Jiayu Shi - Academia.edu (original) (raw)

Papers by Jiayu Shi

Nature Communications

Periodontitis is a common type of inflammatory bone loss and a risk factor for systemic diseases.... more Periodontitis is a common type of inflammatory bone loss and a risk factor for systemic diseases. The pathogenesis of periodontitis involves inflammatory dysregulation, which represents a target for new therapeutic strategies to treat periodontitis. After establishing the correlation of cell-free DNA (cfDNA) level with periodontitis in patient samples, we test the hypothesis that the cfDNA-scavenging approach will benefit periodontitis treatment. We create a nanoparticulate cfDNA scavenger specific for periodontitis by coating selenium-doped hydroxyapatite nanoparticles (SeHANs) with cationic polyamidoamine dendrimers (PAMAM-G3), namely G3@SeHANs, and compare the activities of G3@SeHANs with those of soluble PAMAM-G3 polymer. Both G3@SeHANs and PAMAM-G3 inhibit periodontitis-related proinflammation in vitro by scavenging cfDNA and alleviate inflammatory bone loss in a mouse model of ligature-induced periodontitis. G3@SeHANs also regulate the mononuclear phagocyte system in a periodo...

2021 6th International Conference on Power and Renewable Energy (ICPRE)

LLC resonant converter has gained popularity in a wide number of industrial applications due to i... more LLC resonant converter has gained popularity in a wide number of industrial applications due to its high efficiency and power density. However, disturbances such as input voltage fluctuations and parameter perturbations make the control of output voltage still a challenging problem. In order to reject the influence of disturbances on the stability of the output voltage, the linear active disturbance rejection control (LADRC) method is proposed in this paper. First, based on the equivalent circuit method, the analytical expression for control to output voltage is obtained and compared with the second-order transfer function obtained by the swept frequency method in the frequency domain. The second-order model that does not change the characteristics of the LLC resonant converter is used for analysis and design of the controller. Then, the linear extended observer (LESO) is designed to estimate the value of state variables and total disturbance. Finally, the simulation results demonstrated that LADRC can effectively control the stability of the output voltage compared with PI controller.

International journal of clinical and experimental pathology, 2020

BACKGROUND Genome-wide association studies (GWAS) have found more than 20 genes associated with a... more BACKGROUND Genome-wide association studies (GWAS) have found more than 20 genes associated with a risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). However, the interactions between these risk genes have been rarely reported. METHODS Here we selected 47 Single Nucleotide Polymorphisms (SNP) from previous GWASs and tested for possible interactions among 302 NSCL/P case-parent trios from a western Han Chinese population to further explore the genetic etiology of NSCL/P. Conditional logistic regression models were performed including gene-gene (G×G) interaction. RESULTS Twenty pairwise interactions yielded significant p-values. Most of the signals of interaction between the SNPs were detected at the same gene including v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MAFB), netrin 1 (NTN1), and single nucleotide polymorphic marker within interferon regulatory factor 6 (IRF6). We found evidence of the interaction between rs17563 (bone morphogenetic ...

This paper discussed the problem of trajectory tracking control for the nonholonomic mobile robot... more This paper discussed the problem of trajectory tracking control for the nonholonomic mobile robot’s kinematic model with the angular speed of two actuated wheels as its control input. Based on the backstepping control algorithm, a sliding-mode variable structure switching function is designed, in order to improve the quality of motion control, fuzzy logic is used to adjust sliding-mode reaching law parameters. An adaptive control algorithm is proposed to compensate the unknown parameters, on the other hand. The stability of system is easily proven via the Lyapunov function. The simulation results are provided to illustrate the effectiveness of the controller.

Frontiers in Neurology, 2021

Background: Life-threatening myasthenic crisis (MC) occurs in 10–20% of the patients with myasthe... more Background: Life-threatening myasthenic crisis (MC) occurs in 10–20% of the patients with myasthenia gravis (MG). It is important to identify the predictors of progression to MC and prognosis in the patients with MG with acute exacerbations.Objective: This study aimed to explore the predictors of progression to MC in the patients with MG with acute onset of dyspnea and their short-term and long-term prognosis.Methods: This study is a retrospective cohort study. We collected and analyzed data on all the patients with MG with acute dyspnea over a 10-year period in a single center using the univariate and multivariate analysis.Results: Eighty-six patients with MG were included. In their first acute dyspnea episodes, 36 (41.9%) episodes eventually progressed to MC. A multivariate analysis showed that the early-onset MG (adjusted OR: 3.079, 95% CI 1.052–9.012) and respiratory infection as a trigger (adjusted OR: 3.926, 95% CI 1.141–13.510) were independent risk factors for the progressio...

Cell Discovery, 2021

Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COV... more Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infectio...

