Jodi Gilman - Academia.edu (original) (raw)

Papers by Jodi Gilman

Research paper thumbnail of Polygenic Score for Cigarette Smoking is Associated with Ever Electronic‐Cigarette Use in a College‐Aged Sample

Research paper thumbnail of Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study

PLOS ONE

Objective Numerous adverse prenatal exposures have been individually associated with risk for psy... more Objective Numerous adverse prenatal exposures have been individually associated with risk for psychiatric illness in the offspring. However, such exposures frequently co-occur, raising questions about their cumulative impact. We evaluated effects of cumulative adverse prenatal exposure burden on psychopathology risk in school-aged children. Methods Using baseline surveys from the U.S.-based Adolescent Brain and Cognitive Development (ABCD) Study (7,898 non-adopted, unrelated children from 21 sites, age 9–10, and their primary caregivers), we examined 8 retrospectively-reported adverse prenatal exposures in relation to caregiver-reported total and subscale Child Behavior Checklist (CBCL) scores. We also assessed cumulative effects of these factors on CBCL total as a continuous measure, as well as on odds of clinically significant psychopathology (CBCL total ≥60), in both the initial set and a separate ABCD sample comprising an additional 696 sibling pairs. Analyses were conducted bef...

Research paper thumbnail of Association of Adverse Prenatal Exposures and Maternal Folic Acid Use With Psychopathology at Age 9-10 in the ABCD Study

Research paper thumbnail of T91. Impairments in Resting State Connectivity are Associated With Cannabis Use and Major Depressive Disorder

Research paper thumbnail of White matter integrity differences associated with posttraumatic stress disorder are not normalized by concurrent marijuana use

Psychiatry Research: Neuroimaging

Research paper thumbnail of Urinary 11-nor-9-carboxy-tetrahydrocannabinol elimination in adolescent and young adult cannabis users during one month of sustained and biochemically-verified abstinence

Journal of Psychopharmacology

Background: Despite adolescents and young adults being the most frequent users of cannabis, all i... more Background: Despite adolescents and young adults being the most frequent users of cannabis, all information on cannabis drug testing interpretation is based on data from adults. Aims: This study aimed to define the time course of urinary 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) excretion among 70 adolescent and young adult cannabis users during 1 month of biochemically-verified cannabis abstinence. Methods: Urine specimens were collected at non-abstinent baseline and after 2, 3, 8, 15, 21 and 28 days of abstinence. Specimens were tested for THCCOOH with a ‘rapid’ immunoassay drug test and a confirmatory assay using liquid chromatography-tandem mass spectrometry, with a 5 ng/mL limit of quantitation. Elimination rate was tested using a population pharmacokinetics model. Results/outcomes: Participants had an average of 26 days of abstinence (SD = 6). Initial creatinine-adjusted THCCOOH concentration (CN-THCCOOH) was 148 ng/mg (SD = 157). Half-life was 2 days (SD = 5), with a 10...

Research paper thumbnail of T266. Memory Deficits are Reversible With Sustained Cannabis Abstinence Among Cannabis Using Adolescents

Research paper thumbnail of Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence

Addictive Behaviors Reports

Evins. 2018. "Anterior insula activation during inhibition to smoking cues is associated with abi... more Evins. 2018. "Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence." Addictive Behaviors Reports 7 (1): 40-46.

Research paper thumbnail of Delta-9-tetrahydrocannabinol intoxication is associated with increased prefrontal activation as assessed with functional near-infrared spectroscopy: A report of a potential biomarker of intoxication

Research paper thumbnail of Suggestibility is associated with alcohol self-administration, subjective alcohol effects, and self-reported drinking behavior

Journal of Psychopharmacology

Research paper thumbnail of Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness

