Jing Wang - Academia.edu (original) (raw)

Papers by Jing Wang

Cell, 2002

Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum sented in the insect... more Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum sented in the insect brain. Insects exhibit complex behaviors controlled by an olfactory sensory system that is significantly simpler than that of vertebrates. The recognition of odors in Drosophila is accomplished by senand Molecular Biophysics sory hairs distributed over the surface of the third anten-Howard Hughes Medical Institute nal segment and the maxillary palp. Olfactory neurons College of Physicians and Surgeons within sensory hairs send projections to one of 43 glo-Columbia University meruli within the antennal lobe of the brain (Stocker, 701 West 168th Street 1994; Laissue et al., 1999). The projection neurons (PNs) New York, New York 10032 connect individual glomeruli with higher olfactory centers, the mushroom body, and protocerebrum (Stocker, 1994; Ito et al., 1998). Individual sensory neurons are Summary likely to express only one of about 80 odorant receptor genes (Clyne et al., 1999; Gao and Chess, 1999; Vosshall In the fruit fly, Drosophila, olfactory sensory neurons et al., 2000; Scott et al., 2001; Dunipace et al., 2001; expressing a given receptor project to spatially invari-Stortkuhl and Kettler, 2001; Wetzel et al., 2001). In addiant loci in the antennal lobe to create a topographic tion, about two-thirds of the neurons also express a map of receptor activation. We have asked how the common receptor gene, Or83b, such that neurons exmap in the antennal lobe is represented in higher senpress a private and a public specificity (Vosshall et al., sory centers in the brain. Random labeling of individual 2000). Neurons expressing the same receptors project projection neurons using the FLP-out technique rewith precision to one or rarely two spatially invariant veals that projection neurons that innervate the same glomeruli within the antennal lobe (Gao et al., 2000; glomerulus exhibit strikingly similar axonal topogra-Vosshall et al., 2000; Scott et al., 2001). A topographic phy, whereas neurons from different glomeruli display map of receptor activity in the periphery is therefore very different patterns of projection in the protocererepresented in the antennal lobe. The segregation of brum. These results demonstrate that a topographic like axons in the antennal lobe is in accord with 2-deoxymap of olfactory information is retained in higher brain glucose mapping in the fruit fly (Rodrigues and Buchner, centers, but the character of the map differs from that 1984; Rodrigues, 1988) and calcium imaging in the honof the antennal lobe, affording an opportunity for inteeybee (Joerges et al., 1997; Galizia et al., 1999) that gration of olfactory sensory input.

Cell, 2003

the brain (Stocker, 1994; Laissue et al., 1999). Individual sensory neurons are likely to express... more the brain (Stocker, 1994; Laissue et al., 1999). Individual sensory neurons are likely to express only one of about 80 odorant receptor genes (Clyne et al., 1999; Vosshall

Cell, 2002

Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum sented in the insect... more Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum sented in the insect brain. Insects exhibit complex behaviors controlled by an olfactory sensory system that is significantly simpler than that of vertebrates. The recognition of odors in Drosophila is accomplished by senand Molecular Biophysics sory hairs distributed over the surface of the third anten-Howard Hughes Medical Institute nal segment and the maxillary palp. Olfactory neurons College of Physicians and Surgeons within sensory hairs send projections to one of 43 glo-Columbia University meruli within the antennal lobe of the brain (Stocker, 701 West 168th Street 1994; Laissue et al., 1999). The projection neurons (PNs) New York, New York 10032 connect individual glomeruli with higher olfactory centers, the mushroom body, and protocerebrum (Stocker, 1994; Ito et al., 1998). Individual sensory neurons are Summary likely to express only one of about 80 odorant receptor genes (Clyne et al., 1999; Gao and Chess, 1999; Vosshall In the fruit fly, Drosophila, olfactory sensory neurons et al., 2000; Scott et al., 2001; Dunipace et al., 2001; expressing a given receptor project to spatially invari-Stortkuhl and Kettler, 2001; Wetzel et al., 2001). In addiant loci in the antennal lobe to create a topographic tion, about two-thirds of the neurons also express a map of receptor activation. We have asked how the common receptor gene, Or83b, such that neurons exmap in the antennal lobe is represented in higher senpress a private and a public specificity (Vosshall et al., sory centers in the brain. Random labeling of individual 2000). Neurons expressing the same receptors project projection neurons using the FLP-out technique rewith precision to one or rarely two spatially invariant veals that projection neurons that innervate the same glomeruli within the antennal lobe (Gao et al., 2000; glomerulus exhibit strikingly similar axonal topogra-Vosshall et al., 2000; Scott et al., 2001). A topographic phy, whereas neurons from different glomeruli display map of receptor activity in the periphery is therefore very different patterns of projection in the protocererepresented in the antennal lobe. The segregation of brum. These results demonstrate that a topographic like axons in the antennal lobe is in accord with 2-deoxymap of olfactory information is retained in higher brain glucose mapping in the fruit fly (Rodrigues and Buchner, centers, but the character of the map differs from that 1984; Rodrigues, 1988) and calcium imaging in the honof the antennal lobe, affording an opportunity for inteeybee (Joerges et al., 1997; Galizia et al., 1999) that gration of olfactory sensory input.

Cell, 2003

the brain (Stocker, 1994; Laissue et al., 1999). Individual sensory neurons are likely to express... more the brain (Stocker, 1994; Laissue et al., 1999). Individual sensory neurons are likely to express only one of about 80 odorant receptor genes (Clyne et al., 1999; Vosshall