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Papers by Jelena Radojicic
Serbian Journal of Experimental and Clinical Research, 2021
Lymphangioleiomyomatosis (LAM) is a rare disease that most commonly affects women of reproductive... more Lymphangioleiomyomatosis (LAM) is a rare disease that most commonly affects women of reproductive age. The disease is manifested by diffuse destruction of the pulmonary parenchyma with the formation of cysts on a characteristic finding of multidetector computerized tomography (MD-CT) of the chest. It is thought that the presence of cells with estrogen and progesterone receptors among proliferating smooth muscle cells lead to the spread of cystic structures lined by endothelial cells. Towards the end of pregnancy and after childbirth, collapse of the lung parenchyma or rupture of the cyst wall occurs causing a dramatic clinical picture in the form of pneumothorax. Sirolimus is the only drug of choice that should improve and stabilize the patient’s pulmonary function and quality of life. Unfortunately, this drug is not always effective enough, so only option for treatment is bilateral lung transplantation. The authors present the patient in the last trimester of pregnancy who was admi...
Srpski arhiv za celokupno lekarstvo, 2008
INTRODUCTION Castleman disease was for the first time described in 1956 as a mediastinal tumour m... more INTRODUCTION Castleman disease was for the first time described in 1956 as a mediastinal tumour mass. Etiology of this disease is still unknown. The disease can be solitary and multicentric or rarely of a mixed type. The former is often of hyaline vascular type, while the latter is of plasma cell type. CASE REPORT Castleman disease was diagnosed in a 26-year old male patient when a well defined shadow was incidentally detected in the middle lobe of the right lung. A year before, he was diagnosed with allergic rhinitis to Ambrosia. Two years after surgery the patient was feeling well, and was without any recurrence, however, allergic rhinitis still persisted. CONCLUSION Castleman disease can occur in any organ containing lymph tissues. Most frequently the disease is described as mediastinal, rarely as an intrapulmonary tumorous mass, and it is most frequently seen in younger persons. The solitary type of Castleman disease is surgical treatable with a prospect of good prognosis, while...
Srpski arhiv za celokupno lekarstvo, 2007
Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod Al ... more Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod Al ve o lar ni ade nom pri pa da gru pi be nig nih epi tel nih tu mo ra pluća. Hi sto ge ne za al ve o lar nog ade no ma je kom bi na ci ja umno že nih al ve o lar nih pne u mo ci ta i ve ziv nog tki va ko je po ti če iz sep tal nog me zen hi ma. Prikaz bolesnika Bo le sni ca sta ra 69 go di na pri mqe na je u Insti tut za pluć ne bo le sti i tu ber ku lo zu Kliničkog cen tra Sr bi je u Be o gra du zbog is pi ti va wa i hi rur škog le če wa ja sno ogra ni če ne i ho mo ge ne tu mor ske pro me ne u sred wem re žwu de snog plu ća ko ja je do ve la do ple u ro di ni je. Bron ho skop ski pre gled sa bi op si jom ni je raz ja snio pri ro du pro me ne. Uči we na je tu mo rek to mi ja. Čvor tu mo ra je bio mul ti ci sti čan, a hi sto lo škim, hi sto he mij skim i imu no hi sto he mij skim is pi ti va wem utvr đe no je da je reč o al ve o lar nom ade no mu. Pet go di na po sle ope ra ci je bo le sni ca ne ma te go ba, ni ti zna ko va re ci di va ili ma lig ne al te ra ci je bo le sti. Zakqučak Al ve o lar ni ade nom je be nig ni epi tel ni tu mor plu ća ko ji se naj če šće is po qa va kao pe ri fer ni so li tar ni no dus. Po sle pot pu ne eks ci zi je, al ve o lar ni ade nom ne re ci di vi ra i ma lig no ne al te ri še. Hi rur škom eks ci zi jom tu mo ra po sti že se iz le če we. Ka da se di jag no sti ku je so li tar na pro me na u plu ći ma, tre ba mi sli ti i na ovaj re dak tu mor. Kqučne reči: adenom; plućne alveole; neoplazma pluća
Srpski arhiv za celokupno lekarstvo, 2011
Introduction. Lung cancer is the leading cause of death from malignancy in Serbia. Objective. Thi... more Introduction. Lung cancer is the leading cause of death from malignancy in Serbia. Objective. This is a retrospective analysis of lung cancer epidemiological changes regarding to its histological type and patients? age of both genders. Data were based on surgically treated lung cancer patients from 1985 to 2005. Methods. Data were collected from 972 pathohistological reports of operated patients of both genders divided into age groups. Histological types of lung cancer were distributed in four major groups: squamous cell cancer (SCC), adenocarcinoma (AC), small cell cancer (SCLC) and other rare histological types. Both genders together and separately were analysed. Chi-square with the level of significance p<0.05 and chi-square test for trends were used as statistical methods. Results. SCC predominated in both genders; in 44.7% females and 68.0% males. AC was less frequently diagnosed (21.8%) than SCC (64.0%) in both genders and all age groups. The most frequently operated patien...