Cognitive, Affective, & Behavioral Neuroscience

Marijuana (MJ) use and major depressive disorder (MDD) have both been associated with deficits in... more Marijuana (MJ) use and major depressive disorder (MDD) have both been associated with deficits in verbal learning and memory as well as structural brain abnormalities. It is not known if MJ use by those with MDD confers additional impairment. The goal of this study was to examine unique and combined effects of MDD and MJ use on verbal memory and brain structure. Young adults (n=141) aged 18-25 years with MJ use and no lifetime MDD (MJ, n=46), MDD and no MJ use (MDD, n=23), MJ use and lifetime MDD (MDD+MJ, n=24), and healthy controls without MDD or MJ use (CON, n=48) were enrolled. Participants completed the California Verbal Learning Test, Second Edition (CVLT-II), a measure of verbal learning and memory. A subsample of 82 participants also underwent a structural magnetic resonance imaging (MRI) scan. Group differences in CVLT-II performance, cortical thickness, and hippocampal volume were assessed. We found an additive effect of MDD and MJ on memory recall. Only MDD, but not MJ, was associated with poorer initial learning, fewer words recalled, more intrusion errors, and lower percent retention. There was also an additive effect of MDD and MJ use on reduced cortical thickness in the middle temporal gyrus. Findings indicate that MJ use and MDD have additive adverse associations with verbal recall and cortical thickness in the middle temporal gyrus, suggesting that MJ use among those with MDD may be contraindicated. Prospective studies are warranted to determine whether this association may be causal.

Research paper thumbnail of S260. An Updated Report of Associations Between Cannabis Use and Brain Structure

Research paper thumbnail of Cross-domain correlates of cannabis use disorder severity among young adults

Research paper thumbnail of What Can Neuroimaging of Human Alcohol Drinkers Tell Us About Compulsive Alcohol Use?

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Research paper thumbnail of One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory

The Journal of clinical psychiatry, Jan 30, 2018

Associations between adolescent cannabis use and poor neurocognitive functioning have been report... more Associations between adolescent cannabis use and poor neurocognitive functioning have been reported from cross-sectional studies that cannot determine causality. Prospective designs can assess whether extended cannabis abstinence has a beneficial effect on cognition. Eighty-eight adolescents and young adults (aged 16-25 years) who used cannabis regularly were recruited from the community and a local high school between July 2015 and December 2016. Participants were randomly assigned to 4 weeks of cannabis abstinence, verified by decreasing 11-nor-9-carboxy-∆⁹-tetrahydrocannabinol urine concentration (MJ-Abst; n = 62), or a monitoring control condition with no abstinence requirement (MJ-Mon; n = 26). Attention and memory were assessed at baseline and weekly for 4 weeks with the Cambridge Neuropsychological Test Automated Battery. Among MJ-Abst participants, 55 (88.7%) met a priori criteria for biochemically confirmed 30-day continuous abstinence. There was an effect of abstinence on ...

Research paper thumbnail of Verbal Memory Performance and Reduced Cortical Thickness of Brain Regions Along the Uncinate Fasciculus in Young Adult Cannabis Users

Cannabis and cannabinoid research, 2018

Memory impairment is one of the most commonly reported effects of cannabis use, especially among ... more Memory impairment is one of the most commonly reported effects of cannabis use, especially among those who initiate use earlier, perhaps due to the effects of delta-9- tetrahydrocannabinol on cannabinoid (CB1) receptors in the brain. Studies have increasingly investigated whether cannabis use is associated with impairments in verbal memory, and with alterations in brain structures underlying verbal memory. The uncinate fasciculus (UF), a long-range white matter tract, connects regions with densely localized CB1 receptors that are important in verbal memory. This study investigated the impact of cannabis use on UF structures and its association with memory performance in young adult cannabis users (CU) and non-using controls (CON).Nineteen CU and 22 CON completed a verbal memory task and a neuroimaging protocol, in which diffusion tensor imaging and structural scans were collected. We compared memory performance, diffusion and tractography measures of the UF, and cortical thickness o...

