Jean-Philippe Berteau - Academia.edu (original) (raw)
Papers by Jean-Philippe Berteau
217 For cortical bone, important changes of the elastic properties values have been clearly shown... more 217 For cortical bone, important changes of the elastic properties values have been clearly shown in ageing but not in childhood, furthermore recent works considered osteoporosis as a pediatric disease with geriatric consequences and children are concerned by specific infantile osteo-pathologies. That is why there is a strong interest in the characterisation of the growing process of children bone. However, few mechanical properties of cortical growing bone are available in literature and do not yield to gold standards. Results found in litterature for children bone concern specific location (close to cancerous cells) or cadaveric bone. They indicate a lower Young's modulus for children bone compare to mature bone. The goal of this study is to provide elastic properties values for human growing cortical bone. To reach this goal, we have analysed surgery waste (bone transplantation) from long bone (fibula). In a first step, a non destructive method was used to evaluate the veloci...
For cortical bone, important changes of the elastic properties values have been clearly shown in ... more For cortical bone, important changes of the elastic properties values have been clearly shown in ageing but not in childhood, furthermore recent works considered osteoporosis as a pediatric disease with geriatric consequences and children are concerned by specific infantile osteo-pathologies. That is why there is a strong interest in the characterisation of the growing process of children bone. However, few mechanical properties of cortical growing bone are available in literature and do not yield to gold standards. Results found in litterature for children bone concern specific location (close to cancerous cells) or cadaveric bone. They indicate a lower Young's modulus for children bone compare to mature bone. The goal of this study is to provide elastic properties values for human growing cortical bone. To reach this goal, we have analysed surgery waste (bone transplantation) from long bone (fibula). In a first step, a non destructive method was used to evaluate the velocity o...
Kinésithérapie la Revue
Bone is a biological tissue affected by several environmental factors during growth. In children ... more Bone is a biological tissue affected by several environmental factors during growth. In children orthopedics monitoring, the knowledge of the bone quality can not only help to understand how bone fractures occurred, but also to guide the physiotherapy follow-up. The aim of that review is first to describe the bone growth, and second, to underline elements for physiotherapy follow-up. This review is based on publications about bone growth and on children clinical studies with four criteria: mineralization, geometry, skeletal development and modeling of bone.
La scoliose, déformation tridimensionnelle du rachis, peut être traitée par corset orthopédique. ... more La scoliose, déformation tridimensionnelle du rachis, peut être traitée par corset orthopédique. Notre étude vise à améliorer leur conception, d’une part par la réalisation / exploitation d’un modèle numérique du tronc et d’autre part par l’application de nouvelles stratégies correctives. Les résultats montrent l’efficacité de bandes modulables. Cette étude met en avant la faisabilité et l’efficacité d’une modélisation qualitative.
Scoliosis is a spinal deformation which can be care by a brace treatment. In this study, we are g... more Scoliosis is a spinal deformation which can be care by a brace treatment. In this study, we are going to make a focus on the most important group of scoliotic patients called “idiopathique” (= unknown origin). Most of the times, braces used the mechanical principle of three points flexion. The aim of this study is to optimize this rigid treatment. Our hypothesis is that surface loading in specific place can correct scoliosis deformation. We can evaluate this theory by a squelettal model including disc. On one hand, it requires a numerical modelling and on other hand an exploitation by testing surface loading in order to explore new strategy. Our simple modelling shows good qualitative answers for brace forces treatment. A new loading was tested this way, and the results show its numerical efficacy.
Bone, 2015
As a determinant of skeletal fragility, the organic matrix is responsible for the post-yield and ... more As a determinant of skeletal fragility, the organic matrix is responsible for the post-yield and creep behavior of bone and for its toughness, while the mineral apatite acts on stiffness. Specific to the fibula and ulna in children, greenstick fractures show a plastic in vivo mechanical behavior before bone fracture. During growth, the immature form of collagen enzymatic cross-links gradually decreases, to be replaced by the mature form until adolescence, subsequently remaining constant throughout adult life. However, the link between the cortical bone organic matrix and greenstick fractures in children remains to be explored. Here, we sought to determine: 1) whether plastic bending fractures can occur in vitro, by testing cortical bone samples from children's fibula and 2) whether the post-yield behavior (ω p plastic energy) of cortical bone before fracture is related to total quantity of the collagen matrix, or to the quantity of mature and immature enzymatic cross-links and the quantity of non-enzymatic cross-links. We used a two-step approach; first, a 3-point microbending device tested 22 fibula machined bone samples from 7 children and 3 elderly adults until fracture. Second, biochemical analysis by HPLC was performed on the sample fragments. When pooling two groups of donors, children and elderly adults, results show a rank correlation between total energy dissipated before fracture and age and a linear correlation between plastic energy dissipated before fracture and ratio of immature/mature cross-links. A collagen matrix with more immature cross-links (i.e. a higher immature/mature cross-link ratio) is more likely to plastically deform before fracture. We conclude that this ratio in the sub-nanostructure of the organic matrix in cortical bone from the fibula may go some way towards explaining the variance in post-yield behavior. From a clinical point of view, therefore, our results provide a potential explanation of the presence of greenstick fractures in children.
