Jeik Byun - Academia.edu (original) (raw)

Papers by Jeik Byun

Scientific Reports

To investigate usefulness of 3D printing for preoperative evaluations, student and resident educa... more To investigate usefulness of 3D printing for preoperative evaluations, student and resident education, and communication with parents or guardians of patients with pediatric retroperitoneal tumors. Ten patients planning retroperitoneal tumor resection between March and November 2019 were included. Preoperative computed tomography (CT) images were used for 3D reconstruction and printing. Surveyed items were understanding of preoperative lesions with 3 different modules (CT, 3D reconstruction, and 3D printing) by students, residents, and specialists; satisfaction of specialists; and comprehension by guardians after preoperative explanations with each module. The median age at operation was 4.2 years (range, 1.8–18.1), and 8 patients were diagnosed with neuroblastoma. The 3D printing was the most understandable module for all groups (for students, residents, and specialists, P = 0.002, 0.027, 0.013, respectively). No significant intraoperative adverse events or immediate postoperative ...

For long-term applications of implantable neural probes, a drug-delivery system can be employed t... more For long-term applications of implantable neural probes, a drug-delivery system can be employed to improve the electrical recording/stimulus quality by means of releasing biochemical for reduction of tissue reactions. We report a 128-channel MEA with eight fiber-embedded microfluidic channels. The integration of a large number of electrodes on a flexible surface required an improved flattening method. To verify the feasibility of the proposed device, liquid transportation via microfluidic channels and multi-channel neural recordings were performed. The local field potential of a rodent brain was successfully recorded, and the water-fall analysis showed a constant flow rate in the microfluidic channels.

Surgery Today, 2020

The purpose of this study was to investigate the outcomes after appendectomy in children accordin... more The purpose of this study was to investigate the outcomes after appendectomy in children according to hospital size. Methods The records of 11,565 patients with the diagnosis-related group code for appendectomy were extracted from HIRA-Pediatric Patient Sample from 2012 to 2016. The number of hospital visits and the length of stay in hospital within 30 days after appendectomy were analyzed. Results Patients who were treated at large-sized hospitals were more likely to be younger, more likely to reside in metropolitan areas, and tended to receive laparoscopic surgery. The number of hospital visits within 30 days in patients managed by medium-and large-sized hospitals decreased in comparison to small-sized hospitals. The length of hospital stay in large-sized hospitals was decreased in comparison to small-and medium-sized hospitals. A subgroup analysis revealed that complicated appendectomy did not have a significant impact on the difference in the length of hospital stay between hospital sizes. Conclusion The number of hospital visits and the length of hospital stay was higher in small-sized hospitals in comparison to large-sized hospitals. Appendectomy performed in the larger hospital showed better outcomes in pediatric patients. We recommend that pediatric surgical procedures be performed in large hospitals, and that proper incentives be given for procedures to be performed by pediatric specialists.

Advances in Pediatric Surgery, 2020

Transplantation, 2019

Introduction: Patients requiring long term parenteral nutrition for intestinal failure are at ris... more Introduction: Patients requiring long term parenteral nutrition for intestinal failure are at risk of developing associated liver disease (IFALD) which can progress to cirrhosis that requires liver transplantation along with the intestine. There is evidence to suggest that pre-emptive intestinal transplantation in this setting can prevent progression of liver disease and may improve fibrosis. Methods: A retrospective review of liver biopsies, liver blood tests (at the time of biopsy) intestinal anatomy and outcomes in patients referred to Addenbrooke’s Hospital Cambridge UK between 2008 and 2018 for consideration of transplantation for IFALD. Fibrosis was scored subjectively by pathologists as mild, moderate, severe or cirrhosis. Results: 21 patients (out of a total of 82) underwent transplantation for IFALD. In 13 cases, liver fibrosis was considered too advanced for intestine alone and they required liver containing grafts, the others received intestine without liver. Post transplant survival is shown in fig 1. In addition, 13 patients have been referred and/or listed and 9 died on the waiting list, 5 of which from advanced liver disease. Liver biopsies which showed at least moderate fibrosis (in the absence of additional pathology) from patients with >20cms intestine to stoma were performed at a mean of 11.6 years (SD7yrs) after starting PN (n=15), those with <20cms to stoma were performed at a mean of 2.2 years (SD 0.6yrs) (n=10). LFTs in patients (excluding end stage disease and severe cholestasis) were calculated. Mean bilirubin and ALT in patients with cirrhosis or severe fibrosis were 30 umols/l (+/-11) and 52 U/l (+/34). Only 10 out of 24 patients with at least moderate fibrosis on biopsy showed bilirubin and/or ALT >1.5x ULN. Conclusions: Patients with ultrashort intestine are at risk of early progression to significant degrees of IFALD. Liver blood tests are not predictive of underlying IFALD. Post-transplant survival in patients with IFALD requiring liver transplantation is inferior to that of those receiving intestine alone Earlier detection of IFALD and referral for pre-emptive intestinal transplantation is indicated P4.16

