Jose Rodriguez - Academia.edu (original) (raw)

Papers by Jose Rodriguez

Abstract—Torasemide is a loop diuretic that is effective at low once-daily doses in the treatment... more Abstract—Torasemide is a loop diuretic that is effective at low once-daily doses in the treatment of arterial hypertension. Because its antihypertensive mechanism,of action may,not be based entirely on the elimination of salt and water from the body, a vasodilator effect of this drug can be considered. In the present study, the ability of different concentrations of torasemide to modify angiotensin

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001

To establish the incidence of tuberculosis (TB) in a prison population and its link with latent t... more To establish the incidence of tuberculosis (TB) in a prison population and its link with latent tuberculosis infection treatment (LTIT). From 1991 to 1999 a TB programme was run in a Spanish prison. A cohort study was conducted to know TB incidence and the associated variables. Of 1,050 people studied, 10% were co-infected by the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis. Twenty-three cases of TB were detected, an incidence rate of 6.39 per 1,000 person-years of follow-up. Multivariate analysis showed HIV-infected patients (RR 4.07, 95%CI 2.61-6.35), and those infected by M. tuberculosis who did not undergo LTIT (RR 10.15, 95%CI 0.90-50.59) to be at greater risk of developing TB. In TST reactors, those co-infected with HIV (RR 10.15, 95%CI 3.80-27.07) and those who had not undergone LTIT (RR 8.53, 95%CI 1.12-64.86) were shown to be at the greatest risk of developing TB. The observed incidence of TB is much higher in prisons than in the community at large. HIV...

Proceedings of the 9th annual conference on Genetic and evolutionary computation - GECCO '07, 2007

An Estimation of Distribution Algorithm (EDA) is proposed to approach the Hybrid Flow Shop with S... more An Estimation of Distribution Algorithm (EDA) is proposed to approach the Hybrid Flow Shop with Sequence Dependent Setup Times and Uniform Machines in parallel (HFS-SDST-UM) problem. The latter motivated by the needs of a real world company. The proposed EDA implements a fairly new mechanism to improve the search of more traditional EDAs. This is the Guided Mutation (GM). EDA-GM generates new solutions by using the information from a probability model, as all EDAs, and the local information from a good known solution. The approach is tested on several instances of HFS-SDST-UM and compared with adaptations of meta-heuristics designed for very similar problems. Encouraging results are reported.

Surface Science, 1999

Synchrotron-based high-resolution photoemission has been used to study the interaction of NO2 wit... more Synchrotron-based high-resolution photoemission has been used to study the interaction of NO2 with Rh(111) and Pd/Rh(111) surfaces. Clean Rh(111) reacts readily with nitrogen dioxide which decomposes at temperatures≤150K producing adsorbed NO and oxygen adatoms (NO2→NOa+Oa). The majority of the adsorbed NO further dissociates (NOa→Na+Oa) between 300 and 400K. The bimetallic Pd/Rh(111) system exhibits a significantly lower reactivity towards NO2 in

Studies in Computational Intelligence, 2007

Page 1. A Robust Meta-Hyper-Heuristic Approach José Antonio Vázquez Rodrıguez and Abdellah Salhi ... more Page 1. A Robust Meta-Hyper-Heuristic Approach José Antonio Vázquez Rodrıguez and Abdellah Salhi Mathematical Sciences Department, University of Essex, Wivenhoe Park, Colchester, UK {javazq@gmail.com, as@essex.ac.uk} Summary. ...

Journal of Arthroplasty, 2004

The Journal of Arthroplasty, Volume 19, Issue 2, Pages 254, February 2004, Authors:Vijay Rasquinh... more The Journal of Arthroplasty, Volume 19, Issue 2, Pages 254, February 2004, Authors:Vijay Rasquinha, MD; Chitranjan Ranawat, MD; Vipul Dua, MD; Amar Ranawat, MD; Jose Rodriguez, MD. ...

Surface Science, 2008

The reaction of the amino acid dl-proline is studied over stoichiometric and Ar-ions sputtered (r... more The reaction of the amino acid dl-proline is studied over stoichiometric and Ar-ions sputtered (reduced) TiO2(110) single crystal surfaces by synchrotron High Resolution X-ray Photoelectron Spectroscopy (HRXPS). On the stoichiometric surface proline gives two different species at 300K: dissociated and zwitterionic. Upon heating the zwitterionic structure is removed first from the surface followed by the dissociated form. The C1s signal for the COO function is found close to 288.5eV for both forms while the N1s for the dissociated form is found at 400.0eV and that of the zwitterionic from close to 401.8eV. From the attenuation of the Ti2p signal the surface coverage was estimated less than ½ (about 0.35). This smaller coverage than dissociatively adsorbed carboxylic acids on this surface (usually close to ½), is attributed to lateral repulsion caused by the ring of adjacent proline molecules adsorbed on five-fold coordinated Ti cations along the [001] direction. On the reduced surface the amount of zwitterion structure is found two times higher than that on the stoichiometric surface, at 300K, most likely due to the considerable decrease of the amount of surface oxygen available. The stability of the zwitterionic structure on this surface is however found similar to that found on the stoichiometric surface. In addition, evidence of oxidation of reduced Ti cations upon adsorption at 300K is noticed and explained as breaking of the carbon–oxygen bond of a fraction of adsorbed proline. Variable temperature HRXPS has been collected and results indicated that proline is more stable on the reduced surface compared to the stoichiometric surface.

