J capellan - Academia.edu (original) (raw)

Papers by J capellan

Studies in Conflict & Terrorism, 2015

This study explores the threat of ideological active shooter attacks in the United States. In par... more This study explores the threat of ideological active shooter attacks in the United States. In particular, to understand if these events constitute a new brand of "lone wolf terrorism" or if they are simply "deranged shooters" that happen to be ideological. The results show that ideological and non-ideological active shooters share very similar profiles. Despite the similarities, ideological extremism seems to influence the way these offenders prepare, execute, and conclude their attacks. Most ideological active shooters are "loners" whose attacks tend to be motivated by ideology. Given their sophistication and lethality, ideological active shooters represent a serious threat to national security.

Applied Spatial Analysis and Policy, 2014

ABSTRACT

Vaccine, 2009

We studied the safety and immunogenicity of a Respiratory Syncytial Virus (RSV)-A vaccine contain... more We studied the safety and immunogenicity of a Respiratory Syncytial Virus (RSV)-A vaccine containing subunit antigens F, G and M in older persons, and its effect on influenza vaccine immunogenicity. In a dose-ranging, placebo-controlled, blinded trial 561 adults ≥65 years of age at five Canadian sites were randomized to one intramuscular injection of either 100, 50 or 25 g RSV-A-alum vaccine or 100 g non-adjuvanted RSV-A vaccine, or alum-placebo. All participants were offered inactivated influenza vaccine on day 32. Immunization was well tolerated and reactogenicity was similar between the RSV and influenza vaccines and the alum-placebo. Only the 100 g non-adjuvanted RSV vaccine achieved the primary immunogenicity outcome of eliciting a ≥4-fold rise in neutralizing antibody (NA) titres against RSV-A in ≥50% of participants at day 32. Geometric mean titres against RSV-A and -B at all points were comparable in 100 g adjuvanted and non-adjuvanted groups. At day 32, a ≥4-fold haemagluttinin inhibition (HI) antibody response or HI ≥40 to Influenza (A-H3N2) was seen in >74% of participants; no difference was seen between groups. A subunit non-alum-containing RSV-A vaccine was well tolerated in a large population ≥65 years and did not interfere with influenza vaccine immunogenicity. This RSV-Abased vaccine demonstrated NA rise which could provide seasonal protection against severe RSV illnesses from RSV-A or -B and warrants further testing to determine its efficacy in the prevention of clinical illness in elderly persons.

Vaccine, 2007

To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µ... more To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 µg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (≥4 fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers ≥1:32, ≥1:64, and ≥1:128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly.

Scandinavian Journal of Infectious Diseases, 1993

One of the complications of chronic haemodialysis is infection at the venous access site. A retro... more One of the complications of chronic haemodialysis is infection at the venous access site. A retrospective chart review (1985-1990) was done on patients requiring venoaccess for haemodialysis. 197 patients had 254 arterio-venous (A-V) fistulas created. 40 patients had 71 prosthetic implants and 157 patients had 183 autogenous fistulas created. 16 (22%) prosthetic grafts were infected versus 8 (4.3%) autogenous fistulas (p < 0.0001). Bacteraemia was present in 9/16 (56%) infected prosthetic grafts and 4/8 (50%) infected autogenous fistulas. Seven (43.8%) of the prosthetic grafts required removal; 6 (37.5%) were cured with drainage, irrigation and antibiotics, and 3 (18.8%) with antibiotics alone. One (12.5%) of the autogenous fistulas was removed, 4 (50%) required revision and 3 (37.5%) were treated with antibiotics alone. Whenever possible, A-V fistulas should be created in the arms with an autogenous graft as infections are less and easier to treat.

The Journal of Infectious Diseases, 2009

Influenza-associated morbidity and mortality has not decreased in the last decade, despite increa... more Influenza-associated morbidity and mortality has not decreased in the last decade, despite increased receipt of vaccine. To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed. A multicenter, randomized, double-blind controlled study was conducted to compare HD vaccine (which contains 60 microg of hemagglutinin per strain) with the licensed standard-dose (SD) vaccine (which contains 15 microg of hemagglutinin per strain) in adults > or = 65 years of age. HD vaccine was administered to 2575 subjects, and SD vaccine was administered to 1262 subjects. There was a statistically significant increase in the rates of seroconversion and mean hemagglutination inhibition titers at day 28 after vaccination among those who received HD vaccine, compared with those who received SD vaccine. Mean postvaccination titers for individuals who received HD vaccine were 116 for H1N1, 609 for H3N2, and 69 for B strain; for those who received SD vaccine, mean postvaccination titers were as 67 for H1N1, 333 for H3N2, and 52 for B strain. The HD vaccine met superiority criteria for both A strains, and the responses for B strain met non-inferiority criteria. Seroprotection rates were also higher for those who received HD vaccine than for those who received SD vaccine vaccine, for all strains. Local reactions were more frequent in individuals who received HD vaccine, but the reactions were mild to moderate. There was a statistically significant increase in the level of antibody response induced by HD influenza vaccine, compared with that induced by SD vaccine, without an attendant increase in the rate or severity of clinically relevant adverse reactions. These results suggest that the high-dose vaccine may provide improved protective benefits for older adults. ClinicalTrials.gov identifier: NCT00391053 .

