José Hernández - Academia.edu (original) (raw)
Papers by José Hernández
The Journal of Environment & Development, 2016
The adoption of good practices for the economic valuation of environmental services (ES) has stro... more The adoption of good practices for the economic valuation of environmental services (ES) has strong implications in the evaluation and design of a Payment for Environmental Services program. People’s willingness to pay for an ES is useful to evaluate whether money collected from users will be enough to cover both the providers’ opportunity costs and other costs generated by the institutional arrangements required for implementation. In this article, we use a numerical certainty scale to adjust answers to a valuation question aiming to correct for hypothetical bias associated with stated preference methods. Following this approach, the mean willingness to pay decreases by approximately 70%. Values that are more conservative could assure greater political and social support for the program because more ES users would want to participate in the program; simultaneously, however, it might suggest that the project is not completely funded.
Revista UIS Ingenierías
Offshore cranes placed on the surface of Floating Production Storage and Offloading (FPSO) vessel... more Offshore cranes placed on the surface of Floating Production Storage and Offloading (FPSO) vessels affect the structural response of their main decks, which can alter the safe operation of the FPSO vessels. Generally, classification societies rules are used to predict the structural strength of the main deck of FPSO vessels. However, these classification societies rules are limited to estimate the variation of the structural performance of the main deck caused by the operation of offshore cranes under different hydrodynamic conditions. Here, we present a methodology to determine the alteration of the structural behavior of a main deck of FPSO vessel due to different operation conditions of a board offshore crane. This methodology considers the hydrodynamic response for two ultimate limit states: operating and storm conditions from 1000 m water depth in Gulf of Mexico with a return period of 10 and 100 years, respectively. The methodology includes finite element method (FEM) models o...
Nanomaterials
Natural sources of green energy include sunshine, water, biomass, geothermal heat, and wind. Thes... more Natural sources of green energy include sunshine, water, biomass, geothermal heat, and wind. These energies are alternate forms of electrical energy that do not rely on fossil fuels. Green energy is environmentally benign, as it avoids the generation of greenhouse gases and pollutants. Various systems and equipment have been utilized to gather natural energy. However, most technologies need a huge amount of infrastructure and expensive equipment in order to power electronic gadgets, smart sensors, and wearable devices. Nanogenerators have recently emerged as an alternative technique for collecting energy from both natural and artificial sources, with significant benefits such as light weight, low-cost production, simple operation, easy signal processing, and low-cost materials. These nanogenerators might power electronic components and wearable devices used in a variety of applications such as telecommunications, the medical sector, the military and automotive industries, and intern...
2019 IEEE International Conference on Engineering Veracruz (ICEV)
When a student of naval engineering is introduced to issues related to structures of a ship, it i... more When a student of naval engineering is introduced to issues related to structures of a ship, it is difficult to understand vessel concepts. A graphical user interface (GUI) that helps visually understand the baseline of a ship depending on the pressure, the gravity and tanks level is adequate to accomplish the task with partial ease, quickly and also enjoy the learn experience. This paper describes the development of a user interface for its implementation in the naval Engineering Educational, is designed with structured and modular programming using open source software MyOpenLab©. The goal of this work is calculated longitudinal resistance of the boats, obtaining the diagrams of shear force and bending moment.
Revista UIS Ingenierías
Los buques de apoyo para plataformas de la industria petrolera tienen versatilidad de operación y... more Los buques de apoyo para plataformas de la industria petrolera tienen versatilidad de operación y capacidad de modificación estructural. Este artículo presenta una propuesta de instalación de una grúa sobre orugas sobre la cubierta principal de un buque de apoyo a plataformas petroleras, el cual realizará operaciones de mantenimiento en mar adentro. Esta propuesta incluye los resultados del análisis estructural de la cubierta principal, donde se considera el refuerzo con dos vigas NVA36. Este análisis estructural incorpora la integridad de la cubierta principal considerando la grúa y las cargas mediante modelos del método de elementos finitos (MEF). Los resultados obtenidos muestran que la cubierta principal requiere el refuerzo propuesto para disminuir las tensiones máximas de Von Mises hasta 218,71 MPa para la estructura de la cubierta principal y 201,67 MPa en las vigas de refuerzo. Estas tensiones máximas no superan las tensiones admisibles y de fluencia del material de la cubie...
Additional file 1. Additional Figures S1, S2 and Tables S1–S6.
