Jose R Villada - Academia.edu (original) (raw)

Papers by Jose R Villada

The EuroBiotech Journal

Introduction: The biocompatibility of nitinol in the human body has extensively been demonstrated... more Introduction: The biocompatibility of nitinol in the human body has extensively been demonstrated. Although nitinol is already being used for intraocular surgeries such as lens fragmentation and foreign body extraction, little is known about its intracapsular, long-term behavior. The purpose of this study is to evaluate the long-term uveal and capsular biocompatibility of a nitinol CTR placed in the capsular bag after cataract surgery in an animal model. Method: After approval of the study by the Institutional Animal Care and the Ethics Committee, bilateral phacoemulsification was performed in 6 rabbits; 1 eye received a nitinol CTR and the other a control polymethylmethacrylate (PMMA) open-ended ring. Ophthalmic evaluation for the presence of infections in all 12 eyes was performed after 7 days, 4 weeks, 3 months, and 6 months follow-up period. After a follow-up period of 6 months, the eyes were enucleated, and a histopathologic evaluation was performed. Results: Neither of the gro...

Case Reports in Ophthalmology, 2021

We report a case of ocular injury caused by a bombardier beetle in a young boy. Ocular injuries d... more We report a case of ocular injury caused by a bombardier beetle in a young boy. Ocular injuries due to this coleoptera have not previously been reported. An 11-year-old boy experienced an eye injury while trying to place a bombardier beetle inside an anthill. The boy was diagnosed with a second-degree burn on the skin of the upper right eyelid and conjunctival and corneal erosion in the right eye. The condition resolved completely after 2 weeks of appropriate treatment. Education about the dangers of playing with insects is crucial to prevent this type of lesions.

Irish Journal of Medical Science, 1993

This study aimed to find a diagnostic reading strategy in AMD. In reading patterns, fixation is d... more This study aimed to find a diagnostic reading strategy in AMD. In reading patterns, fixation is defined as the ability to maintain eye position between saccades. Refixation is the ability to locate the start of a following line. Saccade character refers

SUMMARY Previously unreported adverse drug reactions can be dif­ ficult to detect and it may be e... more SUMMARY Previously unreported adverse drug reactions can be dif­ ficult to detect and it may be even more difficult to estab­ lish a cause and effect relationship, particularly if the adverse reacions mimic naturally occurring disease. In a previous paper we reported 29 patients with granuloma­ tous anterior uveitis, blepharoconjunct ivitis, periorbital dermatitis, marginal keratitis and elevation in intra­ ocular pressure (lOP), suspected to be caused by meti­ pranolol (Glauline). With the approval of the District Ethics Committee 7 of those patients were rechallenged with metipranolol 0.3% compared to timolol maleate 0.5% in a double blind trial. The 7 metipranolol treated eyes developed an adverse reaction within 14 days. Meti­ pranolol (Glauline) has been conclusively proven to cause granulomatous anterior uveitis, blepharoconjunct ivitis and elevation in lOP, adverse effects never previously reported with any of the ophthalmic topical beta-block­ ers. The multi dose preparation...

PURPOSE: To evaluate the clinical outcomes of photoreactive keratectomy (PRK) for myopia, using a... more PURPOSE: To evaluate the clinical outcomes of photoreactive keratectomy (PRK) for myopia, using a new combined, ethanol-assisted and blunt mechanical corneal epithelial peeling technique. METHODS: In this prospective cases series, PRK was performed in myopic patients. A circular cellulose cell sponge soaked with 20% ethanol solution was positioned over the central cornea for 50 seconds. The adhesions between the epithelium and corneal stroma were loosened using a Weck-Cel spear, and finally, central loosened corneal epithelium was easily lifted off in a circular epitheliorhexis-like technique. Corneal photoablation was then performed using the usual nomograms and protocols for myopic surface photoablation treatments. Manifest refraction, uncorrected distance visual acuity (UDVA), and corrected distance visual acuity (CDVA) were evaluated preoperatively and postoperatively, and adverse effects were also assessed. RESULTS: The study enrolled 248 eyes of 144 consecutive patients. Mean ...

ABSTRACT: We describe a new surgical maneuver combining chemical and mechanical techniques for de... more ABSTRACT: We describe a new surgical maneuver combining chemical and mechanical techniques for debridement of the corneal epithelium prior to photoablation in surface laser surgery. In this procedure, a circular cellulose cell sponge soaked with 20% ethanol solution is positioned over the central cornea for 50 seconds. The adhesions between the epithelium and the corneal stroma are loosened using another weck cell spear, and finally, the central corneal epithelium is easily lifted off with the same weck cell spear in a circular manner using epitheliorhexis technique. The maneuver has been used in 838 cases, resulting in straightforward and uniform removal of the corneal epithelium with minimal patient discomfort. No intraoperative or early postoperative complications were observed.

