Jitender Chaturvedi - Academia.edu (original) (raw)
Papers by Jitender Chaturvedi
Journal of Neurointensive Care
There is increasing role of routine laboratory parameters in identifying neuroinflammation in var... more There is increasing role of routine laboratory parameters in identifying neuroinflammation in various neurological disorders. This has led to the need to identify reliable, accessible, and cost-effective biomarkers that can help predict the outcome following injury to the brain. The parameters of interest include a neutrophil-to-lymphocyte ratio (NLR), red cell width distribution (RDW), red cell width (RDW)-to-platelet ratio (RPR), and NLR times RPR (NLTRP). The aim of the present systematic review and meta-analysis is to evaluate the prognostic value of Red Cell Distribution Width to Platelet Count Ratio (RPR) in various neuropsychiatric disorders. The studies that reported "Red Cell Distribution Width to Platelet Count Ratio" and "Outcome" in neurological conditions and the full text was published in English were included in the systematic review and if the studies two or more than two a further metanalysis was performed. Two investigators performed the literat...
Indian Journal of Public Health Research and Development, 2012
Cholecystectomy is the surgical removal of the gallbladder. It is the most common method for trea... more Cholecystectomy is the surgical removal of the gallbladder. It is the most common method for treating symptomatic gallstones. Surgical options include the standard procedure, called laparoscopic cholecystectomy, and an older more invasive procedure, called open cholecystectomy. A traditional open cholecystectomy is a major abdominal surgery in which the surgeon removes the gallbladder through a 8–10 cm incision. Laparoscopic cholecystectomy has now replaced open cholecystectomy as the first-choice of treatment for gallstones unless there are contraindications to the laparoscopic approach. The operation usually requires general anaesthesia and is subject to the same risks and complications as open cholecystectomy. However, patients have little pain after the operation, and hospital stays (1–2 days) and recovery (1–2 weeks) are usually shorter than after open cholecystectomy. So, the purpose of the study is the usefulness of laparoscopic cholecystectomy in the treatment of symptomatic...
Neurology India, Mar 3, 2023
Surgical Neurology International
Background: Tarlov cysts are sacral perineural cysts arising between the peri and endoneurium of ... more Background: Tarlov cysts are sacral perineural cysts arising between the peri and endoneurium of the posterior spinal nerve root at the Dorsal Root Ganglion and have a global prevalence rate of 4.27%. These are primarily asymptomatic (only 1% with symptoms) and typically arise in females between the ages of 50–60. Patients’ symptoms include radicular pain, sensory dysesthesias, urinary and/or bowel symptoms, and sexual dysfunction. Non-surgical management with lumbar cerebrospinal fluid drainage and computerized tomography-guided cyst aspiration typically provide only months of improvement before recurring. Surgical treatment includes a laminectomy, cyst, and/or nerve root decompression with fenestration of the cyst and/ or imbrication. Early surgery for large cysts provides the longest symptom-free periods. Case Description: A 30-year-old male presented with a very large magnetic resonance-documented Tarlov cyst (Nabors Type 2) arising from bilateral S2 nerve root sheaths with mark...
Journal of medical evidence, 2022
National Journal of Physiology, Pharmacy and Pharmacology, 2020
Novel corona virus disease (COVID-19) pandemic has seriously affected the entire world; moreover,... more Novel corona virus disease (COVID-19) pandemic has seriously affected the entire world; moreover, infection and case fatality rate is quite high in countries located in North Hemisphere, where a large proportion of the population is living with Vitamin D (Vit D) deficiency. Vit D is a secosteroid hormone, which plays an important role in calcium and phosphorous homeostasis, and hence bone strength and also has a significant role in the immune health of an individual. It induces the expression of antimicrobial peptides that can decrease viral replication and also reduces the level of pro-inflammatory cytokines while enhancing the level of anti-inflammatory cytokines. Vit D supplementation in daily single doses (3002000 IU/day) for 812 weeks had more protective effect for viral infections than large doses given at fixed intervals (100,000 or 200,000 IU per month or every 3 months). This evidence based review emphasizes the role of Vit D in the immune response to viral infections and proposes the immense value of Vit D supplementation, for the prevention and treatment of COVID-19.
