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Papers by John Thompson

2008 IEEE International Conference on Ultra-Wideband, 2008

Conventional correlation models fail to accurately represent the correlation properties of ultraw... more Conventional correlation models fail to accurately represent the correlation properties of ultrawideband (UWB) multiple-input multiple-output (MIMO) channels. In our previous work, a framework for constructing correlated UWB MIMO channel models was proposed, where spatial correlation was introduced into both the multipath amplitude and time-ofarrival (ToA) in the channel impulse response. Based on this framework, in this paper we first present a simplified UWB MIMO channel model that represents a reasonable compromise between analytical tractability and model accuracy. We show that this model yields a structured space-frequency (SF) channel covariance matrix, making it suitable for theoretical system performance analysis. To illustrate the merit of this model, we apply it to evaluate the maximum diversity order in SF coded UWB MIMO systems. In contrast to previous work based on conventional wideband MIMO correlated channel models, we show that the maximum diversity order of a UWB MIMO system is not limited by the sum of the ranks of multipath amplitude correlation matrices.

Methods in enzymology, 2010

Helicos Single-Molecule Sequencing provides a unique view of genome biology through direct sequen... more Helicos Single-Molecule Sequencing provides a unique view of genome biology through direct sequencing of cellular and extracellular nucleic acids in an unbiased manner, providing both quantitation and sequence information. Using a simple sample preparation, involving no ligation or amplification, genomic DNA is sheared, tailed with poly-A and hybridized to the flow-cell surface containing oligo-dT for initiating sequencing-by-synthesis. RNA measurements involving direct RNA hybridization to the flow cell allows for the direct sequencing and quantitation of RNA molecules. From these methods, a diverse array of applications has now been successfully demonstrated with the Helicos Genetic Analysis System, including human genome sequencing for accurate variant detection, ChIP Seq studies involving picogram quantities of DNA obtained from small cell numbers, copy number variation studies from both fresh tumor tissue and formalin-fixed paraffin-embedded tissue and archival tissue samples, ...

Proceedings of SPE Gas Technology Symposium, 1991

·SPE Members ~yrlght 1991, Society 01 Pelroleum Engineers, Inc. :&quot;&#x27;Is p... more ·SPE Members ~yrlght 1991, Society 01 Pelroleum Engineers, Inc. :&quot;&#x27;Is paper wu prepared 10&#x27; pre.entallon allhe SPE Ga. Technology Symposium held In HOUlton, Texas, January 23-25. 1991 .,.hi. pape, wal H&#x27;eclld fo&#x27; presantatlon by an SPE Program Committee ...

APS Meeting …, 2003

Optical interferometry is a powerful tool for mapping gas and plasma distributions in supersonic ... more Optical interferometry is a powerful tool for mapping gas and plasma distributions in supersonic nozzles, plasma opening switches and other pulsed gas/plasma environments. We have developed a versatile, robust and portable interferometer to make such ...