Biomechanics and modeling in mechanobiology, Jan 7, 2015
Articular cartilage maturation is the postnatal development process that adapts joint surfaces to... more Articular cartilage maturation is the postnatal development process that adapts joint surfaces to their site-specific biomechanical demands. Understanding the changes in mechanical tissues properties during growth is a critical step in advancing strategies for orthopedics and for cell- and biomaterial- based therapies dedicated to cartilage repair. We hypothesize that at the microscale, the articular cartilage tissue properties of the mouse (i.e., shear modulus and permeability) change with the growth and are dependent on location within the joint. We tested cartilage on the medial femoral condyle and lateral femoral condyle of seven C57Bl6 mice at different ages (2, 3, 5, 7, 9, 12, and 17 weeks old) using a micro-indentation test. Results indicated that permeability decreased with age from 2 to 17 weeks. Shear modulus reached a peak at the end of the growth (9 weeks). Within an age group, shear modulus was higher in the MFC than in the LFC, but permeability did not change. We have ...
Clinical Anatomy, 2015
The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in d... more The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in diagnosing osteoarthritis. Usually, a single CT scan slice is used to measure the thickness, but the measurement is highly location-dependent. Bone mineral density (BMD) and porosity could be more reliable than thickness for detecting SMZ sclerosis, and linking them to stiffness can provide insights into the mechanism of osteoarthritis progression. The goal of this study was two-fold: (1) to assess spatial heterogeneity in thickness, BMD, and porosity within the non-pathological human facet joint SMZ; (2) to correlate these measurements with the static modulus of elasticity (MOEsta ). Four non-pathological facet joints were excised and imaged using micro-computed tomography (µCT) to measure SMZ thickness, BMD, and porosity. A total of eight parallelepiped SMZ samples were similarly analyzed and then mechanically tested. The mean SMZ BMD, porosity, and thickness (± Standard Deviation) of the whole facet joints were 611 ± 35 mgHA/cc, 9.8 ± 1.3%, and 1.39 ± 0.41 mm, respectively. The mean BMD, porosity, and MOEsta of the eight SMZ samples were 479 ± 23 mgHA/cc, 12 ± 0.01%, and 387 ± 138 MPa, respectively, with a positive rank correlation between BMD and porosity. BMD and porosity were more homogeneous within the facet joint than thickness and they could be more reliable parameters than thickness for detecting SMZ sclerosis. The values for the physiological SMZ and MOEsta of human facets joints obtained here were independent of BMD. SMZ BMD and porosity were related to each other. Clin. Anat., 2015. © 2015 Wiley Periodicals, Inc.
The Spine Journal, 2011
BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) causes a spine and rib cage three-dimen... more BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) causes a spine and rib cage three-dimensional (3D) deformity previously treated by bracing. Whatever the manufacturing process, this rigid system acts biomechanically on the patient through the ''three-point bending'' mechanical principle. It applies corrective forces to a limited area and acts especially in the frontal plane. It seemed to us that a nonrigid system, called ''Cbrace,'' with 3D action allowing distribution of forces could increase compliance and provide better long-term correction prospects. PURPOSE: The aim of this study was to design a nonrigid brace by numerically testing in a finiteelement model developed here. STUDY DESIGN: A finite-element model has been developed to simulate brace effect on AIS right thoracic deformation of a 10-year-old patient. METHODS: A two-step method was needed; first, the reliability of our model is evaluated, and then, the ability to use distributed forces to correct scoliosis deformation is tested. To obtain a 3D correction, several treatments are experimented, leading to a comparison test between the best combination to the ''three-point bending'' principle.