The Pan African medical journal, 2022
PSYCHIATRIA DANUBINA
Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current... more Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current pharmacological treatment options for MDD, which rely on the mono-amine hypothesis, has their limitations with respect to treatment non-response, partial response etc. This propels for a search for a novel neurobiological understanding of MDD that can lead to novel treatment options. A literature search strategy was thus employed using relevant keywords pertaining to the topic in PubMed, Embase and Google Scholar. Systematic reviews and meta-analyses, narrative reviews and clinical trials were reviewed to incorporate the most robust evidence-based literature available. A total of 37 publications were narrowed down based upon the topic. Alterations in brain neuroplasticity, as evidenced by changes in neurotrophic factors and from neuroimaging, has been found to be a strong pathomechanism for MDD. This link has been exploited to stimulate psychopharmacological research to treat MDD.
Surgical Neurology International, 2021
Background: Disorders of consciousness (DoC) includes coma, vegetative state (VS), minimally cons... more Background: Disorders of consciousness (DoC) includes coma, vegetative state (VS), minimally conscious state (MCS), and emergence from the MCS. Aneurysmal rupture with high-grade SAH, traumatic brain injury, and neoplastic brain lesions are some of the frequent pathologies leading to DoC. The diagnostic errors among these DoC are as high as ranging from 25% to 45%, with a probable error in the conclusion of patients’ state, treatment choice, end-of-life decision-making, and prognosis. Some studies also reported that 37–43% of patients were misdiagnosed in VS while demonstrating signs of awareness. Despite its wide acceptance, Coma Recovery Scale-Revised (CRS-r) remained underused or inappropriately utilized, which may lead to substandard or unprofessional patient care. Literature is rare on the knowledge of CRS-r among physicians published from India and across the globe. Therefore, we carried out the present study to ascertain physicians’ knowledge on CRS-r and raise awareness abou...
Journal of Neurosciences in Rural Practice, 2016
This is an open access article distributed under the terms of the Creative Commons Attribution-No... more This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Surgical Neurology International
Background: Vertebro-vertebral fistulas (VVF) are rare. Anatomically, they consist of an arteriov... more Background: Vertebro-vertebral fistulas (VVF) are rare. Anatomically, they consist of an arteriovenous fistula, a direct pathological communication between vertebral veins (including the epidural vertebral venous plexus) and extradural vertebral artery. The various etiologies include trauma, iatrogenic, or spontaneous (e.g., NF-1 or Ehlers Danlos Syndrome). The clinical presentation may include acute/delayed onset of radiculopathy and/or myelopathy. They may further be characterized by the delayed onset hearing loss to tinnitus and/or the sensation of water in the ear. Case Description: We report successful endovascular management for iatrogenic VVF in a 37-year-old female who was diagnosed with an odontoid fracture (Anderson type IIC). She underwent a posterior C1 lateral masses to C2 pedicle/laminar screw fixation. An intraoperative vertebro-vertebral fistulas (VVF) was recognized during the procedure and it was managed successfully with percutaneous transarterial endovascular coi...
