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Research paper thumbnail of Use of Vasopressive Amines in a Limited Resource Country

OALib

Introduction: Vasopressive amines are frequently used in cardioology. The aim of our work was to ... more Introduction: Vasopressive amines are frequently used in cardioology. The aim of our work was to evaluate the practical modalities of use of amines in the cardiology department of University Hospital Yalgado Ouedraogo. Patients and Methods: We conducted a prospective observational study for 6 months, from 01 June to 31 November 2013, including all patients treated with vasopressive amines. We were interested in the different clinical pictures, the indications, the choice of amines, and the practical application of the treatment. Results: Fifty patients were included in the study; the mean age was 58 ± 17.6. The sex ratio was 0.85. Hypertensive heart disease was the underlying cardiac disease in 34% of cases. A known chronic heart failure was observed in 62% of cases. Clinical admission tables were dominated by overall heart failure (74%). Vascular collapse (38%) and shock (36%) were the main indications of treatment. Severe alterations in left ventricular systolic function were found in 74% of cases. Dobutamine was the amine of choice (90%). The average time to start treatment was 96.32 minutes (range 15 - 660 minutes). The time to relay between syringes was more than ten minutes in 72% of the cases, and the nurses’ unavailability was the main cause. Monitoring was manual in almost all cases. The average duration of treatment was 6.64 days. Treatment-related incidents were observed in 26% of cases. The intra-hospital mortality of patients with amines was 48%. Conclusion: The indications of vasopressive amines in the cardiology department are close to the international recommendations. But this treatment suffers in its practical application. The duration of treatment remains excessive but is explained by the lack of therapeutic alternative.

Research paper thumbnail of Additional file 1 of Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Additional file 1: Fig. S1. Locations of GSTM1, GSTT1 and β-globin genes and corresponding bands ... more Additional file 1: Fig. S1. Locations of GSTM1, GSTT1 and β-globin genes and corresponding bands in electrophoresis gel. This file shows locations of GSTM1, GSTT1 and β-globin genes on chromosomes and corresponding bands. The number 1 through 19 represents individual sample and M represents Molecular weight marker. The strategy to identify presence or absence of GSTM1or GSTT1was as followed: to validate a PCR product (corresponding to a sample), we must have a band corresponding to β-globin and presence or absence of GSTM1 or GSTT1 was indicated respectively by the presence or absence of bands corresponding for each gene.

Research paper thumbnail of Additional file 2: of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

Table S2. Distribution of systolic and diastolic blood pressure according to genotypes. This file... more Table S2. Distribution of systolic and diastolic blood pressure according to genotypes. This file presents the results of association analysis between genetic polymorphisms studied and SBP or DBP in cases and controls. (DOCX 13 kb)

Research paper thumbnail of Additional file 1: of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

Table S1. Correlation between blood pressure and cardiovascular risk markers. This file shows cor... more Table S1. Correlation between blood pressure and cardiovascular risk markers. This file shows correlation between known cardiovascular risk markers such as SBP, DBP, age, BMI, WC, serum level of blood sugar, TC, HDL-c, LDL-c and Triglycerides in the general study population. (DOCX 13 kb)

Research paper thumbnail of Research Article Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa

Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the ... more Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results.The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D

Research paper thumbnail of Ampleur, aspects cliniques et paracliniques des cas de cardiomyopathie du péri-partum hospitalisés au Centre Hospitalier Universitaire Sanou Souro de Bobo-Dioulasso

La cardiomyopathie du peri-partum (CMPP) est plus frequente en Afrique. Les auteurs decrivent l’a... more La cardiomyopathie du peri-partum (CMPP) est plus frequente en Afrique. Les auteurs decrivent l’ampleur, les aspects cliniques et paracliniques de cas colliges au CHU Sanou Souro de Bobo-Dioulasso. Une etude transversale descriptive a ete realisee de septembre 2013 a decembre 2014 incluant les femmes hospitalisees dans le service de cardiologie pour une cardiomyopathie dilatee (CMD) confirmee par echocardiographie dans le peri-partum. Au total, sur 128 cas de CMD hospitalises, 27 etaient des cas de CMPP (21,09 %). La mediane d’âge etait de 29 ans [IIQ : 23-36], la gestite mediane etait de 2 [IIQ : 2-5]. La cote d’exposition a la non-scolarisation et au faible niveau socio-economique etait de 4,4. Les signes fonctionnels les plus frequents etaient la dyspnee d’effort (96,3 %), les precordialgies (48 %) et les palpitations (44,4 %). Le ventricule gauche (VG) etait dilate dans 100 % des cas et la fonction systolique VG etait alteree avec une mediane de 35,5 % [IIQ : 26-43]. La CMPP est...

