Jasper Sylvester - Academia.edu (original) (raw)

Uploads

Papers by Jasper Sylvester

Best Weight Loss Tips For Women

If you have been searching continuously for best weight loss tips for women then you have found t... more If you have been searching continuously for best weight loss tips for women then you have found the right article for you. In this modern era of popular television programs, constant peer pressure and even overbearing parents can put an immense heavy pressure on women these days to lose weight and look as slim as they possibly can. My sister is no different and has manage to successfully lose huge amounts of weight through some helpful tips which I am about to share. Having the tag of being the "fat girl" throughout your life or for long periods in life can have a huge negative impact on your mood and self-esteem and there is no easy solution to this problem. Nobody said that losing weight is easy and having constant pressure as a woman to look slim these days only makes it worse. However, having said that here are some tips that can make losing weight as a woman much easier and also more fun. Want some assistance in losing weight click here now and check out whats working for 100´s of women around the world! It is very important as a female to know what exactly young women these days should look like. Lots of young girls in their teens and young female adults have this wrong impression that looking dangerously thin is healthy because they have seen many of their idols on television portraying this kind of image. This is in fact very wrong and such an unhealthy lifestyle to lead. What many young women then proceed to do is to adopt unhealthy eating disorders just so they can look exactly like their favourite actresses on television and believe me I have seen my sister gone through it and it is just the start of a major disaster.

Journal of Dairy Science, 2005

Dairy producers require effective methods of reducing the pain associated with dehorning. Previou... more Dairy producers require effective methods of reducing the pain associated with dehorning. Previous work has shown that analgesics can reduce pain associated with hot-iron dehorning, but these interventions may not be practical for some producers. Some producers favor the use of caustic paste (to cause a chemical burn as opposed to thermal burn), but little is known about how to treat pain caused by caustic burns. In 2 experiments, head shaking and head rubbing behaviors were used to evaluate pain following dehorning using caustic paste. In experiment 1, sedated calves were dehorned using a caustic paste, with or without a lidocaine local block. Calves treated with lidocaine showed no evidence of reduced pain response in the hours after the caustic paste was applied. In experiment 2, response to caustic paste dehorning with a sedative only was compared with hot-iron dehorning using a sedative and local anesthetic. In the first 4 h after dehorning, calves dehorned with a hot iron showed more head shaking than calves dehorned with caustic paste. These results indicate that dehorning with caustic paste combined with a sedative results in less pain to calves than dehorning with a hot iron combined with a sedative and a local anesthetic. (

Contributions To Mineralogy and Petrology, 2010

A natural, altered zircon crystal from an alkaline pegmatite from the Zomba–Malosa Complex of the... more A natural, altered zircon crystal from an alkaline pegmatite from the Zomba–Malosa Complex of the Chilwa Alkaline Province in Malawi has been studied by a wide range of analytical techniques to understand the alteration process. The investigated zircon shows two texturally and chemically different domains. Whereas the central parts of the grain (zircon I) appear homogeneous in backscattered electron images and are characterised by high concentrations of trace elements, particularly Th, U, and Y, the outer regions (zircon II) contain significantly less trace elements, numerous pores, and inclusions of thorite, ytttrialite, and fergusonite. Zircon II contains very low or undetectable concentrations of non-formula elements such as Ca, Al, and Fe, which are commonly observed in high concentrations in altered radiation-damaged zircon. U–Pb dating of both zircon domains by LA-ICPMS and SHRIMP yielded statistically indistinguishable U–Pb weighted average ages of 119.3 ± 2.1 (2σ) and 118 ± 1.2 (2σ) Ma, respectively, demonstrating that the zircon had not accumulated a significant amount of self-irradiation damage at the time of the alteration event. Electron microprobe dating of thorite inclusions in zircon II yielded a Th–U-total Pb model age of 122 ± 5 (2σ) Ma, supporting the age relationship between both zircon domains. The hydrothermal solution responsible for the alteration of the investigated zircon was alkaline and rich in CO32−, as suggested by the occurrence of REE carbonates and CO2-bearing fluid inclusions. The alteration of the crystalline, trace element-rich zircon is explained by an interface-coupled dissolution-reprecipitation mechanism. During such a process, the congruent dissolution of the trace element-rich parent zircon I was spatially and temporally coupled to the precipitation of the trace element-poor zircon II at an inward moving dissolution-precipitation front. The driving force for such a process was merely the difference between the solubility of the trace element-rich and -poor zircon in the hydrothermal solution. The replacement process and the occurrence of mineral inclusions and porosity in the product zircon II is explained by the thermodynamics of solid solution-aqueous solution systems.

The term “dementia” indicates impairment in cognitive functions due to neuropathology. Many condi... more The term “dementia” indicates impairment in cognitive functions due to neuropathology. Many conditions cause degenerative dementia, including Alzheimer’s disease, multiple infarcts (vascular dementia), frontotemporal pathology, Huntington’s disease, Lewy body disease, and Parkinson’s disease. An increasing inability to meet situational demands as well as memory, verbal, and learning deficits are the hallmarks of dementia. Family and friends of the person with dementia may complain about “personality changes” as uncharacteristic emotions, cognitions, and behaviors emerge. Strained social interactions, social withdrawal, and difficulty is completing multistep tasks (e.g., managing finances) are often the first detectable signs. As neuropathology progresses, significant impairment in communication and daily living skills are typical. Persons with degenerative dementia eventually may become bedridden and dependent on others for the provision of all needs.

Cancer Chemotherapy and Pharmacology, 2008

Introduction Cisplatin (cis-diamminedichloroplatinum) was first identified for its anti-bacterial... more Introduction Cisplatin (cis-diamminedichloroplatinum) was first identified for its anti-bacterial activity, and was later also shown to be an efficient anticancer agent. However, the therapeutic use of this anticancer drug is somewhat limited by its toxic side effects, which include nephrotoxicity, nausea, and vomiting. Furthermore the development of drug-resistant tumours is commonly observed following therapy with cisplatin. Hence there is a need for improved platinum derived drugs to overcome these limitations. Aims Apoptosis contributes significantly to the cytotoxic effects of anticancer agents such as cisplatin; therefore in this study the potential anticancer properties of a series of pyrazole palladium(II) and platinum(II) complexes, [(3,5-R2pz)2PdCl2] {R = H (1), R = Me (2)} and [(3,5-R2pz)2PtCl2] {R = H (3), R = Me (4)}, were evaluated by assessment of their pro-apoptotic activity. Methods The induction of apoptosis was measured in CHO cells by the detection of phosphatidylserine (PS) exposure using the annexin V and APOPercentage™ assays; DNA fragmentation using the Terminal deoxynucleotide transferase dUTP Nick End Labelling (TUNEL) assay; and the detection of activated caspase-3. Results The platinum complexes were shown to be considerably more active than the palladium complexes, with complex 3 demonstrating the highest level of cytotoxic and pro-apoptotic activity. The LD50 values for complex 3 and cisplatin were 20 and 70 μM, respectively, demonstrating that the cytotoxic activity for complex 3 was three times higher than for cisplatin. Various human cancer cell lines, including CaSki, HeLa, as well as the p53 mutant Jurkat T cell line were also shown to be susceptible to complex 3. Conclusions Collectively, this in vitro study provides insights into action of palladium and platinum complexes and demonstrates the potential use of these compounds, and in particular complex 3, in the development of new anticancer agents.

Books by Jasper Sylvester