British Journal of Neurosurgery, 2015
Decompressive craniectomy (DC)-a potentially life-saving intervention following traumatic brain i... more Decompressive craniectomy (DC)-a potentially life-saving intervention following traumatic brain injury (TBI) with medically refractory brain swelling-once performed, surviving patients, more often than not, undergo a second procedure with cranioplasty (CP) in the future. This study analyzes complications following CP after DC, as the beneficial effects of the DC can't be extrapolated in long run over a population unless one adds into it the complications associated with the CP in the survivors of TBI. An observational study was performed retrospectively, with the review of case records. Demographic, clinical, and outcome data were collected, and complications were studied for any predictive parameters. A multivariate analysis was performed to identify factors that influenced these complications. Data were collected for a total of 74 patients who underwent CP with a median age of 32, and a mean follow-up time of 2 years and 8 months. The mortality rate was 1.35% and overall complication rate 31%. The most significant factor determining complications were operating time more than 90 min Odds ratio (OR) 4.77 (1.61-14.20); timing of CP less than 3 months after craniectomy, OR 2.86 (1.48-8.11); age more than 20 years, OR 2.59 (1.20-6.53); and female gender, OR 1.91 (1.13-4.17). Although considered as a straight-forward procedure, the risks associated with this elective procedure should be kept in mind by the surgeon so that the patients and families can be apprised judiciously. It should be ascertained that patient and/or family consents for the procedure after being appropriately informed about the benefits and risks associated with the procedure.
Journal of Pediatric Neurosciences
Journal of Neurosciences in Rural Practice, 2021
Background and Objectives Globally, stroke is one of the major causes of disability and mortalit... more Background and Objectives Globally, stroke is one of the major causes of disability and mortality among adults and old age people. The present study aims to evaluate the effects of the health promotion model-based visual learning module (HPM-VLM) on self-efficacy and behavioral modifications among stroke survivors. Methods This nonrandomized controlled trial was conducted on 70 stroke survivors (intervention group, n = 35, and control group, n = 35). The intervention group was subjected to two sessions of the HPM-VLM and the control group received routine instructions. Data were collected through face-to-face structured interview, and observation using a self-structured self-efficacy questionnaire and health promotion behavior questionnaire. Data were analyzed using descriptive (frequency and percentage) and inferential (Chi-square, independent t -test, mixed model, and ANCOVA) values by IBM Statistical Package for Social Sciences (SPSS; version 23) software. Results Eventually, ...
Asian Journal of Neurosurgery, 2021
Background: Cancellation/postponement of ”non-emergent” surgeries during coronavirus disease of 2... more Background: Cancellation/postponement of ”non-emergent” surgeries during coronavirus disease of 2019 (COVID-19) pandemic has created a huge backlog of patients waiting for surgery and has put them at risk of disease progression. We share our institute's policy and our department's attempt to resume ”non-emergent” surgeries. Materials and Methods: We collected details of all patients operated under department of neurosurgery since the onset of COVID-19 pandemic in India and categorized them into ”lockdown” and ”unlock” groups for comparison. COVID-19 tests done in these patients were also analyzed. We also compared our surgical volume with the number of COVID-19 cases in the state. Results: One hundred and forty-eight patients (97 males, 51 females) with mean age of 37.8 years (range-2 months-82 years) underwent surgery in our department during the study period. The operative volume per week increased by 37% during the ”unlock” period as compared to ”lockdown” period. The pro...
Objective: The study objective was to systematically review the impact of the current pandemic on... more Objective: The study objective was to systematically review the impact of the current pandemic on neurosurgical practice and to find out a safe way of practicing neurosurgery amid the highly infectious patients with COVID-19. Materials and Methods: A review of the PubMed and EMBASE databases was performed. The literature was systematically searched using keywords such as “COVID-19” and “Neurosurgery.” Results: Among the 425 records, 128 articles were found to be eligible for analysis. These articles described the perspectives of the neurosurgical departments during the pandemic, departmental models, and organizational schemes for triaging emergent and nonemergent neurosurgical cases for the optimal utilization of limited resources, and solutions to continue academic and research activities. Triaging systems help us to optimally utilize the limited resources available. Guidelines have been developed for safe neurosurgical practice and for the continuation of clinical and academic act...
Traumatic brain injury is associated with high morbidity and mortality. Since the introduction of... more Traumatic brain injury is associated with high morbidity and mortality. Since the introduction of decompressive craniectomy more than a century ago, no major surgical advancement has been introduced in this field in spite of neurosurgery having seen a sea change in general. Basal cisternostomy, introduced recently, is said to have great promise. In this regard, neurosurgeons need to understand the theory behind the recently introduced basal cisternostomy and whether it holds any merit or not.