Journal of Korean Medical Science, 2019

Background: Improvements in perinatal intensive care have improved survival of extremelylow-birth... more Background: Improvements in perinatal intensive care have improved survival of extremelylow-birth-weight (ELBW) neonates, although the risk of acute abdomen has increased. The differential diagnosis resulting in abdominal surgery can be categorized into necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP), meconium-related ileus (MRI), and meconium non-related ileus (MNRI). The purpose of this study was to review our experience with abdominal surgery for ELBW neonates, and to evaluate characteristics and prognosis according to the differential diagnosis. Methods: Medical records of ELBW neonates treated between 2003 and 2015 were retrospectively reviewed. Results: Of 805 ELBW neonates, 65 (8.1%) received abdominal surgery. The numbers of cases by disease category were 29 for NEC, 18 for SIP, 13 for MRI, and 5 for MNRI. Ostoma formation was performed in 61 (93.8%) patients; primary anastomosis without ostoma was performed in 4 (6.2%). All patients without ostoma formation experienced re-perforation of the anastomosis site. Seven patients had 30-day postoperative mortality (6 had NEC). Longterm survival of the surgical and non-surgical groups was not statistically different. NEC was a poor prognostic factor for survival outcome (P = 0.033). Conclusion: Abdominal surgery for ELBW neonates is feasible. Ostoma formation can lead to reduced complications compared to primary anastomosis.

World journal of gastroenterology, Jan 7, 2017

To investigate the rates of pretransplantation fetal-maternal microchimerism (MC) and its effect ... more To investigate the rates of pretransplantation fetal-maternal microchimerism (MC) and its effect on rejection in children receiving maternal liver grafts. DNA or blood samples before liver transplantation (LT) were available in 45 pediatric patients and their mothers. The presence of pretransplantation MC to non-inherited maternal antigens (NIMAs) (NIMA-MC) in the peripheral blood was tested using nested PCR-single-strand conformation polymorphism analysis for the human leukocyte antigen (HLA)-DRB1 alleles. NIMA-MC was successfully evaluated in 26 of the 45 children. Among these 45 pediatric LT recipients, 23 children (51.1%) received transplants from maternal donors and the other 22 from non-maternal donors. Among these 26 children, pretransplantation NIMA-MC was detected in 23.1% ( = 6), 6.1 (range, 0.8-14) years after birth. Among the children with a maternal donor, the rate of biopsy-proven cellular rejection (BPCR) was 0% in patients with NIMA-MC positivity (0/3) and those with...

World journal of gastrointestinal surgery, Jan 27, 2014

To determine the etiology and prognostic factors for neonatal gastric perforation (NGP), a rare b... more To determine the etiology and prognostic factors for neonatal gastric perforation (NGP), a rare but life-threatening disease. Between 1980 and 2011, nine patients underwent surgical intervention for NGP at Seoul National University Children's Hospital. The characteristics and prognosis of the patients were retrospectively analyzed. Among the nine patients, three (33.3%) were preterm babies and five (55.5%) had associated anomalies, which included diaphragmatic eventration (n = 2), congenital diaphragmatic hernia, esophageal atresia with tracheoesophageal fistula, and antral web. Three (33.3%) patients were born before 1990 and three (33.3%) had a birth weight < 2500 g. Pneumoperitoneum was found on preoperative images in six (66.7%) patients, and incidentally in the other three (33.3%) patients. Surgery was performed within 24 h after the onset of symptoms in seven (77.8%) patients. The overall mortality rate was 22.2% (2/9). The time between…

Journal of Korean medical science, 2014

Liver transplantation (LT) has been the key therapy for end stage liver diseases. However, LT in ... more Liver transplantation (LT) has been the key therapy for end stage liver diseases. However, LT in infancy is still understudied. From 1992 to 2010, 152 children had undergone LT in Seoul National University Hospital. Operations were performed on 43 patients aged less than 12 months (Group A) and 109 patients aged over 12 months (Group B). The mean age of the recipients was 7 months in Group A and 74 months in Group B. The patients' survival rates and post-LT complications were analyzed. The mean Pediatric End-stage Liver Disease score was higher in Group A (21.8) than in Group B (13.4) (P = 0.049). Fulminant hepatitis was less common in Group A (4.8%) than in Group B (13.8%) (P = 0.021). The post-transplant lymphoproliferative disorder and portal vein complication were more common in Group A (14.0%, 18.6%) than in Group B (1.8%, 3.7%) (P = 0.005). However, the 1, 5, and 10 yr patient survival rates were 93%, 93%, and 93%, in Group A and 92%, 90%, and 88% in Group B (P = 0.212). T...