Journal of Marine Science and Engineering, 2021
Structural failures in the barge midship sections can cause operational delay, sinking, cargo los... more Structural failures in the barge midship sections can cause operational delay, sinking, cargo loss and environmental damage. These failures can be generated by the barge and cargo weights, and wave load effects on the midships sections. These load types must be considered in the design of the barge midship sections. Here, we present the structural analysis of a barge midship section that has decreased up to 36.4% of its deck thickness caused by corrosion. This analysis is developed using finite element method (FEM) models that include the barge and cargo weights, and wave load effects. The FEM models regarded three cargo tanks in the midship section, containing the main longitudinal and transverse structural elements. In addition, the hull girder section modulus and the required deck thickness of the barge were calculated using Lloyd’s Register rules. These rules were applied to estimate the permissible bending stresses at deck and bottom plates under sagging and hogging conditions,...
El objetivo del presente trabajo es el analisis hidrodinamico de una embarcacion de tendido de du... more El objetivo del presente trabajo es el analisis hidrodinamico de una embarcacion de tendido de ductos, de tipo S. El analisis se realizo para condiciones del Golfo de Mexico, considerando un tendido bajo las condiciones de este mar. El trabajo se realizo con modelos numericos, examinando la embarcacion en diferentes puntos de la misma. De acuerdo con las caracteristicas preestablecidas, en cada uno de los puntos de analisis se valoraron rangos de velocidades de la embarcacion y diferentes angulos de incidencia.
Seminars in Arthritis and Rheumatism, 2021
BACKGROUND Adult-onset Still's disease (AOSD) is a rare inflammatory disease, typically chara... more BACKGROUND Adult-onset Still's disease (AOSD) is a rare inflammatory disease, typically characterized by spiking fever, skin rash, and arthralgia or arthritis. Its conventional treatment includes NSAIDs and corticosteroids, and DMARDs as second-line therapy. Frequently, IL-1 inhibitors are also required, mainly in patients refractory to traditional therapy. Canakinumab is a monoclonal antibody that binds IL-1β with high affinity and specificity, making it appropriate for therapeutic purposes in AOSD. OBJECTIVE The aim of this systematic review was to identify and compile the current data on the efficacy and safety of canakinumab in the treatment of AOSD. METHODS Following the guidelines established by the PRISMA statement, we searched Scopus, Web of Science, Pubmed, and Cochrane Library for relevant literature up to March 2021. The inclusion criteria comprised: randomized controlled trials, pooled analyses, observational studies, case series, and case reports. RESULTS Seventeen studies published from 2012 to 2021 were evaluated; 11 of these correspond to case series or case reports, four observational studies, one placebo-controlled phase II trial, and one analysis of pooled systemic juvenile idiopathic arthritis data. In general, out of a total of 99 patients, 68.7% of these presented a complete remission of the systemic and arthritic manifestations at the end of the observation period, while 16.2% of the patients showed a partial improvement of the symptoms and the remaining (15.1%) did not show clinical improvement or were excluded. Moreover, 210 adverse events were reported in 69 patients during canakinumab treatment, of which the majority correspond to respiratory tract infections, arthralgia, disease flares, abdominal pain, nausea, and diarrhea, whereas the most common severe adverse events included macrophage activation syndrome and serious infections. Also, a corticosteroid-sparing effect was observed in a large percentage of patients. CONCLUSION More studies with solid evidence are needed to support the efficacy of canakinumab in AOSD, although its use is encouraged by the increasing favorable results reported and the efficacy of other IL-1 inhibitors. It was also associated with an acceptable safety profile, similar to expected in IL-1 inhibitor therapy. However, future studies with well-defined endpoints are warranted to examine further the usefulness of canakinumab in AOSD.
Ingeniería Investigación y Tecnología, 2006
En este trabajo se presentan los análisis de esfuerzos y de fractura en el ánima de un cañón de 3... more En este trabajo se presentan los análisis de esfuerzos y de fractura en el ánima de un cañón de 3"/50 calibre, sometido a presión interna de 95 MPa y con dos tipos de grietas utilizando los criterios de falla de la mecánica de la fractura linealmente elástica. En todos los casos se demostró que se podían aplicar estos criterios. Para el estudio se proponen modelos geométricos en 2-D y 3-D, considerando el rayado interno del ánima, mediante el método de elemento finito (MEF) y con la ayuda de un soft ware comercial. La presencia de grietas en el modelo 2-D, registró un incremento significativo del 68.35% en los esfuerzos de Von Mises, pero sin superar el esfuerzo de fluencia del acero ASTM A723. Se determinaron los factores de intensidad de esfuerzos (FIEs) en las grietas de los modelos geométricos y se realizó un estudio de la zona plástica. Los modelos geométricos propuestos del ánima de un cañón reducen el tiempo de cómputo y son de fácil ejecución para la obtención de una aproximación aceptable de los esfuerzos y el FIE que le ocasionan grietas internas.