Research paper thumbnail of Neural Correlates of Social Influence Among Cannabis Users

Current Addiction Reports

Research paper thumbnail of A contingency management method for 30-days abstinence in non-treatment seeking young adult cannabis users

Drug and Alcohol Dependence

Research paper thumbnail of Variable activation in striatal subregions across components of a social influence task in young adult cannabis users

Brain and behavior, May 1, 2016

Decades of research have demonstrated the importance of social influence in initiation and mainte... more Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but little is known about neural mechanisms underlying social influence in young adults who use recreational drugs. To better understand whether the neural and/or behavioral response to social influence differs in young adults using illicit drugs, 20 marijuana-using young adults (MJ) aged 18-25, and 20 controls (CON) performed a decision-making task in the context of social influence, while they underwent functional magnetic resonance imaging scans. A priori analyses focused on the nucleus accumbens (NAc), with post hoc analyses in the rest of the striatum. In this task, participants could choose to either follow or go against group influence. When subjects applied social information to response choice selection (independent of following or going against group influence), we observed activation in the middle striatum (caudate), in the MJ group only, that extended ventr...

Research paper thumbnail of Neural mechanisms of sensitivity to peer information in young adult cannabis users

Cognitive, affective & behavioral neuroscience, Aug 11, 2016

Though social influence is a critical factor in the initiation and maintenance of marijuana use, ... more Though social influence is a critical factor in the initiation and maintenance of marijuana use, the neural correlates of influence in those who use marijuana are unknown. In this study, marijuana-using young adults (MJ; n = 20) and controls (CON; n = 23) performed a decision-making task in which they made a perceptual choice after viewing the choices of unknown peers via photographs, while they underwent functional magnetic resonance imaging scans. The MJ and CON groups did not show differences in the overall number of choices that agreed with versus opposed group influence, but only the MJ group showed reaction time slowing when deciding against group choices. Longer reaction times were associated with greater activation of frontal regions. The MJ goup, compared to CON, showed significantly greater activation in the caudate when presented with peer information. Across groups, caudate activation was associated with self-reported susceptibility to influence. These findings indicate ...

Research paper thumbnail of Polygenic Score for Cigarette Smoking is Associated with Ever Electronic‐Cigarette Use in a College‐Aged Sample

Research paper thumbnail of Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study

PLOS ONE

Objective Numerous adverse prenatal exposures have been individually associated with risk for psy... more Objective Numerous adverse prenatal exposures have been individually associated with risk for psychiatric illness in the offspring. However, such exposures frequently co-occur, raising questions about their cumulative impact. We evaluated effects of cumulative adverse prenatal exposure burden on psychopathology risk in school-aged children. Methods Using baseline surveys from the U.S.-based Adolescent Brain and Cognitive Development (ABCD) Study (7,898 non-adopted, unrelated children from 21 sites, age 9–10, and their primary caregivers), we examined 8 retrospectively-reported adverse prenatal exposures in relation to caregiver-reported total and subscale Child Behavior Checklist (CBCL) scores. We also assessed cumulative effects of these factors on CBCL total as a continuous measure, as well as on odds of clinically significant psychopathology (CBCL total ≥60), in both the initial set and a separate ABCD sample comprising an additional 696 sibling pairs. Analyses were conducted bef...

Research paper thumbnail of Association of Adverse Prenatal Exposures and Maternal Folic Acid Use With Psychopathology at Age 9-10 in the ABCD Study

Research paper thumbnail of T91. Impairments in Resting State Connectivity are Associated With Cannabis Use and Major Depressive Disorder

Research paper thumbnail of White matter integrity differences associated with posttraumatic stress disorder are not normalized by concurrent marijuana use

Psychiatry Research: Neuroimaging

Research paper thumbnail of Urinary 11-nor-9-carboxy-tetrahydrocannabinol elimination in adolescent and young adult cannabis users during one month of sustained and biochemically-verified abstinence