Srpski arhiv za celokupno lekarstvo, 2007
Introduction Sclerosing haemangioma is a benign tumor, also known under the term "pneumocyto... more Introduction Sclerosing haemangioma is a benign tumor, also known under the term "pneumocytoma". It is mostly notified in older females and is usually solitary. According to the histological appearance, sclerosing haemangioma could be: papillary, sclerotic, solid and haemorrhagic. Case outline A 68-year old female patient was radiologically diagnosed with coin lesion in the lower right lobe. Lower right lobectomy was performed after clinical investigations. In pulmonary parenchyma, there was found a well circumscribed node of up to 35 mm in maximal diameter. The tumor was histologically established as sclerosing haemangioma, containing two types of cells with the same immunophenotype. A multiple type of tumor was excluded by postoperative radiological examinations. Two years after surgery, the patient is without disease recurrence. Conclusion Sclerosing haemangioma should be considered in patients with radiologically diagnosed "coin-like" lesions of a solid as we...
Medical Oncology, 2008
The aim of the study was to analyse changes in histological type and age of presentation in femal... more The aim of the study was to analyse changes in histological type and age of presentation in female lung cancer patients during a period of 20 years. The obtained results are compared with those available from the literature published in various parts of the world.
Serbian Journal of Experimental and Clinical Research, 2021
Lymphangioleiomyomatosis (LAM) is a rare disease that most commonly affects women of reproductive... more Lymphangioleiomyomatosis (LAM) is a rare disease that most commonly affects women of reproductive age. The disease is manifested by diffuse destruction of the pulmonary parenchyma with the formation of cysts on a characteristic finding of multidetector computerized tomography (MD-CT) of the chest. It is thought that the presence of cells with estrogen and progesterone receptors among proliferating smooth muscle cells lead to the spread of cystic structures lined by endothelial cells. Towards the end of pregnancy and after childbirth, collapse of the lung parenchyma or rupture of the cyst wall occurs causing a dramatic clinical picture in the form of pneumothorax. Sirolimus is the only drug of choice that should improve and stabilize the patient’s pulmonary function and quality of life. Unfortunately, this drug is not always effective enough, so only option for treatment is bilateral lung transplantation. The authors present the patient in the last trimester of pregnancy who was admi...
Srpski arhiv za celokupno lekarstvo, 2008
INTRODUCTION Castleman disease was for the first time described in 1956 as a mediastinal tumour m... more INTRODUCTION Castleman disease was for the first time described in 1956 as a mediastinal tumour mass. Etiology of this disease is still unknown. The disease can be solitary and multicentric or rarely of a mixed type. The former is often of hyaline vascular type, while the latter is of plasma cell type. CASE REPORT Castleman disease was diagnosed in a 26-year old male patient when a well defined shadow was incidentally detected in the middle lobe of the right lung. A year before, he was diagnosed with allergic rhinitis to Ambrosia. Two years after surgery the patient was feeling well, and was without any recurrence, however, allergic rhinitis still persisted. CONCLUSION Castleman disease can occur in any organ containing lymph tissues. Most frequently the disease is described as mediastinal, rarely as an intrapulmonary tumorous mass, and it is most frequently seen in younger persons. The solitary type of Castleman disease is surgical treatable with a prospect of good prognosis, while...
