John Doe - Academia.edu (original) (raw)

Papers by John Doe

Archives of Toxicology

The long-term investment in new approach methodologies (NAMs) within the EU and other parts of th... more The long-term investment in new approach methodologies (NAMs) within the EU and other parts of the world is beginning to result in an emerging consensus of how to use information from in silico, in vitro and targeted in vivo sources to assess the safety of chemicals. However, this methodology is being adopted very slowly for regulatory purposes. Here, we have developed a framework incorporating in silico, in vitro and in vivo methods designed to meet the requirements of REACH in which both hazard and exposure can be assessed using a tiered approach. The outputs from each tier are classification categories, safe doses, and risk assessments, and progress through the tiers depends on the output from previous tiers. We have exemplified the use of the framework with three examples. The outputs were the same or more conservative than parallel assessments based on conventional studies. The framework allows a transparent and phased introduction of NAMs in chemical safety assessment and enab...

Regulatory Toxicology and Pharmacology

Developments in the understanding of the etiology of cancer have profound implications for the wa... more Developments in the understanding of the etiology of cancer have profound implications for the way the carcinogenicity of chemicals is addressed. This paper proposes a unified theory of carcinogenesis that will illuminate better ways to evaluate and regulate chemicals. In the last four decades, we have come to understand that for a cell and a group of cells to begin the process of unrestrained growth that is defined as cancer, there must be changes in DNA that reprogram the cell from normal to abnormal. Cancer is the consequence of DNA coding errors that arise either directly from mutagenic events or indirectly from cell proliferation especially if sustained. Chemicals that act via direct interaction with DNA can induce cancer because they cause mutations which can be carried forward in dividing cells. Chemicals that act via non-genotoxic mechanisms must be dosed to maintain a proliferative environment so that the steps toward neoplasia have time to occur. Chemicals that induce increased cellular proliferation can be divided into two categories: those which act by a cellular receptor to induce cellular proliferation, and those which act via non-specific mechanisms such as cytotoxicity. This knowledge has implications for testing chemicals for carcinogenic potential and risk management.

Special Thanks to our Editors-in-Chief

CSA News, 2015

Metabolic Clearance and Production Rates of Human Growth Hormone in Subjects with Normal and Abnormal Growth

The Journal of Clinical Endocrinology & Metabolism, 1970

ABSTRACT The metabolic clearance rate (MCR) and production rate (PR) of human growth hormone (HGH... more ABSTRACT The metabolic clearance rate (MCR) and production rate (PR) of human growth hormone (HGH) was estimated bymeans of a continuous infusion of 131I-HGH. Forty-four subjects, ages 4½–60 yr, with normal and abnormal growth, participated in this investigation. A significant correlation (p <.01) was found between MCR and surface area. The MCR/m2 was similar in childhood, adolescence and adult life. The MCR/m2 in ml/min (mean ±se) in 9 normal males (112 ±5) was similar to that in 8 normal females (111 ±10). The results found in hypopituitary (109 ±8) and acromegalic (118 ±16) individuals indicate that the MCR/m2 is independent of plasma HGH concentration. The MCR of HGH was normal in patients with delayed adolescence, hyperthyroidism and gonadal dysgenesis. Reduced MCR was seen in severe hypothyroidism and in one form of primordial dwarfism. The production rate (PR) of HGH in normal patients, calculated on the basis of mean plasma hormone levels, is significantly higher than that observed in hypopituitar...

CSSA Executive Committee Meetings

Crop Science, 2003

Thanks to Our Reviewers, 2012

Crop Science, 2013

CSSA Yearly Reports

Crop Science, 2010

Inorganic solid Li ion conductors: An overview

Solid State Ionics, 2009

... Interestingly, the activation energy of the latter, which are sensitive to long-range Li tran... more ... Interestingly, the activation energy of the latter, which are sensitive to long-range Li transport parameters, is ... doping with Ga 2 S 3 and La 2 S 3 . Clearly higher Li ion conductivity than ... 0.4–0.5 eV), but these glasses are highly hygroscopic, which is problematic for lithium batteries ...

TITLE OF PAPER CENTERED, ALL CAPITALS, USE 14 POINT BOLD TIMES ROMAN FONT, TOP LINE 1 INCH (2.5 cm) BELOW UPPER MARGIN1

clra.ca

Page 1. CLRA⁄IALR Conference August 2006 General Instructions Please try and send manuscripts bef... more Page 1. CLRA⁄IALR Conference August 2006 General Instructions Please try and send manuscripts before June 15th 2006. The absolute final deadline for inclusion in the Proceedings is June 30, 2006!! Authors of accepted ...

Bronchopulmonary function: report of the Main Working Party

… & therapeutics. Part B: …, 1979

1. Pharmacol Ther B. 1979;5(1-3):149-79. Bronchopulmonary function: report of the Main Working Pa... more 1. Pharmacol Ther B. 1979;5(1-3):149-79. Bronchopulmonary function: report of the Main Working Party. Clark DG, Buch S, Doe JE, Frith H, Pullinger DH. PMID: 386365 [PubMed - indexed for MEDLINE]. Publication Types: Review. MeSH Terms. ...

