Jeremy Fine - Academia.edu (original) (raw)

Papers by Jeremy Fine

Research paper thumbnail of Associations Between Prenatal Cannabis Exposure and Childhood Outcomes

JAMA Psychiatry, 2021

In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued ... more In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued an advisory against the use of marijuana during pregnancy. OBJECTIVE To evaluate whether cannabis use during pregnancy is associated with adverse outcomes among offspring. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, data were obtained from the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development Study, which recruited 11 875 children aged 9 to 11 years, as well as a parent or caregiver, from 22 sites across the United States between June 1, 2016, and October 15, 2018. EXPOSURE Prenatal cannabis exposure prior to and after maternal knowledge of pregnancy. MAIN OUTCOMES AND MEASURES Symptoms of psychopathology in children (ie, psychotic-like experiences [PLEs] and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index, and brain structure (ie, total intracranial volume, white matter volume, and gray matter volume). Covariates included familial (eg, income and familial psychopathology), pregnancy (eg, prenatal exposure to alcohol and tobacco), and child (eg, substance use) variables. RESULTS Among 11 489 children (5997 boys [52.2%]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal cannabis exposure data, 655 (5.7%) were exposed to cannabis prenatally. Relative to no exposure, cannabis exposure only before (413 [3.6%]) and after (242 [2.1%]) maternal knowledge of pregnancy were associated with greater offspring psychopathology characteristics (ie, PLEs and internalizing, externalizing, attention, thought and, social problems), sleep problems, and body mass index, as well as lower cognition and gray matter volume (all |β| > 0.02; all false discovery rate [FDR]-corrected P < .03). Only exposure after knowledge of pregnancy was associated with lower birth weight as well as total intracranial volume and white matter volumes relative to no exposure and exposure only before knowledge (all |β| > 0.02; all FDR-corrected P < .04). When including potentially confounding covariates, exposure after maternal knowledge of pregnancy remained associated with greater PLEs and externalizing, attention, thought, and social problems (all β > 0.02; FDR-corrected P < .02). Exposure only prior to maternal knowledge of pregnancy did not differ from no exposure on any outcomes when considering potentially confounding variables (all |β| < 0.02; FDR-corrected P > .70). CONCLUSIONS AND RELEVANCE This study suggests that prenatal cannabis exposure and its correlated factors are associated with greater risk for psychopathology during middle childhood. Cannabis use during pregnancy should be discouraged.

Research paper thumbnail of Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

ABSTRACTImportanceIn light of increasing cannabis use among pregnant women, the Surgeon General o... more ABSTRACTImportanceIn light of increasing cannabis use among pregnant women, the Surgeon General of the United States issued an advisory against the use of marijuana during pregnancy on August 29th, 2019.ObjectiveTo determine whether cannabis use during pregnancy is associated with adverse outcomes among offspring.DesignCross-sectional analysis of the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) study.SettingData were collected from 22 sites across the United States between 2016 and 2018.ParticipantsChildren ages 9-11 (n=11,489) and their parent or caregiver.ExposurePrenatal marijuana exposure prior to and following maternal knowledge of pregnancy.Main Outcomes and MeasuresChild psychopathology symptomatology (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index (BMI), and brain structure (i.e., total intra...

Research paper thumbnail of Association of Prenatal Cannabis Exposure With Psychosis Proneness Among Children in the Adolescent Brain Cognitive Development (ABCD) Study

JAMA Psychiatry, 2019

Mirroring increases in the general population, the prevalence of past-month marijuana use among p... more Mirroring increases in the general population, the prevalence of past-month marijuana use among pregnant mothers in the United States increased by 75% between 2002 (2.85%) and 2016 (4.98%). 1 Although cannabis use has been linked to psychosis, little is known about prenatal exposure. 2,3 Unprecedented increases in marijuana use during pregnancy, alongside evidence that cannabis use is correlated with psychosis and that endocannabinoids play an important role in neurodevelopment, highlight the importance of evaluating potential long-term consequences of prenatal exposure. 4 Methods | We used data from the ongoing Adolescent Brain Cognitive Development (ABCD) study (data release 1.0; https://abcdstudy.org/) to test whether maternal report of cannabis use during pregnancy is associated with psychosis proneness (Prodromal Questionnaire-Brief Child Version total score) among 4361 children aged 8.9 to 11.0 years who were born between 2005 and 2008 to 3774 mothers through 3926 pregnancies (Table). All parents provided written informed consent, and all children provided assent to a research protocol approved by the institutional review board at each data collection site (https://abcdstudy.org/sites/abcdsites.html). The Prodromal Questionnaire-Brief Child version

