.

Research paper thumbnail of Cancer Data and Aboriginal Disparities Project (CanDAD) - an overdue cancer control initiative

European Journal of Cancer Care, Feb 26, 2016

Research paper thumbnail of A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma

The Journal of laryngology and otology, Jan 8, 2017

The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with t... more The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes. This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour-node-metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated. Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group. This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with...

Research paper thumbnail of Cancer Data and Aboriginal Disparities Project (CanDAD) - an overdue cancer control initiative

European journal of cancer care, 2016

Research paper thumbnail of Additional file 1 of Use and uptake of web-based therapeutic interventions amongst Indigenous populations in Australia, New Zealand, the United States of America and Canada: a scoping review

Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension f... more Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Research paper thumbnail of Exploring barriers to and enablers of adequate healthcare for Indigenous Australian prisoners with cancer: a scoping review drawing on evidence from Australia, Canada and the United States

Health & Justice, 2016

Background: International frameworks supported by national principles in Australia stipulate that... more Background: International frameworks supported by national principles in Australia stipulate that prisoners should be provided with health services equivalent to those provided in the general community. However, a number of barriers unique to the prison system may hinder the provision of equitable healthcare for this population. In Australia, Indigenous people carry a greater burden of cancer mortality, which the Cancer Data and Aboriginal Disparities (CanDAD) project is seeking to address. During the course of recruiting participants to the CanDAD study, Indigenous Australian prisoners with cancer emerged as an important, under-researched but difficult to access subgroup. Methods: This scoping review sought to identify barriers and facilitators of access to adequate and equitable healthcare for Indigenous Australian prisoners with cancer in Australia. This review demonstrated a lack of research and, as such, the scoping review was extended to prisoners with cancer in Australia, New Zealand, the United States and Canada. This approach was taken in order to summarise the existing body of evidence regarding the barriers and facilitators of access to adequate and equitable healthcare for those who are incarcerated and suffering from cancer, and highlight areas that may require further investigation. Results: Eight studies or commentaries were found to meet the inclusion criteria. This limited set of findings pointed to a range of possible barriers faced by prisoners with cancer, including a tension between the prisons' concern with security versus the need for timely access to medical care. Conclusion: Findings identified here offer potential starting points for research and policy development. Further research is needed to better elucidate how barriers to adequate cancer care for prisoners may be identified and overcome, in Australia and internationally. Furthermore, given Indigenous Australians' over-burden of cancer mortality and over-representation in the prison system, further research is needed to identify whether there are a unique set of barriers for this group.

Research paper thumbnail of Health-related quality of life after head and neck cancer: Aboriginal patients’ experiences in South and Central Australia

IX Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Is... more IX Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islander XIII Aims and objectives of study XIV Abbreviations and acronyms XV Chapter

Research paper thumbnail of Use and uptake of web-based therapeutic interventions amongst Indigenous populations in Australia, New Zealand, the United States of America and Canada: a scoping review

Research paper thumbnail of Aboriginal experiences of cancer and care coordination: Lessons from the Cancer Data and Aboriginal Disparities (CanDAD) narratives

Health expectations : an international journal of public participation in health care and health policy, Jan 24, 2018

Aboriginal people with cancer experience worse outcomes than other Australians for a range of com... more Aboriginal people with cancer experience worse outcomes than other Australians for a range of complex and interrelated reasons. A younger age at diagnosis, higher likelihood of more advanced cancer or cancer type with poorer prognosis, geographic isolation and cultural and language diversity mean that patient pathways are potentially more complex for Aboriginal people with cancer. In addition, variation in the quality and acceptability of care may influence cancer outcomes. This study sought to understand how care coordination influences Aboriginal people's experiences of cancer treatment. Interviews with 29 Aboriginal patients or cancer survivors, 11 carers and 22 service providers were carried out. Interviews were semi-structured and sought to elicit experiences of cancer and the health-care system. The manifest content of the cancer narratives was entered onto a cancer pathway mapping tool and underlying themes were identified inductively. The practice of cancer care coordina...

