John Cronan - Academia.edu (original) (raw)
Papers by John Cronan
Clinical Radiology, Dec 1, 2001
AIM: To compare power and colour Doppler ultrasonography (US) with nuclear medicine scintigraphy ... more AIM: To compare power and colour Doppler ultrasonography (US) with nuclear medicine scintigraphy (NM) in the preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism (PHPT). MATERIALS AND METHODS: Thirty-one patients with biochemical evidence of PHPT underwent pre-operative US and NM for parathyroid adenoma localization. Both studies were interpreted independently without prior knowledge of the other study's findings. All patients had surgical removal of the parathyroid adenoma utilizing standard neck exploration or minimally invasive unilateral surgical techniques with rapid serum assay of circulating parathyroid hormone levels. RESULTS: All patients had single parathyroid adenomas at surgery. Prospective sensitivities for US, NM and both studies combined were 65%, 68%, and 74%, respectively, with a positive predictive value of 100% each. The adenoma was localized by only one imaging modality in 16% of cases. CONCLUSIONS: US and NM provide complementary roles in the pre-operative localization of parathyroid adenomas in patients with PHPT. Scheiner, J. D.et al. (2001). Clinical Radiology56, 984–988.
Urologic Clinics of North America, 1997
Canadian Association of Radiologists Journal, 2013
Accurate preoperative localization is the key to successful parathyroid surgery in the era of min... more Accurate preoperative localization is the key to successful parathyroid surgery in the era of minimally invasive parathyroid surgery. This article presents and discusses the embryologic basis of parathyroid gland and ectopic location and different imaging modalities helpful in diagnosing and localizing parathyroid adenomas and/or hyperplasia. We also aim to review the current surgical concepts in treatment of parathyroid adenomas and/or hyperplasia, the utility of 4-dimensional computed tomography for accurate preoperative localization of hyperfunctioning parathyroid glands, imaging classification of adenomas and/or hyperplasia, and, finally, present some of the limitations of 4-dimensional computed tomography.
American Journal of Roentgenology, 1986
Percutaneous placement of the Kimray-Greenfield vena cava filter was successfully performed in 12... more Percutaneous placement of the Kimray-Greenfield vena cava filter was successfully performed in 12 consecutive patients, 10 from the right femoral vein, one from the left femoral vein, and one from the right internal jugular vein. Tract dilatation to allow placement of a 24-French sheath was easily performed and well tolerated. There was no occurrence of puncture site hematoma, significant blood loss, or postprocedural femoral vein thrombophlebitis. Percutaneous femoral vein approach is as effective as right internal jugular vein approach. The dependence on surgically obtained access for Kimray-Greenfield filter placement is no longer absolute.
Circulation, 2018
Venous ultrasound is the standard imaging test for patients suspected of having acute deep venous... more Venous ultrasound is the standard imaging test for patients suspected of having acute deep venous thrombosis (DVT). There is variability and disagreement among authoritative groups regarding the necessary components of the test. Some protocols include scanning the entire lower extremity, whereas others recommend scans limited to the thigh and knee supplemented with serial testing. Some protocols use gray-scale ultrasound alone, whereas others include Doppler interrogation. Point-of-care ultrasound is recommended in some settings, and there is heterogeneity of these protocols as well. Heterogeneity of recommendations can lead to errors including incorrect application of guidelines, confusion among requesting physicians, and incorrect follow-up. In October 2016, the Society of Radiologists in Ultrasound convened a multidisciplinary panel of experts to evaluate the current evidence to develop recommendations regarding ultrasound protocols for DVT and the terminology used to communicate...
