Javier Perez - Academia.edu (original) (raw)
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Università Cattolica del Sacro Cuore (Catholic University of the Sacred Heart)
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Papers by Javier Perez
SSRN Electronic Journal, 2015
Proceedings of the Fifth Workshop on Refactoring Tools - WRT '12, 2012
Complex refactoring processes, such as applying big refactorings or removing design smells are di... more Complex refactoring processes, such as applying big refactorings or removing design smells are difficult to perform in practice. The complexity of these processes is partly due to their heuristic nature and to the constraints imposed by preconditions on the applicability of the individual refactorings. We introduce refactoring strategies as heuristic-based, automation-suitable specifications of a complex refactoring process. They allow us to specify correction strategies and big refactorings more formally than it is done in current catalogues. Refactoring strategies can be instantiated, for each particular case, into refactoring plans. We define refactoring plans as sequences of refactorings that are immediately applicable over the current system source code. We have developed an approach for instantiating refactoring strategies into refactoring plans that uses Hierarchical Task Network (HTN) planning. This paper describes this approach and presents a case study, in order to evaluate and characterise it.
European Psychiatry, 2011
IntroductionInvoluntary Ambulatory Treatment (IAT) is a judicial measure existing in Spain. Its a... more IntroductionInvoluntary Ambulatory Treatment (IAT) is a judicial measure existing in Spain. Its aim is to ensure the adherence to treatment of seriously ill patients, with poor insight and repeated hospitalization. This is done by means of the regular and involuntary administration of antipsychotic intramuscular medication.ObjectivesTo assess the treatment used in patients undergoing IAT in a local clinic, to assess the type of medicaments and their dosage and to verify adherence to treatment and evolution.Material and methodA revision was made of the clinical backgrounds of all the patients of a psychiatric outpatient clinic who have been submitted to IAT (n = 37). A note was made of socio-demographic variables as well as psychiatric diagnoses according to DSM-IV-TR criteria and the number of hospitalizations and treatments used.ResultsAll but one patient had been hospitalized and average of 3.53 times before IAT. Since undergoing IAT only 6 patients have been admitted (16%). Four ...
Biomacromolecules, 2013
Amylose, a linear polymer of α(1,4)-linked glucosyl units and a major constituent of starch granu... more Amylose, a linear polymer of α(1,4)-linked glucosyl units and a major constituent of starch granules, can also be enzymatically synthesized in vitro from sucrose by bacterial amylosucrases. Depending on the initial sucrose concentration and the enzyme used, amylose oligomers (or polymers) are formed and self-associate during synthesis into various semicrystalline morphologies. This work describes for the first time a synchrotron SAXS study of the structure in solution of two amylosucrases, namely, NpAS and the thermostable DgAS, under conditions of polymer synthesis and, simultaneously, the amylose conformation. The structure in solution of both amylosucrases during the reaction was shown to be similar to the known crystallographic structures. The conformation of amylose produced at an early stage consists of a mixture of wormlike chains and double helical cylindrical structures. In the case of NpAS, in a second stage, individual double helices pack into clusters before crystallizing and precipitating. Amylose produced by DgAS never self-associates in such clusters due to the higher temperature used for amylose synthesis. All the dimensions determined for wormlike chains and cylindrical conformations at different times of NpAS synthesis are in very good agreement with structural features usually observed on gels of amylose extracted from starch. This provides new insights in understanding the mechanisms of amylose gelation.
SSRN Electronic Journal, 2015
Proceedings of the Fifth Workshop on Refactoring Tools - WRT '12, 2012
Complex refactoring processes, such as applying big refactorings or removing design smells are di... more Complex refactoring processes, such as applying big refactorings or removing design smells are difficult to perform in practice. The complexity of these processes is partly due to their heuristic nature and to the constraints imposed by preconditions on the applicability of the individual refactorings. We introduce refactoring strategies as heuristic-based, automation-suitable specifications of a complex refactoring process. They allow us to specify correction strategies and big refactorings more formally than it is done in current catalogues. Refactoring strategies can be instantiated, for each particular case, into refactoring plans. We define refactoring plans as sequences of refactorings that are immediately applicable over the current system source code. We have developed an approach for instantiating refactoring strategies into refactoring plans that uses Hierarchical Task Network (HTN) planning. This paper describes this approach and presents a case study, in order to evaluate and characterise it.
European Psychiatry, 2011
IntroductionInvoluntary Ambulatory Treatment (IAT) is a judicial measure existing in Spain. Its a... more IntroductionInvoluntary Ambulatory Treatment (IAT) is a judicial measure existing in Spain. Its aim is to ensure the adherence to treatment of seriously ill patients, with poor insight and repeated hospitalization. This is done by means of the regular and involuntary administration of antipsychotic intramuscular medication.ObjectivesTo assess the treatment used in patients undergoing IAT in a local clinic, to assess the type of medicaments and their dosage and to verify adherence to treatment and evolution.Material and methodA revision was made of the clinical backgrounds of all the patients of a psychiatric outpatient clinic who have been submitted to IAT (n = 37). A note was made of socio-demographic variables as well as psychiatric diagnoses according to DSM-IV-TR criteria and the number of hospitalizations and treatments used.ResultsAll but one patient had been hospitalized and average of 3.53 times before IAT. Since undergoing IAT only 6 patients have been admitted (16%). Four ...
Biomacromolecules, 2013
Amylose, a linear polymer of α(1,4)-linked glucosyl units and a major constituent of starch granu... more Amylose, a linear polymer of α(1,4)-linked glucosyl units and a major constituent of starch granules, can also be enzymatically synthesized in vitro from sucrose by bacterial amylosucrases. Depending on the initial sucrose concentration and the enzyme used, amylose oligomers (or polymers) are formed and self-associate during synthesis into various semicrystalline morphologies. This work describes for the first time a synchrotron SAXS study of the structure in solution of two amylosucrases, namely, NpAS and the thermostable DgAS, under conditions of polymer synthesis and, simultaneously, the amylose conformation. The structure in solution of both amylosucrases during the reaction was shown to be similar to the known crystallographic structures. The conformation of amylose produced at an early stage consists of a mixture of wormlike chains and double helical cylindrical structures. In the case of NpAS, in a second stage, individual double helices pack into clusters before crystallizing and precipitating. Amylose produced by DgAS never self-associates in such clusters due to the higher temperature used for amylose synthesis. All the dimensions determined for wormlike chains and cylindrical conformations at different times of NpAS synthesis are in very good agreement with structural features usually observed on gels of amylose extracted from starch. This provides new insights in understanding the mechanisms of amylose gelation.