Journal of Neurointensive Care
There is increasing role of routine laboratory parameters in identifying neuroinflammation in var... more There is increasing role of routine laboratory parameters in identifying neuroinflammation in various neurological disorders. This has led to the need to identify reliable, accessible, and cost-effective biomarkers that can help predict the outcome following injury to the brain. The parameters of interest include a neutrophil-to-lymphocyte ratio (NLR), red cell width distribution (RDW), red cell width (RDW)-to-platelet ratio (RPR), and NLR times RPR (NLTRP). The aim of the present systematic review and meta-analysis is to evaluate the prognostic value of Red Cell Distribution Width to Platelet Count Ratio (RPR) in various neuropsychiatric disorders. The studies that reported "Red Cell Distribution Width to Platelet Count Ratio" and "Outcome" in neurological conditions and the full text was published in English were included in the systematic review and if the studies two or more than two a further metanalysis was performed. Two investigators performed the literat...
Indian Journal of Public Health Research and Development, 2012
Cholecystectomy is the surgical removal of the gallbladder. It is the most common method for trea... more Cholecystectomy is the surgical removal of the gallbladder. It is the most common method for treating symptomatic gallstones. Surgical options include the standard procedure, called laparoscopic cholecystectomy, and an older more invasive procedure, called open cholecystectomy. A traditional open cholecystectomy is a major abdominal surgery in which the surgeon removes the gallbladder through a 8–10 cm incision. Laparoscopic cholecystectomy has now replaced open cholecystectomy as the first-choice of treatment for gallstones unless there are contraindications to the laparoscopic approach. The operation usually requires general anaesthesia and is subject to the same risks and complications as open cholecystectomy. However, patients have little pain after the operation, and hospital stays (1–2 days) and recovery (1–2 weeks) are usually shorter than after open cholecystectomy. So, the purpose of the study is the usefulness of laparoscopic cholecystectomy in the treatment of symptomatic...
Neurology India, Mar 3, 2023
Surgical Neurology International
Background: Tarlov cysts are sacral perineural cysts arising between the peri and endoneurium of ... more Background: Tarlov cysts are sacral perineural cysts arising between the peri and endoneurium of the posterior spinal nerve root at the Dorsal Root Ganglion and have a global prevalence rate of 4.27%. These are primarily asymptomatic (only 1% with symptoms) and typically arise in females between the ages of 50–60. Patients’ symptoms include radicular pain, sensory dysesthesias, urinary and/or bowel symptoms, and sexual dysfunction. Non-surgical management with lumbar cerebrospinal fluid drainage and computerized tomography-guided cyst aspiration typically provide only months of improvement before recurring. Surgical treatment includes a laminectomy, cyst, and/or nerve root decompression with fenestration of the cyst and/ or imbrication. Early surgery for large cysts provides the longest symptom-free periods. Case Description: A 30-year-old male presented with a very large magnetic resonance-documented Tarlov cyst (Nabors Type 2) arising from bilateral S2 nerve root sheaths with mark...
Journal of medical evidence, 2022
National Journal of Physiology, Pharmacy and Pharmacology, 2020
Novel corona virus disease (COVID-19) pandemic has seriously affected the entire world; moreover,... more Novel corona virus disease (COVID-19) pandemic has seriously affected the entire world; moreover, infection and case fatality rate is quite high in countries located in North Hemisphere, where a large proportion of the population is living with Vitamin D (Vit D) deficiency. Vit D is a secosteroid hormone, which plays an important role in calcium and phosphorous homeostasis, and hence bone strength and also has a significant role in the immune health of an individual. It induces the expression of antimicrobial peptides that can decrease viral replication and also reduces the level of pro-inflammatory cytokines while enhancing the level of anti-inflammatory cytokines. Vit D supplementation in daily single doses (3002000 IU/day) for 812 weeks had more protective effect for viral infections than large doses given at fixed intervals (100,000 or 200,000 IU per month or every 3 months). This evidence based review emphasizes the role of Vit D in the immune response to viral infections and proposes the immense value of Vit D supplementation, for the prevention and treatment of COVID-19.