Acta Biotechnologica, 1986

The FASEB Journal, 2014

We studied the role of matrix metalloproteinase-10 (MMP-10) during skeletal muscle repair after i... more We studied the role of matrix metalloproteinase-10 (MMP-10) during skeletal muscle repair after ischemia using a model of femoral artery excision in wild-type (WT) and MMP-10 deficient (Mmp10 2/2 ) mice. Functional changes were analyzed by small animal positron emission tomography and tissue morphology by immunohistochemistry. Gene expression and protein analysis were used to study the molecular mechanisms governed by MMP-10 in hypoxia. Early after ischemia, MMP-10 deficiency resulted in delayed tissue reperfusion (10%, P < 0.01) and in increased necrosis (2-fold, P < 0.01), neutrophil (4-fold, P < 0.01), and macrophage (1.5-fold, P < 0.01) infiltration. These differences at early time points resulted in delayed myotube regeneration in Mmp10 2/2 soleus at later stages (regenerating myofibers: 30 6 9% WT vs. 68 6 10% Mmp10 2/2 , P < 0.01). The injection of MMP-10 into Mmp10 2/2 mice rescued the observed phenotype. A molecular analysis revealed higher levels of Cxcl1 mRNA (10fold, P < 0.05) and protein (30%) in the ischemic Mmp10 2/2 muscle resulting from a lack of transcriptional inhibition by MMP-10. This was further confirmed using siRNA against MMP-10 in vivo. Our results demonstrate an important role of MMP-10 for proper muscle repair after ischemia, and suggest that chemokine regulation such as Cxcl1 by MMP-10 is involved in muscle regeneration.-

Journal of Vascular Surgery, 2015

Peripheral arterial disease (PAD) is associated with poor prognosis in terms of cardiovascular (C... more Peripheral arterial disease (PAD) is associated with poor prognosis in terms of cardiovascular (CV) morbidity and mortality. Matrix metalloproteinases (MMPs) contribute to vascular remodeling by degrading extracellular matrix components and play a role in atherosclerosis as demonstrated for MMP-10 (stromelysin-2). This study analyzed MMP-10 levels in PAD patients according to disease severity and CV risk factors and evaluated the prognostic value of MMP-10 for CV events and mortality in lower limb arterial disease after a follow-up period of 2 years. MMP-10 was measured by enzyme-linked immunosorbent assay in 187 PAD patients and 200 sex-matched controls. PAD patients presented with increased levels of MMP-10 (702 ± 326 pg/mL control vs 946 ± 473 pg/mL PAD;…

Revista médica de Chile, 2009

Background: Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in car... more Background: Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately described. Aim: To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction. Material and methods: Forty nine patients aged 59±10 years (77% men) with a first episode of a ST segment elevation MI, were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects. Results: At baseline, patients with MI had a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%±10%, left ventricular end-diastolic volume (LVEDV) 127±38 mL, interventricular delay (IEV) 29±35 miliseconds (ms), and intraventricular delay (IAV), 234±89 ms. After 6 months, LVEF significantly improved (38%±10%, p =0.042) without significant changes in LVEDV (129±32 mL, p =0.97), IEV (24±17, p =0.96) or IAV (231±97, p =0.34). At baseline there were significant correlations between IAV and LVEF, p =0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r =0.403, p =0.04). Conclusions: The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI (Rev Méd Chile 2009; 137: 1457-62). (

The European project HELATHIS, executed by the five project partners signing this article, is ded... more The European project HELATHIS, executed by the five project partners signing this article, is dedicated to the improvement of the efficiency of very large area (5.7m 2 ) silicon thin film photovoltaic (PV) modules. Optical confinement has been identified by the project partners as a major source for efficiency improvement of thin film silicon PV modules. One reason of the performance gap between highly efficient laboratory solar cells and industrial modules is the poorer electrical and optical performance of the industrial TCO-covered front glass substrate (TCO glass) which is investigated in this work. The glass substrate in industrial PV modules is about 3 times thicker than in laboratory solar cells where frequently Asahi U-type TCO glass (about 1 mm thick) is used. Therefore, the glass quality has an important impact on the transmission of industrial TCO glass. Reducing the iron-content in the float glass substrate increases the integrated transmission in the wavelength range from 400-800nm by nearly 2%. The electrical properties, namely the electrical carrier mobility, of the industrial TCO layer of AGC has been increased by about 15% by improving the industrial deposition process, resulting in a thinner TCO layer with higher transmission by maintaining the sheet resistance of about 9-10 /sq. Combining both developments the integrated transmission of industrial TCO glass has been increased by more than 2%. The TCO layer properties of Asahi U-type and standard industrial TCO glass (AGC AN10) have been investigated by SEM, AFM, XRD and ARS, showing that the Asahi U TCO scatters red light more effectively into larger angles.