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, Apr 1, 2008

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, 2008

Research paper thumbnail of Cancer Data and Aboriginal Disparities (CanDAD)-developing an Advanced Cancer Data System for Aboriginal people in South Australia: a mixed methods research protocol

BMJ open, Dec 23, 2016

In Australia, Aboriginal and Torres Strait Islander People carry a greater burden of cancer-relat... more In Australia, Aboriginal and Torres Strait Islander People carry a greater burden of cancer-related mortality than non-Aboriginal Australians. The Cancer Data and Aboriginal Disparities Project aims to develop and test an integrated, comprehensive cancer monitoring and surveillance system capable of incorporating epidemiological and narrative data to address disparities and advocate for clinical system change. The Advanced Cancer Data System will integrate routinely collected unit record data from the South Australian Population Cancer Registry and a range of other data sources for a retrospective cohort of indigenous people with cancers diagnosed from 1990 to 2010. A randomly drawn non-Aboriginal cohort will be matched by primary cancer site, sex, age and year at diagnosis. Cross-tabulations and regression analyses will examine the extent to which demographic attributes, cancer stage and survival vary between the cohorts. Narratives from Aboriginal people with cancer, their familie...

Research paper thumbnail of Exploring barriers to and enablers of adequate healthcare for Indigenous Australian prisoners with cancer: a scoping review drawing on evidence from Australia, Canada and the United States

Health & Justice, 2016

International frameworks supported by national principles in Australia stipulate that prisoners s... more International frameworks supported by national principles in Australia stipulate that prisoners should be provided with health services equivalent to those provided in the general community. However, a number of barriers unique to the prison system may hinder the provision of equitable healthcare for this population. In Australia, Indigenous people carry a greater burden of cancer mortality, which the Cancer Data and Aboriginal Disparities (CanDAD) project is seeking to address. During the course of recruiting participants to the CanDAD study, Indigenous Australian prisoners with cancer emerged as an important, under-researched but difficult to access sub-group. This scoping review sought to identify barriers and facilitators of access to adequate and equitable healthcare for Indigenous Australian prisoners with cancer in Australia. This review demonstrated a lack of research and, as such, the scoping review was extended to prisoners with cancer in Australia, New Zealand, the United States and Canada. This approach was taken in order to summarise the existing body of evidence regarding the barriers and facilitators of access to adequate and equitable healthcare for those who are incarcerated and suffering from cancer, and highlight areas that may require further investigation. Eight studies or commentaries were found to meet the inclusion criteria. This limited set of findings pointed to a range of possible barriers faced by prisoners with cancer, including a tension between the prisons&amp;amp;amp;amp;amp;amp;#39; concern with security versus the need for timely access to medical care. Findings identified here offer potential starting points for research and policy development. Further research is needed to better elucidate how barriers to adequate cancer care for prisoners may be identified and overcome, in Australia and internationally. Furthermore, given Indigenous Australians&amp;amp;amp;amp;amp;amp;#39; over-burden of cancer mortality and over-representation in the prison system, further research is needed to identify whether there are a unique set of barriers for this group.

Research paper thumbnail of EP-1122: Patterns of care and outcome in HPV p16+ oropharyngeal squamous cell carcinoma treated at a tertiary hospital

Radiotherapy and Oncology

Research paper thumbnail of Self-reported health-related quality-of-life issues for Aboriginal and Torres Strait Islander patients with experience of cancer in Australia

International Journal of Evidence-Based Healthcare, 2015

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, 2008

The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepa... more The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepatotoxic when administered orally to mice, and cytotoxic and genotoxic to human cell lines. To determine the effects of CYN on primary human IVF-derived granulosa cells, 0-1 g/ml CYN was added to cells for 2, 4 or 6 h ± hCG (n = 6), or for 24, 48 and 72 h (n = 6). Cytotoxicity was evaluated by MTT assay, and secreted progesterone or estrogen quantified by radioimmunoassay. 24 h exposure to 1 g/ml CYN was cytotoxic (p < 0.05), whereas 0.0625 g/ml CYN did not cause cytotoxicity or affect estrogen production, but did inhibit basal progesterone production (p < 0.01). Similarly, 6 h exposure to 1 g/ml CYN did not affect cytotoxicity or hCG-stimulated estrogen production, but did inhibit hCG-stimulated progesterone production (p < 0.01). In this in vitro assay, CYN inhibited progesterone production and therefore has the potential to be an endocrine disrupter by changing the progesterone:estrogen ratio in women.