The Pan African medical journal, 2022
PSYCHIATRIA DANUBINA
Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current... more Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current pharmacological treatment options for MDD, which rely on the mono-amine hypothesis, has their limitations with respect to treatment non-response, partial response etc. This propels for a search for a novel neurobiological understanding of MDD that can lead to novel treatment options. A literature search strategy was thus employed using relevant keywords pertaining to the topic in PubMed, Embase and Google Scholar. Systematic reviews and meta-analyses, narrative reviews and clinical trials were reviewed to incorporate the most robust evidence-based literature available. A total of 37 publications were narrowed down based upon the topic. Alterations in brain neuroplasticity, as evidenced by changes in neurotrophic factors and from neuroimaging, has been found to be a strong pathomechanism for MDD. This link has been exploited to stimulate psychopharmacological research to treat MDD.
Surgical Neurology International, 2021
Background: Disorders of consciousness (DoC) includes coma, vegetative state (VS), minimally cons... more Background: Disorders of consciousness (DoC) includes coma, vegetative state (VS), minimally conscious state (MCS), and emergence from the MCS. Aneurysmal rupture with high-grade SAH, traumatic brain injury, and neoplastic brain lesions are some of the frequent pathologies leading to DoC. The diagnostic errors among these DoC are as high as ranging from 25% to 45%, with a probable error in the conclusion of patients’ state, treatment choice, end-of-life decision-making, and prognosis. Some studies also reported that 37–43% of patients were misdiagnosed in VS while demonstrating signs of awareness. Despite its wide acceptance, Coma Recovery Scale-Revised (CRS-r) remained underused or inappropriately utilized, which may lead to substandard or unprofessional patient care. Literature is rare on the knowledge of CRS-r among physicians published from India and across the globe. Therefore, we carried out the present study to ascertain physicians’ knowledge on CRS-r and raise awareness abou...
Journal of Neurosciences in Rural Practice, 2016
This is an open access article distributed under the terms of the Creative Commons Attribution-No... more This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Surgical Neurology International
Background: Vertebro-vertebral fistulas (VVF) are rare. Anatomically, they consist of an arteriov... more Background: Vertebro-vertebral fistulas (VVF) are rare. Anatomically, they consist of an arteriovenous fistula, a direct pathological communication between vertebral veins (including the epidural vertebral venous plexus) and extradural vertebral artery. The various etiologies include trauma, iatrogenic, or spontaneous (e.g., NF-1 or Ehlers Danlos Syndrome). The clinical presentation may include acute/delayed onset of radiculopathy and/or myelopathy. They may further be characterized by the delayed onset hearing loss to tinnitus and/or the sensation of water in the ear. Case Description: We report successful endovascular management for iatrogenic VVF in a 37-year-old female who was diagnosed with an odontoid fracture (Anderson type IIC). She underwent a posterior C1 lateral masses to C2 pedicle/laminar screw fixation. An intraoperative vertebro-vertebral fistulas (VVF) was recognized during the procedure and it was managed successfully with percutaneous transarterial endovascular coi...
British Journal of Neurosurgery, 2015
Decompressive craniectomy (DC)-a potentially life-saving intervention following traumatic brain i... more Decompressive craniectomy (DC)-a potentially life-saving intervention following traumatic brain injury (TBI) with medically refractory brain swelling-once performed, surviving patients, more often than not, undergo a second procedure with cranioplasty (CP) in the future. This study analyzes complications following CP after DC, as the beneficial effects of the DC can't be extrapolated in long run over a population unless one adds into it the complications associated with the CP in the survivors of TBI. An observational study was performed retrospectively, with the review of case records. Demographic, clinical, and outcome data were collected, and complications were studied for any predictive parameters. A multivariate analysis was performed to identify factors that influenced these complications. Data were collected for a total of 74 patients who underwent CP with a median age of 32, and a mean follow-up time of 2 years and 8 months. The mortality rate was 1.35% and overall complication rate 31%. The most significant factor determining complications were operating time more than 90 min Odds ratio (OR) 4.77 (1.61-14.20); timing of CP less than 3 months after craniectomy, OR 2.86 (1.48-8.11); age more than 20 years, OR 2.59 (1.20-6.53); and female gender, OR 1.91 (1.13-4.17). Although considered as a straight-forward procedure, the risks associated with this elective procedure should be kept in mind by the surgeon so that the patients and families can be apprised judiciously. It should be ascertained that patient and/or family consents for the procedure after being appropriately informed about the benefits and risks associated with the procedure.
