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Papers by Jean Tichet
La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce... more La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce questionnaire de 20 items, oriente sur la detection des principales erreurs alimentaires, avait prealablement ete valide pour des populations de sujets tout-venant. Au premier temps de l'enquete, 146 personnes hospitalisees en medecine interne ont rempli le questionnaire avant que la dieteticienne n'effectue un bilan nutritionnel. Les correlations entre les resultats des deux techniques etaient toutes significatives (p < 0,01). Les moyennes quotidiennes calculees pour les principaux nutriments ne differaient pas, exceptee une surestimation moderee des lipides (hommes : 7 g, femmes : 8 g), du saccharose (hommes : 8 g) et du calcium (femmes : 55 mg) en utilisant l'auto-questionnaire. Le second terme de l'etude a consiste a integrer cette pratique dans le fonctionnement quotidien du service. Rempli aisement en 5 a 10 minutes et analyse immediatement, le questionnaire a e...
Santé Publique, 2009
La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que d... more La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Journal of hypertension, Mar 1, 2017
We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hyp... more We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production. The FLI is calculated from BMI, waist circumference, triglycerides and gamma-glutamyltransferase (GGT) and the hepatic insulin resistance index from endogenous glucose production and fasting insulin. The incidence of hypertension increased across the quartiles groups of both baseline GGT and alanine aminotransferase. After adjustment for sex, age, waist circumference, fasting glucose, smoking and alcohol intake, only GGT was significantly related w...
Journal of Sexual Medicine, 2008
Introduction. Detection of androgen deficiency is at least, based on specific questionnaires, def... more Introduction. Detection of androgen deficiency is at least, based on specific questionnaires, defined by sexual, psychological, and somatic variables. Their relationships with sexual hormone levels are poorly understood. Aim. To assess the Aging Male Symptoms (AMS) score and sex hormone levels in normal and complaining men in order to define the relationship between the key parameters related to androgen deficiency. Methods. Nine hundred and three men were interviewed via phone by a trained interviewer who completed the questionnaire; 539 men consulting for a checkup in a health center and 471 complaining men, who completed the AMS scale in clinical setting, were selected, after excluding subjects with major and/or chronic diseases, endocrine disorders, psychological dysfunctions, and metabolic syndrome. Main Outcome Measures. Total AMS score and psychological, somatic and sexual subscores, as a function of age. Results. The AMS questionnaires the were completed in a clinical setting or via calling-up line were comparable. In both cases, total AMS scores and subscores were significantly dependent of age and were correlated to income. In normal men, the only two parameters that significantly changed with age were the AMS sexual subscore and bioavailable testosterone (BT). Complaining men aged more than 50 years old had a significantly higher total AMS scores, subscores, and BT level than normal men up to 60 years old, and these differences weakened with increasing age. In normal and complaining men, whatever the AMS sexual subscore, any variation in testosterone (T) and BT levels was observed. Conclusions. The AMS scale could be defined as a screening test for androgen deficiency symptoms in men between 50 and 65 years of age. The sexual AMS subscore and BT level are the key variables to identify those symptoms; the severity of sexual symptoms can not be explained by a BT level decrease.
Diabetes Care, 1991
Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determinati... more Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determination, and the method of IAA measurement has not been standardized. Research Design and Methods IAAs were determined by radiobinding assay (RBA) and enzyme-linked immunosorbent assay (ELISA) in two large age-matched groups of nondiabetic and newly diagnosed insulin-dependent (type I) diabetic children. Results Positivity for IAA by RBA (≥ to nondiabetic mean + 3SD) was 2 of 178 (1.1%) and 55 of 173 (32%) in nondiabetic and diabetic children, respectively. Prevalence of IAA by RBA was significantly higher in the youngest age-group (63% between 0-4 yr). Positivity for IAA by ELISA was 1 of 178 (0.6%) and 8 of 169 (4.7%) in nondiabetic and diabetic children, respectively. Concordance rates between both assays were 0 of 3 (0%) in control subjects and 5 of 58 (8.6%) in diabetic children. Conclusions We conclude that RBA is more appropriate than ELISA for IAA detection at the onset of the disease...
Psychoneuroendocrinology, 2016
To examine longitudinal associations between antidepressant medication use and the metabolic synd... more To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations. In fully-adjusted longitudinal logistic regression analyses based on generalized estimating equations, antidepressant users had a 9% (p=0.011) and a 6% (p=0.036) greater annual increase in the odds of having the MetS defined by NCEP-ATP III and AHA/NHLBI criteria respectively. Sex-specific analyses showed that this association was confined to men only. When the different types of antidepr...
