José Wilson Carvalho de Mesquita (original) (raw)
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Papers by José Wilson Carvalho de Mesquita
In tropical countries, arboviruses are public health threats, especially those transmitted by Aed... more In tropical countries, arboviruses are public health threats, especially those transmitted by Aedes aegypti mosquitoes. The prevention of such diseases is based on vector control. However, the compounds currently used have disadvantages such toxicity to humans and environment, so larvicide plants is a promising alternative. The purpose of this study is to determine the best season to harvest aerial parts of Mesosphaerum suaveolens (L.) Kuntze to obtain its essential oil, and evaluate the effects of seasons on chemical composition, larvicidal activity against A. aegypti, and toxicology against Artemia salina and Danio rerio using such essential oils and its major compounds. The gas chromatography–mass spectrometry analysis of essential oil samples performed at different times during a year, showed qualitative and quantitative variation in the chemical composition. 1,8-Cineole is the major compound in all seasons. The dry season had a higher yield. The essential oils showed activity a...
Frontiers in pharmacology, 2017
Borreria verticillata (L.) G. Mey. known vassourinha has antibacterial, antimalarial, hepatoprote... more Borreria verticillata (L.) G. Mey. known vassourinha has antibacterial, antimalarial, hepatoprotective, antioxidative, analgesic, and anti-inflammatory, however, its antinociceptive action requires further studies. Aim of the study evaluated the antinociceptive activity of B. verticillata hydroalcoholic extract (EHBv) and ethyl acetate fraction (FAc) by in vivo and in silico studies. In vivo assessment included the paw edema test, writhing test, formalin test and tail flick test. Wistar rats and Swiss mice were divided into 6 groups and given the following treatments oral: 0.9% NaCl control group (CTRL), 10 mg/kg memantine (MEM), 10 mg/kg indomethacin (INDO), 500 mg/kg EHBv (EHBv 500), 25 mg/kg FAc (FAc 25) and 50 mg/kg FAc (FAc 50). EHBv, FAc 25 and 50 treatments exhibited anti-edematous and peripheral antinociceptive effects. For in silico assessment, compounds identified in FAc were subjected to molecular docking with COX-2, GluN1a and GluN2B. Ursolic acid (UA) was the compound w...
Pharmaceuticals, 2019
Essential oil from the leaves of Artemisia vulgaris L. (Compositae) cultivated in Brazil was inve... more Essential oil from the leaves of Artemisia vulgaris L. (Compositae) cultivated in Brazil was investigated for its chemical composition and biological activities including antibacterial, antifungal, and anthelmintic. The constituents of essential oils isolated by hydro-distillation were examined by GC-MS and a total of 18 components were identified. The essential oil was dominated by oxygenated sesquiterpenes (44.4%), sesquiterpene hydrocarbons (33.3%), and oxygenated monoterpenes (16.6%). Caryophyllene (37.45%), germacrene D (16.17%), and humulene (13.66%) were the major components. The essential oils from A. vulgaris showed bactericidal and fungicidal properties against Staphylococcus aureus and Candida albicans, respectively. Anthelmintic activity against Haemonchus contortus was absent in this essential oil. Altogether above results indicate that essential oils from A. vulgaris can be used for various medicinal purposes.
Passiflora edulis Sims (Passifloraceae) is a widely distributed species ranging from tropical and... more Passiflora edulis Sims (Passifloraceae) is a widely distributed species ranging from tropical and sub-tropical regions of the world. It has been commonly used as a food and possesses various medicinal properties. This research aims to see the effect of different extraction methods and drug/solvent ratio on phenolics and flavonoids content as well as the antioxidant capacity in P. edulis leaves. The powdered leaves of P. edulis were extracted with hydroalcoholic solution employing maceration, percolation and Sohxlet extraction and three drug/solvent ratios (1:8, 1:10; 1:12). The total phenolics and flavonoids contents of different extracts were determined by Folin-Ciocalteu and colorimetric AlCl3 methods, respectively. Antioxidant activity was investigated by using in vitro DPPH and FRAP assays. Flavonoids were identified by LC-MS/MS on the basis of mass spectral analysis. The highest content of phenolics (16.30%), flavonoids (3.88%) and antioxidant activity (DPPH IC50 84.23 μg ml -1...
Food research international (Ottawa, Ont.), 2018
Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which ... more Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. vulgaris has a long history in treatment of human ailments by medicinal plants in various parts of the world. This medicinal plant possesses a broad spectrum of therapeutic properties including: anti-malarial, anti-inflammatory, anti-hypertensive, anti-oxidant, anti-tumoral, immunomodulatory, hepatoprotective, anti-spasmodic and anti-septic. These activities are mainly attributed to the presence of various classes of secondary metabolites, including flavonoids, sesquiterpene lactones, coumarins, acetylenes, phenolic acids, organic acids, mono- and sesquiterpenes. Studies related to A. vulgaris morphology, anatomy and phytochemistry has gained a significant in...