Journal of Translational Medicine, 2019
Background: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) a... more Background: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different clinical outcomes. DLBCL classification by immunohistochemistry (IHC)-based decision tree algorithms is a simpler reported technique than gene expression profiling (GEP). There is a significant discrepancy between IHC-decision tree algorithms when they are compared to GEP. Methods: To address these inconsistencies, we applied the machine learning approach considering the same combinations of antibodies as in IHC-decision tree algorithms. Immunohistochemistry data from a public DLBCL database was used to perform comparisons among IHC-decision tree algorithms, and the machine learning structures based on Bayesian, Bayesian simple, Naïve Bayesian, artificial neural networks, and support vector machine to show the best diagnostic model. We implemented the linear discriminant analysis over the complete database, detecting a higher influence of BCL6 antibody for GCB classification and MUM1 for non-GCB classification. Results: The classifier with the highest metrics was the four antibody-based Perfecto-Villela (PV) algorithm with 0.94 accuracy, 0.93 specificity, and 0.95 sensitivity, with a perfect agreement with GEP (κ = 0.88, P < 0.001). After training, a sample of 49 Mexican-mestizo DLBCL patient data was classified by COO for the first time in a testing trial. Conclusions: Harnessing all the available immunohistochemical data without reliance on the order of examination or cutoff value, we conclude that our PV machine learning algorithm outperforms Hans and other IHC-decision tree algorithms currently in use and represents an affordable and time-saving alternative for DLBCL cell-of-origin identification.
Molecules (Basel, Switzerland), Jan 13, 2017
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are a... more Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the Giardia adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity a...
Revista Medica Electronica, Nov 1, 2010
Se presentó un paciente que nace severamente deprimido por parto natural, a las 35,4 semanas, con... more Se presentó un paciente que nace severamente deprimido por parto natural, a las 35,4 semanas, con peso de 2 620 g. Inmediatamente se comenzaron medidas de reanimación, con bolsa, pero al no mejorar se decide intubación traqueal. Se planteó malformación de vías respiratorias por imposibilidad de lograrlo; al intentar traqueotomía, la tráquea está ausente, planteándose el diagnóstico de agenesia traqueal. A pesar de las medidas terapéuticas tomadas, el paciente fallece 8 horas después del nacimiento. En el estudio patológico se comprobó la presencia de agenesia traqueal tipo II, de acuerdo a la clasificación de Floyd.
Revista Medica Electronica, 2003
(3) (1) Especialista 1er. Grado Medicina General Integral. Clínica Municipal M.N.T. U. de Reyes. ... more (3) (1) Especialista 1er. Grado Medicina General Integral. Clínica Municipal M.N.T. U. de Reyes. (2) Especialista 2do. Grado Pediatría. Profesor Asistente. Policlínico Docente "Mártires del 13 de Marzo"Cabezas. (3) Especialista 1er. Grado Pediatría. Profesor Asistente. Máster en Medicina Natural y Tradicional.
Enfermedades infecciosas y microbiología clínica, 2002
1. Enferm Infecc Microbiol Clin. 2002 Apr;20(4):189-90. [Nosocomial infection due to Stenotrophom... more 1. Enferm Infecc Microbiol Clin. 2002 Apr;20(4):189-90. [Nosocomial infection due to Stenotrophomona maltophilia in surgically treated patients] [Article in Spanish] Padilla D, Cubo T, Romero MD, Pardo R, Martín J, Chmielewski ...