Journal of Psychopharmacology

Background: Despite adolescents and young adults being the most frequent users of cannabis, all i... more Background: Despite adolescents and young adults being the most frequent users of cannabis, all information on cannabis drug testing interpretation is based on data from adults. Aims: This study aimed to define the time course of urinary 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) excretion among 70 adolescent and young adult cannabis users during 1 month of biochemically-verified cannabis abstinence. Methods: Urine specimens were collected at non-abstinent baseline and after 2, 3, 8, 15, 21 and 28 days of abstinence. Specimens were tested for THCCOOH with a ‘rapid’ immunoassay drug test and a confirmatory assay using liquid chromatography-tandem mass spectrometry, with a 5 ng/mL limit of quantitation. Elimination rate was tested using a population pharmacokinetics model. Results/outcomes: Participants had an average of 26 days of abstinence (SD = 6). Initial creatinine-adjusted THCCOOH concentration (CN-THCCOOH) was 148 ng/mg (SD = 157). Half-life was 2 days (SD = 5), with a 10...

Research paper thumbnail of T266. Memory Deficits are Reversible With Sustained Cannabis Abstinence Among Cannabis Using Adolescents

Research paper thumbnail of Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence

Addictive Behaviors Reports

Evins. 2018. "Anterior insula activation during inhibition to smoking cues is associated with abi... more Evins. 2018. "Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence." Addictive Behaviors Reports 7 (1): 40-46.

Research paper thumbnail of Delta-9-tetrahydrocannabinol intoxication is associated with increased prefrontal activation as assessed with functional near-infrared spectroscopy: A report of a potential biomarker of intoxication

Research paper thumbnail of Suggestibility is associated with alcohol self-administration, subjective alcohol effects, and self-reported drinking behavior

Journal of Psychopharmacology

Research paper thumbnail of Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness

Cognitive, Affective, & Behavioral Neuroscience

Marijuana (MJ) use and major depressive disorder (MDD) have both been associated with deficits in... more Marijuana (MJ) use and major depressive disorder (MDD) have both been associated with deficits in verbal learning and memory as well as structural brain abnormalities. It is not known if MJ use by those with MDD confers additional impairment. The goal of this study was to examine unique and combined effects of MDD and MJ use on verbal memory and brain structure. Young adults (n=141) aged 18-25 years with MJ use and no lifetime MDD (MJ, n=46), MDD and no MJ use (MDD, n=23), MJ use and lifetime MDD (MDD+MJ, n=24), and healthy controls without MDD or MJ use (CON, n=48) were enrolled. Participants completed the California Verbal Learning Test, Second Edition (CVLT-II), a measure of verbal learning and memory. A subsample of 82 participants also underwent a structural magnetic resonance imaging (MRI) scan. Group differences in CVLT-II performance, cortical thickness, and hippocampal volume were assessed. We found an additive effect of MDD and MJ on memory recall. Only MDD, but not MJ, was associated with poorer initial learning, fewer words recalled, more intrusion errors, and lower percent retention. There was also an additive effect of MDD and MJ use on reduced cortical thickness in the middle temporal gyrus. Findings indicate that MJ use and MDD have additive adverse associations with verbal recall and cortical thickness in the middle temporal gyrus, suggesting that MJ use among those with MDD may be contraindicated. Prospective studies are warranted to determine whether this association may be causal.

Research paper thumbnail of S260. An Updated Report of Associations Between Cannabis Use and Brain Structure

Research paper thumbnail of Cross-domain correlates of cannabis use disorder severity among young adults

Research paper thumbnail of What Can Neuroimaging of Human Alcohol Drinkers Tell Us About Compulsive Alcohol Use?

