Jennifer Baez - Academia.edu (original) (raw)
Papers by Jennifer Baez
Bronchoscopy of the horse
American journal of veterinary research, Oct 1, 1992
The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated hors... more The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated horses was evaluated, using a 200-cm-long, 9.5-mm-diameter videoendoscope. On the basis of these findings, the nomenclature system of Amis and McKiernan was modified for identification of airways of horses during bronchoscopy. Lobar bronchi are identified on the basis of the side of the bronchial tree on which they were found and the order in which they originated from the primary bronchus. Thus, RB1, RB2, and RB3 referred to right cranial lobar bronchus, respectively. On the left side, the designation of LB1 and LB2 refer to the left cranial lobar bronchus and the left caudal lobar bronchus, respectively. Segmental bronchi are identified by consecutive numbers in the order of origination from the lobar bronchus. The direction of the segmental bronchus was denoted by the capital letter D (dorsal), V (ventral), L (lateral), M (medial), R (rostral), and C (caudal). Subsegmental bronchi were identified in the order of origination from the segmental bronchi, using lower case letters (eg, RB2, 1V, a or RB2, 1V, aV). For subsequent branching of the subsegmental bronchi, the branches were numbered consecutively by their order of origination (eg, RB2, 1V, aV, 1D).
Radiographic, ultrasonographic, and endoscopic findings in cats with inflammatory bowel disease of the stomach and small intestine: 33 cases (1990-1997)
PubMed, Aug 1, 1999
Objective: To characterize imaging findings in cats with confirmed inflammatory bowel disease (IB... more Objective: To characterize imaging findings in cats with confirmed inflammatory bowel disease (IBD) of the upper gastrointestinal tract (i.e., stomach and small intestine) and relate these findings to clinical signs and histologic changes. Design: Retrospective study. Animals: 32 cats with clinical and histopathologic diagnoses of IBD. Procedure: Medical records were reviewed for signalment, clinical signs, clinicopathologic findings, radiographic and ultrasonographic findings, and results of endoscopic examination. Histologic findings were reviewed and characterized by severity and type of inflammatory infiltrate. Results: All cats had 1 or more clinical signs (e.g., vomiting, diarrhea, weight loss, and anorexia) consistent with IBD. Lymphocytic and plasmacytic infiltrates were observed in histologic sections of gastrointestinal tissue. Crypt distortion, villous blunting and fusion, and fibrosis were most commonly seen in cats with moderate or severe IBD. Clinicopathologic findings of some cats included anemia, leukocytosis or leukopenia, hypocholesterolemia, and hyper- or hypoproteinemia. Abnormalities were not found on abdominal radiographic views in 9 of 9 cats. However, contrast studies using barium revealed radiographic abnormalities in 1 of 3 cats. In 13 of 17 cats, abdominal ultrasonography revealed several intestinal abnormalities (e.g., poor intestinal wall layer definition, focal thickening) and large mesenteric lymph nodes with hypoechoic changes consistent with IBD. Endoscopic observation revealed findings (e.g., erythema, plaques, mucosal friability) consistent with inflammation in 9 of 18 cats. Conclusions and clinical relevance: Compared with endoscopy of the gastrointestinal tract or abdominal radiography, clinical signs and ultrasonographic findings appear to have the best association with histologic grade of IBD in cats.
Bronchoscopy of the horse
PubMed, Oct 1, 1992
The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated hors... more The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated horses was evaluated, using a 200-cm-long, 9.5-mm-diameter videoendoscope. On the basis of these findings, the nomenclature system of Amis and McKiernan was modified for identification of airways of horses during bronchoscopy. Lobar bronchi are identified on the basis of the side of the bronchial tree on which they were found and the order in which they originated from the primary bronchus. Thus, RB1, RB2, and RB3 referred to right cranial lobar bronchus, respectively. On the left side, the designation of LB1 and LB2 refer to the left cranial lobar bronchus and the left caudal lobar bronchus, respectively. Segmental bronchi are identified by consecutive numbers in the order of origination from the lobar bronchus. The direction of the segmental bronchus was denoted by the capital letter D (dorsal), V (ventral), L (lateral), M (medial), R (rostral), and C (caudal). Subsegmental bronchi were identified in the order of origination from the segmental bronchi, using lower case letters (eg, RB2, 1V, a or RB2, 1V, aV). For subsequent branching of the subsegmental bronchi, the branches were numbered consecutively by their order of origination (eg, RB2, 1V, aV, 1D).