Srpski arhiv za celokupno lekarstvo, 2007
Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod Al ... more Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod Al ve o lar ni ade nom pri pa da gru pi be nig nih epi tel nih tu mo ra pluća. Hi sto ge ne za al ve o lar nog ade no ma je kom bi na ci ja umno že nih al ve o lar nih pne u mo ci ta i ve ziv nog tki va ko je po ti če iz sep tal nog me zen hi ma. Prikaz bolesnika Bo le sni ca sta ra 69 go di na pri mqe na je u Insti tut za pluć ne bo le sti i tu ber ku lo zu Kliničkog cen tra Sr bi je u Be o gra du zbog is pi ti va wa i hi rur škog le če wa ja sno ogra ni če ne i ho mo ge ne tu mor ske pro me ne u sred wem re žwu de snog plu ća ko ja je do ve la do ple u ro di ni je. Bron ho skop ski pre gled sa bi op si jom ni je raz ja snio pri ro du pro me ne. Uči we na je tu mo rek to mi ja. Čvor tu mo ra je bio mul ti ci sti čan, a hi sto lo škim, hi sto he mij skim i imu no hi sto he mij skim is pi ti va wem utvr đe no je da je reč o al ve o lar nom ade no mu. Pet go di na po sle ope ra ci je bo le sni ca ne ma te go ba, ni ti zna ko va re ci di va ili ma lig ne al te ra ci je bo le sti. Zakqučak Al ve o lar ni ade nom je be nig ni epi tel ni tu mor plu ća ko ji se naj če šće is po qa va kao pe ri fer ni so li tar ni no dus. Po sle pot pu ne eks ci zi je, al ve o lar ni ade nom ne re ci di vi ra i ma lig no ne al te ri še. Hi rur škom eks ci zi jom tu mo ra po sti že se iz le če we. Ka da se di jag no sti ku je so li tar na pro me na u plu ći ma, tre ba mi sli ti i na ovaj re dak tu mor. Kqučne reči: adenom; plućne alveole; neoplazma pluća
Srpski arhiv za celokupno lekarstvo, 2011
Introduction. Lung cancer is the leading cause of death from malignancy in Serbia. Objective. Thi... more Introduction. Lung cancer is the leading cause of death from malignancy in Serbia. Objective. This is a retrospective analysis of lung cancer epidemiological changes regarding to its histological type and patients? age of both genders. Data were based on surgically treated lung cancer patients from 1985 to 2005. Methods. Data were collected from 972 pathohistological reports of operated patients of both genders divided into age groups. Histological types of lung cancer were distributed in four major groups: squamous cell cancer (SCC), adenocarcinoma (AC), small cell cancer (SCLC) and other rare histological types. Both genders together and separately were analysed. Chi-square with the level of significance p<0.05 and chi-square test for trends were used as statistical methods. Results. SCC predominated in both genders; in 44.7% females and 68.0% males. AC was less frequently diagnosed (21.8%) than SCC (64.0%) in both genders and all age groups. The most frequently operated patien...
Srpski arhiv za celokupno lekarstvo, 2007
Introduction Sclerosing haemangioma is a benign tumor, also known under the term "pneumocyto... more Introduction Sclerosing haemangioma is a benign tumor, also known under the term "pneumocytoma". It is mostly notified in older females and is usually solitary. According to the histological appearance, sclerosing haemangioma could be: papillary, sclerotic, solid and haemorrhagic. Case outline A 68-year old female patient was radiologically diagnosed with coin lesion in the lower right lobe. Lower right lobectomy was performed after clinical investigations. In pulmonary parenchyma, there was found a well circumscribed node of up to 35 mm in maximal diameter. The tumor was histologically established as sclerosing haemangioma, containing two types of cells with the same immunophenotype. A multiple type of tumor was excluded by postoperative radiological examinations. Two years after surgery, the patient is without disease recurrence. Conclusion Sclerosing haemangioma should be considered in patients with radiologically diagnosed "coin-like" lesions of a solid as we...
Medical Oncology, 2008
The aim of the study was to analyse changes in histological type and age of presentation in femal... more The aim of the study was to analyse changes in histological type and age of presentation in female lung cancer patients during a period of 20 years. The obtained results are compared with those available from the literature published in various parts of the world.