Research paper thumbnail of Apport de l’épreuve d’effort dans la prise en charge des cardiopathies ischémiques

The Pan African Medical Journal, 2018

L’épreuve d’effort est un moyen diagnostic utile pour les cas de suspicion d’angor avec une faibl... more L’épreuve d’effort est un moyen diagnostic utile pour les cas de suspicion d’angor avec une faible sensibilité mais une bonne spécificité. Elle est également très utile dans l’évaluation du risque, de l’efficacité du traitement et la guidance des prescriptions médicales après contrôle des symptômes d’ischémie. L’objectif de notre travail était d’analyser l’apport de l’épreuve d’effort à la prise en charge des cardiopathies ischémiques dans le Service de Cardiologie du CHU YO. Il s’est agi d’une étude rétrospective sur 60 patients ayant bénéficié d’une épreuve d’effort de janvier 2012 à décembre 2013. L’épreuve d’effort a été réalisée sur tapis roulant selon le protocole de Bruce modifié. Soixante patients ont bénéficié d’une épreuve d’effort durant notre période d’étude. L’âge moyen des patients était de 49 ± 10,8 ans. Le sex-ratio était de 1,2. Tous les patients avaient effectué l’épreuve d’effort sur tapis roulant. Un antécédent de coronaropathie était noté chez 22 patients. La re...

Research paper thumbnail of No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population

Journal of Public Health in Africa, 2020

Recent genome-wide association studies and replication analyses have reported the association of ... more Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52;...

Research paper thumbnail of Assessment of Quality of Life in Patients with Chronic Heart Failure in Yalgado Ouédraogo University Hospital of Ouagadougou (Burkina Faso)

OALib, 2018

Objective: Our study aimed at assessing the quality of life (QoL) of patients treated for chronic... more Objective: Our study aimed at assessing the quality of life (QoL) of patients treated for chronic heart failure (HF), and analyzing the impact of certain factors on that QoL, in the cardiology department of Yalgado Ouédraogo University Hospital of Ouagadougou. Means and Method: It was a descriptive cross-sectional study, performed over a six-month period from May to October 2016. In the study, patients with age over 18 years were included, followed up for chronic HF for at least six months in the outpatient unit, from January 1 st to December 31 st 2015. The questionnaire "Minnesota Living with Heart Failure" was used to assess the QoL. Results: Two hundred and four patients were enrolled. Most of them were living in Ouagadougou (82.8%). Sex ratio was 0.98, and mean age was 56.06 + 16.37 years. The mean overall QoL score was 17.8 + 16.5. QoL was considered good in its three dimensions, in more than 70% of patients. Looking at the mean scores, the male patients, the patients living in rural and semi-urban areas, the patients with impaired left ventricular ejection fraction and those with severe or end-stage renal failure had significant QoL impairment. Multiple linear regression reported significant correlation between QoL impairment and the following factors (p value < 0.05 for all variables): marital life, number of hospitalizations for acute HF,

Research paper thumbnail of Electrocardiography of a Top Athlete in Bobo-Dioulasso, Burkina Faso

World Journal of Cardiovascular Diseases, 2019

Elite sport results in electrocardiogram changes. Some are minor, others are likely to cause sudd... more Elite sport results in electrocardiogram changes. Some are minor, others are likely to cause sudden death. The authors intended to describe the electrocardiogram features of top athletes at rest in Bobo-Dioulasso. This descriptive transversal study was carried out from August 2015 to February 2016 in the cardiology department of CHU Sanou Souro in Bobo-Dioulasso. The study sampled top athletes aged 17 to 35 with at least eight hours' training per week for more than six months regardless of the type of discipline. Two hundred top-level athletes from 4 sport disciplines were included. The median age of athletes was 24 years (IIQ: 21-27). The median duration in high level sport was 6 years (IIQ: 4-8) and the median length of weekly training sessions was 10 hours (IIQ: 10-10). Only 4% of the athletes had already conducted an Electrocardiogram (ECG). ECG abnormalities were reported in 90.5% of cases and sinus bradycardia was the most common abnormality reported in 72.5% of cases. Left ventricular and left atrial hypertrophy were reported in 44% and 34.5% of cases respectively. Early repolarization syndrome was registered in 47% of cases. Practicing top-level sport activity can result in electrical changes with athletes. These changes need to be identified by practitioners so that the can differentiate them from heart diseases.

Research paper thumbnail of Long-Term Re-Admission after Hospital Discharge in Patients Admitted with Acute Heart Failure: The Prognostic Value of the Six-Minute Walk Test Distance

OALib, 2018

Background: We sought the value of the six-minute walk test distance in predicting re-admission i... more Background: We sought the value of the six-minute walk test distance in predicting re-admission in patients with chronic heart failure (CHF) in the department of cardiology, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso. Methods: We did a prospective observational study in patients hospitalized with acute decompensated heart failure and who underwent a 6-minute walk test (6-MWT) at their discharge from hospital. The primary end-point was hospital re-admission for heart failure decompensation. Results: Sixty-one patients (52% females, mean age 46.9 ± 14.1 years, mean left ventricular ejection fraction 32.4 ± 8.2%, mean 6-MWT distance 336.3 ± 65 meters) were followed-up for a 277.6 ± 129.8 days' period. Twenty-one patients (45.3 percent person-years) were re-admitted. Re-admitted patients had shorter 6-MWT distance (p = 0.007) and were more likely to die than those who were not re-admitted (RR = 1.72, 95% CI = 1.13-2.62, p = 0.003). Multivariate Cox regression analysis showed that re-admission was independently predicted by shorter 6-MWT distance (p < 0.001), New York Heart Association class III (p = 0.03), older age p = 0.03) and lower LVEF (p = 0.02). Conclusion: Distance covered during the six-minute walk test is an independent predictor of hospital re-admission for heart failure decompensation in patients with chronic heart failure.

