José Tagliarini - Academia.edu (original) (raw)

Papers by José Tagliarini

Diagnostic Cytopathology, 2021

Cristiano Claudino Oliveira MD, PhD | Júlia Thalita Queiróz Rocha MD | Dominique Fonseca Rodrigue... more Cristiano Claudino Oliveira MD, PhD | Júlia Thalita Queiróz Rocha MD | Dominique Fonseca Rodrigues Lacet MD | José Vicente Tagliarini MD, PhD | Glaucia Maria F. Silva Mazeto MD, PhD Department of Pathology, Botucatu School of Medicine, S~ao Paulo State University (FMB UNESP) and S~ao Luiz/D'Or Hospital, S~ao Paulo, Brazil Department of Pathology, Botucatu School of Medicine, S~ao Paulo State University (FMB UNESP) and Salom~ao & Zoppi/DASA, S~ao Paulo, Brazil Department of Pathology, Botucatu School of Medicine, S~ao Paulo State University (FMB UNESP), Botucatu, Brazil Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Botucatu School of Medicine, S~ao Paulo State University, Botucatu, Brazil Department of Internal Medicine, Botucatu School of Medicine, S~ao Paulo State University (FMB UNESP), Botucatu, Brazil

Revista Brasileira De Otorrinolaringologia, 1998

Revista Brasileira De Otorrinolaringologia, 1997

Faculdade de Medicina de Botucatu Universidade Estadual Paulista UNESP, CEP 18618-000 Sao Paulo

Paediatric respiratory physiology and sleep, 2018

Introduction: Obstructive sleep apnea syndrome (OSA) in children is related to hypertrophy of the... more Introduction: Obstructive sleep apnea syndrome (OSA) in children is related to hypertrophy of the tonsils, adenotonsillectomy being the treatment of choice. However, perioperative risks are not well established, assessment of routine preoperative polysomnography not feasible. The objective of the study was to evaluate the economic and technical viability (frequency of failure) of unsupervised polysomnography in children before adenotonsillectomy. Methods: The prospective study was approved by the local research ethics committee. 146 children, 57 male, aged 3 to 11 years, with indication of adenotonsillectomy, were invited to preoperative polygraphic monitoring. We analyzed the frequency of failed exams, failures per sensor, its correlation to age of the children and compared costs to standard full-night polysomnography. Results: General failure rate was 28.08% (n = 41), with no difference between genders (χ2=0.0644 p=0.7997), but a greater risk for preschool children (RR =1.2386 (CI 95%: = 0.724 to 2.118). Failure of oximetry was observed in 14.3%, nasal cannula in 10.2%, combination of both in 4.1%., thoracoabdominal belt in none. Costs of the unsupervised PSG was estimated to be 63% of the standard PSG, even if including the high failure rate being more cost saving. Conclusion: Unsupervised polysomnography was technically and economically feasible, its installation to be performed by trained professionals to avoid failure of sensors, mostly oximetry.

Arquivos de Gastroenterologia, 2001

Racional — A resposta do esfíncter esofágico superior ao refluxo gastroesofágico é controvertida.... more Racional — A resposta do esfíncter esofágico superior ao refluxo gastroesofágico é controvertida. A perfusão esofágica com ácido clorídrico é modelo de estudo da ação do ácido o componente mais agressivo do refluxo sobre o esfíncter. Objetivos - Estudar o efeito da acidificação esofágica sobre o esfíncter esofágico superior através da eletromanometria esofágica. - Material e Métodos - Em 30 cães adultos de ambos os sexos foram registrados estudos eletromanométricos do esôfago. A técnica utilizada foi a de puxada intermitente da sonda e perfusão contínua dos cateteres com água destilada. Estes exames permitiram as medidas da amplitude da pressão (mm Hg) e do comprimento (cm) do esfíncter superior do esôfago em condições basais (momento 1). Após esta fase, os animais foram submetidos a perfusão esofágica e divididos em 3 grupos de 10, na dependência da solução utilizada na perfusão e do momento do estudo: Grupo 1: perfusão esofágica com água destilada e estudos eletromanométricos real...

RESUMO-Racional-A resposta do esfíncter esofágico superior ao refluxo gastroesofágico é controver... more RESUMO-Racional-A resposta do esfíncter esofágico superior ao refluxo gastroesofágico é controvertida. A perfusão esofágica com ácido clorídrico é modelo de estudo da ação do ácido o componente mais agressivo do refluxo sobre o esfíncter. Objetivos-Estudar o efeito da acidificação esofágica sobre o esfíncter esofágico superior através da eletromanometria esofágica.-Material e Métodos-Em 30 cães adultos de ambos os sexos foram registrados estudos eletromanométricos do esôfago. A técnica utilizada foi a de puxada intermitente da sonda e perfusão contínua dos cateteres com água destilada. Estes exames permitiram as medidas da amplitude da pressão (mm Hg) e do comprimento (cm) do esfíncter superior do esôfago em condições basais (momento 1). Após esta fase, os animais foram submetidos a perfusão esofágica e divididos em 3 grupos de 10, na dependência da solução utilizada na perfusão e do momento do estudo: Grupo 1: perfusão esofágica com água destilada e estudos eletromanométricos realizados aos 15 minutos (momento 2) e 30 minutos (momento 3) do término da perfusão; Grupo 2: perfusão esofágica com HCl 0,1 N e estudos eletromanométricos realizados 15 minutos após o término da perfusão (momento 2); Grupo 3: perfusão esofágica com HCl 0,1 N e estudos eletromanométricos realizados 30 minutos após o término da perfusão (momento 3). Resultados/Conclusão-Os resultados observados permitiram concluir que a acidificação do esôfago não provocou alterações significativas sobre a amplitude de pressão e comprimento do esfíncter superior do esôfago. DESCRITORES-Manometria. Junção esofagogástrica. Ácido clorídrico. Cães.