Biological techniques for studying the allergenic components of nematodes. I. Detection of allergenic components in Ascaris suum extracts

Journal of Immunological …, 1972

1. Two allergen fractions A and B have been separated from a whole worm extract of Ascaris suum u... more 1. Two allergen fractions A and B have been separated from a whole worm extract of Ascaris suum using Sephadex gel filtration.2. Both fractions were active in i.

Nanocomposite polymer electrolytes and their impact on the lithium battery technology

Solid State Ionics, 2000

Enhancement of ion transport in polymer electrolytes by addition of nanoscale inorganic oxides

Lithium lanthanum titanium oxides: a fast ionic conductive coating for lithium-ion battery cathodes

Babatunde Shoyombo, a native of Nigeria, entered the United States illegally in July 1993 and fra... more Babatunde Shoyombo, a native of Nigeria, entered the United States illegally in July 1993 and fraudulently filed two asylum applications in different names in 1993 and 1995. The second application, in his own name, was denied and he was ordered deported in absentia in November 1995. Shoyombo remained in the United States and married a United States citizen. His second motion to reopen, filed while he applied for adjustment of status, was granted in February 2002. However, after the Department of Homeland Security ("DHS") discovered Shoyombo had previously filed a second asylum application, the proceedings were reopened on the Immigration Court's own motion. After a hearing, the immigration judge denied adjustment of status but granted Shoyombo's request for voluntary departure. DHS appealed the latter ruling. The BIA affirmed in a January 19, 2010, order that gave Shoyombo sixty days to leave the United States. He did not depart, instead marrying a second United States citizen on February 1, 2010. His attorney filed a new I-130 Visa Petition on March 12, 2010, but failed to file a third motion to reopen the removal proceedings and apply for adjustment of status.

United States District Court for the Southern District of Arcadia

TO: Members of the Division of Nuclear Physics, APS FROM: Benjamin F. Gibson, LANL - Secretary-Treasurer, DNP

Investigation of the Damage Tolerance of Composite Materials at Cryogenic Temperatures

NASA has the mission of providing revolutionary new tools and technology advancements for the Nat... more NASA has the mission of providing revolutionary new tools and technology advancements for the Nation's aeronautics and space needs. The goals of this mission are well-articulated in Daniel Goldin's “Three Pillars for Success.” In all three pillars (Global Civil Aviation, ...

Archives of Toxicology

The long-term investment in new approach methodologies (NAMs) within the EU and other parts of th... more The long-term investment in new approach methodologies (NAMs) within the EU and other parts of the world is beginning to result in an emerging consensus of how to use information from in silico, in vitro and targeted in vivo sources to assess the safety of chemicals. However, this methodology is being adopted very slowly for regulatory purposes. Here, we have developed a framework incorporating in silico, in vitro and in vivo methods designed to meet the requirements of REACH in which both hazard and exposure can be assessed using a tiered approach. The outputs from each tier are classification categories, safe doses, and risk assessments, and progress through the tiers depends on the output from previous tiers. We have exemplified the use of the framework with three examples. The outputs were the same or more conservative than parallel assessments based on conventional studies. The framework allows a transparent and phased introduction of NAMs in chemical safety assessment and enab...

Regulatory Toxicology and Pharmacology

Developments in the understanding of the etiology of cancer have profound implications for the wa... more Developments in the understanding of the etiology of cancer have profound implications for the way the carcinogenicity of chemicals is addressed. This paper proposes a unified theory of carcinogenesis that will illuminate better ways to evaluate and regulate chemicals. In the last four decades, we have come to understand that for a cell and a group of cells to begin the process of unrestrained growth that is defined as cancer, there must be changes in DNA that reprogram the cell from normal to abnormal. Cancer is the consequence of DNA coding errors that arise either directly from mutagenic events or indirectly from cell proliferation especially if sustained. Chemicals that act via direct interaction with DNA can induce cancer because they cause mutations which can be carried forward in dividing cells. Chemicals that act via non-genotoxic mechanisms must be dosed to maintain a proliferative environment so that the steps toward neoplasia have time to occur. Chemicals that induce increased cellular proliferation can be divided into two categories: those which act by a cellular receptor to induce cellular proliferation, and those which act via non-specific mechanisms such as cytotoxicity. This knowledge has implications for testing chemicals for carcinogenic potential and risk management.