Research paper thumbnail of Vascular complications of infective endocarditis in Burkina Faso

Journal of Cardiovascular Medicine and Cardiology, 2018

Introduction: Vascular complications of infective endocarditis are frequent and severe. The aim o... more Introduction: Vascular complications of infective endocarditis are frequent and severe. The aim of this study was to clarify the epidemiological, clinical and prognostic characteristics of these vascular damages and determine their associated factors. Patients and methods: We performed a descriptive cross-sectional study from 1 January 2013 to 31 December 2016 on patients admitted to the cardiology department of Yalgado Ouedraogo teaching Hospital for infective endocarditis and vascular complications recorded. The diagnosis of infective endocarditis was established on the basis of modifi ed Dukef. Results: We recorded a total of 44 infective endocarditis. Vascular complications were found in 10 cases (22.7%) including 6 women and 4 men. The average age of patients was 36.7 years with extremes of 23 and 74 years. In total, seventeen vascular complications were recorded. They were dominated by neurological (7 cases) and acute limb ischemia (4 cases). The average time between the installation of the fever and the occurrence of vascular complications was 41.6 ± 6.5 days. Factors associated with embolization were reaching the mitral valve (RR = 2.5, p = 0.047), infection by Staphylococcus aureus (RR = 1.8, p = 0.022), the size of the upper vegetation 10 mm (RR = 1.8, p = 0.046), the mobility of the vegetation (RR = 1.5, p = 0.048) and late turning on appropriate antibiotics (dual antibiotic beyond 2 weeks after the start of fever) (RR = 1.4; p = 0.038). Mortality was heavy (60%) and neurological involvement was a poor prognostic factor. Conclusion: Vascular complications are frequent in infective endocarditis and are dominated by neurovascular damage. The factors associated with these complications are related to the characteristics of endocarditis. Neurological involvement is a poor prognostic factor.

Research paper thumbnail of Cardiovascular damage during lupus in black African subjects

Journal of Cardiology and Cardiovascular Medicine, 2018

Introduction: Systemic lupus is a disseminated infl ammation of the conjunctive tissue. Cardiovas... more Introduction: Systemic lupus is a disseminated infl ammation of the conjunctive tissue. Cardiovascular lesions are the fi rst cause of morbidity and mortality in the course of that disease. These lesions are prevalent in 30 to 62% of cases, depending on whether the diagnostic tool is clinical, echocardiographic, or autopsic. Any part of the heart can be affected, yielding manifestations of pericarditis, endocarditis, coronary heart disease, conduction disorders, and rarely myocarditis. Objective: Describe cardiac manifestations during the follow up of patients diagnosed with systemic lupus.

Research paper thumbnail of Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

BMC Medical Genetics, 2020

Background Glutathione S-transferases play a key role in the detoxification of persistent oxidati... more Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks factors that may be associated with many types of disease processes such as cancer, diabetes, and hypertension. In the present study, we characterize the null genotypes of GSTM1 and GSTT1 in order to investigate the association between them and the risk of developing essential hypertension. Methods We conducted a case-control study in Burkina Faso, including 245 subjects with essential hypertension as case and 269 control subjects with normal blood pressure. Presence of the GSTT1 and GSTM1 was determined using conventional multiplex polymerase chain reaction followed by gel electrophoresis analysis. Biochemical parameters were measured using chemistry analyzer CYANExpert 130. Results Chi-squared test shows that GSTT1-null (OR = 1.82; p = 0.001) and GSTM1-active/GSTT1-null genotypes (OR = 2.33; p < 0.001) were significantly higher in c...

Research paper thumbnail of Primitive pulmonary arterial hypertension revealed by recurrent ischemic strokes

Sang thrombose vaisseaux, 2017

L’hypertension arterielle pulmonaire (HTAP) precapillaire peut etre decouverte fortuitement mais ... more L’hypertension arterielle pulmonaire (HTAP) precapillaire peut etre decouverte fortuitement mais elle est souvent revelee par une dyspnee ou une insuffisance cardiaque droite. Nous rapportons un cas d’HTAP precapillaire revelee par des accidents vasculaires cerebraux ischemiques paradoxaux recidivants chez un patient de 43 ans. Le bilan a mis en evidence un foramen ovale permeable et un anevrisme du septum interauriculaire. Sous traitement conservateur, l’evolution a ete fatale en trois ans.

Research paper thumbnail of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

BMC Cardiovascular Disorders, 2019

Background: Genetic and environment play a significant role in the etiology of essential hyperten... more Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95% CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95% CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.