Revista Española de Geriatría y Gerontología, 2012
La mayoría de las enfermedades renales asociadas con gammaatías monoclonales resultan del depósit... more La mayoría de las enfermedades renales asociadas con gammaatías monoclonales resultan del depósito de inmunoglobulinas onoclonales o de sus fragmentos en distintos compartimentos del iñón1. La enfermedad por depósitos de inmunoglobulinas monolonales (EDIM) no amiloide se define por depósitos de cadenas igeras y/o pesadas monoclonales en membranas basales de gloérulos, túbulos y vasos2. Se conocen 3 subtipos de EDIM, la nfermedad por depósitos de cadenas ligeras (EDCL), la enfermead por depósitos de cadenas pesadas (EDCP) y la enfermedad por epósitos de cadenas ligeras y pesadas (EDCLP)3. Dentro de las DIM, la EDCL es la más prevalente4 y es la cadena kappa la que e deposita con mayor frecuencia5. Su expresión clínica se caraceriza por insuficiencia renal con proteinuria, tiene un pronóstico rave y suelen acompañarse de un mieloma múltiple u otro proeso linfoproliferativo6. A continuación describimos el caso de un nciano con una EDCL tipo lambda cuya manifestación clínica fue n síndrome nefrótico severo. Se trataba de un varón de 84 años con antecedentes personaes de hipertensión arterial sin tratamiento, estenosis del canal ervical y lumbar, coxartrosis, crisis de ausencia diagnosticada en 992 en tratamiento con lamotrigina, colelitiasis múltiple asinomática, aneurisma de aorta abdominal infrarrenal, adenoma de róstata, hiperparatiroidismo por adenoma intervenido en 2002, erniorrafia inguinal bilateral en 2005, y apendicectomizado. No enía alergias a medicamentos y era independiente para actividades ásicas de la vida diaria, sin antecedentes de deterioro cogniivo (puntuación en las escalas de Cruz Roja funcional y mental e 0/0). El paciente fue remitido por su médico de cabecera a la conulta de Nefrología por el hallazgo de una proteinuria de 3,84 g/día. iez meses antes había estado ingresado en el Servicio de Mediina Interna, por aumento de tamaño de miembro inferior derecho fue etiquetado de linfedema, recibiendo tratamiento con furoseida y heparina de bajo peso molecular. Revisada la historia de ese ngreso en el sistemático de orina ya se constató la presencia de una roteinuria. En la exploración física en la consulta externa destacaba: peso 8 kg, talla 176 cm, presión arterial 120/60 mmHg, frecuencia caríaca 68 lpm. En la auscultación cardiopulmonar presentaba un oplo sistólico i/iv localizado en foco mitroaórtico e hipoventilación n ambas bases pulmonares. Tenía edemas con fóvea en miemros inferiores, más en la extremidad derecha, siendo el resto de la xploración anodina.
Lecture Notes in Computer Science, 2011
The elderly are begining to use more and more new technologies, although several times they find ... more The elderly are begining to use more and more new technologies, although several times they find these are difficult to interact with, especially when they are accessed by a keyboard or the screen is too small. This work proposes a middleware architecture for TV-based applications for the elderly, with a focus on social interaction services like webmail. The elderly feel very confident with their TVs since it is something they use on a daily basis, and the screen is sufficiently large. The architecture contains a Context Manager with an Ontology that models the elderly user impairments and actual context information collected from sensors located at the user's home, and an Interface Adaptation Engine which generates the adapted interface for a particular user, according to his profile and context of use. This architecture is part of an ongoing EU funded project: MyUI 1 and a first prototype is expected by mid 2011.
American Journal of Analytical Chemistry, 2014
Cirugía Española, 2006
Palabras clave: Cirugía laparoscópica del páncreas. Resección laparoscópica del páncreas. Enuclea... more Palabras clave: Cirugía laparoscópica del páncreas. Resección laparoscópica del páncreas. Enucleación laparoscópica de páncreas. ANALYSIS OF THE SPANISH NATIONAL REGISTRY OF LAPAROSCOPIC PANCREATIC SURGERY Introduction. The reported experience with laparoscopic pancreatic surgery remains limited to case reports or small series of patients. A recent European multicenter study has allowed the limits and results of this technique to be known. This article presents an analysis of the results of the Spanish National Registry of Laparoscopic Pancreatic Surgery. Material and methods. A total of 132 patients with lesions in the left pancreas were included in this series. The final diagnosis included 42 neuroendocrine tumors, 40 cystic neoplasms, 24 cysts and pseudocysts, 8 inflammatory tumors, 8 ductal carcinomas, 7 intraductal papillary mucinous tumors, 1 acinar carcinoma and 2 solid pseudopapillary tumors. Results. The conversion rate was 9.7%. Tumor enucleation was performed only in patients with insulinomas. The most frequent technique was spleen-preserving distal pancreatectomy. There were no postoperative deaths. The overall rate of postoperative pancreatic-related complications was 16%. Conclusions. Although only a few Spanish hospitals participated in the registry, a greater number of hospitals are expected to enroll patients in the very near future.