La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce... more La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce questionnaire de 20 items, oriente sur la detection des principales erreurs alimentaires, avait prealablement ete valide pour des populations de sujets tout-venant. Au premier temps de l'enquete, 146 personnes hospitalisees en medecine interne ont rempli le questionnaire avant que la dieteticienne n'effectue un bilan nutritionnel. Les correlations entre les resultats des deux techniques etaient toutes significatives (p < 0,01). Les moyennes quotidiennes calculees pour les principaux nutriments ne differaient pas, exceptee une surestimation moderee des lipides (hommes : 7 g, femmes : 8 g), du saccharose (hommes : 8 g) et du calcium (femmes : 55 mg) en utilisant l'auto-questionnaire. Le second terme de l'etude a consiste a integrer cette pratique dans le fonctionnement quotidien du service. Rempli aisement en 5 a 10 minutes et analyse immediatement, le questionnaire a e...
Comptes Rendus De L Academie Des Sciences Serie 3 Sciences De La Vie, 1995
Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonc... more Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonction de la stature (1,60 m-1,84 m) et de l'âge (18 ans-59 ans) pour aboutir a une nouvelle standardisation. La mise en evidence d'une relation lineaire entre la stature et les poids moyens correspondant a une stature fixee nous indique avec precision l'estimation du deficit ou de l'exces relatif ponderal de tout individu. Cette relation lineaire apporte une signification nouvelle a l'expression algebrique P/T 2 et permet ainsi d'effectuer la comparaison entre les corpulences de sujets de statures et d'âges distincts.
Santé Publique, 2009
La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que d... more La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Journal of hypertension, Mar 1, 2017
We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hyp... more We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production. The FLI is calculated from BMI, waist circumference, triglycerides and gamma-glutamyltransferase (GGT) and the hepatic insulin resistance index from endogenous glucose production and fasting insulin. The incidence of hypertension increased across the quartiles groups of both baseline GGT and alanine aminotransferase. After adjustment for sex, age, waist circumference, fasting glucose, smoking and alcohol intake, only GGT was significantly related w...
Psychoneuroendocrinology, 2016
To examine longitudinal associations between antidepressant medication use and the metabolic synd... more To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations. In fully-adjusted longitudinal logistic regression analyses based on generalized estimating equations, antidepressant users had a 9% (p=0.011) and a 6% (p=0.036) greater annual increase in the odds of having the MetS defined by NCEP-ATP III and AHA/NHLBI criteria respectively. Sex-specific analyses showed that this association was confined to men only. When the different types of antidepr...
Diabetes & Metabolism, 2016
Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète inc... more Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète incident dans la cohorte DESIR B. Balkau* (1) , J. Tichet (2) , F. Bonnet (3)
Comptes Rendus De L Academie Des Sciences Serie 3 Sciences De La Vie, 1995
Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonc... more Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonction de la stature (1,60 m-1,84 m) et de l'âge (18 ans-59 ans) pour aboutir a une nouvelle standardisation. La mise en evidence d'une relation lineaire entre la stature et les poids moyens correspondant a une stature fixee nous indique avec precision l'estimation du deficit ou de l'exces relatif ponderal de tout individu. Cette relation lineaire apporte une signification nouvelle a l'expression algebrique P/T 2 et permet ainsi d'effectuer la comparaison entre les corpulences de sujets de statures et d'âges distincts.
Diabetes & Metabolism, 2016
Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète inc... more Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète incident dans la cohorte DESIR B. Balkau* (1) , J. Tichet (2) , F. Bonnet (3)
Presse medicale (Paris, France : 1983), Jan 24, 2016
To describe cardiovascular risk factors and metabolic disturbances in a French population includi... more To describe cardiovascular risk factors and metabolic disturbances in a French population including shift workers and study whether possible changes were noticeable after non-shift to shift work transition within the last five years. The study population included 4764 attendees of two health examinations (5 years apart), between January 1996 and October 2008, in 11 health examination centres. Clinical, biological and metabolic factors together with their changes over a five-year period were compared between attendees who kept a non-shift daytime job, those who kept working shift and those who switched from non-shift daytime to shift work over the last 5 years. At baseline, working shift was, independently of lifestyle or BMI, significantly related to more elevated plasma triglycerides (β=0.04, P=0.05) and rate of hypertriglyceridemia (β=0.27, P=0.01), lower plasma HDL-C levels (β=-2.03, P=0.006) and less hypertension (β=-0.25, P=0.01) compared to non-shift daytime work. In men, a sl...