Scandinavian Journal of Infectious Diseases, 1993

One of the complications of chronic haemodialysis is infection at the venous access site. A retro... more One of the complications of chronic haemodialysis is infection at the venous access site. A retrospective chart review (1985-1990) was done on patients requiring venoaccess for haemodialysis. 197 patients had 254 arterio-venous (A-V) fistulas created. 40 patients had 71 prosthetic implants and 157 patients had 183 autogenous fistulas created. 16 (22%) prosthetic grafts were infected versus 8 (4.3%) autogenous fistulas (p < 0.0001). Bacteraemia was present in 9/16 (56%) infected prosthetic grafts and 4/8 (50%) infected autogenous fistulas. Seven (43.8%) of the prosthetic grafts required removal; 6 (37.5%) were cured with drainage, irrigation and antibiotics, and 3 (18.8%) with antibiotics alone. One (12.5%) of the autogenous fistulas was removed, 4 (50%) required revision and 3 (37.5%) were treated with antibiotics alone. Whenever possible, A-V fistulas should be created in the arms with an autogenous graft as infections are less and easier to treat.

Headache: The Journal of Head and Face Pain, 1990

Changes in dopaminergic tonus have been hypothesized in patients with common migraine, suggesting... more Changes in dopaminergic tonus have been hypothesized in patients with common migraine, suggesting that prolactin may play a role in the pathogenesis of the migraine. We investigated the prolactin response to domperidone, a dopamine receptor blocker.

Clinical Infectious Diseases, 1993

Professional Development Plan Professional Development Plan PROFESSIONAL DEVELOPMENT PLAN 2

Studies in Conflict & Terrorism, 2015

This study explores the threat of ideological active shooter attacks in the United States. In par... more This study explores the threat of ideological active shooter attacks in the United States. In particular, to understand if these events constitute a new brand of "lone wolf terrorism" or if they are simply "deranged shooters" that happen to be ideological. The results show that ideological and non-ideological active shooters share very similar profiles. Despite the similarities, ideological extremism seems to influence the way these offenders prepare, execute, and conclude their attacks. Most ideological active shooters are "loners" whose attacks tend to be motivated by ideology. Given their sophistication and lethality, ideological active shooters represent a serious threat to national security.

Applied Spatial Analysis and Policy, 2014

ABSTRACT

Vaccine, 2009

We studied the safety and immunogenicity of a Respiratory Syncytial Virus (RSV)-A vaccine contain... more We studied the safety and immunogenicity of a Respiratory Syncytial Virus (RSV)-A vaccine containing subunit antigens F, G and M in older persons, and its effect on influenza vaccine immunogenicity. In a dose-ranging, placebo-controlled, blinded trial 561 adults ≥65 years of age at five Canadian sites were randomized to one intramuscular injection of either 100, 50 or 25 g RSV-A-alum vaccine or 100 g non-adjuvanted RSV-A vaccine, or alum-placebo. All participants were offered inactivated influenza vaccine on day 32. Immunization was well tolerated and reactogenicity was similar between the RSV and influenza vaccines and the alum-placebo. Only the 100 g non-adjuvanted RSV vaccine achieved the primary immunogenicity outcome of eliciting a ≥4-fold rise in neutralizing antibody (NA) titres against RSV-A in ≥50% of participants at day 32. Geometric mean titres against RSV-A and -B at all points were comparable in 100 g adjuvanted and non-adjuvanted groups. At day 32, a ≥4-fold haemagluttinin inhibition (HI) antibody response or HI ≥40 to Influenza (A-H3N2) was seen in >74% of participants; no difference was seen between groups. A subunit non-alum-containing RSV-A vaccine was well tolerated in a large population ≥65 years and did not interfere with influenza vaccine immunogenicity. This RSV-Abased vaccine demonstrated NA rise which could provide seasonal protection against severe RSV illnesses from RSV-A or -B and warrants further testing to determine its efficacy in the prevention of clinical illness in elderly persons.