Archives of Endocrinology and Metabolism

Sleep Science, 2021

Objective: To evaluate the economic and technical viability of the sleep study (type III) in chil... more Objective: To evaluate the economic and technical viability of the sleep study (type III) in children with adenotonsilar hypertrophy. Methods: 141 children were submitted to sleep study (type III), aged between three and 11, all with symptoms of OSA. The frequency of failed examinations and a comparison of cost analysis between complete polysomnography were described. Results: 41 exams lost at least one sensor. The sensor with the highest number of losses was the oximetry, observed in 14.28%. The 100 valid sleep studies allowed the diagnosis of severe OSA in 36 children. Sleep study accounts for approximately 63% of the value of the PSG type I, thus, it showed to be cost effective even with the repetition of the failed one. Conclusion: Sleep study (type III) may have high failure rates and it was a reliable exam for the identification of severe OSA. The cost analysis showed economic feasibility, even with a high failure rate and necessity of repetition.

Endocrine Research, 2016

Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) a... more Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine ((131)I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. This study compared the reliability of the STg/TSH ratio and STg measurement in predicting the success of RIT. Sixty-three DTC patients submitted to TT were assessed retrospectively to compare the ability of STg level and the STg/TSH ratio to predict successful RIT. In this study 48 (76.2%) patients had successful RIT. The successful and unsuccessful groups received different (131)I doses and had different STg levels and STg/TSH ratios. The STg and STg/TSH ratio cutoff values that predicted successful RIT were 4.41 ng/mL (sensitivity of 86.7% and specificity of 77%) and 0.093 (sensitivity of 80% and specificity of 79.2%), respectively. Age, STg level, STg/TSH ratio, and (131)I dose were associated with successful RIT, but after multivariate analysis only STg remained associated (p &amp;amp;amp;lt; 0.05). In conclusion, our data suggest that the STg/TSH ratio and measurement of STg are equally reliable in predicting successful RIT in DTC patients.

Revista Brasileira de Otorrinolaringologia, 2001

Condrossarcoma é o sarcoma mais freqüente da laringe. Sua incidência é maior na cartilagem cricói... more Condrossarcoma é o sarcoma mais freqüente da laringe. Sua incidência é maior na cartilagem cricóide do que nas outras cartilagens da laringe, sendo raro que ele se origine na epiglote. Relatamos no texto um caso de condrossarcoma originado na epiglote, no qual foi realizada laringectomia subtotal com crico-hioidopexia - e realizamos revisão da literatura.

Human Pathology, 2011

The cortactin gene, mapped at 11q13, has been associated with an aggressive clinical course in ma... more The cortactin gene, mapped at 11q13, has been associated with an aggressive clinical course in many cancers because of its function of invasiveness. This study evaluated CTTN protein and its prognostic value in the deep invasive front and superficial areas of laryngeal squamous cell carcinomas. The transcript expression levels were evaluated in a subset of cases. Overexpression of CTTN cytoplasmatic protein (80% of cases in both the deep invasive front and superficial areas) and transcript (30% of samples) was detected in a significant number of cases. In more than 20% of cases, observation verified membrane immunostaining in the deep invasive front and superficial areas. Perineural invasion was significantly associated with N stage and recurrence (P = .0058 and P = .0037, respectively). Higher protein expression levels were correlated with perineural invasion (P = .004) in deep invasive front cells, suggesting that this area should be considered a prognostic tool in laryngeal carcinomas. Although most cases had moderate to strong CTTN expression on the tumor surface, 2 sets of cases revealed a differential expression pattern in the deep invasive front. A group of cases with absent to weak expression of CTTN in the deep invasive front showed good prognosis parameters, and a second group with moderate to strong expression of CTTN were associated with an unfavorable prognosis, suggesting an association with worse outcome. Taken together, these results suggest that the deep