La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce... more La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce questionnaire de 20 items, oriente sur la detection des principales erreurs alimentaires, avait prealablement ete valide pour des populations de sujets tout-venant. Au premier temps de l'enquete, 146 personnes hospitalisees en medecine interne ont rempli le questionnaire avant que la dieteticienne n'effectue un bilan nutritionnel. Les correlations entre les resultats des deux techniques etaient toutes significatives (p < 0,01). Les moyennes quotidiennes calculees pour les principaux nutriments ne differaient pas, exceptee une surestimation moderee des lipides (hommes : 7 g, femmes : 8 g), du saccharose (hommes : 8 g) et du calcium (femmes : 55 mg) en utilisant l'auto-questionnaire. Le second terme de l'etude a consiste a integrer cette pratique dans le fonctionnement quotidien du service. Rempli aisement en 5 a 10 minutes et analyse immediatement, le questionnaire a e...
Santé Publique, 2009
La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que d... more La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Journal of hypertension, Mar 1, 2017
We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hyp... more We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production. The FLI is calculated from BMI, waist circumference, triglycerides and gamma-glutamyltransferase (GGT) and the hepatic insulin resistance index from endogenous glucose production and fasting insulin. The incidence of hypertension increased across the quartiles groups of both baseline GGT and alanine aminotransferase. After adjustment for sex, age, waist circumference, fasting glucose, smoking and alcohol intake, only GGT was significantly related w...
Journal of Sexual Medicine, 2008
Introduction. Detection of androgen deficiency is at least, based on specific questionnaires, def... more Introduction. Detection of androgen deficiency is at least, based on specific questionnaires, defined by sexual, psychological, and somatic variables. Their relationships with sexual hormone levels are poorly understood. Aim. To assess the Aging Male Symptoms (AMS) score and sex hormone levels in normal and complaining men in order to define the relationship between the key parameters related to androgen deficiency. Methods. Nine hundred and three men were interviewed via phone by a trained interviewer who completed the questionnaire; 539 men consulting for a checkup in a health center and 471 complaining men, who completed the AMS scale in clinical setting, were selected, after excluding subjects with major and/or chronic diseases, endocrine disorders, psychological dysfunctions, and metabolic syndrome. Main Outcome Measures. Total AMS score and psychological, somatic and sexual subscores, as a function of age. Results. The AMS questionnaires the were completed in a clinical setting or via calling-up line were comparable. In both cases, total AMS scores and subscores were significantly dependent of age and were correlated to income. In normal men, the only two parameters that significantly changed with age were the AMS sexual subscore and bioavailable testosterone (BT). Complaining men aged more than 50 years old had a significantly higher total AMS scores, subscores, and BT level than normal men up to 60 years old, and these differences weakened with increasing age. In normal and complaining men, whatever the AMS sexual subscore, any variation in testosterone (T) and BT levels was observed. Conclusions. The AMS scale could be defined as a screening test for androgen deficiency symptoms in men between 50 and 65 years of age. The sexual AMS subscore and BT level are the key variables to identify those symptoms; the severity of sexual symptoms can not be explained by a BT level decrease.
Diabetes Care, 1991
Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determinati... more Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determination, and the method of IAA measurement has not been standardized. Research Design and Methods IAAs were determined by radiobinding assay (RBA) and enzyme-linked immunosorbent assay (ELISA) in two large age-matched groups of nondiabetic and newly diagnosed insulin-dependent (type I) diabetic children. Results Positivity for IAA by RBA (≥ to nondiabetic mean + 3SD) was 2 of 178 (1.1%) and 55 of 173 (32%) in nondiabetic and diabetic children, respectively. Prevalence of IAA by RBA was significantly higher in the youngest age-group (63% between 0-4 yr). Positivity for IAA by ELISA was 1 of 178 (0.6%) and 8 of 169 (4.7%) in nondiabetic and diabetic children, respectively. Concordance rates between both assays were 0 of 3 (0%) in control subjects and 5 of 58 (8.6%) in diabetic children. Conclusions We conclude that RBA is more appropriate than ELISA for IAA detection at the onset of the disease...
Psychoneuroendocrinology, 2016
To examine longitudinal associations between antidepressant medication use and the metabolic synd... more To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations. In fully-adjusted longitudinal logistic regression analyses based on generalized estimating equations, antidepressant users had a 9% (p=0.011) and a 6% (p=0.036) greater annual increase in the odds of having the MetS defined by NCEP-ATP III and AHA/NHLBI criteria respectively. Sex-specific analyses showed that this association was confined to men only. When the different types of antidepr...
