Jeong Bae Park - Academia.edu (original) (raw)
Papers by Jeong Bae Park
A significant association between increased arterial stiffness and the development of cardiovascu... more A significant association between increased arterial stiffness and the development of cardiovascular disease has led to the increased use of arterial stiffness in the clinical assessment of cardiovascular risk. Various methods are currently available. With advances in technology, the assessment methods have become easy to use and more acceptable to patients. However, the different techniques that are available measure arterial stiffness at different locations and have unique indices for arterial stiffness. For the appropriate assessment of arterial stiffness, accurate and reproducible measurements of arterial stiffness are essential. Here we review the methodological aspects of the measurement of arterial stiffness and provide information on the measurement methods available and their clinical applications. (Korean Circ J 2008;38:343-350)
PloS one, 2017
The effect of resolving metabolic syndrome on target organ damage in hypertensive patients is not... more The effect of resolving metabolic syndrome on target organ damage in hypertensive patients is not well described. We evaluated whether treating metabolic syndrome (MetS) with an angiotensin receptor blocker subsequently reduced microalbuminuria in the K-MetS cohort. Among 10,601 total metabolic syndrome patients, 3,250 (52.2% male, 56.2±10.0 years) with sufficient data on five specific metabolic components were included in this study. Patients were divided into four groups based on MetS status at baseline and 3 months. All patients received an angiotensin receptor blocker, fimasartan, for these 3 months; thereafter, treatment was modified at the discretion of each patient's physician. Microalbuminuria and the albumin/creatine ratio were evaluated as a proxy of organ damage. Blood pressure and waist circumference decreased from baseline to 3 months and 1 year. The average albumin/creatinine ratio significantly improved during the first three months of the study from 36.0±147.4 to...
Journal of clinical hypertension (Greenwich, Conn.), Jan 4, 2018
Hypertension has been associated with atherosclerosis and cardiovascular disease. Carotid intima ... more Hypertension has been associated with atherosclerosis and cardiovascular disease. Carotid intima media thickness is increased in hypertensive patients. But, the correlation between carotid intima media thickness and antihypertensive agents is still uncertain. Therefore, we investigated carotid intima media thickness based on types of antihypertensive agents. 1809 patients were enrolled in this study and it showed that 1079 hypertensive patients had thicker carotid intima media thickness than non-hypertensive patients, with carotid intima media thicknesses of (0.72 ± 17 mm vs 0.64 ± 15 mm, P < .001), (0.31 ± 0.07 mm vs 0.30 ± 0.06 mm, P < .001), and (0.41 ± 0.13 mm vs 0.35 ± 0.12 mm, P < .001). Additionally, hypertensive patients on beta-blockers also had thicker carotid intima media thickness than the non-beta-blocker group, with carotid intima media thicknesses of (0.74 ± 0.18 mm vs 0.71 ± 0.16 mm, P = .018), (0.33 ± 0.09 mm vs 0.31 ± 0.07 mm, P = .029), and (0.43 ± 0.13 m...
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](Journal of Hypertension, 2017
American Journal of Hypertension, 2002
Clinical therapeutics, Apr 17, 2016
Doubling the dose of antihypertensive drugs is necessary to manage hypertension in patients whose... more Doubling the dose of antihypertensive drugs is necessary to manage hypertension in patients whose disease is uncontrolled. However, this strategy can result in safety issues. This study compared the safety and efficacy of up-titration of the nifedipine gastrointestinal therapeutic system (GITS) with up-titration of valsartan monotherapy; these were also compared with low-dose combinations of the two therapies. This prospective, open-label, randomized, active-controlled, multicenter study lasted 8 weeks. If patients did not meet the target blood pressure (BP) after 4 weeks of treatment with low-dose monotherapy, they were randomized to up-titration of the nifedipine GITS dose from 30 mg (N30) to 60 mg or valsartan from 80 mg to 160 mg or they were randomized to receive a low-dose combination of N30 and valsartan 80 mg for another 4 weeks. BP variability was assessed by using the SD or the %CV of the short-term BP measured at clinic. Of the 391 patients (20~70 years with stage II or h...