Acoustical Imaging, 2012
This study deals with the development of an experimental device for performing ultrasonic compute... more This study deals with the development of an experimental device for performing ultrasonic computed tomography (UCT) on bone in pediatric degrees. The children's bone tomographs obtained in this study, were based on the use of a multiplexed 2-D ring antenna (1 MHz and 3 MHz) designed for performing electronic and mechanical scanning. Although this approach is known to be a potentially valuable means of imaging objects with similar acoustical impedances, problems arise when quantitative images of more highly contrasted media such as bones are required. Various strategies and various mathematical procedures for modeling the wave propagation based on Born approximations have been developed at our laboratory, which are suitable for use with pediatric cases. Inversions of the experimental data obtained are presented.
Revue de Chirurgie Orthopédique et Traumatologique, 2011
S280 86 e réunion annuelle de la Société française de chirurgie orthopédique et traumatologique m... more S280 86 e réunion annuelle de la Société française de chirurgie orthopédique et traumatologique ment libéré en zone portante doit idéalement être réalisé dans les 10 jours mais est encore possible à 2 mois ; il donne régulièrement une consolidation et de bons résultats.
Ultrasonics, 2014
Please cite this article as: J-P. Berteau, C. Baron, M. Pithioux, F. Launay, P. Chabrand, P. Lasa... more Please cite this article as: J-P. Berteau, C. Baron, M. Pithioux, F. Launay, P. Chabrand, P. Lasaygues, In vitro ultrasonic and mechanic characterization of the modulus of elasticity of children cortical bone, Ultrasonics (2013), doi: http://dx.
Kinésithérapie, la Revue, 2013
ABSTRACT Bone is a biological tissue affected by several environmental factors during growth. In ... more ABSTRACT Bone is a biological tissue affected by several environmental factors during growth. In children orthopedics monitoring, the knowledge of the bone quality can not only help to understand how bone fractures occurred, but also to guide the physiotherapy follow-up. The aim of that review is first to describe the bone growth, and second, to underline elements for physiotherapy follow-up. This review is based on publications about bone growth and on children clinical studies with four criteria: mineralization, geometry, skeletal development and modeling of bone. Level of evidence Not applicable.
Journal of Biomechanics, 2012
To cite this version: J.-Ph. Berteau, M. Pithioux, H. Follet, C. Guivier-Curien, Ph Lasaygues, et... more To cite this version: J.-Ph. Berteau, M. Pithioux, H. Follet, C. Guivier-Curien, Ph Lasaygues, et al.. Computed tomography, histological and ultrasonic measurements of adolescent scoliotic rib hump geometrical and material properties. a b s t r a c t
Computer Methods in Biomechanics and Biomedical Engineering, 2013
217 For cortical bone, important changes of the elastic properties values have been clearly shown... more 217 For cortical bone, important changes of the elastic properties values have been clearly shown in ageing but not in childhood, furthermore recent works considered osteoporosis as a pediatric disease with geriatric consequences and children are concerned by specific infantile osteo-pathologies. That is why there is a strong interest in the characterisation of the growing process of children bone. However, few mechanical properties of cortical growing bone are available in literature and do not yield to gold standards. Results found in litterature for children bone concern specific location (close to cancerous cells) or cadaveric bone. They indicate a lower Young's modulus for children bone compare to mature bone. The goal of this study is to provide elastic properties values for human growing cortical bone. To reach this goal, we have analysed surgery waste (bone transplantation) from long bone (fibula). In a first step, a non destructive method was used to evaluate the veloci...
For cortical bone, important changes of the elastic properties values have been clearly shown in ... more For cortical bone, important changes of the elastic properties values have been clearly shown in ageing but not in childhood, furthermore recent works considered osteoporosis as a pediatric disease with geriatric consequences and children are concerned by specific infantile osteo-pathologies. That is why there is a strong interest in the characterisation of the growing process of children bone. However, few mechanical properties of cortical growing bone are available in literature and do not yield to gold standards. Results found in litterature for children bone concern specific location (close to cancerous cells) or cadaveric bone. They indicate a lower Young's modulus for children bone compare to mature bone. The goal of this study is to provide elastic properties values for human growing cortical bone. To reach this goal, we have analysed surgery waste (bone transplantation) from long bone (fibula). In a first step, a non destructive method was used to evaluate the velocity o...
Kinésithérapie la Revue
Bone is a biological tissue affected by several environmental factors during growth. In children ... more Bone is a biological tissue affected by several environmental factors during growth. In children orthopedics monitoring, the knowledge of the bone quality can not only help to understand how bone fractures occurred, but also to guide the physiotherapy follow-up. The aim of that review is first to describe the bone growth, and second, to underline elements for physiotherapy follow-up. This review is based on publications about bone growth and on children clinical studies with four criteria: mineralization, geometry, skeletal development and modeling of bone.
