Jenny Ortiz - Academia.edu (original) (raw)
Papers by Jenny Ortiz
Annals of The New York Academy of Sciences, 2006
Abstract: Experiments were performed to determine whether exogenous cytidine (5′) diphosphocholin... more Abstract: Experiments were performed to determine whether exogenous cytidine (5′) diphosphocholine (CDP-choline) could modify the release of dopamine (DA) in the striatum. Rats were divided into two groups, receiving either a standard diet (UAR 004) or the same diet supplemented with CDP-choline (250 mg/kg day) for 28 days. On the last day the dialysis probes were inserted in the striatum, and DA, homovanillic acid (HVA), and 3,4-dihydroxyphenylacetic acid (DOPAC) efflux were measured in the dialysis stream basally and during K+depolarization (80 mM K+). Basal DA, HVA, and DOPAC did not show any difference between treated and untreated groups. Depolarization with K+ increased DA levels by up to 3,000% in the control group and by up to 4,770% in the CDP-choline-treated group (p<0.05), and reduced extracellular HVA and DOPAC concentration by up to 45 and 35%, respectively, both in the untreated and CDP-choline-treated groups. These results show that long-term treatment with CDP-choline increases the K+ induced release of DA and suggest, in accordance with previous research, that by providing exogenous choline and cytidine, CDP-choline modulates dopaminergic transmission.
Journal of Neural Transmission, 1989
Circulating choline is converted to membrane phosphatidylcholine (PC) in all cells, and, addition... more Circulating choline is converted to membrane phosphatidylcholine (PC) in all cells, and, additionally, to acetylcholine (ACH) within cholinergic neurons. Neither of the enzmyes that initiate these processes (choline kinase and choline acetyltransferase) is substratesaturated; hence supplemental choline can accelerate the formation of both compounds, as well as acetylcholine release from physiologically-active neurons. We have found, using a human neuronal cell
Annals of The New York Academy of Sciences, 1993
Exogenous cytidine 5′diphosphocholine (CDF-choline) is completely metabolized to circulating cyti... more Exogenous cytidine 5′diphosphocholine (CDF-choline) is completely metabolized to circulating cytidine and choline. Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. We administered oral CDP-choline to 12 month-old rats (500 mg/kg/day) for 21, 42, or 90 days to determine whether this treatment would alter brain levels of PC and the other structural phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE). After 42 days, brain PC levels increased significantly (p < 0.01) by 23.3%; after 90 days PC increased by 30% (p < 0.01), PS by 37.2% (p < 0.01), and PE by 13% (not significant). The ratios of each of the phospholipids to total membrane phospholipids were unchanged. These data demonstrate that repeated oral CDP-choline administration can increase the amounts of phospholipids in brain membranes, thus providing a rationale for using this compound in brain diseases that damage neurons.
The effect of mothers&amp;#39; age and the participation in the Kangaroo Mother Care (KMC... more The effect of mothers&amp;#39; age and the participation in the Kangaroo Mother Care (KMC) on attachment relationships, was studied in a group of mothers and their infants from low socio- economic status sample. The mother-infant interaction was observed in daily situations, finding out that the KMC increases the mother&amp;#39;s sensitivity and decreases the negative effects of poverty, prematurity, hospitalisation and
Annals of The New York Academy of Sciences, 2006
Abstract: Experiments were performed to determine whether exogenous cytidine (5′) diphosphocholin... more Abstract: Experiments were performed to determine whether exogenous cytidine (5′) diphosphocholine (CDP-choline) could modify the release of dopamine (DA) in the striatum. Rats were divided into two groups, receiving either a standard diet (UAR 004) or the same diet supplemented with CDP-choline (250 mg/kg day) for 28 days. On the last day the dialysis probes were inserted in the striatum, and DA, homovanillic acid (HVA), and 3,4-dihydroxyphenylacetic acid (DOPAC) efflux were measured in the dialysis stream basally and during K+depolarization (80 mM K+). Basal DA, HVA, and DOPAC did not show any difference between treated and untreated groups. Depolarization with K+ increased DA levels by up to 3,000% in the control group and by up to 4,770% in the CDP-choline-treated group (p<0.05), and reduced extracellular HVA and DOPAC concentration by up to 45 and 35%, respectively, both in the untreated and CDP-choline-treated groups. These results show that long-term treatment with CDP-choline increases the K+ induced release of DA and suggest, in accordance with previous research, that by providing exogenous choline and cytidine, CDP-choline modulates dopaminergic transmission.
Journal of Neural Transmission, 1989
Circulating choline is converted to membrane phosphatidylcholine (PC) in all cells, and, addition... more Circulating choline is converted to membrane phosphatidylcholine (PC) in all cells, and, additionally, to acetylcholine (ACH) within cholinergic neurons. Neither of the enzmyes that initiate these processes (choline kinase and choline acetyltransferase) is substratesaturated; hence supplemental choline can accelerate the formation of both compounds, as well as acetylcholine release from physiologically-active neurons. We have found, using a human neuronal cell
Annals of The New York Academy of Sciences, 1993
Exogenous cytidine 5′diphosphocholine (CDF-choline) is completely metabolized to circulating cyti... more Exogenous cytidine 5′diphosphocholine (CDF-choline) is completely metabolized to circulating cytidine and choline. Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. We administered oral CDP-choline to 12 month-old rats (500 mg/kg/day) for 21, 42, or 90 days to determine whether this treatment would alter brain levels of PC and the other structural phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE). After 42 days, brain PC levels increased significantly (p < 0.01) by 23.3%; after 90 days PC increased by 30% (p < 0.01), PS by 37.2% (p < 0.01), and PE by 13% (not significant). The ratios of each of the phospholipids to total membrane phospholipids were unchanged. These data demonstrate that repeated oral CDP-choline administration can increase the amounts of phospholipids in brain membranes, thus providing a rationale for using this compound in brain diseases that damage neurons.
The effect of mothers&amp;#39; age and the participation in the Kangaroo Mother Care (KMC... more The effect of mothers&amp;#39; age and the participation in the Kangaroo Mother Care (KMC) on attachment relationships, was studied in a group of mothers and their infants from low socio- economic status sample. The mother-infant interaction was observed in daily situations, finding out that the KMC increases the mother&amp;#39;s sensitivity and decreases the negative effects of poverty, prematurity, hospitalisation and