The Journal of Environment & Development, 2016
The adoption of good practices for the economic valuation of environmental services (ES) has stro... more The adoption of good practices for the economic valuation of environmental services (ES) has strong implications in the evaluation and design of a Payment for Environmental Services program. People’s willingness to pay for an ES is useful to evaluate whether money collected from users will be enough to cover both the providers’ opportunity costs and other costs generated by the institutional arrangements required for implementation. In this article, we use a numerical certainty scale to adjust answers to a valuation question aiming to correct for hypothetical bias associated with stated preference methods. Following this approach, the mean willingness to pay decreases by approximately 70%. Values that are more conservative could assure greater political and social support for the program because more ES users would want to participate in the program; simultaneously, however, it might suggest that the project is not completely funded.
Revista UIS Ingenierías
Offshore cranes placed on the surface of Floating Production Storage and Offloading (FPSO) vessel... more Offshore cranes placed on the surface of Floating Production Storage and Offloading (FPSO) vessels affect the structural response of their main decks, which can alter the safe operation of the FPSO vessels. Generally, classification societies rules are used to predict the structural strength of the main deck of FPSO vessels. However, these classification societies rules are limited to estimate the variation of the structural performance of the main deck caused by the operation of offshore cranes under different hydrodynamic conditions. Here, we present a methodology to determine the alteration of the structural behavior of a main deck of FPSO vessel due to different operation conditions of a board offshore crane. This methodology considers the hydrodynamic response for two ultimate limit states: operating and storm conditions from 1000 m water depth in Gulf of Mexico with a return period of 10 and 100 years, respectively. The methodology includes finite element method (FEM) models o...
Nanomaterials
Natural sources of green energy include sunshine, water, biomass, geothermal heat, and wind. Thes... more Natural sources of green energy include sunshine, water, biomass, geothermal heat, and wind. These energies are alternate forms of electrical energy that do not rely on fossil fuels. Green energy is environmentally benign, as it avoids the generation of greenhouse gases and pollutants. Various systems and equipment have been utilized to gather natural energy. However, most technologies need a huge amount of infrastructure and expensive equipment in order to power electronic gadgets, smart sensors, and wearable devices. Nanogenerators have recently emerged as an alternative technique for collecting energy from both natural and artificial sources, with significant benefits such as light weight, low-cost production, simple operation, easy signal processing, and low-cost materials. These nanogenerators might power electronic components and wearable devices used in a variety of applications such as telecommunications, the medical sector, the military and automotive industries, and intern...
2019 IEEE International Conference on Engineering Veracruz (ICEV)
When a student of naval engineering is introduced to issues related to structures of a ship, it i... more When a student of naval engineering is introduced to issues related to structures of a ship, it is difficult to understand vessel concepts. A graphical user interface (GUI) that helps visually understand the baseline of a ship depending on the pressure, the gravity and tanks level is adequate to accomplish the task with partial ease, quickly and also enjoy the learn experience. This paper describes the development of a user interface for its implementation in the naval Engineering Educational, is designed with structured and modular programming using open source software MyOpenLab©. The goal of this work is calculated longitudinal resistance of the boats, obtaining the diagrams of shear force and bending moment.
Revista UIS Ingenierías
Los buques de apoyo para plataformas de la industria petrolera tienen versatilidad de operación y... more Los buques de apoyo para plataformas de la industria petrolera tienen versatilidad de operación y capacidad de modificación estructural. Este artículo presenta una propuesta de instalación de una grúa sobre orugas sobre la cubierta principal de un buque de apoyo a plataformas petroleras, el cual realizará operaciones de mantenimiento en mar adentro. Esta propuesta incluye los resultados del análisis estructural de la cubierta principal, donde se considera el refuerzo con dos vigas NVA36. Este análisis estructural incorpora la integridad de la cubierta principal considerando la grúa y las cargas mediante modelos del método de elementos finitos (MEF). Los resultados obtenidos muestran que la cubierta principal requiere el refuerzo propuesto para disminuir las tensiones máximas de Von Mises hasta 218,71 MPa para la estructura de la cubierta principal y 201,67 MPa en las vigas de refuerzo. Estas tensiones máximas no superan las tensiones admisibles y de fluencia del material de la cubie...
Additional file 1. Additional Figures S1, S2 and Tables S1–S6.