Advances in Ophthalmology & Visual System

Method: Four samples of 3 different CTR manufacturers were evaluated for resistance to compressio... more Method: Four samples of 3 different CTR manufacturers were evaluated for resistance to compression over time while being exposed to a constant tension. The 13 millimetres CTRs were placed in a round rigid container with an 11 millimetres diameter and submerged in BSS at body temperature (37 degrees Celsius). CTRs were divided into two groups. Two samples of each model were introduced in the containers and removed and evaluated at 1 month, while the other two samples of each model were introduced in the containers and removed and evaluated at three months. Size and shape of the CTRs were measured at baseline, at 1 month and 3 months. Every measurement was repeated 3 times by two different observers.

Http Www Libreriasaulamedica Com, 2007

Advances in Ophthalmology & Visual System

PRK after previous LASIK was strongly dis-recommended by some authors8 after severe complications... more PRK after previous LASIK was strongly dis-recommended by some authors8 after severe complications, and during some time considered a "forbidden" procedure. More recently, some publications including a small number of eyes have not reported significant complications. 9-17 In our clinic we have had to deal with a large amount of a patients whose flap thickness was not measured during the first treatment (LASIK) and therefore were retreated with PRK. In this paper we review all these PRK retreatments and the results obtained. Methods This is a retrospective review of cases that having had a primary excimer laser treatment for their refractive error by a LASIK technique

We describe a new surgical maneuver combining chemical and mechanical techniques for debridement ... more We describe a new surgical maneuver combining chemical and mechanical techniques for debridement of the corneal epithelium prior to photoablation in surface laser surgery. In this procedure, a circular cellulose cell sponge soaked with 20% ethanol solution is positioned over the central cornea for 50 seconds. The adhesions between the epithelium and the corneal stroma are loosened using another weck cell spear, and finally, the central corneal epithelium is easily lifted off with the same weck cell spear in a circular manner using epitheliorhexis technique. The maneuver has been used in 838 cases, resulting in straightforward and uniform removal of the corneal epithelium with minimal patient discomfort. No intraoperative or early postoperative complications were observed.

The EuroBiotech Journal

Introduction: The biocompatibility of nitinol in the human body has extensively been demonstrated... more Introduction: The biocompatibility of nitinol in the human body has extensively been demonstrated. Although nitinol is already being used for intraocular surgeries such as lens fragmentation and foreign body extraction, little is known about its intracapsular, long-term behavior. The purpose of this study is to evaluate the long-term uveal and capsular biocompatibility of a nitinol CTR placed in the capsular bag after cataract surgery in an animal model. Method: After approval of the study by the Institutional Animal Care and the Ethics Committee, bilateral phacoemulsification was performed in 6 rabbits; 1 eye received a nitinol CTR and the other a control polymethylmethacrylate (PMMA) open-ended ring. Ophthalmic evaluation for the presence of infections in all 12 eyes was performed after 7 days, 4 weeks, 3 months, and 6 months follow-up period. After a follow-up period of 6 months, the eyes were enucleated, and a histopathologic evaluation was performed. Results: Neither of the gro...

Case Reports in Ophthalmology, 2021

We report a case of ocular injury caused by a bombardier beetle in a young boy. Ocular injuries d... more We report a case of ocular injury caused by a bombardier beetle in a young boy. Ocular injuries due to this coleoptera have not previously been reported. An 11-year-old boy experienced an eye injury while trying to place a bombardier beetle inside an anthill. The boy was diagnosed with a second-degree burn on the skin of the upper right eyelid and conjunctival and corneal erosion in the right eye. The condition resolved completely after 2 weeks of appropriate treatment. Education about the dangers of playing with insects is crucial to prevent this type of lesions.