Asian journal of endoscopic surgery, 2014

Hypertrophic hypersecretory gastropathy with protein loss (HHGP) is a rare form of acquired gastr... more Hypertrophic hypersecretory gastropathy with protein loss (HHGP) is a rare form of acquired gastropathy characterized by giant gastric rugal folds and hypoalbuminemia. It is often misdiagnosed as Ménétrier's disease. We report the case of a 45-year-old man with HHGP who presented with nausea and anorexia. The patient had no underlying disease and was not on medication. Esophagogastroduodenoscopy and CT showed a thickening of the gastric folds in the stomach. As cancer cells were not detected on endoscopic biopsies, the patient was diagnosed with Ménétrier's disease. He was managed with a high-protein diet and annual follow-up by esophagogastroduodenoscopy. Five years after the diagnosis, the patient underwent laparoscopy-assisted total gastrectomy for refractory abdominal pain, diarrhea, and protein loss. A pathological diagnosis of HHGP was made and he was discharged without any surgical complications. The patient was relieved of anorexia, abdominal pain, and diarrhea. Lapa...

World Journal of Gastroenterology, 2014

Duodenal duplication cysts are rare congenital anomalies. Duodenal duplication should be consider... more Duodenal duplication cysts are rare congenital anomalies. Duodenal duplication should be considered in the differential diagnosis of patients who present with abdominal symptoms with cystic structures neighboring the duodenum. Here, we present an 8-year-old girl with a duodenal duplication cyst treated with partial cystectomy with mucosal stripping performed laparoscopically. Laparoscopic surgery can be considered as a treatment option for duodenal duplication cysts, especially in extraluminal locations.

Journal of Perinatology

The aim of this study was to investigate the trends of the incidence of and mortality from necrot... more The aim of this study was to investigate the trends of the incidence of and mortality from necrotizing enterocolitis (NEC) in South Korea. Claim data were extracted with diagnosis code, including all stage of NEC. Kaplan–Meier curves for cumulative mortality rates are presented by birth weight (Bwt) and gestational age (GA). The total number of NEC cases was 5840. The ratio of males to females was 1.2:1. There were 11.9 cases per 10,000 births. There were approximately 10 cases per 1000 preterm births and 50 per 1000 very preterm births. The mortality of patients born under 37 weeks decreased from 38.7% in 2007 to 20.9% in 2017. Male sex, lower GA, and lower Bwt were risk factors for mortality. NEC incidence and mortality have been decreasing over time in South Korea. Male sex, lower GA, and Bwt were risk factors for mortality.

Journal of Clinical Medicine, 2021

This study aimed to create a tailored prediction model of hepatocellular carcinoma (HCC)-specific... more This study aimed to create a tailored prediction model of hepatocellular carcinoma (HCC)-specific survival after transplantation based on pre-transplant parameters. Data collected from June 2006 to July 2018 were used as a derivation dataset and analyzed to create an HCC-specific survival prediction model by combining significant risk factors. Separate data were collected from January 2014 to June 2018 for validation. The prediction model was validated internally and externally. The data were divided into three groups based on risk scores derived from the hazard ratio. A combination of patient demographic, laboratory, radiological data, and tumor-specific characteristics that showed a good prediction of HCC-specific death at a specific time (t) were chosen. Internal and external validations with Uno’s C-index were 0.79 and 0.75 (95% confidence interval (CI) 0.65–0.86), respectively. The predicted survival after liver transplantation for HCC (SALT) at a time “t” was calculated using ...

Very low birth weight (VLBW) neonates experience various problems, including meconium-related ile... more Very low birth weight (VLBW) neonates experience various problems, including meconium-related ileus (MRI). This study investigated the risk factors of MRI and surgical MRI in VLBW infants. VLBW neonates admitted to the Neonatal Intensive Care Unit of Seoul National University Children’s Hospital from October 2002 to September 2016 were included in the study. The diagnostic criteria for MRI were a decreased frequency of defecation with intolerable feeding, vomiting, and increased gastric residue (>50%); meconium-filled bowel dilatation in an imaging study; and no evidence of necrotizing enteritis or spontaneous intestinal perforation. Medical MRIs and surgical MRIs were managed through conventional treatment and surgical intervention. Of 1543 neonates, 69 and 1474 were in the patient and control groups, respectively. The risk factors for MRI include low birth weight (BW), cesarean section delivery, fetal distress, maternal diabetes, maternal hypertension, and maternal steroid use....

Annals of Surgical Treatment and Research

To begin with, choledochal cysts were found to be a congenital biliary tract anomaly, first descr... more To begin with, choledochal cysts were found to be a congenital biliary tract anomaly, first described by Vater and Ezler [1] in 1723, and classified by Todani et al. [2] in 1977. In this sense, choledochal cysts occur more frequently in Asians than in Westerners and are known to have higher incidence in women than men [3]. It is often diagnosed in young children, and the main symptoms are abdominal pain, the presence of a palpable mass, and jaundice. This condition has the potential for malignancy transformation and usually requires surgical treatment. In these cases, it is standard to perform a Roux-en-Y