Joon Park - Academia.edu (original) (raw)

Papers by Joon Park

Journal of Functional Foods, 2021

Erythorbyl laurate (EL) can be produced via lipase-catalyzed esterification between erythorbic ac... more Erythorbyl laurate (EL) can be produced via lipase-catalyzed esterification between erythorbic acid and lauric acid. In this study, we evaluate the anti-inflammatory effect of EL in the early stage of atherosclerosis. EL suppressed tumor necrosis factor (TNF)-α-induced monocyte adhesion to vascular endothelial cells and expression of vascular cell adhesion molecule (VCAM)-1 in human umbilical vein endothelial cells (HUVECs). Additionally, EL suppressed TNF-α-induced p65/IκB kinase (IKK)/IκB phosphorylation in HUVECs. Western blot analysis of cytosolic and nuclear cell fractions and immunofluorescence showed that EL suppressed TNFα-induced translocation of p65 from the cytoplasm to the nucleus. EL also inhibited phosphorylation of extracellular-signal-regulated kinase (ERK) 1/2, p38, and c-Jun N-terminal kinases (JNK) 1/2 in HUVECs. EL suppressed TNF-α-induced phosphorylation of Akt, IRAK1, and TAK1 in HUVECs. Quantitative RT-PCR analysis showed that EL significantly suppressed TNF-α-induced interleukin (IL)1B, IL6, TNFA, and CCL2 mRNA expression in HUVECs. Additionally, oral administration of EL suppressed TNF-α-induced IL6 and TNFA expression in the mouse aorta. EL could represent a promising functional nutrient that can be ingested for the prevention of vascular inflammation via decreased monocyte infiltration to the vascular endothelium and suppression of inflammatory nuclear factor (NF)-κB and mitogen-activated protein kinases (MAPKs) signaling pathways.

Nutrition Research, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Bio-Medical Materials and Engineering, 1994

The present study has examined the efficacy of shock wave treatment to aid in the removal of bone... more The present study has examined the efficacy of shock wave treatment to aid in the removal of bone cement in human cadaver femora after femoral prosthesis implantation. The shock waves were applied to the specimens at four points, in the circumference 90° apart, at three levels. Four hundred shocks were applied at each point with intensity level of 25 k V. Extraction time of the bone cement was significantly (p < 0.002) faster in the treated versus untreated control groups. The average extraction time was decreased by 32%. Shock wave treatment also reduced the amount of residual cement inside the bone surface by an average of 55% (p < 0.006). The number of shocks needed to remove the prosthesis from bone cement also decreased significantly (p < 0.001) after shock wave treatment.

Bioscience, biotechnology, and biochemistry, 2018

Although rice bran consumption is reportedly has numerous beneficial effects on human health, the... more Although rice bran consumption is reportedly has numerous beneficial effects on human health, the relationship between rice bran and the prevention of photoaging has not been investigated in detail. We sought to investigate whether consumption of rice bran supplement (RBS) can elicit preventive effects against UVB-induced photoaging in vivo. Dorsal skin sections of hairless mice were exposed to UVB over 16 weeks. RBS consumption suppressed UVB-induced wrinkle formation and inhibited the loss of water content and epidermal thickening in the mouse skin. Western blot and immunohistochemical analyses revealed that repeated exposure to UVB upregulated matrix metalloproteinase-13 (MMP-13) and cyclooxygenase-2 (COX-2) expression, while consumption of RBS suppressed MMP-13 and COX-2 expression, as well as mitogen-activated protein kinase (MAPK) signaling pathways. These findings suggest that RBS could be a potential bioactive ingredient in nutricosmetics to inhibit wrinkle formation and wat...

Journal of Korea Planning Association, 2017

Molecular Medicine Reports, 2017

The KIPS Transactions:PartD, 2006

Volume 3: Materials Technology; Ocean Engineering; Polar and Arctic Sciences and Technology; Workshops, 2003

While most in-field technologies for structural integrity diagnosis focus on precise crack detect... more While most in-field technologies for structural integrity diagnosis focus on precise crack detection, the instrumented indentation technique has emerged as one of the most practically useful technologies for non-destructive and quantitative in-field measurement of mechanical properties. In a similar vein, here an advanced indentation technique for determining tensile properties and its application to structural integrity assessment are introduced and discussed. This novel indentation technique can enhance the accuracy of fitness-for-service (FFS) assessment by application to failure assessment diagram (FAD) construction.