La scoliose, déformation tridimensionnelle du rachis, peut être traitée par corset orthopédique. ... more La scoliose, déformation tridimensionnelle du rachis, peut être traitée par corset orthopédique. Notre étude vise à améliorer leur conception, d’une part par la réalisation / exploitation d’un modèle numérique du tronc et d’autre part par l’application de nouvelles stratégies correctives. Les résultats montrent l’efficacité de bandes modulables. Cette étude met en avant la faisabilité et l’efficacité d’une modélisation qualitative.
Scoliosis is a spinal deformation which can be care by a brace treatment. In this study, we are g... more Scoliosis is a spinal deformation which can be care by a brace treatment. In this study, we are going to make a focus on the most important group of scoliotic patients called “idiopathique” (= unknown origin). Most of the times, braces used the mechanical principle of three points flexion. The aim of this study is to optimize this rigid treatment. Our hypothesis is that surface loading in specific place can correct scoliosis deformation. We can evaluate this theory by a squelettal model including disc. On one hand, it requires a numerical modelling and on other hand an exploitation by testing surface loading in order to explore new strategy. Our simple modelling shows good qualitative answers for brace forces treatment. A new loading was tested this way, and the results show its numerical efficacy.
Bone, 2015
As a determinant of skeletal fragility, the organic matrix is responsible for the post-yield and ... more As a determinant of skeletal fragility, the organic matrix is responsible for the post-yield and creep behavior of bone and for its toughness, while the mineral apatite acts on stiffness. Specific to the fibula and ulna in children, greenstick fractures show a plastic in vivo mechanical behavior before bone fracture. During growth, the immature form of collagen enzymatic cross-links gradually decreases, to be replaced by the mature form until adolescence, subsequently remaining constant throughout adult life. However, the link between the cortical bone organic matrix and greenstick fractures in children remains to be explored. Here, we sought to determine: 1) whether plastic bending fractures can occur in vitro, by testing cortical bone samples from children's fibula and 2) whether the post-yield behavior (ω p plastic energy) of cortical bone before fracture is related to total quantity of the collagen matrix, or to the quantity of mature and immature enzymatic cross-links and the quantity of non-enzymatic cross-links. We used a two-step approach; first, a 3-point microbending device tested 22 fibula machined bone samples from 7 children and 3 elderly adults until fracture. Second, biochemical analysis by HPLC was performed on the sample fragments. When pooling two groups of donors, children and elderly adults, results show a rank correlation between total energy dissipated before fracture and age and a linear correlation between plastic energy dissipated before fracture and ratio of immature/mature cross-links. A collagen matrix with more immature cross-links (i.e. a higher immature/mature cross-link ratio) is more likely to plastically deform before fracture. We conclude that this ratio in the sub-nanostructure of the organic matrix in cortical bone from the fibula may go some way towards explaining the variance in post-yield behavior. From a clinical point of view, therefore, our results provide a potential explanation of the presence of greenstick fractures in children.
Biomechanics and modeling in mechanobiology, Jan 7, 2015
Articular cartilage maturation is the postnatal development process that adapts joint surfaces to... more Articular cartilage maturation is the postnatal development process that adapts joint surfaces to their site-specific biomechanical demands. Understanding the changes in mechanical tissues properties during growth is a critical step in advancing strategies for orthopedics and for cell- and biomaterial- based therapies dedicated to cartilage repair. We hypothesize that at the microscale, the articular cartilage tissue properties of the mouse (i.e., shear modulus and permeability) change with the growth and are dependent on location within the joint. We tested cartilage on the medial femoral condyle and lateral femoral condyle of seven C57Bl6 mice at different ages (2, 3, 5, 7, 9, 12, and 17 weeks old) using a micro-indentation test. Results indicated that permeability decreased with age from 2 to 17 weeks. Shear modulus reached a peak at the end of the growth (9 weeks). Within an age group, shear modulus was higher in the MFC than in the LFC, but permeability did not change. We have ...