Journal of Marine Science and Engineering, 2021
Structural failures in the barge midship sections can cause operational delay, sinking, cargo los... more Structural failures in the barge midship sections can cause operational delay, sinking, cargo loss and environmental damage. These failures can be generated by the barge and cargo weights, and wave load effects on the midships sections. These load types must be considered in the design of the barge midship sections. Here, we present the structural analysis of a barge midship section that has decreased up to 36.4% of its deck thickness caused by corrosion. This analysis is developed using finite element method (FEM) models that include the barge and cargo weights, and wave load effects. The FEM models regarded three cargo tanks in the midship section, containing the main longitudinal and transverse structural elements. In addition, the hull girder section modulus and the required deck thickness of the barge were calculated using Lloyd’s Register rules. These rules were applied to estimate the permissible bending stresses at deck and bottom plates under sagging and hogging conditions,...
El objetivo del presente trabajo es el analisis hidrodinamico de una embarcacion de tendido de du... more El objetivo del presente trabajo es el analisis hidrodinamico de una embarcacion de tendido de ductos, de tipo S. El analisis se realizo para condiciones del Golfo de Mexico, considerando un tendido bajo las condiciones de este mar. El trabajo se realizo con modelos numericos, examinando la embarcacion en diferentes puntos de la misma. De acuerdo con las caracteristicas preestablecidas, en cada uno de los puntos de analisis se valoraron rangos de velocidades de la embarcacion y diferentes angulos de incidencia.
Seminars in Arthritis and Rheumatism, 2021
BACKGROUND Adult-onset Still's disease (AOSD) is a rare inflammatory disease, typically chara... more BACKGROUND Adult-onset Still's disease (AOSD) is a rare inflammatory disease, typically characterized by spiking fever, skin rash, and arthralgia or arthritis. Its conventional treatment includes NSAIDs and corticosteroids, and DMARDs as second-line therapy. Frequently, IL-1 inhibitors are also required, mainly in patients refractory to traditional therapy. Canakinumab is a monoclonal antibody that binds IL-1β with high affinity and specificity, making it appropriate for therapeutic purposes in AOSD. OBJECTIVE The aim of this systematic review was to identify and compile the current data on the efficacy and safety of canakinumab in the treatment of AOSD. METHODS Following the guidelines established by the PRISMA statement, we searched Scopus, Web of Science, Pubmed, and Cochrane Library for relevant literature up to March 2021. The inclusion criteria comprised: randomized controlled trials, pooled analyses, observational studies, case series, and case reports. RESULTS Seventeen studies published from 2012 to 2021 were evaluated; 11 of these correspond to case series or case reports, four observational studies, one placebo-controlled phase II trial, and one analysis of pooled systemic juvenile idiopathic arthritis data. In general, out of a total of 99 patients, 68.7% of these presented a complete remission of the systemic and arthritic manifestations at the end of the observation period, while 16.2% of the patients showed a partial improvement of the symptoms and the remaining (15.1%) did not show clinical improvement or were excluded. Moreover, 210 adverse events were reported in 69 patients during canakinumab treatment, of which the majority correspond to respiratory tract infections, arthralgia, disease flares, abdominal pain, nausea, and diarrhea, whereas the most common severe adverse events included macrophage activation syndrome and serious infections. Also, a corticosteroid-sparing effect was observed in a large percentage of patients. CONCLUSION More studies with solid evidence are needed to support the efficacy of canakinumab in AOSD, although its use is encouraged by the increasing favorable results reported and the efficacy of other IL-1 inhibitors. It was also associated with an acceptable safety profile, similar to expected in IL-1 inhibitor therapy. However, future studies with well-defined endpoints are warranted to examine further the usefulness of canakinumab in AOSD.
Ingeniería Investigación y Tecnología, 2006
En este trabajo se presentan los análisis de esfuerzos y de fractura en el ánima de un cañón de 3... more En este trabajo se presentan los análisis de esfuerzos y de fractura en el ánima de un cañón de 3"/50 calibre, sometido a presión interna de 95 MPa y con dos tipos de grietas utilizando los criterios de falla de la mecánica de la fractura linealmente elástica. En todos los casos se demostró que se podían aplicar estos criterios. Para el estudio se proponen modelos geométricos en 2-D y 3-D, considerando el rayado interno del ánima, mediante el método de elemento finito (MEF) y con la ayuda de un soft ware comercial. La presencia de grietas en el modelo 2-D, registró un incremento significativo del 68.35% en los esfuerzos de Von Mises, pero sin superar el esfuerzo de fluencia del acero ASTM A723. Se determinaron los factores de intensidad de esfuerzos (FIEs) en las grietas de los modelos geométricos y se realizó un estudio de la zona plástica. Los modelos geométricos propuestos del ánima de un cañón reducen el tiempo de cómputo y son de fácil ejecución para la obtención de una aproximación aceptable de los esfuerzos y el FIE que le ocasionan grietas internas.