European Journal of Biochemistry, 1996

The human and murine pregnancy-specific glycoprotein (PSG) gene families encode a large number of... more The human and murine pregnancy-specific glycoprotein (PSG) gene families encode a large number of closely related proteins which are abundantly expressed in the fetal trophoblast and secreted into the maternal circulation. Although the presence of a well conserved tripeptide sequence His or Arg-Gly-Asp or Glu or Lys (H/RGD/E/K) similar to the RGD motif found in extracellular matrix proteins hints towards a possible interaction with integrin-type receptors, the function of this group of proteins related to the carcinoembryonic antigen family is still unknown. It is also not clear whether the various members of the PSG family exert the same function. Here we describe the cloning of two splice variants of Cea4 (Ceda, Cea4b), a murine PSG family member, which lacks the RGD-related consensus motif. Cea4a, like most of the other rodent PSG members, is composed of three immunoglobulin (Ig) variable-like domains (Nl-N3) and and one Ig constant-like domain (A). In contrast, Cea4b lacks the N2 domain (NIN3A), demonstrating for the first time that PSG isoforms produced by alternative splicing also exist in mice. The mRNAs coding for Cea4a and Cea4b exhibit the same expression kinetics during placental development as found for two other murine PSGs, Cea2 and Cea3, which contain the RGD-like motif. Expression starts after day 12.5 of embryonic development (El 2.5) and maximum steady-state levels are reached around E15.5-E17.5 as determined by RNase protection analyses. At E17.5, PSG transcripts can be detected exclusively in the spongiotrophoblast of the placenta. In addition, PCR analyses revealed that Cea2, Cea3, and Cea4 transcripts are also found in RNA from a pool of embryos (E12-El5) but are absent from a number of adult tissues tested (kidney, lung, testis, ovary, liver, brain, thymus, heart, spleen). These results indicate that the various PSG isoforms exert their function(s) at the same time during placental and embryonic development.

IEEE Transactions on Vehicular Technology, 2010

Conventional multiple-input-multiple-output (MIMO) channel correlation models focus on describing... more Conventional multiple-input-multiple-output (MIMO) channel correlation models focus on describing the complex amplitude correlation of resolvable multipath components (MPCs). It has recently been shown that the time-of-arrival (ToA) correlation of resolvable MPCs, which has largely been ignored in the literature so far, is important for characterizing the space-frequency (SF) correlation of MIMO channels in the ultrawideband (UWB) regime. The proposal of ToA correlation brings forth the following open questions: What is the fundamental difference between amplitude and ToA correlations? Are they mutually replaceable? What impact do they have on system performance? Is this impact related to channel bandwidth? This paper systematically answers the above questions. We demonstrate that, compared with a conventional model that only considers amplitude correlation, a UWB MIMO channel model taking into account both amplitude and ToA correlations leads to different theoretical maximum diversity order, numerical structure of the SF channel covariance matrix, spatial correlation function, and diversity performance. We conclude that ToA correlation is a necessary complement to amplitude correlation when the channel bandwidth exceeds 500 MHz, i.e., UWB channels. This new insight serves as the motivation for more realistic modeling of UWB MIMO channels and the inspiration for designing advanced UWB MIMO systems to fully exploit the SF channel correlation properties.

Cell, 1987

Here we characterize FIS (factor for inversion stimuiation), a new cellular component of the k si... more Here we characterize FIS (factor for inversion stimuiation), a new cellular component of the k site-specific recombination pathway. This host protein binds to a specific region in the h aftP overlapping the Xis binding sites and can bind cooperatively with Xis to these sites. FIS stimulates h excision up to 20-fold in vitro in the presence of suboptimal Xis concentrations, but has no effect in the presence of saturating Xis; FIS has no effect on integrative recombination. FIS can replace one Xis molecule in a series of cooperative and competitive interactions but cannot carry out excision in the absence of Xis. FE's role in the regulation of recombination has been inferred from in vivo modification of DNA. In exponentially growing ceils the h FIS site is fully occupied, whereas in stationary-phase ceils this binding site is vacant.

AAOHN Journal, 2008

The ecological model of disaster management provides a framework to guide occupational health nur... more The ecological model of disaster management provides a framework to guide occupational health nurses who are developing disaster management programs. This ecological model assumes that disaster planning, preparedness, response, and recovery occur at various levels of the organization. These nested, increasingly complex organizational levels include individual and family, workplace, community, state, tribal, federal, and global levels. The ecological model hypothesizes that these levels interact and these dynamic interactions determine disaster planning, preparedness, response, and recovery outcomes. In addition to the features of the hazard or disaster, it is also assumed that parallel disaster planning, preparedness, and response elements, logistical challenges, and flexibility, sustainability, and rehabilitation elements occur at each level of the ecological model. Finally, the model assumes that evaluation of response and recovery efforts should inform future planning and prepare...