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Papers by Jen Wung

Research paper thumbnail of Effect of blood pressure cuffs on neonatal circulation: Their potential application to newborns with persistent pulmonary hypertension

Pediat Cardiol, 1995

The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmon... more The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmonary hypertension of the newborn (PPHN) is hampered by their limited ability to act selectively on different vascular beds. In contrast, blood pressure (BP) cuffs decrease flow and increase resistance only in the extremities around which they are applied. They therefore offer a means of increasing systemic vascular resistance without affecting pulmonary vascular resistance, a hemodynamic effect that may be particularly desirable among PPHN patients receiving vasodilators. We studied the effect of BP cuffs on the circulation of nine healthy neonates and three infants with severe PPHN. Among the healthy neonates, inflation of the cuffs to 20 mmHg had no discernible hemodynamic effect. Inflation to systolic pressures, however, caused the left ventricular preejection period to increase from 36 +/- 9 ms to 45 +/- 10 ms, the end-diastolic dimension to increase from 1.80 +/- 0.16 cm to 1.92 +/- 0.16 cm, and the cardiac output to fall to 87 +/- 12% of baseline (all p < 0.05)--changes indicative of an increase in systemic vascular resistance. Application of BP cuffs to the patients with PPHN was associated with 10-25 mmHg increases in transcutaneous arterial oxygen tensions. Administration of tolazoline to these patients while the cuffs were inflated resulted in additional 10-20 mmHg increases and did not precipitate hypotension. These observations suggest that BP cuffs can play a useful role in the management of patients with PPHN.

Research paper thumbnail of Rationing ventilatory support for the newborn with respiratory distress

Pediatric Radiology, Feb 1, 1995

Research paper thumbnail of Neonatal respiratory care

International journal of pediatrics, 2012

Research paper thumbnail of Subcutaneous emphysema and pneumomediastinum as presenting manifestations of neonatal tracheal injury

Journal of perinatology : official journal of the California Perinatal Association, 2002

Neonatal tracheal injury/perforation is an uncommon complication of traumatic deliveries or endot... more Neonatal tracheal injury/perforation is an uncommon complication of traumatic deliveries or endotracheal intubation. We present a case of neonatal tracheal injury following delivery at term that presented with subcutaneous emphysema and pneumomediastinum before any attempt at intubation. The clinical course, treatment, and outcome are described.

Research paper thumbnail of Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates

International Journal of Pediatrics, 2012

Research paper thumbnail of Weaning Strategy with Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn. 1928

Research paper thumbnail of Inhaled Nitric Oxide (Ino) Decreases the Need for Extracorporeal Membrane Oxygenation (Ecmo) in Neonates with Meconium Aspiration Syndrome (MAS).1926

Research paper thumbnail of Responses of Neonates to Semi-Elective Nasotracheal Intubation With and Without Thiopental † 967

Research paper thumbnail of Long Term Use of Laryngeal Mask Airway (Lma) in Neonates with Robin SEQUENCE.2121

Research paper thumbnail of Thiopental for Endotracheal Intubation of Neonates with Severe Persistent Pulmonary Hypertension (Pphn). 252

Research paper thumbnail of Inhaled Nitric Oxide Therapy without Hyperventilation : A Single Center Study of 182 Neonates with Pulmonary Hypertension † 1657

Research paper thumbnail of Inhaled Nitric Oxide Response in Premature Infants with Persistent Pulmonary Hypertension 1623

Pediatric Research, 1998

Background: Persistent pulmonary hypertension (PPHN) is a significant cause of neonatal morbidity... more Background: Persistent pulmonary hypertension (PPHN) is a significant cause of neonatal morbidity and mortality frequently associated with diseases of term and near-term infants. In recent years, it has also been recognized in preterm infants with respiratory distress ...

Research paper thumbnail of Treatment of giant pulmonary interstitial emphysema by ipsilateral bronchial occlusion with a Swan-Ganz catheter

Pediatric Radiology, 2007

Research paper thumbnail of Effect of blood pressure cuffs on neonatal circulation: Their potential application to newborns with persistent pulmonary hypertension

