Jorge Serrador - Academia.edu (original) (raw)

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Papers by Jorge Serrador

Research paper thumbnail of A new paradigm of electrical stimulation to enhance sensory neural function

The ability to improve peripheral neural transmission would have significant therapeutic potentia... more The ability to improve peripheral neural transmission would have significant therapeutic potential in medicine. A technology of this kind could be used to restore and/or enhance sensory function in individuals with depressed sensory function, such as older adults or patients with peripheral neuropathies. The goal of this study was to investigate if a new paradigm of subsensory electrical noise stimulation enhances somatosensory function. Vibration (50 Hz) was applied with a Neurothesiometer to the plantar aspect of the foot in the presence or absence of subsensory electrical noise (1/f type). The noise was applied at a proximal site, on a defined region of the tibial nerve path above the ankle. Vibration perception thresholds (VPT) of younger adults were measured in control and experimental conditions, in the absence or presence of noise respectively. An improvement of ∼16% in VPT was found in the presence of noise. These are the first data to demonstrate that modulation of axonal transmission with externally applied electrical noise improves perception of tactile stimuli in humans.

Research paper thumbnail of A new paradigm of electrical stimulation to enhance sensory neural function

Medical Engineering & Physics, 2014

The ability to improve peripheral neural transmission would have significant therapeutic potentia... more The ability to improve peripheral neural transmission would have significant therapeutic potential in medicine. A technology of this kind could be used to restore and/or enhance sensory function in individuals with depressed sensory function, such as older adults or patients with peripheral neuropathies. The goal of this study was to investigate if a new paradigm of subsensory electrical noise stimulation enhances somatosensory function. Vibration (50 Hz) was applied with a Neurothesiometer to the plantar aspect of the foot in the presence or absence of subsensory electrical noise (1/f type). The noise was applied at a proximal site, on a defined region of the tibial nerve path above the ankle. Vibration perception thresholds (VPT) of younger adults were measured in control and experimental conditions, in the absence or presence of noise respectively. An improvement of ∼16% in VPT was found in the presence of noise. These are the first data to demonstrate that modulation of axonal transmission with externally applied electrical noise improves perception of tactile stimuli in humans.

Papers from 2007 (Gearóid ÓLaighin) by Jorge Serrador

Research paper thumbnail of The effect of blood pressure calibrations and transcranial Doppler signal loss on transfer function estimates of cerebral autoregulation

There are methodological concerns with combined use of transcranial Doppler (TCD) and Finapres to... more There are methodological concerns with combined use of transcranial Doppler (TCD) and Finapres to measure dynamic cerebral autoregulation. The Finapres calibration mechanism (" physiocal ") causes interruptions to blood pressure recordings. Also, TCD is subject to signal loss due to probe movement. We assessed the effects of " physiocals " and TCD signal loss on transfer function estimates in recordings of 45 healthy subjects. We added artificial " physiocals " and removed sections of TCD signal from 5 min Finapres and TCD recordings. We also compared transfer function results from 5 min time series with time series as short as 1 min. Accurate transfer function estimates can be achieved in the 0.03–0.07 Hz band using beat-by-beat data with linear interpolation, while data loss is less than 10 s. At frequencies between 0.07 and 0.5 Hz, transfer function estimates become unreliable with 5 s of data loss every 50 s. 2 s data loss only affects frequency bands above 0.15 Hz. Finally, accurate transfer function assessment of autoregulatory function can be achieved from time series as short as 1 min, although gain and coherence tend to be overestimated at higher frequencies.

Research paper thumbnail of A new paradigm of electrical stimulation to enhance sensory neural function

The ability to improve peripheral neural transmission would have significant therapeutic potentia... more The ability to improve peripheral neural transmission would have significant therapeutic potential in medicine. A technology of this kind could be used to restore and/or enhance sensory function in individuals with depressed sensory function, such as older adults or patients with peripheral neuropathies. The goal of this study was to investigate if a new paradigm of subsensory electrical noise stimulation enhances somatosensory function. Vibration (50 Hz) was applied with a Neurothesiometer to the plantar aspect of the foot in the presence or absence of subsensory electrical noise (1/f type). The noise was applied at a proximal site, on a defined region of the tibial nerve path above the ankle. Vibration perception thresholds (VPT) of younger adults were measured in control and experimental conditions, in the absence or presence of noise respectively. An improvement of ∼16% in VPT was found in the presence of noise. These are the first data to demonstrate that modulation of axonal transmission with externally applied electrical noise improves perception of tactile stimuli in humans.

Research paper thumbnail of A new paradigm of electrical stimulation to enhance sensory neural function

Medical Engineering & Physics, 2014

The ability to improve peripheral neural transmission would have significant therapeutic potentia... more The ability to improve peripheral neural transmission would have significant therapeutic potential in medicine. A technology of this kind could be used to restore and/or enhance sensory function in individuals with depressed sensory function, such as older adults or patients with peripheral neuropathies. The goal of this study was to investigate if a new paradigm of subsensory electrical noise stimulation enhances somatosensory function. Vibration (50 Hz) was applied with a Neurothesiometer to the plantar aspect of the foot in the presence or absence of subsensory electrical noise (1/f type). The noise was applied at a proximal site, on a defined region of the tibial nerve path above the ankle. Vibration perception thresholds (VPT) of younger adults were measured in control and experimental conditions, in the absence or presence of noise respectively. An improvement of ∼16% in VPT was found in the presence of noise. These are the first data to demonstrate that modulation of axonal transmission with externally applied electrical noise improves perception of tactile stimuli in humans.

Research paper thumbnail of The effect of blood pressure calibrations and transcranial Doppler signal loss on transfer function estimates of cerebral autoregulation

There are methodological concerns with combined use of transcranial Doppler (TCD) and Finapres to... more There are methodological concerns with combined use of transcranial Doppler (TCD) and Finapres to measure dynamic cerebral autoregulation. The Finapres calibration mechanism (" physiocal ") causes interruptions to blood pressure recordings. Also, TCD is subject to signal loss due to probe movement. We assessed the effects of " physiocals " and TCD signal loss on transfer function estimates in recordings of 45 healthy subjects. We added artificial " physiocals " and removed sections of TCD signal from 5 min Finapres and TCD recordings. We also compared transfer function results from 5 min time series with time series as short as 1 min. Accurate transfer function estimates can be achieved in the 0.03–0.07 Hz band using beat-by-beat data with linear interpolation, while data loss is less than 10 s. At frequencies between 0.07 and 0.5 Hz, transfer function estimates become unreliable with 5 s of data loss every 50 s. 2 s data loss only affects frequency bands above 0.15 Hz. Finally, accurate transfer function assessment of autoregulatory function can be achieved from time series as short as 1 min, although gain and coherence tend to be overestimated at higher frequencies.