The Canadian veterinary journal = La revue veterinaire canadienne, 2018
The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the... more The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the haired skin were retrospectively reviewed for overall survival time (OST), progression-free survival time (PFS), and prognostic factors. The post-surgery median PFS and median OST were 1282 days and 1363 days, respectively. The post-surgery metastatic rate was 21.8% with a local recurrence rate of 8%. Increasing mitotic index (MI) was predictive of a significantly decreased OST and PFS on multivariable analysis [hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.02 to 1.07 and HR: 1.04, 95% CI: 1.02 to 1.06, respectively]. Increasing age was likewise predictive of a significantly decreased OST and PFS on multivariable analysis (HR: 1.39, 95% CI: 1.17 to 1.65 and HR: 1.33, 95% CI: 1.14 to 1.54, respectively). These results confirm clinical impressions that long survival times are likely in dogs diagnosed with malignant melanoma of the haired skin when treated with surgery alone.
Pulmonary and Bronchial Neoplasia
Textbook of Respiratory Disease in Dogs and Cats, 2004
Feline Mammary Carcinoma
August's Consultations in Feline Internal Medicine, Volume 7, 2016
Veterinary and Comparative Oncology, 2005
As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is ... more As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is pleased to include these abstracts from the Annual Conference and we hope you find them informative and useful. These abstracts have not been subjected to peer review or editorial revision, however, and it would be prudent for the reader to exercise caution in the interpretation and application of the data presented.
Veterinary and Comparative Oncology, 2005
As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is ... more As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is pleased to include these abstracts from the Annual Conference and we hope you find them informative and useful. These abstracts have not been subjected to peer review or editorial revision, however, and it would be prudent for the reader to exercise caution in the interpretation and application of the data presented.
Efficacy and Toxicity of a Dose-Intensified Doxorubicin Protocol in Canine Hemangiosarcoma
Journal of Veterinary Internal Medicine, 2004
The purpose of this study was to evaluate the efficacy and toxicity of a single‐agent, dose‐inten... more The purpose of this study was to evaluate the efficacy and toxicity of a single‐agent, dose‐intensified doxorubicin protocol in canine hemangiosarcoma (HSA). Canine HSA is a highly malignant tumor, and most affected dogs die within 6 months of diagnosis. Doxorubicin is the most, and possibly the only, effective chemotherapeutic drug for this malignancy, but it provides only moderate improvement in survival. On the basis of previous studies reporting similar survival in dogs treated with doxorubicin as a single agent and doxorubicin‐based combination chemotherapy and the concept of summation dose intensity, a dose‐intensified single‐agent doxorubicin protocol was initiated. Twenty dogs with HSA were recruited to participate in this study. Workup and staging were performed according to standard practice. Chemotherapy was initiated within 3 weeks of surgery. Doxorubicin was scheduled to be administered at 30 mg/m2 IV every 2 weeks for a total of 5 treatments. The dogs were monitored for toxicity and signs of recurrence during and at regular intervals after chemotherapy. The protocol was tolerated well. No dogs were hospitalized because of adverse effects or developed clinical signs consistent with doxorubicin‐induced cardiomyopathy. There was a significant difference in survival in dogs with stage I and II HSA compared with dogs with stage III HSA, with median survival times of 257, 210, and 107 days, respectively. These results are slightly better than the historical control with respect to toxicity and efficacy but are not statistically different from what is achieved with standard treatments. There was no association between dose intensity and outcome.
Evaluation of Adjuvant Doxorubicin-Based Chemotherapy for the Treatment of Feline Mammary Carcinoma
Journal of Veterinary Internal Medicine, 2009
Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the... more Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the high metastatic potential, patients often are treated with adjuvant doxorubicin-based chemotherapy, but little data exist to evaluate the effect of this strategy. Adjuvant doxorubicin-based chemotherapy improves outcome for FMC compared with surgery alone. Cats with naturally occurring, biopsy-confirmed FMC treated with either surgery alone (Sx) or with surgery plus adjuvant doxorubicin-based chemotherapy (Sx + Chemo). Retrospective cohort study. Clinical data were collected and compared to identify differences between groups. Outcome results were determined and compared. Prognostic factors for disease-free survival (DFS) and overall survival were evaluated. Seventy-three cats were evaluated, of which 37 were in the Sx group and 36 in the Sx + Chemo group. No differences in clinical data were found between Sx and Sx + Chemo groups. Median DFS times for the Sx and Sx + Chemo groups were 372 and 676 days, respectively (P= .15) and median survival times (ST) were 1,406 and 848 days, respectively (P= .78). For cats that underwent a unilateral radical mastectomy, ST was significantly longer for the Sx + Chemo compared with the Sx group (1,998 versus 414 days, respectively; P= .03). This study did not find a benefit to adjuvant doxorubicin-based chemotherapy in cats with FMC. Additional studies are required to determine whether patient subgroups with negative prognostic factors may benefit from adjuvant chemotherapy.