International Archives of Otorhinolaryngology, 2012

Brazilian Journal of Otorhinolaryngology, 2017

Introduction: Dysphonia is a common symptom after thyroidectomy. Objective: To analyze the vocal ... more Introduction: Dysphonia is a common symptom after thyroidectomy. Objective: To analyze the vocal symptoms, auditory-perceptual and acoustic vocal, videolaryngoscopy, the surgical procedures and histopathological findings in patients undergoing thyroidectomy. Methods: Prospective study. Patients submitted to thyroidectomy were evaluated as follows: anamnesis, laryngoscopy, and acoustic vocal assessments. Moments: pre-operative, 1st post (15 days), 2nd post (1 month), 3rd post (3 months), and 4th post (6 months). Results: Among the 151 patients (130 women; 21 men). Type of surgery: lobectomy + isthmectomy n = 40, total thyroidectomy n = 88, thyroidectomy + lymph node dissection n = 23. Vocal symptoms were reported by 42 patients in the 1st post (27.8%) decreasing to 7.2% after 6 months. In the acoustic analysis, f0 and APQ were decreased in women. Videolaryngoscopies showed that 144 patients (95.3%) had normal exams in the preoperative moment. Vocal fold palsies were diagnosed in 34 paralyzes at the 1st post, 32 recurrent laryngeal nerve (lobectomy + isthmectomy n = 6; total thyroidectomy n = 17; thyroidectomy + lymph node dissection n = 9) and 2 superior laryngeal nerve (lobectomy + isthmectomy n = 1; Total thyroidectomy + lymph node dissection n = 1). After 6 months, 10 patients persisted with paralysis of the recurrent laryngeal nerve (6.6%). Histopathology and correlation with vocal fold palsy: colloid nodular goiter (n = 76; palsy n = 13), thyroiditis (n = 8; palsy n = 0), and carcinoma (n = 67; palsy n = 21).

Background Thyroid nodules diagnosed as 'atypia of undetermined significance/follicular lesio... more Background Thyroid nodules diagnosed as 'atypia of undetermined significance/follicular lesion of undetermined significance' (AUS/FLUS) or 'follicular neoplasm/suspected follicular neoplasm' (FN/SFN), according to Bethesda’s classification, represent a challenge in clinical practice. Computerized analysis of nuclear images (CANI) could be a useful tool for these cases. Our aim was to evaluate the ability of CANI to correctly classify AUS/FLUS and FN/SFN thyroid nodules for malignancy. Methods We studied 101 nodules cytologically classified as AUS/FLUS (n = 68) or FN/SFN (n = 33) from 97 thyroidectomy patients. Slides with cytological material were submitted for manual selection and analysis of the follicular cell nuclei for morphometric and texture parameters using ImageJ software. The histologically benign and malignant lesions were compared for such parameters which were then evaluated for the capacity to predict malignancy using the classification and regression t...

Archives of Endocrinology and Metabolism, 2021

Objective: Thyrotropin-stimulated thyroglobulin (STg) after total thyroidectomy is a prognosis ma... more Objective: Thyrotropin-stimulated thyroglobulin (STg) after total thyroidectomy is a prognosis marker for differentiated thyroid carcinoma (DTC). As Tg level is influenced by thyrotropin (TSH), perhaps the STg/TSH ratio is also a prognosis marker for these tumours. We aimed to compare STg/TSH ratio and first STg level in differentiated thyroid carcinoma patients for their ability to predict the long-term response to initial treatment. Subjects and methods: This retrospective study evaluated data from 181 DTC patients for first (1 st) STg and STg/TSH ratio, at 1-3 months post-total thyroidectomy and before iodine-131 therapy, according to response to initial therapy [Excellent/Indeterminate or Incomplete (Biochemical/Structural)] observed at final evaluation, and with the survival time with excellent/ indeterminate response. Results: Cases with incomplete response presented higher STg level [225.13 ± 585.26 ng/mL versus (vs) 20.4 ± 192.9 ng/mL; p < 0.001] and STg/TSH ratio (3.01 ± 7.8 vs 0.27 ± 2.58; p < 0.001). Cutoffs of 5 ng/mL for STg and 0.085 for STg/TSH displayed sensitivities of 76.7% and 76.9%, and specificities of 79.2% and 82.6%, respectively, in predicting response to therapy. Values below these cutoffs were associated with longer survival time in excellent/indeterminate response (140.4 vs 15.9 and 144.6 vs 15.9 months, respectively). Conclusion: STg/TSH ratio has a similar performance to the 1 st STg in predicting long-term response to initial therapy.

International Archives of Otorhinolaryngology, 2014

Case Reports in Pathology, 2019

The diagnostic and therapeutic approach for pregnant women with thyroid nodules can present a cha... more The diagnostic and therapeutic approach for pregnant women with thyroid nodules can present a challenge, especially concerning surgical procedures. In the context of malignant diagnosis, by fine needle aspiration (FNA), during pregnancy, the uncertainty lies in performing surgery. This article reports the case of a 41-year-old pregnant woman in her first gestation, who sought medical care complaining of right shoulder pain. Imaging workup depicted the destruction of the humeral head and involvement of the surrounding soft tissue. She was 20 weeks pregnant. The histological report favored the diagnosis of malignancy and the thyroid as the primary site. At 30 weeks of gestation, the patient underwent a cesarean section, a total thyroidectomy, and total resection of the metastasis. The child was born healthy, but one year after the diagnosis, the patient died. Bone and soft tissue metastasis of thyroid neoplasms are not very common and indicate poor prognosis.