Special Thanks to our Editors-in-Chief

CSA News, 2015

Metabolic Clearance and Production Rates of Human Growth Hormone in Subjects with Normal and Abnormal Growth

The Journal of Clinical Endocrinology & Metabolism, 1970

ABSTRACT The metabolic clearance rate (MCR) and production rate (PR) of human growth hormone (HGH... more ABSTRACT The metabolic clearance rate (MCR) and production rate (PR) of human growth hormone (HGH) was estimated bymeans of a continuous infusion of 131I-HGH. Forty-four subjects, ages 4½–60 yr, with normal and abnormal growth, participated in this investigation. A significant correlation (p <.01) was found between MCR and surface area. The MCR/m2 was similar in childhood, adolescence and adult life. The MCR/m2 in ml/min (mean ±se) in 9 normal males (112 ±5) was similar to that in 8 normal females (111 ±10). The results found in hypopituitary (109 ±8) and acromegalic (118 ±16) individuals indicate that the MCR/m2 is independent of plasma HGH concentration. The MCR of HGH was normal in patients with delayed adolescence, hyperthyroidism and gonadal dysgenesis. Reduced MCR was seen in severe hypothyroidism and in one form of primordial dwarfism. The production rate (PR) of HGH in normal patients, calculated on the basis of mean plasma hormone levels, is significantly higher than that observed in hypopituitar...

CSSA Executive Committee Meetings

Crop Science, 2003

Thanks to Our Reviewers, 2012

Crop Science, 2013

CSSA Yearly Reports

Crop Science, 2010

Inorganic solid Li ion conductors: An overview

Solid State Ionics, 2009

... Interestingly, the activation energy of the latter, which are sensitive to long-range Li tran... more ... Interestingly, the activation energy of the latter, which are sensitive to long-range Li transport parameters, is ... doping with Ga 2 S 3 and La 2 S 3 . Clearly higher Li ion conductivity than ... 0.4–0.5 eV), but these glasses are highly hygroscopic, which is problematic for lithium batteries ...

TITLE OF PAPER CENTERED, ALL CAPITALS, USE 14 POINT BOLD TIMES ROMAN FONT, TOP LINE 1 INCH (2.5 cm) BELOW UPPER MARGIN1

clra.ca

Page 1. CLRA⁄IALR Conference August 2006 General Instructions Please try and send manuscripts bef... more Page 1. CLRA⁄IALR Conference August 2006 General Instructions Please try and send manuscripts before June 15th 2006. The absolute final deadline for inclusion in the Proceedings is June 30, 2006!! Authors of accepted ...

Bronchopulmonary function: report of the Main Working Party

… & therapeutics. Part B: …, 1979

1. Pharmacol Ther B. 1979;5(1-3):149-79. Bronchopulmonary function: report of the Main Working Pa... more 1. Pharmacol Ther B. 1979;5(1-3):149-79. Bronchopulmonary function: report of the Main Working Party. Clark DG, Buch S, Doe JE, Frith H, Pullinger DH. PMID: 386365 [PubMed - indexed for MEDLINE]. Publication Types: Review. MeSH Terms. ...

Biological techniques for studying the allergenic components of nematodes. I. Detection of allergenic components in Ascaris suum extracts

Journal of Immunological …, 1972

1. Two allergen fractions A and B have been separated from a whole worm extract of Ascaris suum u... more 1. Two allergen fractions A and B have been separated from a whole worm extract of Ascaris suum using Sephadex gel filtration.2. Both fractions were active in i.

Nanocomposite polymer electrolytes and their impact on the lithium battery technology

Solid State Ionics, 2000

Enhancement of ion transport in polymer electrolytes by addition of nanoscale inorganic oxides

Lithium lanthanum titanium oxides: a fast ionic conductive coating for lithium-ion battery cathodes

Babatunde Shoyombo, a native of Nigeria, entered the United States illegally in July 1993 and fra... more Babatunde Shoyombo, a native of Nigeria, entered the United States illegally in July 1993 and fraudulently filed two asylum applications in different names in 1993 and 1995. The second application, in his own name, was denied and he was ordered deported in absentia in November 1995. Shoyombo remained in the United States and married a United States citizen. His second motion to reopen, filed while he applied for adjustment of status, was granted in February 2002. However, after the Department of Homeland Security ("DHS") discovered Shoyombo had previously filed a second asylum application, the proceedings were reopened on the Immigration Court's own motion. After a hearing, the immigration judge denied adjustment of status but granted Shoyombo's request for voluntary departure. DHS appealed the latter ruling. The BIA affirmed in a January 19, 2010, order that gave Shoyombo sixty days to leave the United States. He did not depart, instead marrying a second United States citizen on February 1, 2010. His attorney filed a new I-130 Visa Petition on March 12, 2010, but failed to file a third motion to reopen the removal proceedings and apply for adjustment of status.

United States District Court for the Southern District of Arcadia

TO: Members of the Division of Nuclear Physics, APS FROM: Benjamin F. Gibson, LANL - Secretary-Treasurer, DNP

Investigation of the Damage Tolerance of Composite Materials at Cryogenic Temperatures

NASA has the mission of providing revolutionary new tools and technology advancements for the Nat... more NASA has the mission of providing revolutionary new tools and technology advancements for the Nation's aeronautics and space needs. The goals of this mission are well-articulated in Daniel Goldin's “Three Pillars for Success.” In all three pillars (Global Civil Aviation, ...