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, Apr 1, 2008

The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepa... more The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepatotoxic when administered orally to mice, and cytotoxic and genotoxic to human cell lines. To determine the effects of CYN on primary human IVF-derived granulosa cells, 0-1 g/ml CYN was added to cells for 2, 4 or 6 h ± hCG (n = 6), or for 24, 48 and 72 h (n = 6). Cytotoxicity was evaluated by MTT assay, and secreted progesterone or estrogen quantified by radioimmunoassay. 24 h exposure to 1 g/ml CYN was cytotoxic (p < 0.05), whereas 0.0625 g/ml CYN did not cause cytotoxicity or affect estrogen production, but did inhibit basal progesterone production (p < 0.01). Similarly, 6 h exposure to 1 g/ml CYN did not affect cytotoxicity or hCG-stimulated estrogen production, but did inhibit hCG-stimulated progesterone production (p < 0.01). In this in vitro assay, CYN inhibited progesterone production and therefore has the potential to be an endocrine disrupter by changing the progesterone:estrogen ratio in women.

Research paper thumbnail of Health-related quality of life after head and neck cancer: Aboriginal patients’ experiences in South and Central Australia

Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islan... more Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islander XIII Aims and objectives of study XIV Abbreviations and acronyms XV Chapter 1. Introduction and background 2

Research paper thumbnail of A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma

Journal of Laryngology and Otology, May 8, 2017

The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with t... more The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes. This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour-node-metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated. Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group. This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with primary surgery compared with primary chemoradiotherapy. This reflects overall lower tumour stage and higher human papillomavirus status in this group.

Research paper thumbnail of Self-reported health-related quality-of-life issues for Aboriginal and Torres Strait Islander patients with experience of cancer in Australia

International Journal of Evidence-based Healthcare, Dec 1, 2015

Background: Aboriginal peoples and Torres Strait Islander peoples (who comprise the indigenous pe... more Background: Aboriginal peoples and Torres Strait Islander peoples (who comprise the indigenous people or the original inhabitants of Australia before colonization) are more likely to experience cancers with poorer prognoses, are more likely to be diagnosed with cancer at a later stage of disease progression, are less likely to receive adequate cancer treatment and are more likely to pass away due to cancer, compared with other Australians. Cancer and biomedical therapies for cancer often have significant, ongoing effects on patient health-related quality of life (HRQL). Therefore, consideration of HRQL for Aboriginal and Torres Strait Islander peoples with experience of cancer in Australia is imperative. This article examines the literature for HRQL issues self-reported by Aboriginal and/or Torres Strait Islander people with experience of cancer in Australia. Methods: A search of peer-reviewed journal articles, government reports, and other literature was undertaken using electronic databases and citation snowballing. Self-reports from Aboriginal and/or Torres Strait Islander people with experience of cancer were examined. HRQL issues were determined utilizing the Australian Psycho-Oncology Cooperative Research Group's definition of HRQL. Results: Fifty-two documents were found with original data from Aboriginal and/or Torres Strait Islander people who self-reported their experiences of cancer. No published reports were found that specifically examined selfreports from Aboriginal and/or Torres Strait Islander people on the impact of cancer and biomedical treatment on their HRQL. Conclusion: Previous literature suggests that there is urgency for improved communication and cultural competency in cancer care for Aboriginal and Torres Strait Islander patients in Australia, with a stronger focus on meeting patient needs and improving HRQL. This review has provided insight into HRQL issues for Aboriginal and Torres Strait Islander patients with cancer in Australia. Further work using patient-reported outcomes measures would provide greater insight into the impact of cancer and biomedical treatments on Aboriginal and Torres Strait Islander patients' HRQL.

Research paper thumbnail of Cancer Data and Aboriginal Disparities Project (CanDAD) - an overdue cancer control initiative

European Journal of Cancer Care, Feb 26, 2016

Research paper thumbnail of A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma

The Journal of laryngology and otology, Jan 8, 2017

The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with t... more The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes. This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour-node-metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated. Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group. This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with...