Journal of the American College of Radiology : JACR, 2017
Thyroid nodules are a frequent finding on neck sonography. Most nodules are benign; therefore, ma... more Thyroid nodules are a frequent finding on neck sonography. Most nodules are benign; therefore, many nodules are biopsied to identify the small number that are malignant or require surgery for a definitive diagnosis. Since 2009, many professional societies and investigators have proposed ultrasound-based risk stratification systems to identify nodules that warrant biopsy or sonographic follow-up. Because some of these systems were founded on the BI-RADS(®) classification that is widely used in breast imaging, their authors chose to apply the acronym TI-RADS, for Thyroid Imaging, Reporting and Data System. In 2012, the ACR convened committees to (1) provide recommendations for reporting incidental thyroid nodules, (2) develop a set of standard terms (lexicon) for ultrasound reporting, and (3) propose a TI-RADS on the basis of the lexicon. The committees published the results of the first two efforts in 2015. In this article, the authors present the ACR TI-RADS Committee's recommen...
Journal of the American College of Radiology, 2015
Ultrasound is the most commonly used imaging technique for the evaluation of thyroid nodules. Son... more Ultrasound is the most commonly used imaging technique for the evaluation of thyroid nodules. Sonographic findings are often not specific, and definitive diagnosis is usually made through fine-needle aspiration biopsy or even surgery. In reviewing the literature, terms used to describe nodules are often poorly defined and inconsistently applied. Several authors have recently described a standardized risk stratification system called the Thyroid Imaging, Reporting and Data System (TIRADS), modeled on the BI-RADS system for breast imaging. However, most of these TIRADS classifications have come from individual institutions, and none has been widely adopted in the United States. Under the auspices of the ACR, a committee was organized to develop TIRADS. The eventual goal is to provide practitioners with evidence-based recommendations for the management of thyroid nodules on the basis of a set of well-defined sonographic features or terms that can be applied to every lesion. Terms were chosen on the basis of demonstration of consistency with regard to performance in the diagnosis of thyroid cancer or, conversely, classifying a nodule as benign and avoiding follow-up. The initial portion of this project was aimed at standardizing the diagnostic approach to thyroid nodules with regard to terminology through the development of a lexicon. This white paper describes the consensus process and the resultant lexicon.
Thyroid : official journal of the American Thyroid Association, Jan 17, 2015
American Journal of Roentgenology, 2014
N e u r o r a d io l og y/ H e a d a n d N e c k I m ag i ng • O r ig i n a l R e s e a rc h
Rhode Island medical journal (2013), 2013
Journal of the American College of Radiology, 2015
The incidental thyroid nodule (ITN) is one of the most common incidental findings on imaging stud... more The incidental thyroid nodule (ITN) is one of the most common incidental findings on imaging studies that include the neck. An ITN is defined as a nodule not previously detected or suspected clinically, but identified by an imaging study. The workup of ITNs has led to increased costs from additional procedures, and in some cases, to increased risk to the patient because physicians are naturally concerned about the risk of malignancy and a delayed cancer diagnosis. However, the majority of ITNs are benign, and small, incidental thyroid malignancies typically have indolent behavior. The ACR formed the Incidental Thyroid Findings Committee to derive a practical approach to managing ITNs on CT, MRI, nuclear medicine, and ultrasound studies. This white paper describes consensus recommendations representing this committee's review of the literature and their practice experience.
Radiology, 2005
The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medic... more The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medical disciplines to come to a consensus on the management of thyroid nodules identified with thyroid ultrasonography (US), with particular focus on which nodules should be subjected to US-guided fine needle aspiration and which thyroid nodules need not be subjected to fine-needle aspiration. The panel met in Washington, DC, October 26-27, 2004, and created this consensus statement. The recommendations in this consensus statement, which are based on analysis of the current literature and common practice strategies, are thought to represent a reasonable approach to thyroid nodular disease.