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Research paper thumbnail of One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory

The Journal of clinical psychiatry, Jan 30, 2018

Associations between adolescent cannabis use and poor neurocognitive functioning have been report... more Associations between adolescent cannabis use and poor neurocognitive functioning have been reported from cross-sectional studies that cannot determine causality. Prospective designs can assess whether extended cannabis abstinence has a beneficial effect on cognition. Eighty-eight adolescents and young adults (aged 16-25 years) who used cannabis regularly were recruited from the community and a local high school between July 2015 and December 2016. Participants were randomly assigned to 4 weeks of cannabis abstinence, verified by decreasing 11-nor-9-carboxy-∆⁹-tetrahydrocannabinol urine concentration (MJ-Abst; n = 62), or a monitoring control condition with no abstinence requirement (MJ-Mon; n = 26). Attention and memory were assessed at baseline and weekly for 4 weeks with the Cambridge Neuropsychological Test Automated Battery. Among MJ-Abst participants, 55 (88.7%) met a priori criteria for biochemically confirmed 30-day continuous abstinence. There was an effect of abstinence on ...

Research paper thumbnail of Verbal Memory Performance and Reduced Cortical Thickness of Brain Regions Along the Uncinate Fasciculus in Young Adult Cannabis Users

Cannabis and cannabinoid research, 2018

Memory impairment is one of the most commonly reported effects of cannabis use, especially among ... more Memory impairment is one of the most commonly reported effects of cannabis use, especially among those who initiate use earlier, perhaps due to the effects of delta-9- tetrahydrocannabinol on cannabinoid (CB1) receptors in the brain. Studies have increasingly investigated whether cannabis use is associated with impairments in verbal memory, and with alterations in brain structures underlying verbal memory. The uncinate fasciculus (UF), a long-range white matter tract, connects regions with densely localized CB1 receptors that are important in verbal memory. This study investigated the impact of cannabis use on UF structures and its association with memory performance in young adult cannabis users (CU) and non-using controls (CON).Nineteen CU and 22 CON completed a verbal memory task and a neuroimaging protocol, in which diffusion tensor imaging and structural scans were collected. We compared memory performance, diffusion and tractography measures of the UF, and cortical thickness o...

Research paper thumbnail of Neural Correlates of Social Influence Among Cannabis Users

Current Addiction Reports

Research paper thumbnail of A contingency management method for 30-days abstinence in non-treatment seeking young adult cannabis users

Drug and Alcohol Dependence

Research paper thumbnail of Variable activation in striatal subregions across components of a social influence task in young adult cannabis users

Brain and behavior, May 1, 2016

Decades of research have demonstrated the importance of social influence in initiation and mainte... more Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but little is known about neural mechanisms underlying social influence in young adults who use recreational drugs. To better understand whether the neural and/or behavioral response to social influence differs in young adults using illicit drugs, 20 marijuana-using young adults (MJ) aged 18-25, and 20 controls (CON) performed a decision-making task in the context of social influence, while they underwent functional magnetic resonance imaging scans. A priori analyses focused on the nucleus accumbens (NAc), with post hoc analyses in the rest of the striatum. In this task, participants could choose to either follow or go against group influence. When subjects applied social information to response choice selection (independent of following or going against group influence), we observed activation in the middle striatum (caudate), in the MJ group only, that extended ventr...

Research paper thumbnail of Neural mechanisms of sensitivity to peer information in young adult cannabis users

Cognitive, affective & behavioral neuroscience, Aug 11, 2016

Though social influence is a critical factor in the initiation and maintenance of marijuana use, ... more Though social influence is a critical factor in the initiation and maintenance of marijuana use, the neural correlates of influence in those who use marijuana are unknown. In this study, marijuana-using young adults (MJ; n = 20) and controls (CON; n = 23) performed a decision-making task in which they made a perceptual choice after viewing the choices of unknown peers via photographs, while they underwent functional magnetic resonance imaging scans. The MJ and CON groups did not show differences in the overall number of choices that agreed with versus opposed group influence, but only the MJ group showed reaction time slowing when deciding against group choices. Longer reaction times were associated with greater activation of frontal regions. The MJ goup, compared to CON, showed significantly greater activation in the caudate when presented with peer information. Across groups, caudate activation was associated with self-reported susceptibility to influence. These findings indicate ...