Ecological Indicators, 2020

Quantifying the carbon dynamics in arid and semi-arid ecosystems is a key issue in determining th... more Quantifying the carbon dynamics in arid and semi-arid ecosystems is a key issue in determining the global carbon budget. Carbon turnover time (CTT) and carbon uptake are the key indicators that determine the C dynamics and the potential C sequestration, but it has not been well quantified in a specific ecosystem. Our study combined a field inventory in a desert steppe ecosystem with data synthesis and the Terrestrial Ecosystem Regional model (TECO-R) for desert steppes to invert the key parameters of the ecosystem's carbon cycle. The average CTT in the leaf, root, and soil carbon pools (to a depth of 50 cm) and for the whole ecosystem was 1.43, 10.1, 76.96, and 37.65 years, respectively. The study area's net primary productivity (NPP) averaged 131.93 g C m −2 yr −1 from 2000 to 2018 based on the Carnegie-Ames-Stanford approach, and the ecosystem C uptake averaged 28.86 g C m −2 yr −1 , driven by an increasing NPP trend. The whole-ecosystem CTT (CTTE) increased significantly, by about 6 years per 25-mm increase in precipitation, 0.45°increase in latitude, 1000-g increase in SOC, and 50-g C m −2 yr −1 increase in NPP. The threshold temperature for CTT in the desert steppe was around 6°C. CTTE was significantly negatively correlated with temperature above this temperature, but below this value is the opposite. However, the pattern of ecosystem potential C uptake was affected by climate, NPP, and the intensity of human activities, with no clearly dominant factor. These analyses of the desert steppe's carbon cycle will help to improve the assessment of dryland carbon dynamics and global carbon budgets.

Acta Pharmaceutica Sinica B, 2020

When nanoparticles were introduced into the biological media, the protein corona would be formed,... more When nanoparticles were introduced into the biological media, the protein corona would be formed, which endowed the nanoparticles with new bio-identities. Thus, controlling protein corona formation is critical to in vivo therapeutic effect. Controlling the particle size is the most feasible method during design, and the influence of media pH which varies with disease condition is quite important. The impact of particle size and pH on bovine serum albumin (BSA) corona formation of solid lipid nanoparticles (SLNs) was studied here. The BSA corona formation of SLNs with increasing particle size (120e480 nm) in pH 6.0 and 7.4 was investigated. Multiple techniques were employed for visualization study, conformational structure study and mechanism study, etc. "BSA corona-caused aggregation" of SLN2-3 was revealed in pH 6.0 while the dispersed state of SLNs was maintained in pH 7.4, which significantly affected the secondary structure of BSA and cell uptake of SLNs. The main interaction was driven by van der Waals force plus hydrogen bonding in pH 7.4, while by electrostatic attraction in pH 6.0, and size-dependent adsorption was confirmed. This study provides a systematic insight to the understanding of protein corona formation of SLNs.

Annals of Palliative Medicine, 2020

Polymyositis (PM) and dermatomyositis (DM) are autoimmune diseases characterized by inflammation ... more Polymyositis (PM) and dermatomyositis (DM) are autoimmune diseases characterized by inflammation of skeletal muscle, primarily manifesting as chronic muscle weakness. Extramuscular organs can also be affected. Cardiac involvement is one of the visceral organ damages whose prevalence is underestimated and is a marker of poor prognosis leading to irreversible dysfunction or even death. Although early and accurate recognition of cardiac involvement remains a key barrier to improving survival in PM/ DM patients, considerable progress has been made, and an overview will be provided in this review. The new concept of multimodality imaging, which involves an integrated approach of echocardiography (Echo), cardiac magnetic resonance and sometimes positron emission tomography (PET), can facilitate diagnosis. The development of ultrasound technology, including strain analysis, stress Echo and contrast-enhanced Echo, helps disclose early cardiac dysfunction more sensitively than conventional Echo. Cardiac magnetic resonance unveils silent, acute or chronic myocarditis in PM/DM and is used to monitor treatment efficacy due to its excellent tissue characterization. PET can be useful thanks to the appearance of new tracers that can eliminate the effects of glucose uptake by normal cardiomyocytes. The sensitivity of endomyocardial biopsy may be increased by targeted sampling with the guidance of cardiac imaging. Troponin I is specific to cardiac injury, and investigations into antibodies against cardiac tissue are being carried out. Disease-specific mechanisms and therapies are also discussed to give more insights into cardiac involvement in PM and DM.

Journal of Asia-Pacific Entomology, 2020

Aphids are among the most destructive phytophagous pests of host plants, because of their rapid r... more Aphids are among the most destructive phytophagous pests of host plants, because of their rapid reproduction, parthenogenesis, extensive crop damage, and the transmission of many plant viruses. Since lady beetles are important predatory natural enemies of aphids, developing lady beetle attractants to increase their field abundance is vital for aphid control. Floral volatiles and other semiochemicals are reportedly attractive to lady beetles. In this research, a total of 58 floral volatiles were tested by Y-tube olfactometer assays, among which 29 were highly attractive to both Harmonia axyridis (Coleoptera: Coccinellidae) and Coccinella septempunctata (Coleoptera: Coccinellidae). Meanwhile, the results of wind tunnel trials showed that only isoamyl acetate, αhumulene, trans-3-hexen-1-ol, methyl salicylate, and β-pinene lure these two species. Thereafter, 15 semiochemicals from pests, natural enemies, and pest-infested crops were mixed with the selected floral volatiles, to determine optimum formulations for attracting lady beetles through wind tunnels and further field trials.