The Korean Journal of Critical Care Medicine, 2010

Pulmonary actinomycosis is an indolent and slowly progressive infectious disease, accompanied by ... more Pulmonary actinomycosis is an indolent and slowly progressive infectious disease, accompanied by pleural effusion and empyema in about 50% of cases. The size of the effusion is usually small, though, and it responds to appropriate antibiotics. We report a case of rapidly progressing, severe empyema leading to respiratory failure that was caused by pulmonary actinomycosis. A 57-year-old man presented with pleuritic chest pain for 5 days. The initial plain chest radiograph and CT scan showed pleural effusion. Gross pus was observed during the thoracentesis and laboratory test of pleural effusion revealed empyema. In spite of empirical antibiotics and chest tube drainage, the empyema rapidly progressed and the patient reached respiratory failure. Mechanical ventilation applied and decortication via video-assisted thoracotomy was performed. Microscopic examination of both the pleural and adjacent lung biopsy specimen revealed actinomycosis.

Oncology Reports, 2006

The current study demonstrates that COX-2 expression is positively regulated by IFN-•, which is m... more The current study demonstrates that COX-2 expression is positively regulated by IFN-•, which is mediated by activation of STAT1 in A549 cells. The IFN-•induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-•pretreated cells. While IFN-• or COX-2 inhibitors alone did not result in growth inhibition of A549 cells, the combination of IFN-• and celecoxib or curcumin resulted in a significant growth inhibition of A549 cells, which was associated with down-regulation of CDK2, 4, and 6 and up-regulation of p27. We demonstrate that the expression of COX-2 was induced by IFN-• possibly via STAT1 activation in the A549 human non-small cell lung cancer cell line, which may partly account for its IFN-• resistance. The addition of curcumin or celecoxib to the IFN-•-pretreated A549 cells altered the IFN-• sensitivity of cell growth inhibition.

Annals of Biomedical Engineering, 2012

Mechanical stress on the intervertebral disc (IVD) may contribute significantly to IVD degenerati... more Mechanical stress on the intervertebral disc (IVD) may contribute significantly to IVD degeneration, although its pathomechanism has not been fully understood. The purpose of this study was to test the hypothesis that sustained application of static shear force would result in IVD degeneration with minimum injury. We applied shear force on the rat lumbar spine (L5-L6) using a customdesigned loading device for 1 or 2 weeks. Degenerative changes such as nucleus pulposus cavity loss and border disruption were observed from the histology sections, indicating that the application of sustained dorsoventral shear force on the L6 vertebra induced degeneration of the IVDs in L5-L6 and adjacent levels of motion segment in 1 and 2 weeks. The findings of the present study could be useful for gaining a more relevant understanding of the biomechanical load factors of IVD degeneration not only for enabling better therapeutic interventions but also reducing the risk of low back injury.

American Journal of Reproductive Immunology, 2010

Citation Kwak‐Kim J, Park JC, Ahn HK, Kim JW, Gilman‐Sachs A. Immunological modes of pregnancy lo... more Citation Kwak‐Kim J, Park JC, Ahn HK, Kim JW, Gilman‐Sachs A. Immunological modes of pregnancy loss. Am J Reprod Immunol 2010During the implantation period, a significant portion of embryos are lost and eventually less than half of clinically established pregnancies end as full‐term pregnancies without obstetrical complications. A significant portion of these pregnancy losses is associated with immune etiologies, including autoimmune and cellular immune abnormalities. Although an autoimmune etiology such as anti‐phospholipid antibodies (APAs) has been reported to induce placental infarct and thrombosis at maternal–fetal interface, APAs induce inflammatory immune responses as well. Inflammatory immune responses, such as increased proportions of NK cells and Th1/Th2 cell ratios in peripheral blood are related to recurrent pregnancy losses and multiple implantation failures. Systemic and local inflammatory immune responses seem to be induced by activation of Toll‐like receptors with in...

Composites Part A: Applied Science and Manufacturing, 1998

An expensive and time consuming aspect of a product development cycle is manufacturing the protot... more An expensive and time consuming aspect of a product development cycle is manufacturing the prototype of the design concept. The goal of current research is to devise a methodology for the rapid process development of,resin transfer molding (RTM) in order to reduce product development cycle time and lower the cost of developing composite parts. As a first step towards this goal the feasibility of an alternative rapid prototyping technique, namely laminated object manufacturing (LOM), to fabricate molds has been investigated. The durability and dimensional stability of such a mold, as well as its economic practicality in the RTM manufacturing of a composite I-beam were considered. To keep tooling and fixturing simple, vacuum pressure was used to draw'resin into the mold. However, injection at this low pressure proved difficult. To remedy the situation a high permeability layer (HPL) was incorporated into the process. The benefits and drawbacks of utilizing such a layer are also discussed in the paper. Furthermore, an RTM simulation program developed at UCLA was employed to deteumine optimum gate locations. Finally, the total hours to manufacture the first acceptable part were quantified for comparison with future studies.