Surface Science, 2008

The morphology and structure of nanosized ceria particles prepared by several in vacuo deposition... more The morphology and structure of nanosized ceria particles prepared by several in vacuo deposition methods on a Au(1 1 1) template were investigated by scanning tunneling microscopy. Cerium metal nanoparticles on gold have limited reactivity toward molecular oxygen and NO 2 , due to the formation of Ce-Au alloys, and their oxidation leads to formation of non-uniform substoichiometric three-dimensional (3D) oxide particles. Cerium metal deposition onto condensed multilayers of water or NO 2 generates fully oxidized but poorly ordered ceria particles after annealing. Ultra-thin flat and ordered ceria nanoislands were prepared by deposition of cerium metal on the gold surface at elevated temperatures under an oxygen background pressure. Atomically resolved images show an oxygen-terminated surface of CeO 2 (1 1 1) with oxygen vacancies.

2005 IEEE Congress on Evolutionary Computation, 2005

This is a report on the performance of a set of techniques for the solution of the problem of sch... more This is a report on the performance of a set of techniques for the solution of the problem of scheduling flexible flow shops (FFS). Four variants of the single stage representation genetic algorithm (SSRGA) and four well known dispatching rules, first in first out (FIFO), shortest processing times (SPT), longest processing times (LPT), and shortest due dates (SDD), are considered

IECON 2010 - 36th Annual Conference on IEEE Industrial Electronics Society, 2010

Abstract A simple and intuitive Doubly Fed Induction Generator (DFIG) predictive rotor current co... more Abstract A simple and intuitive Doubly Fed Induction Generator (DFIG) predictive rotor current control scheme is presented. Predictive control of an Indirect Matrix Converter (IMC) is combined with predictive rotor current control of a DFIG to achieve a very good dynamic response as the rotor currents smoothly follow the applied reference in a±30% range of the generator nominal rpm. Simulation results are presented for constant torque and rotational speed, as well as for variable rotational speed corresponding to a 10 kW generator ...

2007 IEEE Congress on Evolutionary Computation, 2007

Hyper-heuristics or "heuristics that coordinate heuristics" are fastly becoming popular for solvi... more Hyper-heuristics or "heuristics that coordinate heuristics" are fastly becoming popular for solving combinatorial optimisation problems. These methods do not search directly the solution space; they do it indirectly through the exploration of the space of heuristics and/or their combinations. This space is named the associated space. The task of finding the best element in the associated space is referred to as the associated problem. This paper presents a formal definition of the associated problem, and investigates several of its properties. An empirical study of the associated problem is performed using a production scheduling problem as experimental environment. Obtained results allow us to partly explain what are the advantages of hyper-heuristic solution representations over other traditional ones, and, to give recommendations on hyperheuristic design.

IEEE Congress on Evolutionary Computation, 2010

An important challenge within hyper-heuristic research is to design search methodologies that wor... more An important challenge within hyper-heuristic research is to design search methodologies that work well, not only across different instances of the same problem, but also across different problem domains. This article conducts an empirical study involving three different domains in combinatorial optimisation: bin packing, permutation flow shop and personnel scheduling. Using a common software interface (HyFlex), the same algorithms (high-level strategies or hyperheuristics) can be readily run on all of them. The study is intended as a proof of concept of the proposed interface and domain modules, as a benchmark for testing the generalisation abilities of heuristic search algorithms. Several algorithms and variants from the literature were implemented and tested. From them, the implementation of iterated local search produced the best overall performance. Interestingly, this is one of the most conceptually simple competing algorithms, its advantage as a robust algorithm is probably due to two factors: (i) the simple yet powerful exploration/exploitation balance achieved by systematically combining a perturbation followed by local search; and (ii) its parameter-less nature. We believe that the challenge is still open for the design of robust algorithms that can learn and adapt to the available low-level heuristics, and thus select and apply them accordingly.

Biochimica Et Biophysica Acta-general Subjects, 2000

BackgroundTraditional cancer therapy can be successful in destroying tumors, but can also cause d... more BackgroundTraditional cancer therapy can be successful in destroying tumors, but can also cause dangerous side effects. Therefore, many targeted therapies are in development. The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin. This receptor is an attractive molecule for the targeted therapy of cancer since it is upregulated on the surface of many cancer types

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001

Proceedings of the 9th annual conference on Genetic and evolutionary computation - GECCO '07, 2007

Surface Science, 1999

Studies in Computational Intelligence, 2007

Journal of Arthroplasty, 2004

Surface Science, 2008

Acta Biotechnologica, 1986

The FASEB Journal, 2014

Journal of Vascular Surgery, 2015

Revista médica de Chile, 2009

Surface Science, 2008

2005 IEEE Congress on Evolutionary Computation, 2005

IECON 2010 - 36th Annual Conference on IEEE Industrial Electronics Society, 2010

2007 IEEE Congress on Evolutionary Computation, 2007

IEEE Congress on Evolutionary Computation, 2010

Biochimica Et Biophysica Acta-general Subjects, 2000