Journal of Veterinary Internal Medicine, 2008
Background: Feline visceral hemangiosarcoma (HSA) is an uncommon tumor, and the clinical progress... more Background: Feline visceral hemangiosarcoma (HSA) is an uncommon tumor, and the clinical progression and outcome are rarely reported. Hypothesis: The prognosis of feline visceral HSA is poor because of severe clinical signs, anemia, and a high rate of metastasis. The medical records of 26 client-owned cats with visceral HSA were reviewed. Methods: Multi-institutional retrospective study. The most common historical findings and clinical signs included lethargy, anorexia, respiratory difficulty, collapse, and vocalizing. Eighty-two percent of cats were anemic, and aspartate transaminase was increased in 53% of the study population. Metastatic lung disease was noted in 33% of affected cats. In 75% of the cats, abdominal ultrasonography identified a specific location of HSA. However, ultrasound identification of all multifocal lesions was successful only in 3/9 cats (33%). Tumor location was identified in the following organs: liver (35%), small intestine (31%), large intestine (31%), abdominal lymph node (31%), mesentery (27%), spleen (23%), lung (19%), omentum (12%), brain (8%), pancreas (8%), and diaphragm (8%). Multifocal HSA was noted in 77% of cats. Three cats received adjuvant chemotherapy (doxorubicin). Seventy-one percent of euthanized cats were euthanized within 1 day of diagnosis. The median survival time of the remaining cats (n 5 6) was 77 days (range, 23-296 days). Conclusion and Clinical Importance: Feline visceral HSA is most often multifocal at the time of diagnosis. The prognosis appears poor, and the number of cats receiving chemotherapy is low.
Journal of the American Veterinary Medical Association, 2007
Objective—To reexamine (via immunohistochemical techniques) canine tissue samples that had been p... more Objective—To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs. Design—Retrospective case series. Animals—42 dogs. Procedures—Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians. Results—On the basis of...
Journal of the American Veterinary Medical Association, 2004
Objective—To determine the biological behavior of liposarcomas in dogs and identify clinical sign... more Objective—To determine the biological behavior of liposarcomas in dogs and identify clinical signs, the effect of treatment on survival time, and potential prognostic factors. Design—Retrospective study. Animals—56 dogs with histologically confirmed liposarcoma. Procedure—Information was obtained on signalment, tumor size, location of the tumor, stage of disease, remission duration, overall survival time, cause of death, type of surgery (incisional biopsy, marginal excision, or wide excision), and any additional treatments given. Results—Surgery consisted of incisional biopsy in 6 dogs, marginal excision in 34, and wide excision in 16. Twenty-five dogs had histologic evidence of tumor cells at the surgical margins and 28 did not (status of the margins was unknown in 3 dogs). Twelve of 43 dogs had local recurrence. Median survival time was 694 days, and the only factor significantly associated with survival time was type of surgery performed. Median survival times were 1,188, 649, an...
Lomustine for treatment of mast cell tumors in cats: 38 cases (1999–2005)
Journal of the American Veterinary Medical Association, 2008
Objective—To determine clinical activity and toxic effects of lomustine when used to treat cats w... more Objective—To determine clinical activity and toxic effects of lomustine when used to treat cats with mast cell tumors (MCTs). Design—Retrospective case series. Animals—38 cats with measurable, histologically or cytologically confirmed MCTs treated with lomustine at a dosage ≥ 50 mg/m2. Procedures—Medical records were reviewed to determine response to treatment and evidence of drug toxicoses. The Kaplan-Meier method was used to estimate remission duration. Results—26 cats had cutaneous MCTs, 7 had MCTs of the mesenteric lymph nodes, 2 had gastrointestinal tract MCTs, 2 had hepatic MCTs, and 1 had MCTs involving multiple organs. Targeted lomustine dosage was 50 mg/m2 in 22 cats and 60 mg/m2 in 16 cats. Median administered dosage of lomustine was 56 mg/m2 (range, 48 to 65 mg/m2), and median number of doses administered was 2 (range, 1 to 12). Seven cats had a complete response and 12 had a partial response, for an overall response rate of 50%. Median response duration was 168 days (ran...
