Jose Pons - Academia.edu (original) (raw)
Papers by Jose Pons
Transplantation Proceedings, 1995
Revista Puertorriquena De Psicologia, 2008
Journal De Gynecologie Obstetrique Et Biologie De La Reproduction, 1987
Transplantation Proceedings, Oct 1, 1999
Gastroenterologia Y Hepatologia, Mar 1, 2011
The liver is a privileged organ and has a lower incidence of rejection than other organs. However... more The liver is a privileged organ and has a lower incidence of rejection than other organs. However, immunosuppressive regimens are still required to control the alloreactive T-lymphocyte response after transplantation. These treatments may lead to severe complications, such as infectious diseases, cancers, cardiovascular diseases and chronic renal insufficiency. In clinical transplantation there is increasing evidence that some liver transplant recipients who cease taking immunosuppressive (IS) drugs maintain allograft function, suggesting that tolerance is already present. This strategy is feasible in 25-33% of liver transplant recipients. A series of experimental and clinical observations indicates that liver allografts can even provide "tolerogenic" properties for other organ grafts. In the clinical setting, clinical operational tolerance (COT) is defined as the absence of acute and chronic rejection and graft survival with normal function and histology in an IS-free, fully immunocompetent host, usually as an end result of a successful attempt at IS withdrawal. The exact mechanisms involved in achieving transplant tolerance remain unknown, although animal models suggest a possible role for regulatory T cells (Treg). Recent data have demonstrated an increase in the frequency of CD4+ CD25(high) T cells and FoxP3 transcripts during IS withdrawal in operationally tolerant liver transplant recipients. The data obtained from transcriptional profiling of the peripheral blood of IS-free liver transplant recipients suggest that there is a molecular signature of tolerance that could be employed to identify tolerant liver transplant recipients and that innate immune cells are likely to play a major role in the maintenance of COT after liver transplantation.
Space Science Reviews, Mar 21, 2015
Journal of the European Ceramic Society, 2007
In the present work finite element analysis, FEA, ATILA ® models were generated to analyse the fr... more In the present work finite element analysis, FEA, ATILA ® models were generated to analyse the frequency behaviour of cymbals as a function of the bonding layer. The experimental frequency responses were correlated with predicted values. The epoxy thickness variation, the presence of epoxy meniscus or lacks of adhesive contribute to the frequency dispersion of the vibration modes.
Clin Transplant, 2009
After liver transplantation, long-term immunosuppression (IS) administration is commonly complica... more After liver transplantation, long-term immunosuppression (IS) administration is commonly complicated by renal dysfunction and cardiovascular complications. Twenty liver transplant patients on cyclosporine (CyA)-based IS were followed up prospectively after IS withdrawal. They consisted of 10 electively weaned patients and 10 either forcibly or incidentally weaned patients. Liver biochemical tests, blood pressure, serum creatinine, serum urea, serum uric acid, triglycerides, cholesterol and glucose were monitored after the start of weaning. Eight of the 20 patients (40%) were IS therapy free for a mean period of 61 +/- 39 months (range: 10-132 months). Of the remaining 12 patients, mild or moderate acute rejection occurred in six patients (30%), and mixed inflammatory portal tract infiltrate was seen in another six patients (30%). At the end of the study, mean (SD) serum creatinine had fallen by 0.28 (0.10) mg/dL (p < 0.001) in operationally tolerant (T) patients whereas the serum creatinine level increased in IS-dependent patients [+0.35 (0.35) mg/dL] (p = 0.005). In T patients, serum cholesterol, serum uric acid, fasting glucose and diastolic arterial pressure values significantly decreased. IS withdrawal can be achieved in selected liver transplant patients, and can improve not only kidney function, but also other CyA-associated side effects, such as hypercholesterolemia, hyperuricemia, hypertension and diabetes.
Inorg Chim Acta, 2005
Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means... more Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means of 1H, 13C{1H} 2-D NOESY and HMQC NMR spectral methods. NMR data agree with C1 and Cs symmetries for complexes 1 and 2, respectively. NOESY cross-peaks allowed the assignment of signals to CH arene protons and in the case of complex 2 the determination of the molecular stereochemistry. These results are in agreement with the X-ray molecular structures of both complexes.Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means of 1H, 13C{1H} 2-D NOESY and HMQC NMR spectral methods. NMR data agree with C1 and Cs symmetries for complexes 1 and 2, respectively. NOESY cross-peaks allowed the assignment of signals to CH arene protons and in the case of complex 2 the determination of the molecular stereochemistry. These results are in agreement with the X-ray molecular structures of both complexes.
