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Information flow in brain networks is reflected in intracerebral local field potential (LFP) meas... more Information flow in brain networks is reflected in intracerebral local field potential (LFP) measurements that have both periodic and aperiodic components. The 1/fχbroadband aperiodic component of the power spectra has been shown to track arousal level and to correlate with other physiological and pathophysiological states, with consistent patterns across cortical regions. Previous studies have focused almost exclusively on cortical neurophysiology. Here we explored the aperiodic activity of subcortical nuclei from the human thalamus and basal ganglia, in relation to simultaneously recorded cortical activity. We elaborated on the FOOOF (fitting of one over f) method by creating a new parameterization of the aperiodic component with independent and more easily interpretable parameters, which allows seamlessly fitting spectra with and without anaperiodic knee, a component of the signal that reflects the dominant timescale of aperiodic fluctuations. First, we found that the aperiodic e...
2022 Conference on Cognitive Computational Neuroscience, 2022
Maladaptive cerebral neuroplasticity is a well-established consequence of limb amputation. Howeve... more Maladaptive cerebral neuroplasticity is a well-established consequence of limb amputation. However, little is known about the potentially causal role of neuromuscular feedback in preserving the cortical and subcortical structures essential for sensation and motor planning, or modulating phantom limb sensation and pain. In this investigation, we study the impact of the agonist-antagonist myoneural interface (AMI) amputation procedure, which preserves proprioceptive neuromuscular feedback, on subcortical and cortical reorganization. We perform neuroimaging on subjects with AMI amputation (AA, n = 10), traditional amputation (TA, n = 10) and no amputation (NA, controls, n = 10). While TAs demonstrate diminished subcortical gray matter volume in the pallidum, accumbens and thalamus (p < 0.05) as compared to NAs, AAs had no significant changes when compared to NAs (p < 0.05). Cortical thickness of Broadmann area 3a and 3b were also significantly increased in TAs, but remained uncha...
Science Translational Medicine, 2020
Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback t... more Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback to the brain.
Journal of Parkinson's Disease
Background: PRESENCE was a Phase 2 trial assessing mevidalen for symptomatic treatment of Lewy bo... more Background: PRESENCE was a Phase 2 trial assessing mevidalen for symptomatic treatment of Lewy body dementia (LBD). Participants received daily doses (10, 30, or 75 mg) of mevidalen (LY3154207) or placebo for 12 weeks. Objective: To evaluate if frequent cognitive and motor tests using an iPad app and wrist-worn actigraphy to track activity and sleep could detect mevidalen treatment effects in LBD. Methods: Of 340 participants enrolled in PRESENCE, 238 wore actigraphy for three 2-week periods: pre-, during, and post-intervention. A subset of participants (n = 160) enrolled in a sub-study using an iPad trial app with 3 tests: digital symbol substitution (DSST), spatial working memory (SWM), and finger-tapping. Compliance was defined as daily test completion or watch-wearing ≥23 h/day. Change from baseline to week 12 (app) or week 8 (actigraphy) was used to assess treatment effects using Mixed Model Repeated Measures analysis. Pearson correlations between sensor-derived features and cl...
Information flow in brain networks is reflected in intracerebral local field potential (LFP) meas... more Information flow in brain networks is reflected in intracerebral local field potential (LFP) measurements that have both periodic and aperiodic components. The 1/fχbroadband aperiodic component of the power spectra has been shown to track arousal level and to correlate with other physiological and pathophysiological states, with consistent patterns across cortical regions. Previous studies have focused almost exclusively on cortical neurophysiology. Here we explored the aperiodic activity of subcortical nuclei from the human thalamus and basal ganglia, in relation to simultaneously recorded cortical activity. We elaborated on the FOOOF (fitting of one over f) method by creating a new parameterization of the aperiodic component with independent and more easily interpretable parameters, which allows seamlessly fitting spectra with and without anaperiodic knee, a component of the signal that reflects the dominant timescale of aperiodic fluctuations. First, we found that the aperiodic e...
2022 Conference on Cognitive Computational Neuroscience, 2022
Maladaptive cerebral neuroplasticity is a well-established consequence of limb amputation. Howeve... more Maladaptive cerebral neuroplasticity is a well-established consequence of limb amputation. However, little is known about the potentially causal role of neuromuscular feedback in preserving the cortical and subcortical structures essential for sensation and motor planning, or modulating phantom limb sensation and pain. In this investigation, we study the impact of the agonist-antagonist myoneural interface (AMI) amputation procedure, which preserves proprioceptive neuromuscular feedback, on subcortical and cortical reorganization. We perform neuroimaging on subjects with AMI amputation (AA, n = 10), traditional amputation (TA, n = 10) and no amputation (NA, controls, n = 10). While TAs demonstrate diminished subcortical gray matter volume in the pallidum, accumbens and thalamus (p < 0.05) as compared to NAs, AAs had no significant changes when compared to NAs (p < 0.05). Cortical thickness of Broadmann area 3a and 3b were also significantly increased in TAs, but remained uncha...
Science Translational Medicine, 2020
Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback t... more Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback to the brain.
Journal of Parkinson's Disease
Background: PRESENCE was a Phase 2 trial assessing mevidalen for symptomatic treatment of Lewy bo... more Background: PRESENCE was a Phase 2 trial assessing mevidalen for symptomatic treatment of Lewy body dementia (LBD). Participants received daily doses (10, 30, or 75 mg) of mevidalen (LY3154207) or placebo for 12 weeks. Objective: To evaluate if frequent cognitive and motor tests using an iPad app and wrist-worn actigraphy to track activity and sleep could detect mevidalen treatment effects in LBD. Methods: Of 340 participants enrolled in PRESENCE, 238 wore actigraphy for three 2-week periods: pre-, during, and post-intervention. A subset of participants (n = 160) enrolled in a sub-study using an iPad trial app with 3 tests: digital symbol substitution (DSST), spatial working memory (SWM), and finger-tapping. Compliance was defined as daily test completion or watch-wearing ≥23 h/day. Change from baseline to week 12 (app) or week 8 (actigraphy) was used to assess treatment effects using Mixed Model Repeated Measures analysis. Pearson correlations between sensor-derived features and cl...