Jorge Cueto - Academia.edu (original) (raw)
Papers by Jorge Cueto
International journal of radiation oncology, biology, physics, 2018
There are no curative therapies for patients with recurrent or de novo metastatic prostate cancer... more There are no curative therapies for patients with recurrent or de novo metastatic prostate cancer (1). The cornerstone of treatment for these men was androgen deprivation therapy (ADT) (2, 3) alone until 2 landmark studies demonstrated survival benefits with docetaxel in combination with ADT when given earlier to men with metastatic hormonesensitive prostate cancer (mHSPC) (4, 5). Consistent survival benefits were also seen with the addition of the oral biosynthesis inhibitor abiraterone acetate (AA) to ADT in a similar patient population (6, 7). The overall survival benefit seen with docetaxel and ADT in the CHAARTED trial (4) was only statistically significant for the highvolume cohort (visceral lesions or 4 bone lesions with 1 beyond vertebral bodies or pelvis). This cemented docetaxel and ADT as the standard of care for high-volume mHSPC, with debate regarding its role in low-volume disease. The combination of AA with ADT versus ADT alone in the LATTITUDE (6) and STAMPEDE trials (7) showed similar overall survival benefit (roughly a 40% relative risk reduction for death for men treated with ADT and AA) to the CHAARTED trial with docetaxel and ADT; yet the benefits seen with STAMPEDE also included patients with high-risk nonmetastatic nodenegative (approximately 28%), nonmetastatic nodepositive (approximately 20%), metastatic (approximately 52%), and recurrent disease (7). Thus, the use of AA has emerged as a new standard of care for mHSPC, regardless of volume of disease. Metastatic hormone-sensitive prostate cancer remains a heterogeneous disease, with the possibility that a subset of patients may exhibit an indolent behavior and potentially benefit from metastasis-directed therapy (8, 9). These patients have been defined by the terms oligometastatic (OM) or “low-volume disease.” There remains no uniform consensus definition for OM (ie, number of lesions or sites of disease). A recent consensus panel had difficulty agreeing to a standard definition, other than including patients with 5 sites of nodal or bony lesions detected on conventional imaging (10). There currently are no completed prospective randomized trials to guide therapy for OM patients after receiving local therapy, yet enthusiasm exists regarding the ability ofmetastasis-directed therapy to achieve local control and delay the need for ADT. For patients with low-volume/OM prostate cancer, we believe that ADT plus the addition of AA is the new standard of care, on the basis of overall survival benefits. Metastasis-directed therapy to nodal recurrence or bony lesions is currently not the standard of care; however, future ongoing prospective trials will clarify its role and determine whether it can improve clinical outcomes above and beyond systemic therapy alone.
ABSTRACT The emission of a neutral exciton in a symmetric semiconductor quantum dot is split by t... more ABSTRACT The emission of a neutral exciton in a symmetric semiconductor quantum dot is split by the isotropic electron-hole exchange interaction into dark and bright states. We demonstrate that for a doubly charged exciton, there are also two states split by the electron-hole exchange, but both states are now bright. We also uncover a fine structure in the emission from the triply charged exciton, the singly and doubly charged biexcitons. By measuring these splittings we can access the isotropic exchange energies for holes in the ground and electrons ground and excited states.