Medicina Clinica, Apr 1, 2011
Multimedia network systems require image and video compression schemes in order to efficiently ta... more Multimedia network systems require image and video compression schemes in order to efficiently take profit from the available bandwidth. In this paper, we present a wavelet still-image coder, called LTW (Lower-Tree Wavelet), based on the construction and codification of coefficient trees as other proposals do. This algorithm is fast and symmetric (except in extremely low bit rates), which makes it adequate for real-time interactive multimedia applications. We have compared our algorithm with several well-known coders in terms of rate/distortion performance using the standard Lena image. Results show that LTW, with lower temporal complexity, achieves better results than EZW (0.9 dB PSNR) and stack-run (0.25 dB). Also, we have tested the temporal complexity of LTW algorithm, resulting 3.5 times faster than an optimized EZW. On the other hand, compared to DCT-based standards, like JPEG, our algorithm outperforms them in 5 dB approx. (at similar bit rates)
Revista Espanola De Cardiologia, 1998
Recibido el 1 de abril de 1998. Aceptado para su publicación el 1 de junio de 1998.
Transplantation Proceedings, 2001
2014 Ieee 19th International Functional Electrical Stimulation Society Annual Conference, Sep 1, 2014
Revista Puertorriquena De Psicologia, 2008
Microsystem Technologies, 2011
Promising results on flexible and large area pressure sensors for human-neuroprostheses and human... more Promising results on flexible and large area pressure sensors for human-neuroprostheses and humanneurobotic interface assessment are presented. Array sensors of 4x4 and 8x8 based on polymer and plastic electronics have been fabricated and characterized with a resolution of 1 and 0.25 cm2. The working pressure range is between 0 and 1 Kg/cm2 and the offset measured is around 0.03 Kg/cm2. The response time is around 1 ms.
Transplantation Proceedings, 1995
Revista Puertorriquena De Psicologia, 2008
Journal De Gynecologie Obstetrique Et Biologie De La Reproduction, 1987
Transplantation Proceedings, Oct 1, 1999
Gastroenterologia Y Hepatologia, Mar 1, 2011
The liver is a privileged organ and has a lower incidence of rejection than other organs. However... more The liver is a privileged organ and has a lower incidence of rejection than other organs. However, immunosuppressive regimens are still required to control the alloreactive T-lymphocyte response after transplantation. These treatments may lead to severe complications, such as infectious diseases, cancers, cardiovascular diseases and chronic renal insufficiency. In clinical transplantation there is increasing evidence that some liver transplant recipients who cease taking immunosuppressive (IS) drugs maintain allograft function, suggesting that tolerance is already present. This strategy is feasible in 25-33% of liver transplant recipients. A series of experimental and clinical observations indicates that liver allografts can even provide "tolerogenic" properties for other organ grafts. In the clinical setting, clinical operational tolerance (COT) is defined as the absence of acute and chronic rejection and graft survival with normal function and histology in an IS-free, fully immunocompetent host, usually as an end result of a successful attempt at IS withdrawal. The exact mechanisms involved in achieving transplant tolerance remain unknown, although animal models suggest a possible role for regulatory T cells (Treg). Recent data have demonstrated an increase in the frequency of CD4+ CD25(high) T cells and FoxP3 transcripts during IS withdrawal in operationally tolerant liver transplant recipients. The data obtained from transcriptional profiling of the peripheral blood of IS-free liver transplant recipients suggest that there is a molecular signature of tolerance that could be employed to identify tolerant liver transplant recipients and that innate immune cells are likely to play a major role in the maintenance of COT after liver transplantation.
Space Science Reviews, Mar 21, 2015
Journal of the European Ceramic Society, 2007
In the present work finite element analysis, FEA, ATILA ® models were generated to analyse the fr... more In the present work finite element analysis, FEA, ATILA ® models were generated to analyse the frequency behaviour of cymbals as a function of the bonding layer. The experimental frequency responses were correlated with predicted values. The epoxy thickness variation, the presence of epoxy meniscus or lacks of adhesive contribute to the frequency dispersion of the vibration modes.