Research paper thumbnail of Le cœur d’athlète de haut niveau d’entraînement : résultats d’une enquête transversale menée à Bobo-Dioulasso, Burkina Faso

Annales de Cardiologie et d'Angéiologie, 2019

Annales de Cardiologie et d'Angéiologie xxx (2018) xxx-xxx Article original Le coeur d'athlète de... more Annales de Cardiologie et d'Angéiologie xxx (2018) xxx-xxx Article original Le coeur d'athlète de haut niveau d'entraînement : résultats d'une enquête transversale menée à Bobo-Dioulasso, Burkina Faso High performance athlete's heart: Results of a cross-sectional survey conducted in Bobo

Research paper thumbnail of Maternal and fetal prognosis of subsequent pregnancy in black African women with peripartum cardiomyopathy

Archives of Cardiovascular Diseases Supplements, 2019

Background: The aim of this study was to describe maternal and fetal outcomes after pregnancy com... more Background: The aim of this study was to describe maternal and fetal outcomes after pregnancy complicated by peripartum cardiomyopathy (PPCM). Methods: We included women that had subsequent pregnancy (SSP) after PPCM and assessed maternal prognosis and pregnancy outcomes, in-hospital up to one week after discharge. Clinical and echocardiographic data were collected comparing alive and deceased women. Factors associated with pregnancy outcomes were assessed. Results: Twenty-nine patients were included, with a mean age of 26.7 ± 4.6 years and a mean gravidity number of 2.3 ± 0.5 of. At the last medical control before subsequent pregnancy, there was no congestive heart failure, the mean left ventricular diastolic diameter (LVDD) was 53 ± 4 mm and the left ventricular ejection fraction (LVEF) was ≥50% in 13 cases (44.8%). Maternal outcomes were marked by 14 deaths (48.3%). Among the factors tested in univariate analysis, LVEF at admission had an excellent receiver-operating characteristic (ROC) curve to predict maternal mortality (AUC = 0.95; 95% CI 0.87-1, p < 0.001), with a cut off value of < 40% (sensitivity = 93% and specificity = 87%). Concerning fetal outcomes, baseline LVEF had the best area under the curve (AUC) to predict abortion or prematurity among all variables (AUC = 0.75; 95% CI 0.58-092, p = 0.003), with a cutoff value of < 50% (sensitivity = 79%, specificity = 67%). Conclusions: SSP outcomes are still severe in our practice. Maternal mortality remains high and is linked to ventricular systolic function at admission (due to pregnancy), while fetal outcomes are linked to baseline LVEF before pregnancy.

Research paper thumbnail of Cardiologic Medical Evacuations in Burkina Faso: Contribution of Three Philanthropic Sponsors over a 10-Year Period

OALib, 2017

Introduction: This study aimed at describing the socioeconomic , diagnostic, and progressive feat... more Introduction: This study aimed at describing the socioeconomic , diagnostic, and progressive features of patients evacuated thanks to philanthropic sponsors. Patients and methods: all evacuated patients, contacted through the phone and interviewed, were included in the study. A questionnaire helped in collecting data which were analyzed through the software Epi-Info (version 7). Outcomes: A total of 63 patients out of 134 were included in the study among which there are 22 adults and 41 children. The sex-ratio was 1.30. Patients living in Ouagadougou accounted for 79% of cases. The children's average age at evacuation was 3.58 ± 3.86 years against 27.52 ± 12.54 years for adults. Ventricular septal defects among children (58.53%) and mitral valve diseases among adults (72.72%) were the main diagnoses at the time of evacuation. The average fall was 47 months for children, and 54 months for adults in the post-operative period. 68% of adults had an income below 50,000 FCFA per month. The evacuation average cost was estimated at 21,083,000 FCFA per patient, corresponding to 2,825,122,000 FCA over 10 years. Each adult patient spent an average of 15,000 FCFA per month for the follow up, against 8725 FCFA for children. 16% of patients were lost of sight in the post-operative. Conclusion: Philanthropic sponsors significantly contribute to the management of cardiac patients, and their efforts should be supported by a better monitoring. Setting-up cardiac surgery and interventional cardiology in Burkina Faso are required to address these health shortcomings.

Research paper thumbnail of Venous thromboembolic disease in Burkina Faso: results of the prospective registry REMAVET (registry of Venous Thromboembolic)

Open Journal of Cardiology, 2017

Introduction-Objectives The objective of this work was to determine the epidemiological and clini... more Introduction-Objectives The objective of this work was to determine the epidemiological and clinical profile of patients and the causative factors of deep venous thromboembolic (DVT) diseases in Burkina Faso, using data from a prospective registry called REMAVET(registry of Thromboembolic Disease). Materials and methods REMAVET is a prospective registry collecting data on thromboembolic diseases since January 2014. We included all patients hospitalized for venous thromboembolic diseases in the cardiology department of University Hospital, from January 1, 2014 to May 31, 2015. Diagnoses were confirmed by venous Doppler ultrasound, pulmonary angiography or lung scintigraphy. Results We collected one hundred ninety-four (194) patients over a period of 17 months. Hospital prevalence in 2014 was 20.26%. The overall mean age was 49 (range 17 to 92 years) .The sex ratio was 0.76. Sixty-nine percent (69%) of patients were admitted from the emergency department. Pulmonary embolism accounted for 50.5%, thrombophlebitis for38.14% and the association pulmonary embolism-thrombophlebitis for 11.34%. The most frequently reported risk factors were physical inactivity (38.5%), obesity (33%), non-O blood type (21.1%) and pregnancy and postpartum (20.6%). In 11.85% no risk factor was identified. The average hospital stay was 12 days (range 1-4 days) .The patient mortality was 10%. Conclusion Thromboembolic diseases are increasing severe affection in Sub-Saharan Africa with multiple etiological factors.