Clinical Anatomy, 2015
The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in d... more The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in diagnosing osteoarthritis. Usually, a single CT scan slice is used to measure the thickness, but the measurement is highly location-dependent. Bone mineral density (BMD) and porosity could be more reliable than thickness for detecting SMZ sclerosis, and linking them to stiffness can provide insights into the mechanism of osteoarthritis progression. The goal of this study was two-fold: (1) to assess spatial heterogeneity in thickness, BMD, and porosity within the non-pathological human facet joint SMZ; (2) to correlate these measurements with the static modulus of elasticity (MOEsta ). Four non-pathological facet joints were excised and imaged using micro-computed tomography (µCT) to measure SMZ thickness, BMD, and porosity. A total of eight parallelepiped SMZ samples were similarly analyzed and then mechanically tested. The mean SMZ BMD, porosity, and thickness (± Standard Deviation) of the whole facet joints were 611 ± 35 mgHA/cc, 9.8 ± 1.3%, and 1.39 ± 0.41 mm, respectively. The mean BMD, porosity, and MOEsta of the eight SMZ samples were 479 ± 23 mgHA/cc, 12 ± 0.01%, and 387 ± 138 MPa, respectively, with a positive rank correlation between BMD and porosity. BMD and porosity were more homogeneous within the facet joint than thickness and they could be more reliable parameters than thickness for detecting SMZ sclerosis. The values for the physiological SMZ and MOEsta of human facets joints obtained here were independent of BMD. SMZ BMD and porosity were related to each other. Clin. Anat., 2015. © 2015 Wiley Periodicals, Inc.
The Spine Journal, 2011
BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) causes a spine and rib cage three-dimen... more BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) causes a spine and rib cage three-dimensional (3D) deformity previously treated by bracing. Whatever the manufacturing process, this rigid system acts biomechanically on the patient through the ''three-point bending'' mechanical principle. It applies corrective forces to a limited area and acts especially in the frontal plane. It seemed to us that a nonrigid system, called ''Cbrace,'' with 3D action allowing distribution of forces could increase compliance and provide better long-term correction prospects. PURPOSE: The aim of this study was to design a nonrigid brace by numerically testing in a finiteelement model developed here. STUDY DESIGN: A finite-element model has been developed to simulate brace effect on AIS right thoracic deformation of a 10-year-old patient. METHODS: A two-step method was needed; first, the reliability of our model is evaluated, and then, the ability to use distributed forces to correct scoliosis deformation is tested. To obtain a 3D correction, several treatments are experimented, leading to a comparison test between the best combination to the ''three-point bending'' principle.
Acoustical Imaging, 2012
This study deals with the development of an experimental device for performing ultrasonic compute... more This study deals with the development of an experimental device for performing ultrasonic computed tomography (UCT) on bone in pediatric degrees. The children's bone tomographs obtained in this study, were based on the use of a multiplexed 2-D ring antenna (1 MHz and 3 MHz) designed for performing electronic and mechanical scanning. Although this approach is known to be a potentially valuable means of imaging objects with similar acoustical impedances, problems arise when quantitative images of more highly contrasted media such as bones are required. Various strategies and various mathematical procedures for modeling the wave propagation based on Born approximations have been developed at our laboratory, which are suitable for use with pediatric cases. Inversions of the experimental data obtained are presented.
Revue de Chirurgie Orthopédique et Traumatologique, 2011
S280 86 e réunion annuelle de la Société française de chirurgie orthopédique et traumatologique m... more S280 86 e réunion annuelle de la Société française de chirurgie orthopédique et traumatologique ment libéré en zone portante doit idéalement être réalisé dans les 10 jours mais est encore possible à 2 mois ; il donne régulièrement une consolidation et de bons résultats.
Ultrasonics, 2014
Please cite this article as: J-P. Berteau, C. Baron, M. Pithioux, F. Launay, P. Chabrand, P. Lasa... more Please cite this article as: J-P. Berteau, C. Baron, M. Pithioux, F. Launay, P. Chabrand, P. Lasaygues, In vitro ultrasonic and mechanic characterization of the modulus of elasticity of children cortical bone, Ultrasonics (2013), doi: http://dx.
Kinésithérapie, la Revue, 2013
ABSTRACT Bone is a biological tissue affected by several environmental factors during growth. In ... more ABSTRACT Bone is a biological tissue affected by several environmental factors during growth. In children orthopedics monitoring, the knowledge of the bone quality can not only help to understand how bone fractures occurred, but also to guide the physiotherapy follow-up. The aim of that review is first to describe the bone growth, and second, to underline elements for physiotherapy follow-up. This review is based on publications about bone growth and on children clinical studies with four criteria: mineralization, geometry, skeletal development and modeling of bone. Level of evidence Not applicable.
Journal of Biomechanics, 2012
To cite this version: J.-Ph. Berteau, M. Pithioux, H. Follet, C. Guivier-Curien, Ph Lasaygues, et... more To cite this version: J.-Ph. Berteau, M. Pithioux, H. Follet, C. Guivier-Curien, Ph Lasaygues, et al.. Computed tomography, histological and ultrasonic measurements of adolescent scoliotic rib hump geometrical and material properties. a b s t r a c t
Computer Methods in Biomechanics and Biomedical Engineering, 2013