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Research paper thumbnail of Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation

American Journal of Surgical Pathology, 2014

A 29-year-old woman with no disease history of interest consulted with a painless right infra-aur... more A 29-year-old woman with no disease history of interest consulted with a painless right infra-auricular mass of one month's onset with no other clinical symptoms. FNA revealed moderately atypical glandular cells, and occasional squamous cell groups with no accompanying stroma. The report was positive for malignant cells. MRI reported the presence of a nodule, 14 mm×16 mm in the posterior area of the right parotid tail, of discretely hyperintense contour on T2 with a centre of lower signal intensity, well-defined limits hypointense on T1, suggestive of a benign parotid tumour (Fig. 1). A parotidectomy I-II was performed together with partial resection of the sternocleidomastoid muscle, as the tumour was adhering to it. The result of the perioperative biopsy was compatible with mucoepidermoid parotid carcinoma, and therefore a radical neck dissection was performed of right area II. The deferred pathological study showed a low-grade parotid carcinoma with morphological features of a mammary analogue secretory carcinoma (MASC), 1.2 cm in size.

Research paper thumbnail of Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation

American Journal of Surgical Pathology, 2014

A 29-year-old woman with no disease history of interest consulted with a painless right infra-aur... more A 29-year-old woman with no disease history of interest consulted with a painless right infra-auricular mass of one month's onset with no other clinical symptoms. FNA revealed moderately atypical glandular cells, and occasional squamous cell groups with no accompanying stroma. The report was positive for malignant cells. MRI reported the presence of a nodule, 14 mm×16 mm in the posterior area of the right parotid tail, of discretely hyperintense contour on T2 with a centre of lower signal intensity, well-defined limits hypointense on T1, suggestive of a benign parotid tumour (Fig. 1). A parotidectomy I-II was performed together with partial resection of the sternocleidomastoid muscle, as the tumour was adhering to it. The result of the perioperative biopsy was compatible with mucoepidermoid parotid carcinoma, and therefore a radical neck dissection was performed of right area II. The deferred pathological study showed a low-grade parotid carcinoma with morphological features of a mammary analogue secretory carcinoma (MASC), 1.2 cm in size.

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