Research paper thumbnail of Use of Vasopressive Amines in a Limited Resource Country

OALib

Introduction: Vasopressive amines are frequently used in cardioology. The aim of our work was to ... more Introduction: Vasopressive amines are frequently used in cardioology. The aim of our work was to evaluate the practical modalities of use of amines in the cardiology department of University Hospital Yalgado Ouedraogo. Patients and Methods: We conducted a prospective observational study for 6 months, from 01 June to 31 November 2013, including all patients treated with vasopressive amines. We were interested in the different clinical pictures, the indications, the choice of amines, and the practical application of the treatment. Results: Fifty patients were included in the study; the mean age was 58 ± 17.6. The sex ratio was 0.85. Hypertensive heart disease was the underlying cardiac disease in 34% of cases. A known chronic heart failure was observed in 62% of cases. Clinical admission tables were dominated by overall heart failure (74%). Vascular collapse (38%) and shock (36%) were the main indications of treatment. Severe alterations in left ventricular systolic function were found in 74% of cases. Dobutamine was the amine of choice (90%). The average time to start treatment was 96.32 minutes (range 15 - 660 minutes). The time to relay between syringes was more than ten minutes in 72% of the cases, and the nurses’ unavailability was the main cause. Monitoring was manual in almost all cases. The average duration of treatment was 6.64 days. Treatment-related incidents were observed in 26% of cases. The intra-hospital mortality of patients with amines was 48%. Conclusion: The indications of vasopressive amines in the cardiology department are close to the international recommendations. But this treatment suffers in its practical application. The duration of treatment remains excessive but is explained by the lack of therapeutic alternative.

Research paper thumbnail of Additional file 1 of Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Additional file 1: Fig. S1. Locations of GSTM1, GSTT1 and β-globin genes and corresponding bands ... more Additional file 1: Fig. S1. Locations of GSTM1, GSTT1 and β-globin genes and corresponding bands in electrophoresis gel. This file shows locations of GSTM1, GSTT1 and β-globin genes on chromosomes and corresponding bands. The number 1 through 19 represents individual sample and M represents Molecular weight marker. The strategy to identify presence or absence of GSTM1or GSTT1was as followed: to validate a PCR product (corresponding to a sample), we must have a band corresponding to β-globin and presence or absence of GSTM1 or GSTT1 was indicated respectively by the presence or absence of bands corresponding for each gene.

Research paper thumbnail of Additional file 2: of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

Table S2. Distribution of systolic and diastolic blood pressure according to genotypes. This file... more Table S2. Distribution of systolic and diastolic blood pressure according to genotypes. This file presents the results of association analysis between genetic polymorphisms studied and SBP or DBP in cases and controls. (DOCX 13 kb)

Research paper thumbnail of Additional file 1: of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

Table S1. Correlation between blood pressure and cardiovascular risk markers. This file shows cor... more Table S1. Correlation between blood pressure and cardiovascular risk markers. This file shows correlation between known cardiovascular risk markers such as SBP, DBP, age, BMI, WC, serum level of blood sugar, TC, HDL-c, LDL-c and Triglycerides in the general study population. (DOCX 13 kb)

Research paper thumbnail of Research Article Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa

Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the ... more Copyright © 2015 Daméhan Tchelougou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results.The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D

Research paper thumbnail of Ampleur, aspects cliniques et paracliniques des cas de cardiomyopathie du péri-partum hospitalisés au Centre Hospitalier Universitaire Sanou Souro de Bobo-Dioulasso

La cardiomyopathie du peri-partum (CMPP) est plus frequente en Afrique. Les auteurs decrivent l’a... more La cardiomyopathie du peri-partum (CMPP) est plus frequente en Afrique. Les auteurs decrivent l’ampleur, les aspects cliniques et paracliniques de cas colliges au CHU Sanou Souro de Bobo-Dioulasso. Une etude transversale descriptive a ete realisee de septembre 2013 a decembre 2014 incluant les femmes hospitalisees dans le service de cardiologie pour une cardiomyopathie dilatee (CMD) confirmee par echocardiographie dans le peri-partum. Au total, sur 128 cas de CMD hospitalises, 27 etaient des cas de CMPP (21,09 %). La mediane d’âge etait de 29 ans [IIQ : 23-36], la gestite mediane etait de 2 [IIQ : 2-5]. La cote d’exposition a la non-scolarisation et au faible niveau socio-economique etait de 4,4. Les signes fonctionnels les plus frequents etaient la dyspnee d’effort (96,3 %), les precordialgies (48 %) et les palpitations (44,4 %). Le ventricule gauche (VG) etait dilate dans 100 % des cas et la fonction systolique VG etait alteree avec une mediane de 35,5 % [IIQ : 26-43]. La CMPP est...