American Journal of Roentgenology, 2014
Not all patients with abnormal liver function tests have or go on to develop cirrhosis. Emerging ... more Not all patients with abnormal liver function tests have or go on to develop cirrhosis. Emerging treatment options to slow progression or potentially cure the disease are being developed but are costly and may be appropriate only in certain patient populations, depending on disease activity. This requires accurate fibrosis staging, generally by liver biopsy. Although the random liver biopsy is considered the reference standard for evaluating diffuse liver disease, it is not a perfect test. Given that the distribution of fibrosis in the liver may be heterogeneous, histologic staging based on a biopsy specimen that represents at most 1/50,000 of the total liver mass is suboptimal [3]. A liver biopsy is also expensive and has a risk of bleeding, particularly in patients with advanced liver disease who often have dysfunctional clotting cascade and plate
Radiology, 2002
PURPOSE: To compare the diagnostic yield of abdominal radiography with that of computed tomograph... more PURPOSE: To compare the diagnostic yield of abdominal radiography with that of computed tomography (CT) in adult patients presenting to the emergency department with nontraumatic abdominal pain. MATERIALS AND METHODS: Records of 1,000 consecutive patients presenting to the emergency department with acute abdominal pain from April to June 1998 were retrospectively reviewed. A total of 871 patients underwent abdominal radiography, and 188 underwent abdominal CT. The report interpretations of the abdominal radiographs and CT scans were divided into normal, nonspecific, and abnormal categories. Final discharge diagnoses were compared with the interpretations of the imaging examination results, and sensitivities and specificities of each modality were calculated and compared. RESULTS: Interpretation of abdominal radiographs was nonspecific in 588 (68%) of 871 patients, normal in 200 (23%), and abnormal in 83 (10%). The highest sensitivity of abdominal radiography was 90% for intraabdominal foreign body and 49% for bowel obstruction. Abdominal radiography had 0% sensitivity for appendicitis, pyelonephritis, pancreatitis, and diverticulitis. Sensitivities of abdominal CT were highest for bowel obstruction and urolithiasis at 75% and 68%, respectively.
Journal of Vascular Surgery, 1987
American Journal of Roentgenology, 2010
Subjects and Methods Subjects Patients from six geographically diverse U.S. medical centers were ... more Subjects and Methods Subjects Patients from six geographically diverse U.S. medical centers were included in our HIPAA-compliant study, which was approved by the institutional review boards of each participating institution. All patients at least 18 years old who underwent diagnostic thyroid ultrasound examinations and ultrasound-guided fine-needle aspirations of a focal nodule between August 2006 and December 2007 and who signed a consent form were eligible for the study. A nodule was defined as an intrathyroidal lesion of any size that was sonographically distinct from the surrounding thyroid tissue. During this period, 1,522 patients were enrolled in the study.
American Journal of Roentgenology, 2010
N e u r o r a d io l og y / H e a d a n d N e c k I m ag i ng • O r ig i n a l R e s e a rc h
American Journal of Roentgenology, 1987
Ventilation-perfusion scans were used in a prospective study to determine the prevalence of occul... more Ventilation-perfusion scans were used in a prospective study to determine the prevalence of occult pulmonary embolus in proven deep venous thrombosis. Fifty-eight patients without symptoms of pulmonary embolism, but with venographically proven deep venous thrombosis, were subjected to chest radiographs, "Tc macroaggregatedalbumin perfusion scans, and IUXe ventilation scans. Of the 49 patients with deep venous thrombosis proximal to the calf veins, 17 (35%) had high-probability scans. Of all 58 patients, only 12 (21%) had normal scans. When the study population was compared with a group of 430 patients described in reports of pulmonary perfusion in asymptomatic persons, a significantly higher percentage of high-probability scans was found in the study population with deep venous thrombosis. Baseline ventilationperfusion lung scanning is valuable for patients with proven above-knee deep venous thrombosis.
American Journal of Roentgenology, 1988
Fig. 1.-Normal male urethra. Retrograde urethrogram shows smooth margins of urethra with gentle t... more Fig. 1.-Normal male urethra. Retrograde urethrogram shows smooth margins of urethra with gentle taperIng in region of membranous urethra (white arrow). Note filling defectin prostatic urethra caused by verumontanum (black arrow).
