Jesus Castiblanco - Academia.edu (original) (raw)
Papers by Jesus Castiblanco
IEEE Antennas and Wireless Propagation Letters, 2000
Copyright (c) 2009 IEEE. Personal use is permitted. For any other purposes, Permission must be ob... more Copyright (c) 2009 IEEE. Personal use is permitted. For any other purposes, Permission must be obtained from the IEEE by emailing pubs-permissions@ieee.org. ... This article has been accepted for publication in a future issue of this journal, but has not been fully edited. ...
JCR: Journal of Clinical Rheumatology, 2006
Genes and Immunity, 2004
Interleukin-1 beta (IL-1b) exerts a range of inflammatory and immunomodulatory activities that ar... more Interleukin-1 beta (IL-1b) exerts a range of inflammatory and immunomodulatory activities that are important in host defense and autoimmune response. The IL-1b gene, located on chromosome 2 (2q13), is polymorphic. The influence of its polymorphism on 355 patients with autoimmune rheumatic diseases was examined. To this effect, 172 patients with rheumatoid arthritis (RA), 114 with systemic lupus erythematosus (SLE), and 69 with primary Sjö gren's syndrome (pSS) were studied. The control group consisted of 392 matched healthy individuals. Genotyping of IL-1b single-nucleotide polymorphisms (SNPs) at positions À511 (C/T) and þ 3953 (C/T) was performed by the polymerase chain reaction-restriction fragment length polymorphism technique. In addition, levels of IL-1b were measured by immunoassay in supernatants of lipopolysaccharide (LPS)-stimulated and nonstimulated peripheral blood monocytes (PBM) obtained from 19 homozygous individuals for the three most common IL-1b likely haplotypes, all belonging to the control group. Allele þ 3953T was protective for SLE (odds ratio (OR) ¼ 0.57, 95% confidence intervals (CI) ¼ 0.34-0.88, P ¼ 0.01) as was the haplotype À511C þ 3953T (OR ¼ 0.43, 95%CI ¼ 0.25-0.74, pc ¼ 0.006). The latter was associated with a lower LPS-stimulated-PBM IL-1b secretion. Results suggest that IL-1b polymorphism influences the susceptibility to acquire SLE in our population. The protective association might be explained by the observed inhibitory effect of IL-1b þ 3953T allele on the secretion of IL-1b under inflammatory circumstances.
Annals of the New York Academy of Sciences, 2007
Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immu... more Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Although their heterogeneity is due to a collection of diverse conditions based on epidemiology, pathology, or diagnostic criteria, the underlying immunogenetic mechanism might be similar. Herein the nature and nurture of autoimmune diseases considered as a trait are reviewed, and a discussion is given on their multifactorial characteristics.
IEEE Antennas and Wireless Propagation Letters, 2000
Copyright (c) 2009 IEEE. Personal use is permitted. For any other purposes, Permission must be ob... more Copyright (c) 2009 IEEE. Personal use is permitted. For any other purposes, Permission must be obtained from the IEEE by emailing pubs-permissions@ieee.org. ... This article has been accepted for publication in a future issue of this journal, but has not been fully edited. ...
JCR: Journal of Clinical Rheumatology, 2006
Genes and Immunity, 2004
Interleukin-1 beta (IL-1b) exerts a range of inflammatory and immunomodulatory activities that ar... more Interleukin-1 beta (IL-1b) exerts a range of inflammatory and immunomodulatory activities that are important in host defense and autoimmune response. The IL-1b gene, located on chromosome 2 (2q13), is polymorphic. The influence of its polymorphism on 355 patients with autoimmune rheumatic diseases was examined. To this effect, 172 patients with rheumatoid arthritis (RA), 114 with systemic lupus erythematosus (SLE), and 69 with primary Sjö gren's syndrome (pSS) were studied. The control group consisted of 392 matched healthy individuals. Genotyping of IL-1b single-nucleotide polymorphisms (SNPs) at positions À511 (C/T) and þ 3953 (C/T) was performed by the polymerase chain reaction-restriction fragment length polymorphism technique. In addition, levels of IL-1b were measured by immunoassay in supernatants of lipopolysaccharide (LPS)-stimulated and nonstimulated peripheral blood monocytes (PBM) obtained from 19 homozygous individuals for the three most common IL-1b likely haplotypes, all belonging to the control group. Allele þ 3953T was protective for SLE (odds ratio (OR) ¼ 0.57, 95% confidence intervals (CI) ¼ 0.34-0.88, P ¼ 0.01) as was the haplotype À511C þ 3953T (OR ¼ 0.43, 95%CI ¼ 0.25-0.74, pc ¼ 0.006). The latter was associated with a lower LPS-stimulated-PBM IL-1b secretion. Results suggest that IL-1b polymorphism influences the susceptibility to acquire SLE in our population. The protective association might be explained by the observed inhibitory effect of IL-1b þ 3953T allele on the secretion of IL-1b under inflammatory circumstances.
Annals of the New York Academy of Sciences, 2007
Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immu... more Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Although their heterogeneity is due to a collection of diverse conditions based on epidemiology, pathology, or diagnostic criteria, the underlying immunogenetic mechanism might be similar. Herein the nature and nurture of autoimmune diseases considered as a trait are reviewed, and a discussion is given on their multifactorial characteristics.