Industrial Crops and Products
Food Reviews International
In tropical countries, arboviruses are public health threats, especially those transmitted by Aed... more In tropical countries, arboviruses are public health threats, especially those transmitted by Aedes aegypti mosquitoes. The prevention of such diseases is based on vector control. However, the compounds currently used have disadvantages such toxicity to humans and environment, so larvicide plants is a promising alternative. The purpose of this study is to determine the best season to harvest aerial parts of Mesosphaerum suaveolens (L.) Kuntze to obtain its essential oil, and evaluate the effects of seasons on chemical composition, larvicidal activity against A. aegypti, and toxicology against Artemia salina and Danio rerio using such essential oils and its major compounds. The gas chromatography–mass spectrometry analysis of essential oil samples performed at different times during a year, showed qualitative and quantitative variation in the chemical composition. 1,8-Cineole is the major compound in all seasons. The dry season had a higher yield. The essential oils showed activity a...
Frontiers in pharmacology, 2017
Borreria verticillata (L.) G. Mey. known vassourinha has antibacterial, antimalarial, hepatoprote... more Borreria verticillata (L.) G. Mey. known vassourinha has antibacterial, antimalarial, hepatoprotective, antioxidative, analgesic, and anti-inflammatory, however, its antinociceptive action requires further studies. Aim of the study evaluated the antinociceptive activity of B. verticillata hydroalcoholic extract (EHBv) and ethyl acetate fraction (FAc) by in vivo and in silico studies. In vivo assessment included the paw edema test, writhing test, formalin test and tail flick test. Wistar rats and Swiss mice were divided into 6 groups and given the following treatments oral: 0.9% NaCl control group (CTRL), 10 mg/kg memantine (MEM), 10 mg/kg indomethacin (INDO), 500 mg/kg EHBv (EHBv 500), 25 mg/kg FAc (FAc 25) and 50 mg/kg FAc (FAc 50). EHBv, FAc 25 and 50 treatments exhibited anti-edematous and peripheral antinociceptive effects. For in silico assessment, compounds identified in FAc were subjected to molecular docking with COX-2, GluN1a and GluN2B. Ursolic acid (UA) was the compound w...
Pharmaceuticals, 2019
Essential oil from the leaves of Artemisia vulgaris L. (Compositae) cultivated in Brazil was inve... more Essential oil from the leaves of Artemisia vulgaris L. (Compositae) cultivated in Brazil was investigated for its chemical composition and biological activities including antibacterial, antifungal, and anthelmintic. The constituents of essential oils isolated by hydro-distillation were examined by GC-MS and a total of 18 components were identified. The essential oil was dominated by oxygenated sesquiterpenes (44.4%), sesquiterpene hydrocarbons (33.3%), and oxygenated monoterpenes (16.6%). Caryophyllene (37.45%), germacrene D (16.17%), and humulene (13.66%) were the major components. The essential oils from A. vulgaris showed bactericidal and fungicidal properties against Staphylococcus aureus and Candida albicans, respectively. Anthelmintic activity against Haemonchus contortus was absent in this essential oil. Altogether above results indicate that essential oils from A. vulgaris can be used for various medicinal purposes.
Passiflora edulis Sims (Passifloraceae) is a widely distributed species ranging from tropical and... more Passiflora edulis Sims (Passifloraceae) is a widely distributed species ranging from tropical and sub-tropical regions of the world. It has been commonly used as a food and possesses various medicinal properties. This research aims to see the effect of different extraction methods and drug/solvent ratio on phenolics and flavonoids content as well as the antioxidant capacity in P. edulis leaves. The powdered leaves of P. edulis were extracted with hydroalcoholic solution employing maceration, percolation and Sohxlet extraction and three drug/solvent ratios (1:8, 1:10; 1:12). The total phenolics and flavonoids contents of different extracts were determined by Folin-Ciocalteu and colorimetric AlCl3 methods, respectively. Antioxidant activity was investigated by using in vitro DPPH and FRAP assays. Flavonoids were identified by LC-MS/MS on the basis of mass spectral analysis. The highest content of phenolics (16.30%), flavonoids (3.88%) and antioxidant activity (DPPH IC50 84.23 μg ml -1...
Food research international (Ottawa, Ont.), 2018
Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which ... more Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. vulgaris has a long history in treatment of human ailments by medicinal plants in various parts of the world. This medicinal plant possesses a broad spectrum of therapeutic properties including: anti-malarial, anti-inflammatory, anti-hypertensive, anti-oxidant, anti-tumoral, immunomodulatory, hepatoprotective, anti-spasmodic and anti-septic. These activities are mainly attributed to the presence of various classes of secondary metabolites, including flavonoids, sesquiterpene lactones, coumarins, acetylenes, phenolic acids, organic acids, mono- and sesquiterpenes. Studies related to A. vulgaris morphology, anatomy and phytochemistry has gained a significant in...
Industrial Crops and Products
Food Reviews International