Research paper thumbnail of Apport de l’épreuve d’effort dans la prise en charge des cardiopathies ischémiques

The Pan African Medical Journal, 2018

L’épreuve d’effort est un moyen diagnostic utile pour les cas de suspicion d’angor avec une faibl... more L’épreuve d’effort est un moyen diagnostic utile pour les cas de suspicion d’angor avec une faible sensibilité mais une bonne spécificité. Elle est également très utile dans l’évaluation du risque, de l’efficacité du traitement et la guidance des prescriptions médicales après contrôle des symptômes d’ischémie. L’objectif de notre travail était d’analyser l’apport de l’épreuve d’effort à la prise en charge des cardiopathies ischémiques dans le Service de Cardiologie du CHU YO. Il s’est agi d’une étude rétrospective sur 60 patients ayant bénéficié d’une épreuve d’effort de janvier 2012 à décembre 2013. L’épreuve d’effort a été réalisée sur tapis roulant selon le protocole de Bruce modifié. Soixante patients ont bénéficié d’une épreuve d’effort durant notre période d’étude. L’âge moyen des patients était de 49 ± 10,8 ans. Le sex-ratio était de 1,2. Tous les patients avaient effectué l’épreuve d’effort sur tapis roulant. Un antécédent de coronaropathie était noté chez 22 patients. La re...

Research paper thumbnail of No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population

Journal of Public Health in Africa, 2020

Recent genome-wide association studies and replication analyses have reported the association of ... more Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52;...

Research paper thumbnail of Assessment of Quality of Life in Patients with Chronic Heart Failure in Yalgado Ouédraogo University Hospital of Ouagadougou (Burkina Faso)

OALib, 2018

Objective: Our study aimed at assessing the quality of life (QoL) of patients treated for chronic... more Objective: Our study aimed at assessing the quality of life (QoL) of patients treated for chronic heart failure (HF), and analyzing the impact of certain factors on that QoL, in the cardiology department of Yalgado Ouédraogo University Hospital of Ouagadougou. Means and Method: It was a descriptive cross-sectional study, performed over a six-month period from May to October 2016. In the study, patients with age over 18 years were included, followed up for chronic HF for at least six months in the outpatient unit, from January 1 st to December 31 st 2015. The questionnaire "Minnesota Living with Heart Failure" was used to assess the QoL. Results: Two hundred and four patients were enrolled. Most of them were living in Ouagadougou (82.8%). Sex ratio was 0.98, and mean age was 56.06 + 16.37 years. The mean overall QoL score was 17.8 + 16.5. QoL was considered good in its three dimensions, in more than 70% of patients. Looking at the mean scores, the male patients, the patients living in rural and semi-urban areas, the patients with impaired left ventricular ejection fraction and those with severe or end-stage renal failure had significant QoL impairment. Multiple linear regression reported significant correlation between QoL impairment and the following factors (p value < 0.05 for all variables): marital life, number of hospitalizations for acute HF,

Research paper thumbnail of Electrocardiography of a Top Athlete in Bobo-Dioulasso, Burkina Faso

World Journal of Cardiovascular Diseases, 2019

Elite sport results in electrocardiogram changes. Some are minor, others are likely to cause sudd... more Elite sport results in electrocardiogram changes. Some are minor, others are likely to cause sudden death. The authors intended to describe the electrocardiogram features of top athletes at rest in Bobo-Dioulasso. This descriptive transversal study was carried out from August 2015 to February 2016 in the cardiology department of CHU Sanou Souro in Bobo-Dioulasso. The study sampled top athletes aged 17 to 35 with at least eight hours' training per week for more than six months regardless of the type of discipline. Two hundred top-level athletes from 4 sport disciplines were included. The median age of athletes was 24 years (IIQ: 21-27). The median duration in high level sport was 6 years (IIQ: 4-8) and the median length of weekly training sessions was 10 hours (IIQ: 10-10). Only 4% of the athletes had already conducted an Electrocardiogram (ECG). ECG abnormalities were reported in 90.5% of cases and sinus bradycardia was the most common abnormality reported in 72.5% of cases. Left ventricular and left atrial hypertrophy were reported in 44% and 34.5% of cases respectively. Early repolarization syndrome was registered in 47% of cases. Practicing top-level sport activity can result in electrical changes with athletes. These changes need to be identified by practitioners so that the can differentiate them from heart diseases.

Research paper thumbnail of Long-Term Re-Admission after Hospital Discharge in Patients Admitted with Acute Heart Failure: The Prognostic Value of the Six-Minute Walk Test Distance

OALib, 2018

Background: We sought the value of the six-minute walk test distance in predicting re-admission i... more Background: We sought the value of the six-minute walk test distance in predicting re-admission in patients with chronic heart failure (CHF) in the department of cardiology, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso. Methods: We did a prospective observational study in patients hospitalized with acute decompensated heart failure and who underwent a 6-minute walk test (6-MWT) at their discharge from hospital. The primary end-point was hospital re-admission for heart failure decompensation. Results: Sixty-one patients (52% females, mean age 46.9 ± 14.1 years, mean left ventricular ejection fraction 32.4 ± 8.2%, mean 6-MWT distance 336.3 ± 65 meters) were followed-up for a 277.6 ± 129.8 days' period. Twenty-one patients (45.3 percent person-years) were re-admitted. Re-admitted patients had shorter 6-MWT distance (p = 0.007) and were more likely to die than those who were not re-admitted (RR = 1.72, 95% CI = 1.13-2.62, p = 0.003). Multivariate Cox regression analysis showed that re-admission was independently predicted by shorter 6-MWT distance (p < 0.001), New York Heart Association class III (p = 0.03), older age p = 0.03) and lower LVEF (p = 0.02). Conclusion: Distance covered during the six-minute walk test is an independent predictor of hospital re-admission for heart failure decompensation in patients with chronic heart failure.