The Journal of Membrane Biology, 1991
A doublet of proteins (-48,000 Mr) from the Paramecium cell body membrane fits several criteria f... more A doublet of proteins (-48,000 Mr) from the Paramecium cell body membrane fits several criteria for the external cAMP chemoreceptor. These criteria include: (i) selective elution from a cAMP affinity column, matching a specificity that could be predicted from the behavioral response and whole-cell binding; (ii) binding to wheat germ agglutinin indicating the presence of carbohydrate moieties indicating surface exposure; and (iii) selective inhibition of the intact cells' chemoresponse to cAMP by antibodies against the doublet. Additional evidence for the existence of a receptor, in general, comes from selective elimination of the cAMP ehemoresponse by photoaffinity labeling of whole cells with 8-N3~cAMP. The doublet proteins are not identical to the regulatory subunit of a cAMP-dependent protein kinase from Paramecium, the Dictyostelium cAMP chemoreceptor, or the 42-45 kDa range proteins related to the large surface glycoprotein in Paramecium. The doublet proteins are not readily separable and, as in Dictyostelium, may represent two different covalent modification states of the same protein. Amino acid analysis indicates that the proteins are similar, but does not distinguish between the possibilities ofproteolysis and covalent modification. Once cloned, this doublet may prove to be only the fifth external, eukaryotic chemoreceptor to be identified.
![Research paper thumbnail of Corrigendum to “A prospective investigation of the prevalence and prognostic significance of weight loss and changes in body condition in feline cancer patients” [Journal of Feline Medicine and Surgery 9 (2007) 411–417]](https://attachments.academia-assets.com/120886645/thumbnails/1.jpg)
](Journal of Feline Medicine & Surgery, 2007
The paper was published as a Review Article when it is in fact an Original Paper. We apologise to... more The paper was published as a Review Article when it is in fact an Original Paper. We apologise to readers of the journal for any inconvenience caused.
A prospective investigation of the prevalence and prognostic significance of weight loss and changes in body condition in feline cancer patients
Journal of Feline Medicine and Surgery, 2007
The objectives of this study were to prospectively identify and characterize weight loss and chan... more The objectives of this study were to prospectively identify and characterize weight loss and changes in body condition in feline cancer patients and to investigate the prognostic significance of these findings. Fifty-seven cats with neoplasia were evaluated. Body condition was assessed with a nine-point scoring system (BCS) and multiple sites were assessed for muscle and fat mass using four-point scoring systems. Feline cancer patients had a mean BCS of 4.4±2.1 kg (1=cachectic, 5=optimal, 9=obese). Fat mass was reduced in both sites assessed in 60% of the patients. Muscle mass was reduced at all three sites assessed in 91% of the patients. Feline cancer patients having a BCS <5 had a median survival time (MST) of 3.3 months compared to that of 16.7 months for cats with a BCS of ≥5 ( P=0.008).
Veterinary and Comparative Oncology, 2008
Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant ... more Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant of feline lymphoma. Limited information exists in the literature regarding pathological and immunohistochemical descriptions, clinical fi ndings, treatment and survival times. The purpose of this study was to describe clinical features, treatment and outcome in feline LGL lymphoma. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. Decreased appetite/anorexia, weight loss, lethargy and vomiting were the most commonly reported clinical signs. All cats tested for feline leukaemia virus and feline immunodefi ciency virus infection were negative. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis. perforin-like immunoreactivity. 1,3 -5 In a recent report, cells from a majority of patients were found to be T cells (CD3+) that expressed CD8 ␣ ␣ and CD103, which is consistent with the phenotype of feline and human intestinal intra-epithelial lymphocytes. Although very limited clinical information about feline LGL lymphoma is available, some consistent fi ndings have been reported. Anorexia, vomiting and lethargy are the most commonly reported clinical signs, while a palpable abdominal mass is consistently reported as a common physical exam fi nding. 2,4,6 -11 Feline LGL lymphoma does not appear to be associated with feline leukaemia virus (FeLV) infection, as few affected cats have tested positive for it. Although there are no consistent haematological or serum chemistry
Bronchoscopy of the horse
American journal of veterinary research, Oct 1, 1992
The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated hors... more The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated horses was evaluated, using a 200-cm-long, 9.5-mm-diameter videoendoscope. On the basis of these findings, the nomenclature system of Amis and McKiernan was modified for identification of airways of horses during bronchoscopy. Lobar bronchi are identified on the basis of the side of the bronchial tree on which they were found and the order in which they originated from the primary bronchus. Thus, RB1, RB2, and RB3 referred to right cranial lobar bronchus, respectively. On the left side, the designation of LB1 and LB2 refer to the left cranial lobar bronchus and the left caudal lobar bronchus, respectively. Segmental bronchi are identified by consecutive numbers in the order of origination from the lobar bronchus. The direction of the segmental bronchus was denoted by the capital letter D (dorsal), V (ventral), L (lateral), M (medial), R (rostral), and C (caudal). Subsegmental bronchi were identified in the order of origination from the segmental bronchi, using lower case letters (eg, RB2, 1V, a or RB2, 1V, aV). For subsequent branching of the subsegmental bronchi, the branches were numbered consecutively by their order of origination (eg, RB2, 1V, aV, 1D).