Irish Journal of Medical Science, 1993

This study aimed to find a diagnostic reading strategy in AMD. In reading patterns, fixation is d... more This study aimed to find a diagnostic reading strategy in AMD. In reading patterns, fixation is defined as the ability to maintain eye position between saccades. Refixation is the ability to locate the start of a following line. Saccade character refers

SUMMARY Previously unreported adverse drug reactions can be dif­ ficult to detect and it may be e... more SUMMARY Previously unreported adverse drug reactions can be dif­ ficult to detect and it may be even more difficult to estab­ lish a cause and effect relationship, particularly if the adverse reacions mimic naturally occurring disease. In a previous paper we reported 29 patients with granuloma­ tous anterior uveitis, blepharoconjunct ivitis, periorbital dermatitis, marginal keratitis and elevation in intra­ ocular pressure (lOP), suspected to be caused by meti­ pranolol (Glauline). With the approval of the District Ethics Committee 7 of those patients were rechallenged with metipranolol 0.3% compared to timolol maleate 0.5% in a double blind trial. The 7 metipranolol treated eyes developed an adverse reaction within 14 days. Meti­ pranolol (Glauline) has been conclusively proven to cause granulomatous anterior uveitis, blepharoconjunct ivitis and elevation in lOP, adverse effects never previously reported with any of the ophthalmic topical beta-block­ ers. The multi dose preparation...

PURPOSE: To evaluate the clinical outcomes of photoreactive keratectomy (PRK) for myopia, using a... more PURPOSE: To evaluate the clinical outcomes of photoreactive keratectomy (PRK) for myopia, using a new combined, ethanol-assisted and blunt mechanical corneal epithelial peeling technique. METHODS: In this prospective cases series, PRK was performed in myopic patients. A circular cellulose cell sponge soaked with 20% ethanol solution was positioned over the central cornea for 50 seconds. The adhesions between the epithelium and corneal stroma were loosened using a Weck-Cel spear, and finally, central loosened corneal epithelium was easily lifted off in a circular epitheliorhexis-like technique. Corneal photoablation was then performed using the usual nomograms and protocols for myopic surface photoablation treatments. Manifest refraction, uncorrected distance visual acuity (UDVA), and corrected distance visual acuity (CDVA) were evaluated preoperatively and postoperatively, and adverse effects were also assessed. RESULTS: The study enrolled 248 eyes of 144 consecutive patients. Mean ...

ABSTRACT: We describe a new surgical maneuver combining chemical and mechanical techniques for de... more ABSTRACT: We describe a new surgical maneuver combining chemical and mechanical techniques for debridement of the corneal epithelium prior to photoablation in surface laser surgery. In this procedure, a circular cellulose cell sponge soaked with 20% ethanol solution is positioned over the central cornea for 50 seconds. The adhesions between the epithelium and the corneal stroma are loosened using another weck cell spear, and finally, the central corneal epithelium is easily lifted off with the same weck cell spear in a circular manner using epitheliorhexis technique. The maneuver has been used in 838 cases, resulting in straightforward and uniform removal of the corneal epithelium with minimal patient discomfort. No intraoperative or early postoperative complications were observed.

Advances in Ophthalmology & Visual System

Method: Four samples of 3 different CTR manufacturers were evaluated for resistance to compressio... more Method: Four samples of 3 different CTR manufacturers were evaluated for resistance to compression over time while being exposed to a constant tension. The 13 millimetres CTRs were placed in a round rigid container with an 11 millimetres diameter and submerged in BSS at body temperature (37 degrees Celsius). CTRs were divided into two groups. Two samples of each model were introduced in the containers and removed and evaluated at 1 month, while the other two samples of each model were introduced in the containers and removed and evaluated at three months. Size and shape of the CTRs were measured at baseline, at 1 month and 3 months. Every measurement was repeated 3 times by two different observers.

Http Www Libreriasaulamedica Com, 2007

Advances in Ophthalmology & Visual System

PRK after previous LASIK was strongly dis-recommended by some authors8 after severe complications... more PRK after previous LASIK was strongly dis-recommended by some authors8 after severe complications, and during some time considered a "forbidden" procedure. More recently, some publications including a small number of eyes have not reported significant complications. 9-17 In our clinic we have had to deal with a large amount of a patients whose flap thickness was not measured during the first treatment (LASIK) and therefore were retreated with PRK. In this paper we review all these PRK retreatments and the results obtained. Methods This is a retrospective review of cases that having had a primary excimer laser treatment for their refractive error by a LASIK technique

We describe a new surgical maneuver combining chemical and mechanical techniques for debridement ... more We describe a new surgical maneuver combining chemical and mechanical techniques for debridement of the corneal epithelium prior to photoablation in surface laser surgery. In this procedure, a circular cellulose cell sponge soaked with 20% ethanol solution is positioned over the central cornea for 50 seconds. The adhesions between the epithelium and the corneal stroma are loosened using another weck cell spear, and finally, the central corneal epithelium is easily lifted off with the same weck cell spear in a circular manner using epitheliorhexis technique. The maneuver has been used in 838 cases, resulting in straightforward and uniform removal of the corneal epithelium with minimal patient discomfort. No intraoperative or early postoperative complications were observed.