19 páginas, 6 figuras.-- Fecha de solicitud: 17/12/2008.-- Titular: Alcatel-Lucent Usa Inc.A meth... more 19 páginas, 6 figuras.-- Fecha de solicitud: 17/12/2008.-- Titular: Alcatel-Lucent Usa Inc.A method includes an act of providing a crystalline substrate with a diamond- type lattice and an exposed substantially (11 1)-surface. The method also includes an act of forming a graphene layer or a graphene-like layer on the exposed substantially (11 1)-surface.Peer reviewe
Cirugía Cardiovascular, 2010
18th International Conference and Exhibition on Electricity Distribution (CIRED 2005), 2005
We report the observation of a large magnetoresistance effect in the granular hybrid ferromagnet ... more We report the observation of a large magnetoresistance effect in the granular hybrid ferromagnet semiconductor system LT-GaAs:MnAs (LT=low temperature grown). We have shown earlier(P.J.Wellmann, J.M.Garcia, J.-L.Feng and P.M.Petroff, Appl.Phys.Lett. 71(17), 2532(1997)) that MnAs crystallites can be formed in LT-GaAs using Manganese ion implantation and subsequent rapid thermal annealing at 750^oC. The magnetoresistance has been studied in a vertically biased p^+-GaAs/LT-GaAs:MnAs/p^+-GaAs
Advanced Optical Materials, 2014
NanoScience and Technology, 2013
2008 Winter Simulation Conference, 2008
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](The Astronomical Journal, 1998
physica status solidi (c), 2004
ABSTRACT We review the optics of negatively charged excitons in self assembled InAs/GaAs quantum ... more ABSTRACT We review the optics of negatively charged excitons in self assembled InAs/GaAs quantum dots. The charging state of a quantum dot was tuned electrostatically in a field effect structure. We investigated in this way the neutral exciton as well as the negatively singly, doubly and triply charged excitons, namely the X0, X1–, X2– and X3– excitons. A Zeeman splitting and a diamagnetic shift in the photoluminescence emission line is clearly observed for X0, X1– and X2– exciton as a function of magnetic field. In contrast the triply negatively charged exciton shows a completely different magnetic behaviour. Here, under the influence of a high magnetic field, the quantum dot electronic states are found to be hybridized with the continuum of states in the wetting layer. Such a hybridization turns out to be induced by photon emission of the X3– exciton. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Physica E: Low-dimensional Systems and Nanostructures, 2003
Journal of Neuroimaging, 2011
Journal of Biomechanical Engineering, 1999
Articular cartilage is known to behave nonlinearly for large deformations. Mechanical properties ... more Articular cartilage is known to behave nonlinearly for large deformations. Mechanical properties derived from small strain experiments yield excessively large deformations in finite element models used in the study of severe blunt impact to joints. In this manuscript, a method is presented to determine the nonlinear elastic properties of biphasic cartilage based on a transversely isotropic hypo-elastic model. The elastic properties were estimated by fitting two force-displacement curves (in rapid loading and at equilibrium) obtained from large deformation indentation relaxation tests on cartilage using a nonporous spherical indentor. The solid skeleton of the cartilage was modeled as a transversely isotropic hypo-elastic material and a commercial finite element program was employed to solve the problem of a layer indented by a rigid sphere. Components of the hypo-elasticity tensor were made dependent on deformation according to the variations defined by a transversely isotropic hype...
Journal of Allergy and Clinical Immunology, 2003
International Journal of Rehabilitation Research, 1991
International journal of radiation oncology, biology, physics, 2018
There are no curative therapies for patients with recurrent or de novo metastatic prostate cancer... more There are no curative therapies for patients with recurrent or de novo metastatic prostate cancer (1). The cornerstone of treatment for these men was androgen deprivation therapy (ADT) (2, 3) alone until 2 landmark studies demonstrated survival benefits with docetaxel in combination with ADT when given earlier to men with metastatic hormonesensitive prostate cancer (mHSPC) (4, 5). Consistent survival benefits were also seen with the addition of the oral biosynthesis inhibitor abiraterone acetate (AA) to ADT in a similar patient population (6, 7). The overall survival benefit seen with docetaxel and ADT in the CHAARTED trial (4) was only statistically significant for the highvolume cohort (visceral lesions or 4 bone lesions with 1 beyond vertebral bodies or pelvis). This cemented docetaxel and ADT as the standard of care for high-volume mHSPC, with debate regarding its role in low-volume disease. The combination of AA with ADT versus ADT alone in the LATTITUDE (6) and STAMPEDE trials (7) showed similar overall survival benefit (roughly a 40% relative risk reduction for death for men treated with ADT and AA) to the CHAARTED trial with docetaxel and ADT; yet the benefits seen with STAMPEDE also included patients with high-risk nonmetastatic nodenegative (approximately 28%), nonmetastatic nodepositive (approximately 20%), metastatic (approximately 52%), and recurrent disease (7). Thus, the use of AA has emerged as a new standard of care for mHSPC, regardless of volume of disease. Metastatic hormone-sensitive prostate cancer remains a heterogeneous disease, with the possibility that a subset of patients may exhibit an indolent behavior and potentially benefit from metastasis-directed therapy (8, 9). These patients have been defined by the terms oligometastatic (OM) or “low-volume disease.” There remains no uniform consensus definition for OM (ie, number of lesions or sites of disease). A recent consensus panel had difficulty agreeing to a standard definition, other than including patients with 5 sites of nodal or bony lesions detected on conventional imaging (10). There currently are no completed prospective randomized trials to guide therapy for OM patients after receiving local therapy, yet enthusiasm exists regarding the ability ofmetastasis-directed therapy to achieve local control and delay the need for ADT. For patients with low-volume/OM prostate cancer, we believe that ADT plus the addition of AA is the new standard of care, on the basis of overall survival benefits. Metastasis-directed therapy to nodal recurrence or bony lesions is currently not the standard of care; however, future ongoing prospective trials will clarify its role and determine whether it can improve clinical outcomes above and beyond systemic therapy alone.