Journal of Translational Medicine, 2019
Background: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) a... more Background: Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different clinical outcomes. DLBCL classification by immunohistochemistry (IHC)-based decision tree algorithms is a simpler reported technique than gene expression profiling (GEP). There is a significant discrepancy between IHC-decision tree algorithms when they are compared to GEP. Methods: To address these inconsistencies, we applied the machine learning approach considering the same combinations of antibodies as in IHC-decision tree algorithms. Immunohistochemistry data from a public DLBCL database was used to perform comparisons among IHC-decision tree algorithms, and the machine learning structures based on Bayesian, Bayesian simple, Naïve Bayesian, artificial neural networks, and support vector machine to show the best diagnostic model. We implemented the linear discriminant analysis over the complete database, detecting a higher influence of BCL6 antibody for GCB classification and MUM1 for non-GCB classification. Results: The classifier with the highest metrics was the four antibody-based Perfecto-Villela (PV) algorithm with 0.94 accuracy, 0.93 specificity, and 0.95 sensitivity, with a perfect agreement with GEP (κ = 0.88, P < 0.001). After training, a sample of 49 Mexican-mestizo DLBCL patient data was classified by COO for the first time in a testing trial. Conclusions: Harnessing all the available immunohistochemical data without reliance on the order of examination or cutoff value, we conclude that our PV machine learning algorithm outperforms Hans and other IHC-decision tree algorithms currently in use and represents an affordable and time-saving alternative for DLBCL cell-of-origin identification.
Molecules (Basel, Switzerland), Jan 13, 2017
Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are a... more Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5'-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the Giardia adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity a...
Revista Medica Electronica, Nov 1, 2010
Se presentó un paciente que nace severamente deprimido por parto natural, a las 35,4 semanas, con... more Se presentó un paciente que nace severamente deprimido por parto natural, a las 35,4 semanas, con peso de 2 620 g. Inmediatamente se comenzaron medidas de reanimación, con bolsa, pero al no mejorar se decide intubación traqueal. Se planteó malformación de vías respiratorias por imposibilidad de lograrlo; al intentar traqueotomía, la tráquea está ausente, planteándose el diagnóstico de agenesia traqueal. A pesar de las medidas terapéuticas tomadas, el paciente fallece 8 horas después del nacimiento. En el estudio patológico se comprobó la presencia de agenesia traqueal tipo II, de acuerdo a la clasificación de Floyd.
Revista Medica Electronica, 2003
(3) (1) Especialista 1er. Grado Medicina General Integral. Clínica Municipal M.N.T. U. de Reyes. ... more (3) (1) Especialista 1er. Grado Medicina General Integral. Clínica Municipal M.N.T. U. de Reyes. (2) Especialista 2do. Grado Pediatría. Profesor Asistente. Policlínico Docente "Mártires del 13 de Marzo"Cabezas. (3) Especialista 1er. Grado Pediatría. Profesor Asistente. Máster en Medicina Natural y Tradicional.
Enfermedades infecciosas y microbiología clínica, 2002
1. Enferm Infecc Microbiol Clin. 2002 Apr;20(4):189-90. [Nosocomial infection due to Stenotrophom... more 1. Enferm Infecc Microbiol Clin. 2002 Apr;20(4):189-90. [Nosocomial infection due to Stenotrophomona maltophilia in surgically treated patients] [Article in Spanish] Padilla D, Cubo T, Romero MD, Pardo R, Martín J, Chmielewski ...