Journal of the Korean Medical Association, 2014
In 2013 and 2014, many guidelines regarding the management of hypertension were released from var... more In 2013 and 2014, many guidelines regarding the management of hypertension were released from various worldwide professional bodies. These guidelines are similar in their recommendations, but some differences are evident due to different choices and interpretations of evidence from clinical trials used in setting the guidelines. A noticeable change that is common to all the guidelines is an increase in the target blood pressure for the treatment of hypertension to 140/90 mmHg. The guidelines also introduce invasive approaches, such as renal sympathetic denervation, as additional measures to better manage resistant hypertension. This review gives a summary of recent guidelines from North America, Europe, and Asia for the management of hypertension, with a focus on pharmacological treatment, and compares these guidelines with the Korean guidelines.
Clinical Hypertension, 2015
Treatment strategies are provided in accordance with the level of global cardiovascular risk, fro... more Treatment strategies are provided in accordance with the level of global cardiovascular risk, from lifestyle modification in the lower risk group to more comprehensive treatment in the higher risk group. Considering the common trend of combination drug regimen, the choice of the first drug is suggested more liberally according to the physician's discretion.
Journal of the Korean Medical Association, 2014
American Journal of Hypertension, 2002
Korean Circulation Journal, 2008
A significant association between increased arterial stiffness and the development of cardiovascu... more A significant association between increased arterial stiffness and the development of cardiovascular disease has led to the increased use of arterial stiffness in the clinical assessment of cardiovascular risk. Various methods are currently available. With advances in technology, the assessment methods have become easy to use and more acceptable to patients. However, the different techniques that are available measure arterial stiffness at different locations and have unique indices for arterial stiffness. For the appropriate assessment of arterial stiffness, accurate and reproducible measurements of arterial stiffness are essential. Here we review the methodological aspects of the measurement of arterial stiffness and provide information on the measurement methods available and their clinical applications.
Journal of Korean Medical Science, 2008
Korean diabetes journal, 2010
Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic... more Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic dysfunction. Some studies have shown that diabetes itself may also be an independent risk factor for LV diastolic dysfunction, although this is controversial. The aim of this study was to determine the factors associated with LV diastolic dysfunction in patients with type 2 diabetes in the absence of hypertension or ischemic heart disease (IHD). Participants in this study consisted of 65 type 2 diabetes patients (M : F = 45 : 20; mean age 51 [26 to 76] years; mean body mass index [BMI] 25.0 +/- 2.5 kg/m(2)) without hypertension, heart disease, or renal disease. Individuals with ischemic electrocardiographic changes were excluded. LV diastolic function was evaluated by Doppler echocardiographic studies. Fifteen patients (23.1%) showed LV diastolic dysfunction on Doppler echocardiographic studies. Patients with LV diastolic dysfunction were older than those without diastolic dysfunction (...
Journal of the Renin-Angiotensin-Aldosterone System, 2000
In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geome... more In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor antagonist. In previous studies of human hypertension, interruption of the renin-angiotensin system corrected small artery structure and endothelial dysfunction, whereas the β-blocker atenolol did not. We hypothesized that the AT1R antagonist losartan, but not the β-blocker atenolol, would reduce stiffness of gluteal subcutaneous small arteries in essential hypertensive patients. Seventeen untreated mild essential hypertensive patients (47±2years; 75% male) were randomly assigned in double-blind fashion to losartan or atenolol treatment for one year. Small, resistance size arteries were studied on pressurized myographs. Blood pressure (mmHg) was reduced (p<0.01) from 145±4/101±2 and 147±6/98±2 to 128±4/86±2 and 131±3/84±1 by losartan and atenolol, respectively.The media/lumen ratio of small arteries was unaffec...
Journal of International Medical Research, 2013
Objective To examine factors affecting systolic blood pressure (SBP) variability during a single ... more Objective To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients. Methods Hypertensive patients were recruited to this observational study. Blood pressure was measured using an automated blood pressure monitor when each patient arrived at the outpatient clinic and again when they saw the physician. Mean SBP and SBP variability during a single clinic visit were calculated. The cardio–ankle vascular index (CAVI), as a marker of arterial stiffness, was also measured. Results A total of 57 treated hypertensive patients (mean age 71 years) were included in the study. The mean SBP was positively correlated with age ( r = 0.457), while SBP variability was positively correlated with age ( r = 0.383), CAVI ( r = 0.330), and glycosylated haemoglobin ( r = 0.345) and triglyceride levels (r = 0.299). Conclusion Variability in SBP during a single clinic visit showed better correlations with arterial stiffness and risk...
