John Oertle - Academia.edu (original) (raw)

Papers by John Oertle

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution... more ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License

Chronic Lyme disease complex describes the burden carried by patients infected with Borrelia burg... more Chronic Lyme disease complex describes the burden carried by patients infected with Borrelia burgdorferi as well as other co-infections or secondary co-infections (opportunistic infections). These infections can cause a significant burden on patients more so than Lyme disease alone. Along with the many underdiagnosed cases of Lyme disease throughout the world exists numer-ous undiagnosed co-infection and secondary co-infections leading to debilitating symptoms for many patients. The potential for co-infections varies by location as well as to the exposure to var-ious species of ticks. Since there is potential for patients to experience several tick bites including those of different species, additional microorganisms also commonly transmitted via tick bite are included that are typically left out of the conversation of potential Borrelia burgdorferi co-infec-tions. The most common co-infections of Lyme disease include anaplasmosis, babasiosis, barto-nellosis and ehrlichiosis. Second...

Various kinds of immunotherapy treatment for cancer are either available to the public or are in ... more Various kinds of immunotherapy treatment for cancer are either available to the public or are in the process of clinical trials. Immunotherapy treatments have the potential to treat cancer with significantly less toxicity than chemotherapy and radiation treatments. An emphasis on cellular infusion as a method of either enhancing the immune system by creating an environment for se-questering the host immune system to attack cancer cells or more directly inserting cells to di-rectly attack cancer cells will be provided in this review. Various forms of cancer vaccines are also discussed in this paper as an important aspect in immunotherapy. This review seeks to describe various methodologies associated with administering immunotherapy in the treatment of cancer.

Chronic Lyme disease is predicated by an infection with Borrelia burgdorferi via tick vector. B. ... more Chronic Lyme disease is predicated by an infection with Borrelia burgdorferi via tick vector. B. burgdorferi has been extensively researched with regard to its genome and cell biology. There are many unique characteristics to the bacteria itself; however, serological diagnostics and diagnosis based on symptoms can be complicated and potentially misleading. Other promising diagnostics were also evaluated in this review. Treatment of the chronic Lyme disease can be complicated and at times ineffective. The purpose of this review is to examine B. burgdorferi from a biological and clinical perspective.

There are several factors involved in the ability of Borrelia burgdorferi to retain a persistent ... more There are several factors involved in the ability of Borrelia burgdorferi to retain a persistent infec-tion within a mammalian host. These factors of immune evasion include regulation of membrane proteins, variable epitopes of surface proteins, protection against the immune system through tick saliva, the ability to migrate to regions where it is not exposed to the immune system or antibiotics, invagination or invasion within various cells, pleomorphic forms, and the potential to produce biofilms. The window of conventional treatment for Lyme disease is short and has the potential to display different symptoms depending on the strain of Borrelia bugdorferi. These symptoms are dependent on the localization of Borrelia burgdorferi which correlates to the significance of diag-nosing Lyme disease early to prevent such a spread throughout the body. Such complications of Borrelia burgdorferi may demand new clinical treatment discoveries for patient fighting the chron-ic form.

Advances in Infectious Diseases

Journal of Cancer Therapy, 2020

Melatonin is an established hormone supplement and has been well recognized for its effect on the... more Melatonin is an established hormone supplement and has been well recognized for its effect on the circadian cycle to improve sleep, REM (rapid eye movement), and aiding in jetlag recovery. The utility of melatonin extends beyond sleep aid, however. This hormone also possesses less well-known antioxidant action and even robust anticancer activity. Melatonin may be a key supplement for addressing age-related neurologic decline while serving as a valuable adjunctive cancer treatment that reduces drug resistance in tumors and downregulates angiogenesis. In immunotherapy, melatonin activates Natural Killer (NK) cells nested within tumoral tissue and does not have the side effect profile of other immunoreactive agents used for chemotherapy. Since melatonin is found in high concentrations in the brain and other hormone-linked tissues, the relevance of melatonin is increased for the treatment of estrogen-linked cancers. The immunomodulatory effect of melatonin may also help with chronic inf...