ABSTRACT The emission of a neutral exciton in a symmetric semiconductor quantum dot is split by t... more ABSTRACT The emission of a neutral exciton in a symmetric semiconductor quantum dot is split by the isotropic electron-hole exchange interaction into dark and bright states. We demonstrate that for a doubly charged exciton, there are also two states split by the electron-hole exchange, but both states are now bright. We also uncover a fine structure in the emission from the triply charged exciton, the singly and doubly charged biexcitons. By measuring these splittings we can access the isotropic exchange energies for holes in the ground and electrons ground and excited states.
19 páginas, 6 figuras.-- Fecha de solicitud: 17/12/2008.-- Titular: Alcatel-Lucent Usa Inc.A meth... more 19 páginas, 6 figuras.-- Fecha de solicitud: 17/12/2008.-- Titular: Alcatel-Lucent Usa Inc.A method includes an act of providing a crystalline substrate with a diamond- type lattice and an exposed substantially (11 1)-surface. The method also includes an act of forming a graphene layer or a graphene-like layer on the exposed substantially (11 1)-surface.Peer reviewe
Cirugía Cardiovascular, 2010
18th International Conference and Exhibition on Electricity Distribution (CIRED 2005), 2005
We report the observation of a large magnetoresistance effect in the granular hybrid ferromagnet ... more We report the observation of a large magnetoresistance effect in the granular hybrid ferromagnet semiconductor system LT-GaAs:MnAs (LT=low temperature grown). We have shown earlier(P.J.Wellmann, J.M.Garcia, J.-L.Feng and P.M.Petroff, Appl.Phys.Lett. 71(17), 2532(1997)) that MnAs crystallites can be formed in LT-GaAs using Manganese ion implantation and subsequent rapid thermal annealing at 750^oC. The magnetoresistance has been studied in a vertically biased p^+-GaAs/LT-GaAs:MnAs/p^+-GaAs
Advanced Optical Materials, 2014
NanoScience and Technology, 2013
2008 Winter Simulation Conference, 2008
The Astronomical Journal, 1998
physica status solidi (c), 2004
ABSTRACT We review the optics of negatively charged excitons in self assembled InAs/GaAs quantum ... more ABSTRACT We review the optics of negatively charged excitons in self assembled InAs/GaAs quantum dots. The charging state of a quantum dot was tuned electrostatically in a field effect structure. We investigated in this way the neutral exciton as well as the negatively singly, doubly and triply charged excitons, namely the X0, X1–, X2– and X3– excitons. A Zeeman splitting and a diamagnetic shift in the photoluminescence emission line is clearly observed for X0, X1– and X2– exciton as a function of magnetic field. In contrast the triply negatively charged exciton shows a completely different magnetic behaviour. Here, under the influence of a high magnetic field, the quantum dot electronic states are found to be hybridized with the continuum of states in the wetting layer. Such a hybridization turns out to be induced by photon emission of the X3– exciton. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Physica E: Low-dimensional Systems and Nanostructures, 2003
Journal of Neuroimaging, 2011
Journal of Biomechanical Engineering, 1999
Articular cartilage is known to behave nonlinearly for large deformations. Mechanical properties ... more Articular cartilage is known to behave nonlinearly for large deformations. Mechanical properties derived from small strain experiments yield excessively large deformations in finite element models used in the study of severe blunt impact to joints. In this manuscript, a method is presented to determine the nonlinear elastic properties of biphasic cartilage based on a transversely isotropic hypo-elastic model. The elastic properties were estimated by fitting two force-displacement curves (in rapid loading and at equilibrium) obtained from large deformation indentation relaxation tests on cartilage using a nonporous spherical indentor. The solid skeleton of the cartilage was modeled as a transversely isotropic hypo-elastic material and a commercial finite element program was employed to solve the problem of a layer indented by a rigid sphere. Components of the hypo-elasticity tensor were made dependent on deformation according to the variations defined by a transversely isotropic hype...
Journal of Allergy and Clinical Immunology, 2003
International Journal of Rehabilitation Research, 1991