Radiographic, ultrasonographic, and endoscopic findings in cats with inflammatory bowel disease of the stomach and small intestine: 33 cases (1990-1997)
PubMed, Aug 1, 1999
Objective: To characterize imaging findings in cats with confirmed inflammatory bowel disease (IB... more Objective: To characterize imaging findings in cats with confirmed inflammatory bowel disease (IBD) of the upper gastrointestinal tract (i.e., stomach and small intestine) and relate these findings to clinical signs and histologic changes. Design: Retrospective study. Animals: 32 cats with clinical and histopathologic diagnoses of IBD. Procedure: Medical records were reviewed for signalment, clinical signs, clinicopathologic findings, radiographic and ultrasonographic findings, and results of endoscopic examination. Histologic findings were reviewed and characterized by severity and type of inflammatory infiltrate. Results: All cats had 1 or more clinical signs (e.g., vomiting, diarrhea, weight loss, and anorexia) consistent with IBD. Lymphocytic and plasmacytic infiltrates were observed in histologic sections of gastrointestinal tissue. Crypt distortion, villous blunting and fusion, and fibrosis were most commonly seen in cats with moderate or severe IBD. Clinicopathologic findings of some cats included anemia, leukocytosis or leukopenia, hypocholesterolemia, and hyper- or hypoproteinemia. Abnormalities were not found on abdominal radiographic views in 9 of 9 cats. However, contrast studies using barium revealed radiographic abnormalities in 1 of 3 cats. In 13 of 17 cats, abdominal ultrasonography revealed several intestinal abnormalities (e.g., poor intestinal wall layer definition, focal thickening) and large mesenteric lymph nodes with hypoechoic changes consistent with IBD. Endoscopic observation revealed findings (e.g., erythema, plaques, mucosal friability) consistent with inflammation in 9 of 18 cats. Conclusions and clinical relevance: Compared with endoscopy of the gastrointestinal tract or abdominal radiography, clinical signs and ultrasonographic findings appear to have the best association with histologic grade of IBD in cats.
Bronchoscopy of the horse
PubMed, Oct 1, 1992
The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated hors... more The endobronchial anatomy of 12 lung specimens from horses and 12 healthy, standing, sedated horses was evaluated, using a 200-cm-long, 9.5-mm-diameter videoendoscope. On the basis of these findings, the nomenclature system of Amis and McKiernan was modified for identification of airways of horses during bronchoscopy. Lobar bronchi are identified on the basis of the side of the bronchial tree on which they were found and the order in which they originated from the primary bronchus. Thus, RB1, RB2, and RB3 referred to right cranial lobar bronchus, respectively. On the left side, the designation of LB1 and LB2 refer to the left cranial lobar bronchus and the left caudal lobar bronchus, respectively. Segmental bronchi are identified by consecutive numbers in the order of origination from the lobar bronchus. The direction of the segmental bronchus was denoted by the capital letter D (dorsal), V (ventral), L (lateral), M (medial), R (rostral), and C (caudal). Subsegmental bronchi were identified in the order of origination from the segmental bronchi, using lower case letters (eg, RB2, 1V, a or RB2, 1V, aV). For subsequent branching of the subsegmental bronchi, the branches were numbered consecutively by their order of origination (eg, RB2, 1V, aV, 1D).