Clin Transplant, 2009
After liver transplantation, long-term immunosuppression (IS) administration is commonly complica... more After liver transplantation, long-term immunosuppression (IS) administration is commonly complicated by renal dysfunction and cardiovascular complications. Twenty liver transplant patients on cyclosporine (CyA)-based IS were followed up prospectively after IS withdrawal. They consisted of 10 electively weaned patients and 10 either forcibly or incidentally weaned patients. Liver biochemical tests, blood pressure, serum creatinine, serum urea, serum uric acid, triglycerides, cholesterol and glucose were monitored after the start of weaning. Eight of the 20 patients (40%) were IS therapy free for a mean period of 61 +/- 39 months (range: 10-132 months). Of the remaining 12 patients, mild or moderate acute rejection occurred in six patients (30%), and mixed inflammatory portal tract infiltrate was seen in another six patients (30%). At the end of the study, mean (SD) serum creatinine had fallen by 0.28 (0.10) mg/dL (p < 0.001) in operationally tolerant (T) patients whereas the serum creatinine level increased in IS-dependent patients [+0.35 (0.35) mg/dL] (p = 0.005). In T patients, serum cholesterol, serum uric acid, fasting glucose and diastolic arterial pressure values significantly decreased. IS withdrawal can be achieved in selected liver transplant patients, and can improve not only kidney function, but also other CyA-associated side effects, such as hypercholesterolemia, hyperuricemia, hypertension and diabetes.
Inorg Chim Acta, 2005
Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means... more Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means of 1H, 13C{1H} 2-D NOESY and HMQC NMR spectral methods. NMR data agree with C1 and Cs symmetries for complexes 1 and 2, respectively. NOESY cross-peaks allowed the assignment of signals to CH arene protons and in the case of complex 2 the determination of the molecular stereochemistry. These results are in agreement with the X-ray molecular structures of both complexes.Complexes [Ru(p-cymene)Cl2(PPh2Py)] (1) and [Ru(p-cymene)Cl(PPh2Py)]BF4 (2) were studied by means of 1H, 13C{1H} 2-D NOESY and HMQC NMR spectral methods. NMR data agree with C1 and Cs symmetries for complexes 1 and 2, respectively. NOESY cross-peaks allowed the assignment of signals to CH arene protons and in the case of complex 2 the determination of the molecular stereochemistry. These results are in agreement with the X-ray molecular structures of both complexes.
Medicina Clinica, Apr 1, 2011
Multimedia network systems require image and video compression schemes in order to efficiently ta... more Multimedia network systems require image and video compression schemes in order to efficiently take profit from the available bandwidth. In this paper, we present a wavelet still-image coder, called LTW (Lower-Tree Wavelet), based on the construction and codification of coefficient trees as other proposals do. This algorithm is fast and symmetric (except in extremely low bit rates), which makes it adequate for real-time interactive multimedia applications. We have compared our algorithm with several well-known coders in terms of rate/distortion performance using the standard Lena image. Results show that LTW, with lower temporal complexity, achieves better results than EZW (0.9 dB PSNR) and stack-run (0.25 dB). Also, we have tested the temporal complexity of LTW algorithm, resulting 3.5 times faster than an optimized EZW. On the other hand, compared to DCT-based standards, like JPEG, our algorithm outperforms them in 5 dB approx. (at similar bit rates)
Revista Espanola De Cardiologia, 1998
Recibido el 1 de abril de 1998. Aceptado para su publicación el 1 de junio de 1998.
Transplantation Proceedings, 2001
2014 Ieee 19th International Functional Electrical Stimulation Society Annual Conference, Sep 1, 2014
Revista Puertorriquena De Psicologia, 2008
Microsystem Technologies, 2011
Promising results on flexible and large area pressure sensors for human-neuroprostheses and human... more Promising results on flexible and large area pressure sensors for human-neuroprostheses and humanneurobotic interface assessment are presented. Array sensors of 4x4 and 8x8 based on polymer and plastic electronics have been fabricated and characterized with a resolution of 1 and 0.25 cm2. The working pressure range is between 0 and 1 Kg/cm2 and the offset measured is around 0.03 Kg/cm2. The response time is around 1 ms.