Revista Española de Geriatría y Gerontología, 2012
La mayoría de las enfermedades renales asociadas con gammaatías monoclonales resultan del depósit... more La mayoría de las enfermedades renales asociadas con gammaatías monoclonales resultan del depósito de inmunoglobulinas onoclonales o de sus fragmentos en distintos compartimentos del iñón1. La enfermedad por depósitos de inmunoglobulinas monolonales (EDIM) no amiloide se define por depósitos de cadenas igeras y/o pesadas monoclonales en membranas basales de gloérulos, túbulos y vasos2. Se conocen 3 subtipos de EDIM, la nfermedad por depósitos de cadenas ligeras (EDCL), la enfermead por depósitos de cadenas pesadas (EDCP) y la enfermedad por epósitos de cadenas ligeras y pesadas (EDCLP)3. Dentro de las DIM, la EDCL es la más prevalente4 y es la cadena kappa la que e deposita con mayor frecuencia5. Su expresión clínica se caraceriza por insuficiencia renal con proteinuria, tiene un pronóstico rave y suelen acompañarse de un mieloma múltiple u otro proeso linfoproliferativo6. A continuación describimos el caso de un nciano con una EDCL tipo lambda cuya manifestación clínica fue n síndrome nefrótico severo. Se trataba de un varón de 84 años con antecedentes personaes de hipertensión arterial sin tratamiento, estenosis del canal ervical y lumbar, coxartrosis, crisis de ausencia diagnosticada en 992 en tratamiento con lamotrigina, colelitiasis múltiple asinomática, aneurisma de aorta abdominal infrarrenal, adenoma de róstata, hiperparatiroidismo por adenoma intervenido en 2002, erniorrafia inguinal bilateral en 2005, y apendicectomizado. No enía alergias a medicamentos y era independiente para actividades ásicas de la vida diaria, sin antecedentes de deterioro cogniivo (puntuación en las escalas de Cruz Roja funcional y mental e 0/0). El paciente fue remitido por su médico de cabecera a la conulta de Nefrología por el hallazgo de una proteinuria de 3,84 g/día. iez meses antes había estado ingresado en el Servicio de Mediina Interna, por aumento de tamaño de miembro inferior derecho fue etiquetado de linfedema, recibiendo tratamiento con furoseida y heparina de bajo peso molecular. Revisada la historia de ese ngreso en el sistemático de orina ya se constató la presencia de una roteinuria. En la exploración física en la consulta externa destacaba: peso 8 kg, talla 176 cm, presión arterial 120/60 mmHg, frecuencia caríaca 68 lpm. En la auscultación cardiopulmonar presentaba un oplo sistólico i/iv localizado en foco mitroaórtico e hipoventilación n ambas bases pulmonares. Tenía edemas con fóvea en miemros inferiores, más en la extremidad derecha, siendo el resto de la xploración anodina.
Lecture Notes in Computer Science, 2011
The elderly are begining to use more and more new technologies, although several times they find ... more The elderly are begining to use more and more new technologies, although several times they find these are difficult to interact with, especially when they are accessed by a keyboard or the screen is too small. This work proposes a middleware architecture for TV-based applications for the elderly, with a focus on social interaction services like webmail. The elderly feel very confident with their TVs since it is something they use on a daily basis, and the screen is sufficiently large. The architecture contains a Context Manager with an Ontology that models the elderly user impairments and actual context information collected from sensors located at the user's home, and an Interface Adaptation Engine which generates the adapted interface for a particular user, according to his profile and context of use. This architecture is part of an ongoing EU funded project: MyUI 1 and a first prototype is expected by mid 2011.
American Journal of Analytical Chemistry, 2014
Cirugía Española, 2006
Palabras clave: Cirugía laparoscópica del páncreas. Resección laparoscópica del páncreas. Enuclea... more Palabras clave: Cirugía laparoscópica del páncreas. Resección laparoscópica del páncreas. Enucleación laparoscópica de páncreas. ANALYSIS OF THE SPANISH NATIONAL REGISTRY OF LAPAROSCOPIC PANCREATIC SURGERY Introduction. The reported experience with laparoscopic pancreatic surgery remains limited to case reports or small series of patients. A recent European multicenter study has allowed the limits and results of this technique to be known. This article presents an analysis of the results of the Spanish National Registry of Laparoscopic Pancreatic Surgery. Material and methods. A total of 132 patients with lesions in the left pancreas were included in this series. The final diagnosis included 42 neuroendocrine tumors, 40 cystic neoplasms, 24 cysts and pseudocysts, 8 inflammatory tumors, 8 ductal carcinomas, 7 intraductal papillary mucinous tumors, 1 acinar carcinoma and 2 solid pseudopapillary tumors. Results. The conversion rate was 9.7%. Tumor enucleation was performed only in patients with insulinomas. The most frequent technique was spleen-preserving distal pancreatectomy. There were no postoperative deaths. The overall rate of postoperative pancreatic-related complications was 16%. Conclusions. Although only a few Spanish hospitals participated in the registry, a greater number of hospitals are expected to enroll patients in the very near future.