Clinical Radiology, Dec 1, 2001
AIM: To compare power and colour Doppler ultrasonography (US) with nuclear medicine scintigraphy ... more AIM: To compare power and colour Doppler ultrasonography (US) with nuclear medicine scintigraphy (NM) in the preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism (PHPT). MATERIALS AND METHODS: Thirty-one patients with biochemical evidence of PHPT underwent pre-operative US and NM for parathyroid adenoma localization. Both studies were interpreted independently without prior knowledge of the other study's findings. All patients had surgical removal of the parathyroid adenoma utilizing standard neck exploration or minimally invasive unilateral surgical techniques with rapid serum assay of circulating parathyroid hormone levels. RESULTS: All patients had single parathyroid adenomas at surgery. Prospective sensitivities for US, NM and both studies combined were 65%, 68%, and 74%, respectively, with a positive predictive value of 100% each. The adenoma was localized by only one imaging modality in 16% of cases. CONCLUSIONS: US and NM provide complementary roles in the pre-operative localization of parathyroid adenomas in patients with PHPT. Scheiner, J. D.et al. (2001). Clinical Radiology56, 984–988.
Urologic Clinics of North America, 1997
Canadian Association of Radiologists Journal, 2013
Accurate preoperative localization is the key to successful parathyroid surgery in the era of min... more Accurate preoperative localization is the key to successful parathyroid surgery in the era of minimally invasive parathyroid surgery. This article presents and discusses the embryologic basis of parathyroid gland and ectopic location and different imaging modalities helpful in diagnosing and localizing parathyroid adenomas and/or hyperplasia. We also aim to review the current surgical concepts in treatment of parathyroid adenomas and/or hyperplasia, the utility of 4-dimensional computed tomography for accurate preoperative localization of hyperfunctioning parathyroid glands, imaging classification of adenomas and/or hyperplasia, and, finally, present some of the limitations of 4-dimensional computed tomography.
American Journal of Roentgenology, 1986
Percutaneous placement of the Kimray-Greenfield vena cava filter was successfully performed in 12... more Percutaneous placement of the Kimray-Greenfield vena cava filter was successfully performed in 12 consecutive patients, 10 from the right femoral vein, one from the left femoral vein, and one from the right internal jugular vein. Tract dilatation to allow placement of a 24-French sheath was easily performed and well tolerated. There was no occurrence of puncture site hematoma, significant blood loss, or postprocedural femoral vein thrombophlebitis. Percutaneous femoral vein approach is as effective as right internal jugular vein approach. The dependence on surgically obtained access for Kimray-Greenfield filter placement is no longer absolute.
Circulation, 2018
Venous ultrasound is the standard imaging test for patients suspected of having acute deep venous... more Venous ultrasound is the standard imaging test for patients suspected of having acute deep venous thrombosis (DVT). There is variability and disagreement among authoritative groups regarding the necessary components of the test. Some protocols include scanning the entire lower extremity, whereas others recommend scans limited to the thigh and knee supplemented with serial testing. Some protocols use gray-scale ultrasound alone, whereas others include Doppler interrogation. Point-of-care ultrasound is recommended in some settings, and there is heterogeneity of these protocols as well. Heterogeneity of recommendations can lead to errors including incorrect application of guidelines, confusion among requesting physicians, and incorrect follow-up. In October 2016, the Society of Radiologists in Ultrasound convened a multidisciplinary panel of experts to evaluate the current evidence to develop recommendations regarding ultrasound protocols for DVT and the terminology used to communicate...