Vaccine, 2007

To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µ... more To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 µg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (≥4 fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers ≥1:32, ≥1:64, and ≥1:128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly.

Scandinavian Journal of Infectious Diseases, 1993

One of the complications of chronic haemodialysis is infection at the venous access site. A retro... more One of the complications of chronic haemodialysis is infection at the venous access site. A retrospective chart review (1985-1990) was done on patients requiring venoaccess for haemodialysis. 197 patients had 254 arterio-venous (A-V) fistulas created. 40 patients had 71 prosthetic implants and 157 patients had 183 autogenous fistulas created. 16 (22%) prosthetic grafts were infected versus 8 (4.3%) autogenous fistulas (p < 0.0001). Bacteraemia was present in 9/16 (56%) infected prosthetic grafts and 4/8 (50%) infected autogenous fistulas. Seven (43.8%) of the prosthetic grafts required removal; 6 (37.5%) were cured with drainage, irrigation and antibiotics, and 3 (18.8%) with antibiotics alone. One (12.5%) of the autogenous fistulas was removed, 4 (50%) required revision and 3 (37.5%) were treated with antibiotics alone. Whenever possible, A-V fistulas should be created in the arms with an autogenous graft as infections are less and easier to treat.

The Journal of Infectious Diseases, 2009

Influenza-associated morbidity and mortality has not decreased in the last decade, despite increa... more Influenza-associated morbidity and mortality has not decreased in the last decade, despite increased receipt of vaccine. To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed. A multicenter, randomized, double-blind controlled study was conducted to compare HD vaccine (which contains 60 microg of hemagglutinin per strain) with the licensed standard-dose (SD) vaccine (which contains 15 microg of hemagglutinin per strain) in adults > or = 65 years of age. HD vaccine was administered to 2575 subjects, and SD vaccine was administered to 1262 subjects. There was a statistically significant increase in the rates of seroconversion and mean hemagglutination inhibition titers at day 28 after vaccination among those who received HD vaccine, compared with those who received SD vaccine. Mean postvaccination titers for individuals who received HD vaccine were 116 for H1N1, 609 for H3N2, and 69 for B strain; for those who received SD vaccine, mean postvaccination titers were as 67 for H1N1, 333 for H3N2, and 52 for B strain. The HD vaccine met superiority criteria for both A strains, and the responses for B strain met non-inferiority criteria. Seroprotection rates were also higher for those who received HD vaccine than for those who received SD vaccine vaccine, for all strains. Local reactions were more frequent in individuals who received HD vaccine, but the reactions were mild to moderate. There was a statistically significant increase in the level of antibody response induced by HD influenza vaccine, compared with that induced by SD vaccine, without an attendant increase in the rate or severity of clinically relevant adverse reactions. These results suggest that the high-dose vaccine may provide improved protective benefits for older adults. ClinicalTrials.gov identifier: NCT00391053 .

Scandinavian Journal of Infectious Diseases, 1993

One of the complications of chronic haemodialysis is infection at the venous access site. A retro... more One of the complications of chronic haemodialysis is infection at the venous access site. A retrospective chart review (1985-1990) was done on patients requiring venoaccess for haemodialysis. 197 patients had 254 arterio-venous (A-V) fistulas created. 40 patients had 71 prosthetic implants and 157 patients had 183 autogenous fistulas created. 16 (22%) prosthetic grafts were infected versus 8 (4.3%) autogenous fistulas (p < 0.0001). Bacteraemia was present in 9/16 (56%) infected prosthetic grafts and 4/8 (50%) infected autogenous fistulas. Seven (43.8%) of the prosthetic grafts required removal; 6 (37.5%) were cured with drainage, irrigation and antibiotics, and 3 (18.8%) with antibiotics alone. One (12.5%) of the autogenous fistulas was removed, 4 (50%) required revision and 3 (37.5%) were treated with antibiotics alone. Whenever possible, A-V fistulas should be created in the arms with an autogenous graft as infections are less and easier to treat.

Headache: The Journal of Head and Face Pain, 1990

Changes in dopaminergic tonus have been hypothesized in patients with common migraine, suggesting... more Changes in dopaminergic tonus have been hypothesized in patients with common migraine, suggesting that prolactin may play a role in the pathogenesis of the migraine. We investigated the prolactin response to domperidone, a dopamine receptor blocker.

Clinical Infectious Diseases, 1993

Professional Development Plan Professional Development Plan PROFESSIONAL DEVELOPMENT PLAN 2