Thoracic Cancer, 2019

Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incide... more Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%–12% and 80% of nervous system adverse reactions occur within the first four months of application. ICIs can cause diseases of various parts of the nervous system including central nervous system diseases such as aseptic meningitis, meningeal encephalitis, necrotizing encephalitis, brainstem encephalitis, transverse myelitis, etc., and peripheral neuropathy such as cranial nerve peripheral neuropathy, multifocal nerve root neuropathy, Guillain‐Barré syndrome, spinal nerve root neuropathy, myasthenia gravis, myopathy, etc. For these complications of the nervous system, diagnosis could be difficult. Physicians require a specific collection of nervous system symptoms and signs, combined with supplementary examinations including imaging, cerebrospinal fluid cytology, EEG or electromyography in order to exclude infection or malignant tumor before reaching a final diagnosis. Wi...

Journal of Arid Environments, 2019

Anthropogenic activities have increased nitrogen (N) inputs to grassland ecosystems, greatly affe... more Anthropogenic activities have increased nitrogen (N) inputs to grassland ecosystems, greatly affecting ecosystem carbon cycling. To investigate the litter decomposition and nutrient dynamics for different litter types under N addition, we conducted a 2-year litter bag experiment at N addition rates ranging from 0 to 25 g N m −2 yr −1. The decomposition rates (k) of Leymus chinensis and Stipa grandis were both highest in the 25 g N m −2 yr −1 treatment, whereas decomposition of mixed litter (aboveground) was highest in the 10 g N m −2 yr −1 (N10) treatment. The decomposition rate of all the aboveground litter was significantly positively correlated with the NO 3 −-N:NH 4 +-N ratio. Mixed litter and mixed roots exhibited net C, N, and P release in all treatments. Nitrogen addition promoted N immobilization and slowed P release for S. grandis. For L. chinensis, net P immobilization occurred in most N-addition treatments except for N10 in the first year, followed by a net P release. Soil C:N and C:P ratios were significantly negatively correlated with the litter C:N and C:P ratios, respectively, of L. chinensis. This result may indicate that the N release and P immobilization during decomposition of L. chinensis litter were the main factors influencing the soil stoichiometric ratios.

Materials Research Bulletin, 2019

Surface morphology control of Cu 2 ZnSnS 4 by addition of cellulose in solution process for high ... more Surface morphology control of Cu 2 ZnSnS 4 by addition of cellulose in solution process for high performance superstrate solar cell,

Journal of neurology, neurosurgery, and psychiatry, 2018

To examine the frequency and clinical features of excessive daytime sleepiness (EDS) and its asso... more To examine the frequency and clinical features of excessive daytime sleepiness (EDS) and its association with cognitive and behavioural impairments in patients with amyotrophic lateral sclerosis (ALS). We conducted a cross-sectional investigation to explore the frequency and clinical features of EDS in a group of 121 Chinese patients with ALS compared with 121 age-matched and sex-matched healthy subjects. EDS was diagnosed using the Epworth Sleepiness Scale (ESS). Other characteristics of patients with ALS including sleep quality, REM sleep behaviour disorder (RBD), restless legs syndrome (RLS), cognition, behaviour, depression and anxiety were also evaluated. EDS was significantly more frequent in patients with ALS than in controls (26.4% vs 8.3%; p<0.05). Patients with ALS with EDS scored lower scores on the revised ALS Functional Rating Scale (ALSFRS-R), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and MMSE and MoCA delayed memory subitems and hig...

Neurobiology of aging, Jan 9, 2018

Amyotrophic lateral sclerosis (ALS) is an age-related fatal neurodegenerative orphan disorder tha... more Amyotrophic lateral sclerosis (ALS) is an age-related fatal neurodegenerative orphan disorder that is characterized by progressive injury of both the upper and lower motor neurons. Recently, loss-of-function mutations predominately disrupting the C-terminal amino acid sequence of KIF5A via aberrant exon 27 splicing have been reported in European ALS cohorts. However, the contributions of KIF5A mutations in Asian patients with ALS remain unclear. KIF5A sequences, including exons 26 and 27, were analyzed in a large Chinese ALS cohort comprising 33 unrelated familial ALS probands, 645 sporadic ALS (SALS) patients, 15 ALS patients presenting with concomitant frontotemporal dementia, 400 in-house controls, and 12,951 East Asian individuals from the Exome Aggregation Consortium and Genome Aggregation Database databases. As a result, the previously reported canonical splicing site mutation c.2993-1G>A was found in 1 SALS patient, while no mutations were detected in familial ALS case or ...

Plastic & Reconstructive Surgery, 2017

Fig. 1. Illustrations showing the new design of how to balance the tissue between tightening of t... more Fig. 1. Illustrations showing the new design of how to balance the tissue between tightening of the alar base and correcting nasal alar rim and valve collapse.