Research paper thumbnail of Vascular complications of infective endocarditis in Burkina Faso

Journal of Cardiovascular Medicine and Cardiology, 2018

Introduction: Vascular complications of infective endocarditis are frequent and severe. The aim o... more Introduction: Vascular complications of infective endocarditis are frequent and severe. The aim of this study was to clarify the epidemiological, clinical and prognostic characteristics of these vascular damages and determine their associated factors. Patients and methods: We performed a descriptive cross-sectional study from 1 January 2013 to 31 December 2016 on patients admitted to the cardiology department of Yalgado Ouedraogo teaching Hospital for infective endocarditis and vascular complications recorded. The diagnosis of infective endocarditis was established on the basis of modifi ed Dukef. Results: We recorded a total of 44 infective endocarditis. Vascular complications were found in 10 cases (22.7%) including 6 women and 4 men. The average age of patients was 36.7 years with extremes of 23 and 74 years. In total, seventeen vascular complications were recorded. They were dominated by neurological (7 cases) and acute limb ischemia (4 cases). The average time between the installation of the fever and the occurrence of vascular complications was 41.6 ± 6.5 days. Factors associated with embolization were reaching the mitral valve (RR = 2.5, p = 0.047), infection by Staphylococcus aureus (RR = 1.8, p = 0.022), the size of the upper vegetation 10 mm (RR = 1.8, p = 0.046), the mobility of the vegetation (RR = 1.5, p = 0.048) and late turning on appropriate antibiotics (dual antibiotic beyond 2 weeks after the start of fever) (RR = 1.4; p = 0.038). Mortality was heavy (60%) and neurological involvement was a poor prognostic factor. Conclusion: Vascular complications are frequent in infective endocarditis and are dominated by neurovascular damage. The factors associated with these complications are related to the characteristics of endocarditis. Neurological involvement is a poor prognostic factor.

Research paper thumbnail of Cardiovascular damage during lupus in black African subjects

Journal of Cardiology and Cardiovascular Medicine, 2018

Introduction: Systemic lupus is a disseminated infl ammation of the conjunctive tissue. Cardiovas... more Introduction: Systemic lupus is a disseminated infl ammation of the conjunctive tissue. Cardiovascular lesions are the fi rst cause of morbidity and mortality in the course of that disease. These lesions are prevalent in 30 to 62% of cases, depending on whether the diagnostic tool is clinical, echocardiographic, or autopsic. Any part of the heart can be affected, yielding manifestations of pericarditis, endocarditis, coronary heart disease, conduction disorders, and rarely myocarditis. Objective: Describe cardiac manifestations during the follow up of patients diagnosed with systemic lupus.

Research paper thumbnail of Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

BMC Medical Genetics, 2020

Background Glutathione S-transferases play a key role in the detoxification of persistent oxidati... more Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks factors that may be associated with many types of disease processes such as cancer, diabetes, and hypertension. In the present study, we characterize the null genotypes of GSTM1 and GSTT1 in order to investigate the association between them and the risk of developing essential hypertension. Methods We conducted a case-control study in Burkina Faso, including 245 subjects with essential hypertension as case and 269 control subjects with normal blood pressure. Presence of the GSTT1 and GSTM1 was determined using conventional multiplex polymerase chain reaction followed by gel electrophoresis analysis. Biochemical parameters were measured using chemistry analyzer CYANExpert 130. Results Chi-squared test shows that GSTT1-null (OR = 1.82; p = 0.001) and GSTM1-active/GSTT1-null genotypes (OR = 2.33; p < 0.001) were significantly higher in c...

Research paper thumbnail of Primitive pulmonary arterial hypertension revealed by recurrent ischemic strokes

Sang thrombose vaisseaux, 2017

L’hypertension arterielle pulmonaire (HTAP) precapillaire peut etre decouverte fortuitement mais ... more L’hypertension arterielle pulmonaire (HTAP) precapillaire peut etre decouverte fortuitement mais elle est souvent revelee par une dyspnee ou une insuffisance cardiaque droite. Nous rapportons un cas d’HTAP precapillaire revelee par des accidents vasculaires cerebraux ischemiques paradoxaux recidivants chez un patient de 43 ans. Le bilan a mis en evidence un foramen ovale permeable et un anevrisme du septum interauriculaire. Sous traitement conservateur, l’evolution a ete fatale en trois ans.

Research paper thumbnail of Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa

BMC Cardiovascular Disorders, 2019

Background: Genetic and environment play a significant role in the etiology of essential hyperten... more Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95% CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95% CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.