Research paper thumbnail of Associations Between Prenatal Cannabis Exposure and Childhood Outcomes

JAMA Psychiatry, 2021

In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued ... more In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued an advisory against the use of marijuana during pregnancy. OBJECTIVE To evaluate whether cannabis use during pregnancy is associated with adverse outcomes among offspring. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, data were obtained from the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development Study, which recruited 11 875 children aged 9 to 11 years, as well as a parent or caregiver, from 22 sites across the United States between June 1, 2016, and October 15, 2018. EXPOSURE Prenatal cannabis exposure prior to and after maternal knowledge of pregnancy. MAIN OUTCOMES AND MEASURES Symptoms of psychopathology in children (ie, psychotic-like experiences [PLEs] and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index, and brain structure (ie, total intracranial volume, white matter volume, and gray matter volume). Covariates included familial (eg, income and familial psychopathology), pregnancy (eg, prenatal exposure to alcohol and tobacco), and child (eg, substance use) variables. RESULTS Among 11 489 children (5997 boys [52.2%]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal cannabis exposure data, 655 (5.7%) were exposed to cannabis prenatally. Relative to no exposure, cannabis exposure only before (413 [3.6%]) and after (242 [2.1%]) maternal knowledge of pregnancy were associated with greater offspring psychopathology characteristics (ie, PLEs and internalizing, externalizing, attention, thought and, social problems), sleep problems, and body mass index, as well as lower cognition and gray matter volume (all |β| > 0.02; all false discovery rate [FDR]-corrected P < .03). Only exposure after knowledge of pregnancy was associated with lower birth weight as well as total intracranial volume and white matter volumes relative to no exposure and exposure only before knowledge (all |β| > 0.02; all FDR-corrected P < .04). When including potentially confounding covariates, exposure after maternal knowledge of pregnancy remained associated with greater PLEs and externalizing, attention, thought, and social problems (all β > 0.02; FDR-corrected P < .02). Exposure only prior to maternal knowledge of pregnancy did not differ from no exposure on any outcomes when considering potentially confounding variables (all |β| < 0.02; FDR-corrected P > .70). CONCLUSIONS AND RELEVANCE This study suggests that prenatal cannabis exposure and its correlated factors are associated with greater risk for psychopathology during middle childhood. Cannabis use during pregnancy should be discouraged.

Research paper thumbnail of Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

ABSTRACTImportanceIn light of increasing cannabis use among pregnant women, the Surgeon General o... more ABSTRACTImportanceIn light of increasing cannabis use among pregnant women, the Surgeon General of the United States issued an advisory against the use of marijuana during pregnancy on August 29th, 2019.ObjectiveTo determine whether cannabis use during pregnancy is associated with adverse outcomes among offspring.DesignCross-sectional analysis of the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) study.SettingData were collected from 22 sites across the United States between 2016 and 2018.ParticipantsChildren ages 9-11 (n=11,489) and their parent or caregiver.ExposurePrenatal marijuana exposure prior to and following maternal knowledge of pregnancy.Main Outcomes and MeasuresChild psychopathology symptomatology (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index (BMI), and brain structure (i.e., total intra...

Research paper thumbnail of Association of Prenatal Cannabis Exposure With Psychosis Proneness Among Children in the Adolescent Brain Cognitive Development (ABCD) Study

JAMA Psychiatry, 2019

Mirroring increases in the general population, the prevalence of past-month marijuana use among p... more Mirroring increases in the general population, the prevalence of past-month marijuana use among pregnant mothers in the United States increased by 75% between 2002 (2.85%) and 2016 (4.98%). 1 Although cannabis use has been linked to psychosis, little is known about prenatal exposure. 2,3 Unprecedented increases in marijuana use during pregnancy, alongside evidence that cannabis use is correlated with psychosis and that endocannabinoids play an important role in neurodevelopment, highlight the importance of evaluating potential long-term consequences of prenatal exposure. 4 Methods | We used data from the ongoing Adolescent Brain Cognitive Development (ABCD) study (data release 1.0; https://abcdstudy.org/) to test whether maternal report of cannabis use during pregnancy is associated with psychosis proneness (Prodromal Questionnaire-Brief Child Version total score) among 4361 children aged 8.9 to 11.0 years who were born between 2005 and 2008 to 3774 mothers through 3926 pregnancies (Table). All parents provided written informed consent, and all children provided assent to a research protocol approved by the institutional review board at each data collection site (https://abcdstudy.org/sites/abcdsites.html). The Prodromal Questionnaire-Brief Child version