Pediatric Cardiology, 1995

The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmon... more The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmonary hypertension of the newborn (PPHN) is hampered by their limited ability to act selectively on different vascular beds. In contrast, blood pressure (BP) cuffs decrease flow and increase resistance only in the extremities around which they are applied. They therefore offer a means of increasing systemic vascular resistance without affecting pulmonary vascular resistance, a hemodynamic effect that may be particularly desirable among PPHN patients receiving vasodilators. We studied the effect of BP cuffs on the circulation of nine healthy neonates and three infants with severe PPHN. Among the healthy neonates, inflation of the cuffs to 20 mmHg had no discernible hemodynamic effect. Inflation to systolic pressures, however, caused the left ventricular preejection period to increase from 36 +/- 9 ms to 45 +/- 10 ms, the end-diastolic dimension to increase from 1.80 +/- 0.16 cm to 1.92 +/- 0.16 cm, and the cardiac output to fall to 87 +/- 12% of baseline (all p < 0.05)--changes indicative of an increase in systemic vascular resistance. Application of BP cuffs to the patients with PPHN was associated with 10-25 mmHg increases in transcutaneous arterial oxygen tensions. Administration of tolazoline to these patients while the cuffs were inflated resulted in additional 10-20 mmHg increases and did not precipitate hypotension. These observations suggest that BP cuffs can play a useful role in the management of patients with PPHN.

Research paper thumbnail of Early or Late Surgical Ligation of Medical Refractory Patent Ductus Arteriosus in Premature Infants

Journal of the Formosan Medical Association, 2009

Research paper thumbnail of Subcutaneous Emphysema and Pneumomediastinum as Presenting Manifestations of Neonatal Tracheal Injury

Journal of Perinatology, 2002

Research paper thumbnail of Inhaled Nitric Oxide and Gentle Ventilation in the Treatment of Pulmonary Hypertension of the Newborn — a Single-Center, 5-Year Experience

Journal of Perinatology, 2002

Research paper thumbnail of Is the New Definition of Bronchopulmonary Dysplasia More Useful?

Journal of Perinatology, 2005

Research paper thumbnail of Variables Associated with the Early Failure of Nasal CPAP in Very Low Birth Weight Infants

The Journal of Pediatrics, 2005

Research paper thumbnail of Changing incidence of bronchopulmonary dysplasia

The Journal of Pediatrics, 1979

1. J Pediatr. 1979 Nov;95(5 Pt 2):845-7. Changing incidence of bronchopulmonary dysplasia. Wung J... more 1. J Pediatr. 1979 Nov;95(5 Pt 2):845-7. Changing incidence of bronchopulmonary dysplasia. Wung JT, Koons AH, Driscoll JM Jr, James LS. PMID: 385817 [PubMed - indexed for MEDLINE]. MeSH Terms: Humans; Infant; Infant ...

Research paper thumbnail of Effect of blood pressure cuffs on neonatal circulation: Their potential application to newborns with persistent pulmonary hypertension

Pediat Cardiol, 1995

The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmon... more The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmonary hypertension of the newborn (PPHN) is hampered by their limited ability to act selectively on different vascular beds. In contrast, blood pressure (BP) cuffs decrease flow and increase resistance only in the extremities around which they are applied. They therefore offer a means of increasing systemic vascular resistance without affecting pulmonary vascular resistance, a hemodynamic effect that may be particularly desirable among PPHN patients receiving vasodilators. We studied the effect of BP cuffs on the circulation of nine healthy neonates and three infants with severe PPHN. Among the healthy neonates, inflation of the cuffs to 20 mmHg had no discernible hemodynamic effect. Inflation to systolic pressures, however, caused the left ventricular preejection period to increase from 36 +/- 9 ms to 45 +/- 10 ms, the end-diastolic dimension to increase from 1.80 +/- 0.16 cm to 1.92 +/- 0.16 cm, and the cardiac output to fall to 87 +/- 12% of baseline (all p < 0.05)--changes indicative of an increase in systemic vascular resistance. Application of BP cuffs to the patients with PPHN was associated with 10-25 mmHg increases in transcutaneous arterial oxygen tensions. Administration of tolazoline to these patients while the cuffs were inflated resulted in additional 10-20 mmHg increases and did not precipitate hypotension. These observations suggest that BP cuffs can play a useful role in the management of patients with PPHN.

Research paper thumbnail of Rationing ventilatory support for the newborn with respiratory distress

Pediatric Radiology, Feb 1, 1995

Research paper thumbnail of Neonatal respiratory care

International journal of pediatrics, 2012

Research paper thumbnail of Subcutaneous emphysema and pneumomediastinum as presenting manifestations of neonatal tracheal injury

Journal of perinatology : official journal of the California Perinatal Association, 2002

Neonatal tracheal injury/perforation is an uncommon complication of traumatic deliveries or endot... more Neonatal tracheal injury/perforation is an uncommon complication of traumatic deliveries or endotracheal intubation. We present a case of neonatal tracheal injury following delivery at term that presented with subcutaneous emphysema and pneumomediastinum before any attempt at intubation. The clinical course, treatment, and outcome are described.