Research paper thumbnail of Le cœur d’athlète de haut niveau d’entraînement : résultats d’une enquête transversale menée à Bobo-Dioulasso, Burkina Faso

Annales de Cardiologie et d'Angéiologie, 2019

Annales de Cardiologie et d'Angéiologie xxx (2018) xxx-xxx Article original Le coeur d'athlète de... more Annales de Cardiologie et d'Angéiologie xxx (2018) xxx-xxx Article original Le coeur d'athlète de haut niveau d'entraînement : résultats d'une enquête transversale menée à Bobo-Dioulasso, Burkina Faso High performance athlete's heart: Results of a cross-sectional survey conducted in Bobo

Research paper thumbnail of Maternal and fetal prognosis of subsequent pregnancy in black African women with peripartum cardiomyopathy

Archives of Cardiovascular Diseases Supplements, 2019

Background: The aim of this study was to describe maternal and fetal outcomes after pregnancy com... more Background: The aim of this study was to describe maternal and fetal outcomes after pregnancy complicated by peripartum cardiomyopathy (PPCM). Methods: We included women that had subsequent pregnancy (SSP) after PPCM and assessed maternal prognosis and pregnancy outcomes, in-hospital up to one week after discharge. Clinical and echocardiographic data were collected comparing alive and deceased women. Factors associated with pregnancy outcomes were assessed. Results: Twenty-nine patients were included, with a mean age of 26.7 ± 4.6 years and a mean gravidity number of 2.3 ± 0.5 of. At the last medical control before subsequent pregnancy, there was no congestive heart failure, the mean left ventricular diastolic diameter (LVDD) was 53 ± 4 mm and the left ventricular ejection fraction (LVEF) was ≥50% in 13 cases (44.8%). Maternal outcomes were marked by 14 deaths (48.3%). Among the factors tested in univariate analysis, LVEF at admission had an excellent receiver-operating characteristic (ROC) curve to predict maternal mortality (AUC = 0.95; 95% CI 0.87-1, p < 0.001), with a cut off value of < 40% (sensitivity = 93% and specificity = 87%). Concerning fetal outcomes, baseline LVEF had the best area under the curve (AUC) to predict abortion or prematurity among all variables (AUC = 0.75; 95% CI 0.58-092, p = 0.003), with a cutoff value of < 50% (sensitivity = 79%, specificity = 67%). Conclusions: SSP outcomes are still severe in our practice. Maternal mortality remains high and is linked to ventricular systolic function at admission (due to pregnancy), while fetal outcomes are linked to baseline LVEF before pregnancy.

Research paper thumbnail of Cardiologic Medical Evacuations in Burkina Faso: Contribution of Three Philanthropic Sponsors over a 10-Year Period

OALib, 2017

Introduction: This study aimed at describing the socioeconomic , diagnostic, and progressive feat... more Introduction: This study aimed at describing the socioeconomic , diagnostic, and progressive features of patients evacuated thanks to philanthropic sponsors. Patients and methods: all evacuated patients, contacted through the phone and interviewed, were included in the study. A questionnaire helped in collecting data which were analyzed through the software Epi-Info (version 7). Outcomes: A total of 63 patients out of 134 were included in the study among which there are 22 adults and 41 children. The sex-ratio was 1.30. Patients living in Ouagadougou accounted for 79% of cases. The children's average age at evacuation was 3.58 ± 3.86 years against 27.52 ± 12.54 years for adults. Ventricular septal defects among children (58.53%) and mitral valve diseases among adults (72.72%) were the main diagnoses at the time of evacuation. The average fall was 47 months for children, and 54 months for adults in the post-operative period. 68% of adults had an income below 50,000 FCFA per month. The evacuation average cost was estimated at 21,083,000 FCFA per patient, corresponding to 2,825,122,000 FCA over 10 years. Each adult patient spent an average of 15,000 FCFA per month for the follow up, against 8725 FCFA for children. 16% of patients were lost of sight in the post-operative. Conclusion: Philanthropic sponsors significantly contribute to the management of cardiac patients, and their efforts should be supported by a better monitoring. Setting-up cardiac surgery and interventional cardiology in Burkina Faso are required to address these health shortcomings.

Research paper thumbnail of Venous thromboembolic disease in Burkina Faso: results of the prospective registry REMAVET (registry of Venous Thromboembolic)

Open Journal of Cardiology, 2017

Introduction-Objectives The objective of this work was to determine the epidemiological and clini... more Introduction-Objectives The objective of this work was to determine the epidemiological and clinical profile of patients and the causative factors of deep venous thromboembolic (DVT) diseases in Burkina Faso, using data from a prospective registry called REMAVET(registry of Thromboembolic Disease). Materials and methods REMAVET is a prospective registry collecting data on thromboembolic diseases since January 2014. We included all patients hospitalized for venous thromboembolic diseases in the cardiology department of University Hospital, from January 1, 2014 to May 31, 2015. Diagnoses were confirmed by venous Doppler ultrasound, pulmonary angiography or lung scintigraphy. Results We collected one hundred ninety-four (194) patients over a period of 17 months. Hospital prevalence in 2014 was 20.26%. The overall mean age was 49 (range 17 to 92 years) .The sex ratio was 0.76. Sixty-nine percent (69%) of patients were admitted from the emergency department. Pulmonary embolism accounted for 50.5%, thrombophlebitis for38.14% and the association pulmonary embolism-thrombophlebitis for 11.34%. The most frequently reported risk factors were physical inactivity (38.5%), obesity (33%), non-O blood type (21.1%) and pregnancy and postpartum (20.6%). In 11.85% no risk factor was identified. The average hospital stay was 12 days (range 1-4 days) .The patient mortality was 10%. Conclusion Thromboembolic diseases are increasing severe affection in Sub-Saharan Africa with multiple etiological factors.