Journal of the American College of Radiology : JACR, 2017
Thyroid nodules are a frequent finding on neck sonography. Most nodules are benign; therefore, ma... more Thyroid nodules are a frequent finding on neck sonography. Most nodules are benign; therefore, many nodules are biopsied to identify the small number that are malignant or require surgery for a definitive diagnosis. Since 2009, many professional societies and investigators have proposed ultrasound-based risk stratification systems to identify nodules that warrant biopsy or sonographic follow-up. Because some of these systems were founded on the BI-RADS(®) classification that is widely used in breast imaging, their authors chose to apply the acronym TI-RADS, for Thyroid Imaging, Reporting and Data System. In 2012, the ACR convened committees to (1) provide recommendations for reporting incidental thyroid nodules, (2) develop a set of standard terms (lexicon) for ultrasound reporting, and (3) propose a TI-RADS on the basis of the lexicon. The committees published the results of the first two efforts in 2015. In this article, the authors present the ACR TI-RADS Committee's recommen...
Journal of the American College of Radiology, 2015
Ultrasound is the most commonly used imaging technique for the evaluation of thyroid nodules. Son... more Ultrasound is the most commonly used imaging technique for the evaluation of thyroid nodules. Sonographic findings are often not specific, and definitive diagnosis is usually made through fine-needle aspiration biopsy or even surgery. In reviewing the literature, terms used to describe nodules are often poorly defined and inconsistently applied. Several authors have recently described a standardized risk stratification system called the Thyroid Imaging, Reporting and Data System (TIRADS), modeled on the BI-RADS system for breast imaging. However, most of these TIRADS classifications have come from individual institutions, and none has been widely adopted in the United States. Under the auspices of the ACR, a committee was organized to develop TIRADS. The eventual goal is to provide practitioners with evidence-based recommendations for the management of thyroid nodules on the basis of a set of well-defined sonographic features or terms that can be applied to every lesion. Terms were chosen on the basis of demonstration of consistency with regard to performance in the diagnosis of thyroid cancer or, conversely, classifying a nodule as benign and avoiding follow-up. The initial portion of this project was aimed at standardizing the diagnostic approach to thyroid nodules with regard to terminology through the development of a lexicon. This white paper describes the consensus process and the resultant lexicon.
Thyroid : official journal of the American Thyroid Association, Jan 17, 2015
American Journal of Roentgenology, 2014
N e u r o r a d io l og y/ H e a d a n d N e c k I m ag i ng • O r ig i n a l R e s e a rc h
Rhode Island medical journal (2013), 2013
Journal of the American College of Radiology, 2015
The incidental thyroid nodule (ITN) is one of the most common incidental findings on imaging stud... more The incidental thyroid nodule (ITN) is one of the most common incidental findings on imaging studies that include the neck. An ITN is defined as a nodule not previously detected or suspected clinically, but identified by an imaging study. The workup of ITNs has led to increased costs from additional procedures, and in some cases, to increased risk to the patient because physicians are naturally concerned about the risk of malignancy and a delayed cancer diagnosis. However, the majority of ITNs are benign, and small, incidental thyroid malignancies typically have indolent behavior. The ACR formed the Incidental Thyroid Findings Committee to derive a practical approach to managing ITNs on CT, MRI, nuclear medicine, and ultrasound studies. This white paper describes consensus recommendations representing this committee's review of the literature and their practice experience.
Radiology, 2005
The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medic... more The Society of Radiologists in Ultrasound convened a panel of specialists from a variety of medical disciplines to come to a consensus on the management of thyroid nodules identified with thyroid ultrasonography (US), with particular focus on which nodules should be subjected to US-guided fine needle aspiration and which thyroid nodules need not be subjected to fine-needle aspiration. The panel met in Washington, DC, October 26-27, 2004, and created this consensus statement. The recommendations in this consensus statement, which are based on analysis of the current literature and common practice strategies, are thought to represent a reasonable approach to thyroid nodular disease.