Research paper thumbnail of Cancer Data and Aboriginal Disparities Project (CanDAD) - an overdue cancer control initiative

European journal of cancer care, 2016

Research paper thumbnail of Additional file 1 of Use and uptake of web-based therapeutic interventions amongst Indigenous populations in Australia, New Zealand, the United States of America and Canada: a scoping review

Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension f... more Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Research paper thumbnail of Exploring barriers to and enablers of adequate healthcare for Indigenous Australian prisoners with cancer: a scoping review drawing on evidence from Australia, Canada and the United States

Health & Justice, 2016

Background: International frameworks supported by national principles in Australia stipulate that... more Background: International frameworks supported by national principles in Australia stipulate that prisoners should be provided with health services equivalent to those provided in the general community. However, a number of barriers unique to the prison system may hinder the provision of equitable healthcare for this population. In Australia, Indigenous people carry a greater burden of cancer mortality, which the Cancer Data and Aboriginal Disparities (CanDAD) project is seeking to address. During the course of recruiting participants to the CanDAD study, Indigenous Australian prisoners with cancer emerged as an important, under-researched but difficult to access subgroup. Methods: This scoping review sought to identify barriers and facilitators of access to adequate and equitable healthcare for Indigenous Australian prisoners with cancer in Australia. This review demonstrated a lack of research and, as such, the scoping review was extended to prisoners with cancer in Australia, New Zealand, the United States and Canada. This approach was taken in order to summarise the existing body of evidence regarding the barriers and facilitators of access to adequate and equitable healthcare for those who are incarcerated and suffering from cancer, and highlight areas that may require further investigation. Results: Eight studies or commentaries were found to meet the inclusion criteria. This limited set of findings pointed to a range of possible barriers faced by prisoners with cancer, including a tension between the prisons' concern with security versus the need for timely access to medical care. Conclusion: Findings identified here offer potential starting points for research and policy development. Further research is needed to better elucidate how barriers to adequate cancer care for prisoners may be identified and overcome, in Australia and internationally. Furthermore, given Indigenous Australians' over-burden of cancer mortality and over-representation in the prison system, further research is needed to identify whether there are a unique set of barriers for this group.

Research paper thumbnail of Health-related quality of life after head and neck cancer: Aboriginal patients’ experiences in South and Central Australia

IX Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Is... more IX Acknowledgements XI Definition of the use of terms Indigenous, Aboriginal and Torres Strait Islander XIII Aims and objectives of study XIV Abbreviations and acronyms XV Chapter

Research paper thumbnail of Use and uptake of web-based therapeutic interventions amongst Indigenous populations in Australia, New Zealand, the United States of America and Canada: a scoping review

Research paper thumbnail of Aboriginal experiences of cancer and care coordination: Lessons from the Cancer Data and Aboriginal Disparities (CanDAD) narratives

Health expectations : an international journal of public participation in health care and health policy, Jan 24, 2018

Aboriginal people with cancer experience worse outcomes than other Australians for a range of com... more Aboriginal people with cancer experience worse outcomes than other Australians for a range of complex and interrelated reasons. A younger age at diagnosis, higher likelihood of more advanced cancer or cancer type with poorer prognosis, geographic isolation and cultural and language diversity mean that patient pathways are potentially more complex for Aboriginal people with cancer. In addition, variation in the quality and acceptability of care may influence cancer outcomes. This study sought to understand how care coordination influences Aboriginal people's experiences of cancer treatment. Interviews with 29 Aboriginal patients or cancer survivors, 11 carers and 22 service providers were carried out. Interviews were semi-structured and sought to elicit experiences of cancer and the health-care system. The manifest content of the cancer narratives was entered onto a cancer pathway mapping tool and underlying themes were identified inductively. The practice of cancer care coordina...