The Canadian veterinary journal = La revue veterinaire canadienne, 2018
The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the... more The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the haired skin were retrospectively reviewed for overall survival time (OST), progression-free survival time (PFS), and prognostic factors. The post-surgery median PFS and median OST were 1282 days and 1363 days, respectively. The post-surgery metastatic rate was 21.8% with a local recurrence rate of 8%. Increasing mitotic index (MI) was predictive of a significantly decreased OST and PFS on multivariable analysis [hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.02 to 1.07 and HR: 1.04, 95% CI: 1.02 to 1.06, respectively]. Increasing age was likewise predictive of a significantly decreased OST and PFS on multivariable analysis (HR: 1.39, 95% CI: 1.17 to 1.65 and HR: 1.33, 95% CI: 1.14 to 1.54, respectively). These results confirm clinical impressions that long survival times are likely in dogs diagnosed with malignant melanoma of the haired skin when treated with surgery alone.
Pulmonary and Bronchial Neoplasia
Textbook of Respiratory Disease in Dogs and Cats, 2004
Feline Mammary Carcinoma
August's Consultations in Feline Internal Medicine, Volume 7, 2016
Veterinary and Comparative Oncology, 2005
As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is ... more As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is pleased to include these abstracts from the Annual Conference and we hope you find them informative and useful. These abstracts have not been subjected to peer review or editorial revision, however, and it would be prudent for the reader to exercise caution in the interpretation and application of the data presented.
Veterinary and Comparative Oncology, 2005
As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is ... more As the official journal of the Veterinary Cancer Society, Veterinary and Comparative Oncology is pleased to include these abstracts from the Annual Conference and we hope you find them informative and useful. These abstracts have not been subjected to peer review or editorial revision, however, and it would be prudent for the reader to exercise caution in the interpretation and application of the data presented.
Efficacy and Toxicity of a Dose-Intensified Doxorubicin Protocol in Canine Hemangiosarcoma
Journal of Veterinary Internal Medicine, 2004
The purpose of this study was to evaluate the efficacy and toxicity of a single‐agent, dose‐inten... more The purpose of this study was to evaluate the efficacy and toxicity of a single‐agent, dose‐intensified doxorubicin protocol in canine hemangiosarcoma (HSA). Canine HSA is a highly malignant tumor, and most affected dogs die within 6 months of diagnosis. Doxorubicin is the most, and possibly the only, effective chemotherapeutic drug for this malignancy, but it provides only moderate improvement in survival. On the basis of previous studies reporting similar survival in dogs treated with doxorubicin as a single agent and doxorubicin‐based combination chemotherapy and the concept of summation dose intensity, a dose‐intensified single‐agent doxorubicin protocol was initiated. Twenty dogs with HSA were recruited to participate in this study. Workup and staging were performed according to standard practice. Chemotherapy was initiated within 3 weeks of surgery. Doxorubicin was scheduled to be administered at 30 mg/m2 IV every 2 weeks for a total of 5 treatments. The dogs were monitored for toxicity and signs of recurrence during and at regular intervals after chemotherapy. The protocol was tolerated well. No dogs were hospitalized because of adverse effects or developed clinical signs consistent with doxorubicin‐induced cardiomyopathy. There was a significant difference in survival in dogs with stage I and II HSA compared with dogs with stage III HSA, with median survival times of 257, 210, and 107 days, respectively. These results are slightly better than the historical control with respect to toxicity and efficacy but are not statistically different from what is achieved with standard treatments. There was no association between dose intensity and outcome.
Evaluation of Adjuvant Doxorubicin-Based Chemotherapy for the Treatment of Feline Mammary Carcinoma
Journal of Veterinary Internal Medicine, 2009
Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the... more Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the high metastatic potential, patients often are treated with adjuvant doxorubicin-based chemotherapy, but little data exist to evaluate the effect of this strategy. Adjuvant doxorubicin-based chemotherapy improves outcome for FMC compared with surgery alone. Cats with naturally occurring, biopsy-confirmed FMC treated with either surgery alone (Sx) or with surgery plus adjuvant doxorubicin-based chemotherapy (Sx + Chemo). Retrospective cohort study. Clinical data were collected and compared to identify differences between groups. Outcome results were determined and compared. Prognostic factors for disease-free survival (DFS) and overall survival were evaluated. Seventy-three cats were evaluated, of which 37 were in the Sx group and 36 in the Sx + Chemo group. No differences in clinical data were found between Sx and Sx + Chemo groups. Median DFS times for the Sx and Sx + Chemo groups were 372 and 676 days, respectively (P= .15) and median survival times (ST) were 1,406 and 848 days, respectively (P= .78). For cats that underwent a unilateral radical mastectomy, ST was significantly longer for the Sx + Chemo compared with the Sx group (1,998 versus 414 days, respectively; P= .03). This study did not find a benefit to adjuvant doxorubicin-based chemotherapy in cats with FMC. Additional studies are required to determine whether patient subgroups with negative prognostic factors may benefit from adjuvant chemotherapy.