La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce... more La fiabilite d'un auto-questionnaire alimentaire court a ete testee en milieu hospitalier. Ce questionnaire de 20 items, oriente sur la detection des principales erreurs alimentaires, avait prealablement ete valide pour des populations de sujets tout-venant. Au premier temps de l'enquete, 146 personnes hospitalisees en medecine interne ont rempli le questionnaire avant que la dieteticienne n'effectue un bilan nutritionnel. Les correlations entre les resultats des deux techniques etaient toutes significatives (p < 0,01). Les moyennes quotidiennes calculees pour les principaux nutriments ne differaient pas, exceptee une surestimation moderee des lipides (hommes : 7 g, femmes : 8 g), du saccharose (hommes : 8 g) et du calcium (femmes : 55 mg) en utilisant l'auto-questionnaire. Le second terme de l'etude a consiste a integrer cette pratique dans le fonctionnement quotidien du service. Rempli aisement en 5 a 10 minutes et analyse immediatement, le questionnaire a e...
Comptes Rendus De L Academie Des Sciences Serie 3 Sciences De La Vie, 1995
Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonc... more Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonction de la stature (1,60 m-1,84 m) et de l'âge (18 ans-59 ans) pour aboutir a une nouvelle standardisation. La mise en evidence d'une relation lineaire entre la stature et les poids moyens correspondant a une stature fixee nous indique avec precision l'estimation du deficit ou de l'exces relatif ponderal de tout individu. Cette relation lineaire apporte une signification nouvelle a l'expression algebrique P/T 2 et permet ainsi d'effectuer la comparaison entre les corpulences de sujets de statures et d'âges distincts.
Santé Publique, 2009
La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que d... more La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf accord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
Journal of hypertension, Mar 1, 2017
We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hyp... more We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production. The FLI is calculated from BMI, waist circumference, triglycerides and gamma-glutamyltransferase (GGT) and the hepatic insulin resistance index from endogenous glucose production and fasting insulin. The incidence of hypertension increased across the quartiles groups of both baseline GGT and alanine aminotransferase. After adjustment for sex, age, waist circumference, fasting glucose, smoking and alcohol intake, only GGT was significantly related w...
Psychoneuroendocrinology, 2016
To examine longitudinal associations between antidepressant medication use and the metabolic synd... more To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations. In fully-adjusted longitudinal logistic regression analyses based on generalized estimating equations, antidepressant users had a 9% (p=0.011) and a 6% (p=0.036) greater annual increase in the odds of having the MetS defined by NCEP-ATP III and AHA/NHLBI criteria respectively. Sex-specific analyses showed that this association was confined to men only. When the different types of antidepr...
Diabetes & Metabolism, 2016
Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète inc... more Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète incident dans la cohorte DESIR B. Balkau* (1) , J. Tichet (2) , F. Bonnet (3)
Comptes Rendus De L Academie Des Sciences Serie 3 Sciences De La Vie, 1995
Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonc... more Cette etude porte sur la modelisation de la corpulence de 54360 Francais de sexe masculin en fonction de la stature (1,60 m-1,84 m) et de l'âge (18 ans-59 ans) pour aboutir a une nouvelle standardisation. La mise en evidence d'une relation lineaire entre la stature et les poids moyens correspondant a une stature fixee nous indique avec precision l'estimation du deficit ou de l'exces relatif ponderal de tout individu. Cette relation lineaire apporte une signification nouvelle a l'expression algebrique P/T 2 et permet ainsi d'effectuer la comparaison entre les corpulences de sujets de statures et d'âges distincts.
Diabetes & Metabolism, 2016
Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète inc... more Dimorphisme sexuel vis-à-vis de l'influence de l'hérédité du diabète sur le risque de diabète incident dans la cohorte DESIR B. Balkau* (1) , J. Tichet (2) , F. Bonnet (3)
Presse medicale (Paris, France : 1983), Jan 24, 2016
To describe cardiovascular risk factors and metabolic disturbances in a French population includi... more To describe cardiovascular risk factors and metabolic disturbances in a French population including shift workers and study whether possible changes were noticeable after non-shift to shift work transition within the last five years. The study population included 4764 attendees of two health examinations (5 years apart), between January 1996 and October 2008, in 11 health examination centres. Clinical, biological and metabolic factors together with their changes over a five-year period were compared between attendees who kept a non-shift daytime job, those who kept working shift and those who switched from non-shift daytime to shift work over the last 5 years. At baseline, working shift was, independently of lifestyle or BMI, significantly related to more elevated plasma triglycerides (β=0.04, P=0.05) and rate of hypertriglyceridemia (β=0.27, P=0.01), lower plasma HDL-C levels (β=-2.03, P=0.006) and less hypertension (β=-0.25, P=0.01) compared to non-shift daytime work. In men, a sl...