American Journal of Roentgenology, 2014
Not all patients with abnormal liver function tests have or go on to develop cirrhosis. Emerging ... more Not all patients with abnormal liver function tests have or go on to develop cirrhosis. Emerging treatment options to slow progression or potentially cure the disease are being developed but are costly and may be appropriate only in certain patient populations, depending on disease activity. This requires accurate fibrosis staging, generally by liver biopsy. Although the random liver biopsy is considered the reference standard for evaluating diffuse liver disease, it is not a perfect test. Given that the distribution of fibrosis in the liver may be heterogeneous, histologic staging based on a biopsy specimen that represents at most 1/50,000 of the total liver mass is suboptimal [3]. A liver biopsy is also expensive and has a risk of bleeding, particularly in patients with advanced liver disease who often have dysfunctional clotting cascade and plate
Radiology, 2002
PURPOSE: To compare the diagnostic yield of abdominal radiography with that of computed tomograph... more PURPOSE: To compare the diagnostic yield of abdominal radiography with that of computed tomography (CT) in adult patients presenting to the emergency department with nontraumatic abdominal pain. MATERIALS AND METHODS: Records of 1,000 consecutive patients presenting to the emergency department with acute abdominal pain from April to June 1998 were retrospectively reviewed. A total of 871 patients underwent abdominal radiography, and 188 underwent abdominal CT. The report interpretations of the abdominal radiographs and CT scans were divided into normal, nonspecific, and abnormal categories. Final discharge diagnoses were compared with the interpretations of the imaging examination results, and sensitivities and specificities of each modality were calculated and compared. RESULTS: Interpretation of abdominal radiographs was nonspecific in 588 (68%) of 871 patients, normal in 200 (23%), and abnormal in 83 (10%). The highest sensitivity of abdominal radiography was 90% for intraabdominal foreign body and 49% for bowel obstruction. Abdominal radiography had 0% sensitivity for appendicitis, pyelonephritis, pancreatitis, and diverticulitis. Sensitivities of abdominal CT were highest for bowel obstruction and urolithiasis at 75% and 68%, respectively.
Journal of Vascular Surgery, 1987
American Journal of Roentgenology, 2010
Subjects and Methods Subjects Patients from six geographically diverse U.S. medical centers were ... more Subjects and Methods Subjects Patients from six geographically diverse U.S. medical centers were included in our HIPAA-compliant study, which was approved by the institutional review boards of each participating institution. All patients at least 18 years old who underwent diagnostic thyroid ultrasound examinations and ultrasound-guided fine-needle aspirations of a focal nodule between August 2006 and December 2007 and who signed a consent form were eligible for the study. A nodule was defined as an intrathyroidal lesion of any size that was sonographically distinct from the surrounding thyroid tissue. During this period, 1,522 patients were enrolled in the study.
American Journal of Roentgenology, 2010
N e u r o r a d io l og y / H e a d a n d N e c k I m ag i ng • O r ig i n a l R e s e a rc h
American Journal of Roentgenology, 1987
Ventilation-perfusion scans were used in a prospective study to determine the prevalence of occul... more Ventilation-perfusion scans were used in a prospective study to determine the prevalence of occult pulmonary embolus in proven deep venous thrombosis. Fifty-eight patients without symptoms of pulmonary embolism, but with venographically proven deep venous thrombosis, were subjected to chest radiographs, "Tc macroaggregatedalbumin perfusion scans, and IUXe ventilation scans. Of the 49 patients with deep venous thrombosis proximal to the calf veins, 17 (35%) had high-probability scans. Of all 58 patients, only 12 (21%) had normal scans. When the study population was compared with a group of 430 patients described in reports of pulmonary perfusion in asymptomatic persons, a significantly higher percentage of high-probability scans was found in the study population with deep venous thrombosis. Baseline ventilationperfusion lung scanning is valuable for patients with proven above-knee deep venous thrombosis.
American Journal of Roentgenology, 1988
Fig. 1.-Normal male urethra. Retrograde urethrogram shows smooth margins of urethra with gentle t... more Fig. 1.-Normal male urethra. Retrograde urethrogram shows smooth margins of urethra with gentle taperIng in region of membranous urethra (white arrow). Note filling defectin prostatic urethra caused by verumontanum (black arrow).