Journal of Veterinary Internal Medicine, 2008
Background: Feline visceral hemangiosarcoma (HSA) is an uncommon tumor, and the clinical progress... more Background: Feline visceral hemangiosarcoma (HSA) is an uncommon tumor, and the clinical progression and outcome are rarely reported. Hypothesis: The prognosis of feline visceral HSA is poor because of severe clinical signs, anemia, and a high rate of metastasis. The medical records of 26 client-owned cats with visceral HSA were reviewed. Methods: Multi-institutional retrospective study. The most common historical findings and clinical signs included lethargy, anorexia, respiratory difficulty, collapse, and vocalizing. Eighty-two percent of cats were anemic, and aspartate transaminase was increased in 53% of the study population. Metastatic lung disease was noted in 33% of affected cats. In 75% of the cats, abdominal ultrasonography identified a specific location of HSA. However, ultrasound identification of all multifocal lesions was successful only in 3/9 cats (33%). Tumor location was identified in the following organs: liver (35%), small intestine (31%), large intestine (31%), abdominal lymph node (31%), mesentery (27%), spleen (23%), lung (19%), omentum (12%), brain (8%), pancreas (8%), and diaphragm (8%). Multifocal HSA was noted in 77% of cats. Three cats received adjuvant chemotherapy (doxorubicin). Seventy-one percent of euthanized cats were euthanized within 1 day of diagnosis. The median survival time of the remaining cats (n 5 6) was 77 days (range, 23-296 days). Conclusion and Clinical Importance: Feline visceral HSA is most often multifocal at the time of diagnosis. The prognosis appears poor, and the number of cats receiving chemotherapy is low.
Journal of the American Veterinary Medical Association, 2007
Objective—To reexamine (via immunohistochemical techniques) canine tissue samples that had been p... more Objective—To reexamine (via immunohistochemical techniques) canine tissue samples that had been previously classified as gastrointestinal leiomyosarcomas (GILMSs), identify and differentiate gastrointestinal stromal tumors (GISTs) from GILMSs, and compare the biological behavior and clinical course of GISTs and GILMSs in dogs. Design—Retrospective case series. Animals—42 dogs. Procedures—Medical records of 42 dogs for which a histologic diagnosis of GILMS was confirmed were reviewed for signalment, clinical signs, physical examination findings, results of initial diagnostic tests, surgical findings, adjunctive treatment, location of the tumor, completeness of resection, and outcome after surgery. Archived tumor tissue specimens from each dog were restained via immunohistochemical techniques to differentiate tumor types. Long-term follow-up information was obtained from the medical record or through telephone interviews with owners and referring veterinarians. Results—On the basis of...
Journal of the American Veterinary Medical Association, 2004
Objective—To determine the biological behavior of liposarcomas in dogs and identify clinical sign... more Objective—To determine the biological behavior of liposarcomas in dogs and identify clinical signs, the effect of treatment on survival time, and potential prognostic factors. Design—Retrospective study. Animals—56 dogs with histologically confirmed liposarcoma. Procedure—Information was obtained on signalment, tumor size, location of the tumor, stage of disease, remission duration, overall survival time, cause of death, type of surgery (incisional biopsy, marginal excision, or wide excision), and any additional treatments given. Results—Surgery consisted of incisional biopsy in 6 dogs, marginal excision in 34, and wide excision in 16. Twenty-five dogs had histologic evidence of tumor cells at the surgical margins and 28 did not (status of the margins was unknown in 3 dogs). Twelve of 43 dogs had local recurrence. Median survival time was 694 days, and the only factor significantly associated with survival time was type of surgery performed. Median survival times were 1,188, 649, an...