Research paper thumbnail of Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates

International Journal of Pediatrics, 2012

Research paper thumbnail of Weaning Strategy with Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn. 1928

Research paper thumbnail of Inhaled Nitric Oxide (Ino) Decreases the Need for Extracorporeal Membrane Oxygenation (Ecmo) in Neonates with Meconium Aspiration Syndrome (MAS).1926

Research paper thumbnail of Responses of Neonates to Semi-Elective Nasotracheal Intubation With and Without Thiopental † 967

Research paper thumbnail of Long Term Use of Laryngeal Mask Airway (Lma) in Neonates with Robin SEQUENCE.2121

Research paper thumbnail of Thiopental for Endotracheal Intubation of Neonates with Severe Persistent Pulmonary Hypertension (Pphn). 252

Research paper thumbnail of Inhaled Nitric Oxide Therapy without Hyperventilation : A Single Center Study of 182 Neonates with Pulmonary Hypertension † 1657

Research paper thumbnail of Inhaled Nitric Oxide Response in Premature Infants with Persistent Pulmonary Hypertension 1623

Pediatric Research, 1998

Background: Persistent pulmonary hypertension (PPHN) is a significant cause of neonatal morbidity... more Background: Persistent pulmonary hypertension (PPHN) is a significant cause of neonatal morbidity and mortality frequently associated with diseases of term and near-term infants. In recent years, it has also been recognized in preterm infants with respiratory distress ...

Research paper thumbnail of Treatment of giant pulmonary interstitial emphysema by ipsilateral bronchial occlusion with a Swan-Ganz catheter

Pediatric Radiology, 2007

Research paper thumbnail of Effect of blood pressure cuffs on neonatal circulation: Their potential application to newborns with persistent pulmonary hypertension

Pediatric Cardiology, 1995

The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmon... more The contribution of vasoactive pharmacologic agents to the care of the infant with primary pulmonary hypertension of the newborn (PPHN) is hampered by their limited ability to act selectively on different vascular beds. In contrast, blood pressure (BP) cuffs decrease flow and increase resistance only in the extremities around which they are applied. They therefore offer a means of increasing systemic vascular resistance without affecting pulmonary vascular resistance, a hemodynamic effect that may be particularly desirable among PPHN patients receiving vasodilators. We studied the effect of BP cuffs on the circulation of nine healthy neonates and three infants with severe PPHN. Among the healthy neonates, inflation of the cuffs to 20 mmHg had no discernible hemodynamic effect. Inflation to systolic pressures, however, caused the left ventricular preejection period to increase from 36 +/- 9 ms to 45 +/- 10 ms, the end-diastolic dimension to increase from 1.80 +/- 0.16 cm to 1.92 +/- 0.16 cm, and the cardiac output to fall to 87 +/- 12% of baseline (all p < 0.05)--changes indicative of an increase in systemic vascular resistance. Application of BP cuffs to the patients with PPHN was associated with 10-25 mmHg increases in transcutaneous arterial oxygen tensions. Administration of tolazoline to these patients while the cuffs were inflated resulted in additional 10-20 mmHg increases and did not precipitate hypotension. These observations suggest that BP cuffs can play a useful role in the management of patients with PPHN.

Research paper thumbnail of Early or Late Surgical Ligation of Medical Refractory Patent Ductus Arteriosus in Premature Infants

Journal of the Formosan Medical Association, 2009

Research paper thumbnail of Subcutaneous Emphysema and Pneumomediastinum as Presenting Manifestations of Neonatal Tracheal Injury

Journal of Perinatology, 2002

Research paper thumbnail of Inhaled Nitric Oxide and Gentle Ventilation in the Treatment of Pulmonary Hypertension of the Newborn — a Single-Center, 5-Year Experience

Journal of Perinatology, 2002

Research paper thumbnail of Is the New Definition of Bronchopulmonary Dysplasia More Useful?

Journal of Perinatology, 2005

Research paper thumbnail of Variables Associated with the Early Failure of Nasal CPAP in Very Low Birth Weight Infants

The Journal of Pediatrics, 2005

Research paper thumbnail of Changing incidence of bronchopulmonary dysplasia

The Journal of Pediatrics, 1979

1. J Pediatr. 1979 Nov;95(5 Pt 2):845-7. Changing incidence of bronchopulmonary dysplasia. Wung J... more 1. J Pediatr. 1979 Nov;95(5 Pt 2):845-7. Changing incidence of bronchopulmonary dysplasia. Wung JT, Koons AH, Driscoll JM Jr, James LS. PMID: 385817 [PubMed - indexed for MEDLINE]. MeSH Terms: Humans; Infant; Infant ...

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