Journal of Hypertension, 2011
Journal of Hypertension, 2004
A significant association between increased arterial stiffness and the development of cardiovascu... more A significant association between increased arterial stiffness and the development of cardiovascular disease has led to the increased use of arterial stiffness in the clinical assessment of cardiovascular risk. Various methods are currently available. With advances in technology, the assessment methods have become easy to use and more acceptable to patients. However, the different techniques that are available measure arterial stiffness at different locations and have unique indices for arterial stiffness. For the appropriate assessment of arterial stiffness, accurate and reproducible measurements of arterial stiffness are essential. Here we review the methodological aspects of the measurement of arterial stiffness and provide information on the measurement methods available and their clinical applications. (Korean Circ J 2008;38:343-350)
PloS one, 2017
The effect of resolving metabolic syndrome on target organ damage in hypertensive patients is not... more The effect of resolving metabolic syndrome on target organ damage in hypertensive patients is not well described. We evaluated whether treating metabolic syndrome (MetS) with an angiotensin receptor blocker subsequently reduced microalbuminuria in the K-MetS cohort. Among 10,601 total metabolic syndrome patients, 3,250 (52.2% male, 56.2±10.0 years) with sufficient data on five specific metabolic components were included in this study. Patients were divided into four groups based on MetS status at baseline and 3 months. All patients received an angiotensin receptor blocker, fimasartan, for these 3 months; thereafter, treatment was modified at the discretion of each patient's physician. Microalbuminuria and the albumin/creatine ratio were evaluated as a proxy of organ damage. Blood pressure and waist circumference decreased from baseline to 3 months and 1 year. The average albumin/creatinine ratio significantly improved during the first three months of the study from 36.0±147.4 to...
Journal of clinical hypertension (Greenwich, Conn.), Jan 4, 2018
Hypertension has been associated with atherosclerosis and cardiovascular disease. Carotid intima ... more Hypertension has been associated with atherosclerosis and cardiovascular disease. Carotid intima media thickness is increased in hypertensive patients. But, the correlation between carotid intima media thickness and antihypertensive agents is still uncertain. Therefore, we investigated carotid intima media thickness based on types of antihypertensive agents. 1809 patients were enrolled in this study and it showed that 1079 hypertensive patients had thicker carotid intima media thickness than non-hypertensive patients, with carotid intima media thicknesses of (0.72 ± 17 mm vs 0.64 ± 15 mm, P < .001), (0.31 ± 0.07 mm vs 0.30 ± 0.06 mm, P < .001), and (0.41 ± 0.13 mm vs 0.35 ± 0.12 mm, P < .001). Additionally, hypertensive patients on beta-blockers also had thicker carotid intima media thickness than the non-beta-blocker group, with carotid intima media thicknesses of (0.74 ± 0.18 mm vs 0.71 ± 0.16 mm, P = .018), (0.33 ± 0.09 mm vs 0.31 ± 0.07 mm, P = .029), and (0.43 ± 0.13 m...
Journal of Hypertension, 2017
American Journal of Hypertension, 2002
Clinical therapeutics, Apr 17, 2016
Doubling the dose of antihypertensive drugs is necessary to manage hypertension in patients whose... more Doubling the dose of antihypertensive drugs is necessary to manage hypertension in patients whose disease is uncontrolled. However, this strategy can result in safety issues. This study compared the safety and efficacy of up-titration of the nifedipine gastrointestinal therapeutic system (GITS) with up-titration of valsartan monotherapy; these were also compared with low-dose combinations of the two therapies. This prospective, open-label, randomized, active-controlled, multicenter study lasted 8 weeks. If patients did not meet the target blood pressure (BP) after 4 weeks of treatment with low-dose monotherapy, they were randomized to up-titration of the nifedipine GITS dose from 30 mg (N30) to 60 mg or valsartan from 80 mg to 160 mg or they were randomized to receive a low-dose combination of N30 and valsartan 80 mg for another 4 weeks. BP variability was assessed by using the SD or the %CV of the short-term BP measured at clinic. Of the 391 patients (20~70 years with stage II or h...
Journal of the Korean Medical Association, 2014
In 2013 and 2014, many guidelines regarding the management of hypertension were released from var... more In 2013 and 2014, many guidelines regarding the management of hypertension were released from various worldwide professional bodies. These guidelines are similar in their recommendations, but some differences are evident due to different choices and interpretations of evidence from clinical trials used in setting the guidelines. A noticeable change that is common to all the guidelines is an increase in the target blood pressure for the treatment of hypertension to 140/90 mmHg. The guidelines also introduce invasive approaches, such as renal sympathetic denervation, as additional measures to better manage resistant hypertension. This review gives a summary of recent guidelines from North America, Europe, and Asia for the management of hypertension, with a focus on pharmacological treatment, and compares these guidelines with the Korean guidelines.