Advances in Infectious Diseases

Background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatm... more Background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatment. Hydroxychloroquine and azithromycin are not without cardiovascular risk or complications, and these treatments can fail to aid in full recovery from COVID-19. As new treatments become approved for the pandemic, an inexpensive, non-toxic, and safe adjunctive therapy is needed. Case Presentation: A 59-year-old male presented with respiratory symptoms. Chest X-ray revealed classic indications of COVID-19 pneumonia. A PCR nasopharyngeal swab test confirmed a COVID-19 infection and hospital doctors prescribed Rocephin, azithromycin, and hydroxychloroquine. The patient was then prescribed Quercinex, a nebulized formula of quercetin-(cyclodextrin) (20 mg/mL) and N-acetylcysteine (100 mg/mL) three times daily for 14 days by physicians at Envita Medical Center for continued COVID-19 respiratory symptoms. Following 30 minutes after each nebulization treatment, the patient experienced immediate deep breathing relief that lasted for multiple hours. Within the following 48 hours after the first treatment, respiratory symptoms continued to diminish and resolve quickly. Finally, post-treatment follow-up chest X-rays revealed no pulmonary fibrosis (scarring) and clear lung fields. Conclusion: The Quercinex formula appeared to greatly alleviate the unresolved respiratory symptoms rapidly. Several mechanisms of the formula, namely antiviral and anti-inflammatory action, with direct administration via nebulizer to the deep lung tissue, could potentially explain the fast and complete recovery. We recommend that the Quercinex formula be considered for further clinical study as an adjuvant or on its own for COVID-19 and possibly other viral pulmonary conditions.

Open Journal of Molecular and Integrative Physiology

Journal of Cellular Immunotherapy, 2016

Open Journal of Medical Microbiology, Nov 14, 2014

Open Journal of Oncology, Dec 1, 2014

Environmental carcinogens are ubiquitous but often avoidable if aware of the inherent dangers. Th... more Environmental carcinogens are ubiquitous but often avoidable if aware of the inherent dangers. These environmental carcinogens often involve synthetic derivatives of industrial byproducts in addition to solvents, heavy metals, pesticides, radioisotopes, and even carcinogenic microbes. The likelihood of being exposed to carcinogens in one’s lifetime is highly probable, especially with regard to sun exposure or even radon. Although there are far too many carcinogens to either list or explain in one review, this document contains a wide variety of well-known and lesser known carcinogens found in the environment.

Journal of Cancer Therapy, 2015

Open Journal of Medical Microbiology, 2015

Open Journal of Medical Microbiology, 2014

Journal of Cancer Therapy, 2016

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution... more ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License

Chronic Lyme disease complex describes the burden carried by patients infected with Borrelia burg... more Chronic Lyme disease complex describes the burden carried by patients infected with Borrelia burgdorferi as well as other co-infections or secondary co-infections (opportunistic infections). These infections can cause a significant burden on patients more so than Lyme disease alone. Along with the many underdiagnosed cases of Lyme disease throughout the world exists numer-ous undiagnosed co-infection and secondary co-infections leading to debilitating symptoms for many patients. The potential for co-infections varies by location as well as to the exposure to var-ious species of ticks. Since there is potential for patients to experience several tick bites including those of different species, additional microorganisms also commonly transmitted via tick bite are included that are typically left out of the conversation of potential Borrelia burgdorferi co-infec-tions. The most common co-infections of Lyme disease include anaplasmosis, babasiosis, barto-nellosis and ehrlichiosis. Second...

Various kinds of immunotherapy treatment for cancer are either available to the public or are in ... more Various kinds of immunotherapy treatment for cancer are either available to the public or are in the process of clinical trials. Immunotherapy treatments have the potential to treat cancer with significantly less toxicity than chemotherapy and radiation treatments. An emphasis on cellular infusion as a method of either enhancing the immune system by creating an environment for se-questering the host immune system to attack cancer cells or more directly inserting cells to di-rectly attack cancer cells will be provided in this review. Various forms of cancer vaccines are also discussed in this paper as an important aspect in immunotherapy. This review seeks to describe various methodologies associated with administering immunotherapy in the treatment of cancer.

Chronic Lyme disease is predicated by an infection with Borrelia burgdorferi via tick vector. B. ... more Chronic Lyme disease is predicated by an infection with Borrelia burgdorferi via tick vector. B. burgdorferi has been extensively researched with regard to its genome and cell biology. There are many unique characteristics to the bacteria itself; however, serological diagnostics and diagnosis based on symptoms can be complicated and potentially misleading. Other promising diagnostics were also evaluated in this review. Treatment of the chronic Lyme disease can be complicated and at times ineffective. The purpose of this review is to examine B. burgdorferi from a biological and clinical perspective.