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, Apr 1, 2008

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, 2008

Research paper thumbnail of Cancer Data and Aboriginal Disparities (CanDAD)-developing an Advanced Cancer Data System for Aboriginal people in South Australia: a mixed methods research protocol

BMJ open, Dec 23, 2016

In Australia, Aboriginal and Torres Strait Islander People carry a greater burden of cancer-relat... more In Australia, Aboriginal and Torres Strait Islander People carry a greater burden of cancer-related mortality than non-Aboriginal Australians. The Cancer Data and Aboriginal Disparities Project aims to develop and test an integrated, comprehensive cancer monitoring and surveillance system capable of incorporating epidemiological and narrative data to address disparities and advocate for clinical system change. The Advanced Cancer Data System will integrate routinely collected unit record data from the South Australian Population Cancer Registry and a range of other data sources for a retrospective cohort of indigenous people with cancers diagnosed from 1990 to 2010. A randomly drawn non-Aboriginal cohort will be matched by primary cancer site, sex, age and year at diagnosis. Cross-tabulations and regression analyses will examine the extent to which demographic attributes, cancer stage and survival vary between the cohorts. Narratives from Aboriginal people with cancer, their familie...

Research paper thumbnail of Exploring barriers to and enablers of adequate healthcare for Indigenous Australian prisoners with cancer: a scoping review drawing on evidence from Australia, Canada and the United States

Health & Justice, 2016

International frameworks supported by national principles in Australia stipulate that prisoners s... more International frameworks supported by national principles in Australia stipulate that prisoners should be provided with health services equivalent to those provided in the general community. However, a number of barriers unique to the prison system may hinder the provision of equitable healthcare for this population. In Australia, Indigenous people carry a greater burden of cancer mortality, which the Cancer Data and Aboriginal Disparities (CanDAD) project is seeking to address. During the course of recruiting participants to the CanDAD study, Indigenous Australian prisoners with cancer emerged as an important, under-researched but difficult to access sub-group. This scoping review sought to identify barriers and facilitators of access to adequate and equitable healthcare for Indigenous Australian prisoners with cancer in Australia. This review demonstrated a lack of research and, as such, the scoping review was extended to prisoners with cancer in Australia, New Zealand, the United States and Canada. This approach was taken in order to summarise the existing body of evidence regarding the barriers and facilitators of access to adequate and equitable healthcare for those who are incarcerated and suffering from cancer, and highlight areas that may require further investigation. Eight studies or commentaries were found to meet the inclusion criteria. This limited set of findings pointed to a range of possible barriers faced by prisoners with cancer, including a tension between the prisons&amp;amp;amp;amp;amp;amp;#39; concern with security versus the need for timely access to medical care. Findings identified here offer potential starting points for research and policy development. Further research is needed to better elucidate how barriers to adequate cancer care for prisoners may be identified and overcome, in Australia and internationally. Furthermore, given Indigenous Australians&amp;amp;amp;amp;amp;amp;#39; over-burden of cancer mortality and over-representation in the prison system, further research is needed to identify whether there are a unique set of barriers for this group.

Research paper thumbnail of EP-1122: Patterns of care and outcome in HPV p16+ oropharyngeal squamous cell carcinoma treated at a tertiary hospital

Radiotherapy and Oncology

Research paper thumbnail of Self-reported health-related quality-of-life issues for Aboriginal and Torres Strait Islander patients with experience of cancer in Australia

International Journal of Evidence-Based Healthcare, 2015

Research paper thumbnail of Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro

Reproductive Toxicology, 2008

The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepa... more The blue-green algal toxin cylindrospermopsin (CYN) occurs in public water supplies. CYN was hepatotoxic when administered orally to mice, and cytotoxic and genotoxic to human cell lines. To determine the effects of CYN on primary human IVF-derived granulosa cells, 0-1 g/ml CYN was added to cells for 2, 4 or 6 h ± hCG (n = 6), or for 24, 48 and 72 h (n = 6). Cytotoxicity was evaluated by MTT assay, and secreted progesterone or estrogen quantified by radioimmunoassay. 24 h exposure to 1 g/ml CYN was cytotoxic (p < 0.05), whereas 0.0625 g/ml CYN did not cause cytotoxicity or affect estrogen production, but did inhibit basal progesterone production (p < 0.01). Similarly, 6 h exposure to 1 g/ml CYN did not affect cytotoxicity or hCG-stimulated estrogen production, but did inhibit hCG-stimulated progesterone production (p < 0.01). In this in vitro assay, CYN inhibited progesterone production and therefore has the potential to be an endocrine disrupter by changing the progesterone:estrogen ratio in women.