Clinical Hypertension, 2015
Treatment strategies are provided in accordance with the level of global cardiovascular risk, fro... more Treatment strategies are provided in accordance with the level of global cardiovascular risk, from lifestyle modification in the lower risk group to more comprehensive treatment in the higher risk group. Considering the common trend of combination drug regimen, the choice of the first drug is suggested more liberally according to the physician's discretion.
Journal of the Korean Medical Association, 2014
American Journal of Hypertension, 2002
Korean Circulation Journal, 2008
A significant association between increased arterial stiffness and the development of cardiovascu... more A significant association between increased arterial stiffness and the development of cardiovascular disease has led to the increased use of arterial stiffness in the clinical assessment of cardiovascular risk. Various methods are currently available. With advances in technology, the assessment methods have become easy to use and more acceptable to patients. However, the different techniques that are available measure arterial stiffness at different locations and have unique indices for arterial stiffness. For the appropriate assessment of arterial stiffness, accurate and reproducible measurements of arterial stiffness are essential. Here we review the methodological aspects of the measurement of arterial stiffness and provide information on the measurement methods available and their clinical applications.
Journal of Korean Medical Science, 2008
Korean diabetes journal, 2010
Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic... more Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic dysfunction. Some studies have shown that diabetes itself may also be an independent risk factor for LV diastolic dysfunction, although this is controversial. The aim of this study was to determine the factors associated with LV diastolic dysfunction in patients with type 2 diabetes in the absence of hypertension or ischemic heart disease (IHD). Participants in this study consisted of 65 type 2 diabetes patients (M : F = 45 : 20; mean age 51 [26 to 76] years; mean body mass index [BMI] 25.0 +/- 2.5 kg/m(2)) without hypertension, heart disease, or renal disease. Individuals with ischemic electrocardiographic changes were excluded. LV diastolic function was evaluated by Doppler echocardiographic studies. Fifteen patients (23.1%) showed LV diastolic dysfunction on Doppler echocardiographic studies. Patients with LV diastolic dysfunction were older than those without diastolic dysfunction (...
Journal of the Renin-Angiotensin-Aldosterone System, 2000
In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geome... more In spontaneously hypertensive rats resistance artery structure, endothelial dysfunction and geometry-independent wall stiffness were reduced by an angiotensin AT1-receptor antagonist. In previous studies of human hypertension, interruption of the renin-angiotensin system corrected small artery structure and endothelial dysfunction, whereas the β-blocker atenolol did not. We hypothesized that the AT1R antagonist losartan, but not the β-blocker atenolol, would reduce stiffness of gluteal subcutaneous small arteries in essential hypertensive patients. Seventeen untreated mild essential hypertensive patients (47±2years; 75% male) were randomly assigned in double-blind fashion to losartan or atenolol treatment for one year. Small, resistance size arteries were studied on pressurized myographs. Blood pressure (mmHg) was reduced (p<0.01) from 145±4/101±2 and 147±6/98±2 to 128±4/86±2 and 131±3/84±1 by losartan and atenolol, respectively.The media/lumen ratio of small arteries was unaffec...
Journal of International Medical Research, 2013
Objective To examine factors affecting systolic blood pressure (SBP) variability during a single ... more Objective To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients. Methods Hypertensive patients were recruited to this observational study. Blood pressure was measured using an automated blood pressure monitor when each patient arrived at the outpatient clinic and again when they saw the physician. Mean SBP and SBP variability during a single clinic visit were calculated. The cardio–ankle vascular index (CAVI), as a marker of arterial stiffness, was also measured. Results A total of 57 treated hypertensive patients (mean age 71 years) were included in the study. The mean SBP was positively correlated with age ( r = 0.457), while SBP variability was positively correlated with age ( r = 0.383), CAVI ( r = 0.330), and glycosylated haemoglobin ( r = 0.345) and triglyceride levels (r = 0.299). Conclusion Variability in SBP during a single clinic visit showed better correlations with arterial stiffness and risk...
Journal of Hypertension, 2011
Journal of Hypertension, 2004