There are several factors involved in the ability of Borrelia burgdorferi to retain a persistent ... more There are several factors involved in the ability of Borrelia burgdorferi to retain a persistent infec-tion within a mammalian host. These factors of immune evasion include regulation of membrane proteins, variable epitopes of surface proteins, protection against the immune system through tick saliva, the ability to migrate to regions where it is not exposed to the immune system or antibiotics, invagination or invasion within various cells, pleomorphic forms, and the potential to produce biofilms. The window of conventional treatment for Lyme disease is short and has the potential to display different symptoms depending on the strain of Borrelia bugdorferi. These symptoms are dependent on the localization of Borrelia burgdorferi which correlates to the significance of diag-nosing Lyme disease early to prevent such a spread throughout the body. Such complications of Borrelia burgdorferi may demand new clinical treatment discoveries for patient fighting the chron-ic form.

Advances in Infectious Diseases

Journal of Cancer Therapy, 2020

Melatonin is an established hormone supplement and has been well recognized for its effect on the... more Melatonin is an established hormone supplement and has been well recognized for its effect on the circadian cycle to improve sleep, REM (rapid eye movement), and aiding in jetlag recovery. The utility of melatonin extends beyond sleep aid, however. This hormone also possesses less well-known antioxidant action and even robust anticancer activity. Melatonin may be a key supplement for addressing age-related neurologic decline while serving as a valuable adjunctive cancer treatment that reduces drug resistance in tumors and downregulates angiogenesis. In immunotherapy, melatonin activates Natural Killer (NK) cells nested within tumoral tissue and does not have the side effect profile of other immunoreactive agents used for chemotherapy. Since melatonin is found in high concentrations in the brain and other hormone-linked tissues, the relevance of melatonin is increased for the treatment of estrogen-linked cancers. The immunomodulatory effect of melatonin may also help with chronic inf...

Advances in Infectious Diseases

Background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatm... more Background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatment. Hydroxychloroquine and azithromycin are not without cardiovascular risk or complications, and these treatments can fail to aid in full recovery from COVID-19. As new treatments become approved for the pandemic, an inexpensive, non-toxic, and safe adjunctive therapy is needed. Case Presentation: A 59-year-old male presented with respiratory symptoms. Chest X-ray revealed classic indications of COVID-19 pneumonia. A PCR nasopharyngeal swab test confirmed a COVID-19 infection and hospital doctors prescribed Rocephin, azithromycin, and hydroxychloroquine. The patient was then prescribed Quercinex, a nebulized formula of quercetin-(cyclodextrin) (20 mg/mL) and N-acetylcysteine (100 mg/mL) three times daily for 14 days by physicians at Envita Medical Center for continued COVID-19 respiratory symptoms. Following 30 minutes after each nebulization treatment, the patient experienced immediate deep breathing relief that lasted for multiple hours. Within the following 48 hours after the first treatment, respiratory symptoms continued to diminish and resolve quickly. Finally, post-treatment follow-up chest X-rays revealed no pulmonary fibrosis (scarring) and clear lung fields. Conclusion: The Quercinex formula appeared to greatly alleviate the unresolved respiratory symptoms rapidly. Several mechanisms of the formula, namely antiviral and anti-inflammatory action, with direct administration via nebulizer to the deep lung tissue, could potentially explain the fast and complete recovery. We recommend that the Quercinex formula be considered for further clinical study as an adjuvant or on its own for COVID-19 and possibly other viral pulmonary conditions.

Open Journal of Molecular and Integrative Physiology

Journal of Cellular Immunotherapy, 2016

Open Journal of Medical Microbiology, Nov 14, 2014

Open Journal of Oncology, Dec 1, 2014

Environmental carcinogens are ubiquitous but often avoidable if aware of the inherent dangers. Th... more Environmental carcinogens are ubiquitous but often avoidable if aware of the inherent dangers. These environmental carcinogens often involve synthetic derivatives of industrial byproducts in addition to solvents, heavy metals, pesticides, radioisotopes, and even carcinogenic microbes. The likelihood of being exposed to carcinogens in one’s lifetime is highly probable, especially with regard to sun exposure or even radon. Although there are far too many carcinogens to either list or explain in one review, this document contains a wide variety of well-known and lesser known carcinogens found in the environment.

Journal of Cancer Therapy, 2015

Open Journal of Medical Microbiology, 2015

Open Journal of Medical Microbiology, 2014

Journal of Cancer Therapy, 2016