Journal of Pediatric Neurosciences
Journal of Neurosciences in Rural Practice, 2021
Background and Objectives Globally, stroke is one of the major causes of disability and mortalit... more Background and Objectives Globally, stroke is one of the major causes of disability and mortality among adults and old age people. The present study aims to evaluate the effects of the health promotion model-based visual learning module (HPM-VLM) on self-efficacy and behavioral modifications among stroke survivors. Methods This nonrandomized controlled trial was conducted on 70 stroke survivors (intervention group, n = 35, and control group, n = 35). The intervention group was subjected to two sessions of the HPM-VLM and the control group received routine instructions. Data were collected through face-to-face structured interview, and observation using a self-structured self-efficacy questionnaire and health promotion behavior questionnaire. Data were analyzed using descriptive (frequency and percentage) and inferential (Chi-square, independent t -test, mixed model, and ANCOVA) values by IBM Statistical Package for Social Sciences (SPSS; version 23) software. Results Eventually, ...
Asian Journal of Neurosurgery, 2021
Background: Cancellation/postponement of ”non-emergent” surgeries during coronavirus disease of 2... more Background: Cancellation/postponement of ”non-emergent” surgeries during coronavirus disease of 2019 (COVID-19) pandemic has created a huge backlog of patients waiting for surgery and has put them at risk of disease progression. We share our institute's policy and our department's attempt to resume ”non-emergent” surgeries. Materials and Methods: We collected details of all patients operated under department of neurosurgery since the onset of COVID-19 pandemic in India and categorized them into ”lockdown” and ”unlock” groups for comparison. COVID-19 tests done in these patients were also analyzed. We also compared our surgical volume with the number of COVID-19 cases in the state. Results: One hundred and forty-eight patients (97 males, 51 females) with mean age of 37.8 years (range-2 months-82 years) underwent surgery in our department during the study period. The operative volume per week increased by 37% during the ”unlock” period as compared to ”lockdown” period. The pro...
Objective: The study objective was to systematically review the impact of the current pandemic on... more Objective: The study objective was to systematically review the impact of the current pandemic on neurosurgical practice and to find out a safe way of practicing neurosurgery amid the highly infectious patients with COVID-19. Materials and Methods: A review of the PubMed and EMBASE databases was performed. The literature was systematically searched using keywords such as “COVID-19” and “Neurosurgery.” Results: Among the 425 records, 128 articles were found to be eligible for analysis. These articles described the perspectives of the neurosurgical departments during the pandemic, departmental models, and organizational schemes for triaging emergent and nonemergent neurosurgical cases for the optimal utilization of limited resources, and solutions to continue academic and research activities. Triaging systems help us to optimally utilize the limited resources available. Guidelines have been developed for safe neurosurgical practice and for the continuation of clinical and academic act...
Traumatic brain injury is associated with high morbidity and mortality. Since the introduction of... more Traumatic brain injury is associated with high morbidity and mortality. Since the introduction of decompressive craniectomy more than a century ago, no major surgical advancement has been introduced in this field in spite of neurosurgery having seen a sea change in general. Basal cisternostomy, introduced recently, is said to have great promise. In this regard, neurosurgeons need to understand the theory behind the recently introduced basal cisternostomy and whether it holds any merit or not.