Lomustine for treatment of mast cell tumors in cats: 38 cases (1999–2005)
Journal of the American Veterinary Medical Association, 2008
Objective—To determine clinical activity and toxic effects of lomustine when used to treat cats w... more Objective—To determine clinical activity and toxic effects of lomustine when used to treat cats with mast cell tumors (MCTs). Design—Retrospective case series. Animals—38 cats with measurable, histologically or cytologically confirmed MCTs treated with lomustine at a dosage ≥ 50 mg/m2. Procedures—Medical records were reviewed to determine response to treatment and evidence of drug toxicoses. The Kaplan-Meier method was used to estimate remission duration. Results—26 cats had cutaneous MCTs, 7 had MCTs of the mesenteric lymph nodes, 2 had gastrointestinal tract MCTs, 2 had hepatic MCTs, and 1 had MCTs involving multiple organs. Targeted lomustine dosage was 50 mg/m2 in 22 cats and 60 mg/m2 in 16 cats. Median administered dosage of lomustine was 56 mg/m2 (range, 48 to 65 mg/m2), and median number of doses administered was 2 (range, 1 to 12). Seven cats had a complete response and 12 had a partial response, for an overall response rate of 50%. Median response duration was 168 days (ran...
The Journal of Membrane Biology, 1991
A doublet of proteins (-48,000 Mr) from the Paramecium cell body membrane fits several criteria f... more A doublet of proteins (-48,000 Mr) from the Paramecium cell body membrane fits several criteria for the external cAMP chemoreceptor. These criteria include: (i) selective elution from a cAMP affinity column, matching a specificity that could be predicted from the behavioral response and whole-cell binding; (ii) binding to wheat germ agglutinin indicating the presence of carbohydrate moieties indicating surface exposure; and (iii) selective inhibition of the intact cells' chemoresponse to cAMP by antibodies against the doublet. Additional evidence for the existence of a receptor, in general, comes from selective elimination of the cAMP ehemoresponse by photoaffinity labeling of whole cells with 8-N3~cAMP. The doublet proteins are not identical to the regulatory subunit of a cAMP-dependent protein kinase from Paramecium, the Dictyostelium cAMP chemoreceptor, or the 42-45 kDa range proteins related to the large surface glycoprotein in Paramecium. The doublet proteins are not readily separable and, as in Dictyostelium, may represent two different covalent modification states of the same protein. Amino acid analysis indicates that the proteins are similar, but does not distinguish between the possibilities ofproteolysis and covalent modification. Once cloned, this doublet may prove to be only the fifth external, eukaryotic chemoreceptor to be identified.
Journal of Feline Medicine & Surgery, 2007
The paper was published as a Review Article when it is in fact an Original Paper. We apologise to... more The paper was published as a Review Article when it is in fact an Original Paper. We apologise to readers of the journal for any inconvenience caused.
A prospective investigation of the prevalence and prognostic significance of weight loss and changes in body condition in feline cancer patients
Journal of Feline Medicine and Surgery, 2007
The objectives of this study were to prospectively identify and characterize weight loss and chan... more The objectives of this study were to prospectively identify and characterize weight loss and changes in body condition in feline cancer patients and to investigate the prognostic significance of these findings. Fifty-seven cats with neoplasia were evaluated. Body condition was assessed with a nine-point scoring system (BCS) and multiple sites were assessed for muscle and fat mass using four-point scoring systems. Feline cancer patients had a mean BCS of 4.4±2.1 kg (1=cachectic, 5=optimal, 9=obese). Fat mass was reduced in both sites assessed in 60% of the patients. Muscle mass was reduced at all three sites assessed in 91% of the patients. Feline cancer patients having a BCS <5 had a median survival time (MST) of 3.3 months compared to that of 16.7 months for cats with a BCS of ≥5 ( P=0.008).
Veterinary and Comparative Oncology, 2008
Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant ... more Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant of feline lymphoma. Limited information exists in the literature regarding pathological and immunohistochemical descriptions, clinical fi ndings, treatment and survival times. The purpose of this study was to describe clinical features, treatment and outcome in feline LGL lymphoma. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. Decreased appetite/anorexia, weight loss, lethargy and vomiting were the most commonly reported clinical signs. All cats tested for feline leukaemia virus and feline immunodefi ciency virus infection were negative. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis. perforin-like immunoreactivity. 1,3 -5 In a recent report, cells from a majority of patients were found to be T cells (CD3+) that expressed CD8 ␣ ␣ and CD103, which is consistent with the phenotype of feline and human intestinal intra-epithelial lymphocytes. Although very limited clinical information about feline LGL lymphoma is available, some consistent fi ndings have been reported. Anorexia, vomiting and lethargy are the most commonly reported clinical signs, while a palpable abdominal mass is consistently reported as a common physical exam fi nding. 2,4,6 -11 Feline LGL lymphoma does not appear to be associated with feline leukaemia virus (FeLV) infection, as few affected cats have tested positive for it. Although there are no consistent haematological or serum chemistry