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Papers by John Michael

Research paper thumbnail of Price and Advertising Signals of Product Quality

Journal of Political Economy, 1986

Research paper thumbnail of Argonaute2 Is the Catalytic Engine of Mammalian RNAi

Research paper thumbnail of The American Disease: Origins of Narcotic Control

American Historical Review, 1973

The word" narcotics" has usually connoted more than sim... more The word" narcotics" has usually connoted more than simply opium and its derivatives. In law and in custom" narcotics" has included the coca leaf and its active ingred. ent cocaine, and the cannabis plant, the source of marihuana and the powerful resin hashish. In this ...

Research paper thumbnail of Moderate Alcohol Intake, Increased Levels of High-Density Lipoprotein and Its Subfractions, and Decreased Risk of Myocardial Infarction

New England Journal of Medicine, 1993

Previous studies have suggested that moderate alcohol intake exerts a protective effect against c... more Previous studies have suggested that moderate alcohol intake exerts a protective effect against coronary heart disease. Alterations in plasma lipoprotein levels represent one plausible mechanism of this apparent protective effect. We therefore examined the interrelation among alcohol consumption, plasma lipoprotein levels, and the risk of myocardial infarction in 340 patients who had had myocardial infarctions and an equal number of age- and sex-matched controls. The case patients were men or women less than 76 years of age with no history of coronary disease who were discharged from one of six hospitals in the Boston area with a diagnosis of a confirmed myocardial infarction. Alcohol consumption was estimated by means of a food-frequency questionnaire. We observed a significant inverse association between alcohol consumption and the risk of myocardial infarction (P for trend, < 0.001 after control for known coronary risk factors). In multivariate analyses, the relative risk for the highest intake category (subjects who consumed three or more drinks per day) as compared with the lowest (those who had less than one drink a month) was 0.45 (95 percent confidence interval, 0.26 to 0.80). The levels of total high-density lipoprotein cholesterol (HDL) and its HDL2 and HDL3 subfractions were strongly associated with alcohol consumption (P for trend, < 0.001 for each). The addition of HDL or either of its subfractions to the multivariate model substantially reduced the inverse association between alcohol intake and myocardial infarction, whereas the addition of the other plasma lipid measurements did not materially alter the relation. These data confirm the inverse association of moderate alcohol intake with the risk of myocardial infarction and support the view that the effect is mediated, in large part, by increases in both HDL2 and HDL3.

Research paper thumbnail of Complementarities and fit strategy, structure, and organizational change in manufacturing

Journal of Accounting & Economics, 1995

Research paper thumbnail of Martingales and Arbitrage in Multiperiod Securities Markets

... EconPapers has moved to http://EconPapers.repec.org! Please update your bookmarks. Martingale... more ... EconPapers has moved to http://EconPapers.repec.org! Please update your bookmarks. Martingales and arbitrage in multiperiod securities markets. J. Michael Harrison and David M. Kreps. Journal of Economic Theory, 1979, vol. 20, issue 3, pages 381-408. ...

Research paper thumbnail of Price and Advertising Signals of Product Quality

Journal of Political Economy, 1986

Research paper thumbnail of Argonaute2 Is the Catalytic Engine of Mammalian RNAi

Research paper thumbnail of The American Disease: Origins of Narcotic Control

American Historical Review, 1973

The word" narcotics" has usually connoted more than sim... more The word" narcotics" has usually connoted more than simply opium and its derivatives. In law and in custom" narcotics" has included the coca leaf and its active ingred. ent cocaine, and the cannabis plant, the source of marihuana and the powerful resin hashish. In this ...

Research paper thumbnail of Moderate Alcohol Intake, Increased Levels of High-Density Lipoprotein and Its Subfractions, and Decreased Risk of Myocardial Infarction

New England Journal of Medicine, 1993

Previous studies have suggested that moderate alcohol intake exerts a protective effect against c... more Previous studies have suggested that moderate alcohol intake exerts a protective effect against coronary heart disease. Alterations in plasma lipoprotein levels represent one plausible mechanism of this apparent protective effect. We therefore examined the interrelation among alcohol consumption, plasma lipoprotein levels, and the risk of myocardial infarction in 340 patients who had had myocardial infarctions and an equal number of age- and sex-matched controls. The case patients were men or women less than 76 years of age with no history of coronary disease who were discharged from one of six hospitals in the Boston area with a diagnosis of a confirmed myocardial infarction. Alcohol consumption was estimated by means of a food-frequency questionnaire. We observed a significant inverse association between alcohol consumption and the risk of myocardial infarction (P for trend, < 0.001 after control for known coronary risk factors). In multivariate analyses, the relative risk for the highest intake category (subjects who consumed three or more drinks per day) as compared with the lowest (those who had less than one drink a month) was 0.45 (95 percent confidence interval, 0.26 to 0.80). The levels of total high-density lipoprotein cholesterol (HDL) and its HDL2 and HDL3 subfractions were strongly associated with alcohol consumption (P for trend, < 0.001 for each). The addition of HDL or either of its subfractions to the multivariate model substantially reduced the inverse association between alcohol intake and myocardial infarction, whereas the addition of the other plasma lipid measurements did not materially alter the relation. These data confirm the inverse association of moderate alcohol intake with the risk of myocardial infarction and support the view that the effect is mediated, in large part, by increases in both HDL2 and HDL3.

Research paper thumbnail of Complementarities and fit strategy, structure, and organizational change in manufacturing

Journal of Accounting & Economics, 1995

Research paper thumbnail of Martingales and Arbitrage in Multiperiod Securities Markets

... EconPapers has moved to http://EconPapers.repec.org! Please update your bookmarks. Martingale... more ... EconPapers has moved to http://EconPapers.repec.org! Please update your bookmarks. Martingales and arbitrage in multiperiod securities markets. J. Michael Harrison and David M. Kreps. Journal of Economic Theory, 1979, vol. 20, issue 3, pages 381-408. ...

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