Jose Valera - Academia.edu (original) (raw)
Papers by Jose Valera
HIV Medicine, 2013
Pulmonary abnormalities are often present in patients infected with the human immunodeficiency vi... more Pulmonary abnormalities are often present in patients infected with the human immunodeficiency virus (HIV). The aim of the study was to determine the prevalence and characteristics of, and risk factors for, pulmonary abnormalities in HIV-positive patients. A total of 275 HIV-positive patients [mean (± standard deviation) age 48.5 ± 6.6 years] were included in the study, of whom 95.6% had been receiving highly active antiretroviral therapy (HAART) for a mean (± standard deviation) duration of 11.9 ± 5.4 years. The median (interquartile range) CD4 lymphocyte count was 541 (392-813) cells/μL, and 92% of the patients had an undetectable viral load. We determined: (1) spirometry, static lung volumes, lung diffusing capacity, pulmonary gas exchange and exercise tolerance, and (2) the amount of emphysema via a computed tomography (CT) scan. Chronic cough and expectoration (47%) and breathlessness during exercise (33.9%) were commonly reported. Airflow limitation (AL) was present in 17.2%, low pulmonary diffusing capacity in 52.2% and emphysema in 10.5-37.7% of patients, depending on the method used for quantification. Most of these abnormalities had not been diagnosed or treated previously. Smoking exposure and previous tuberculosis were the main risk factors for AL, whereas smoking exposure and several variables related to HIV infection appeared to contribute to the risk of emphysema and low diffusing capacity. Despite HAART, pulmonary structural and functional abnormalities are frequent in HIV-positive patients. They are probably attributable to both environmental (smoking and tuberculosis) and HIV-related factors. Most of these abnormalities remain unnoticed and untreated. Given the relatively young age of these patients, these results anticipate a significant health problem in the next few years as, thanks to the efficacy of HAART, patients survive longer and experience the effects of aging.
European Respiratory Journal, Sep 1, 2012
Number: 2219 Publication Number: P3471 Abstract Group: 1.12. Clinical Problems -COPD
Ciencia, Sep 1, 2007
... Tra ba jo pre sen ta do en el V Con gre so de la So cie dad Ve ne zo la na de Fí si ca, Uni v... more ... Tra ba jo pre sen ta do en el V Con gre so de la So cie dad Ve ne zo la na de Fí si ca, Uni ver si dad del Zu lia. Nu cleo Pun to Fijo - Edo. Fal cón, Ve ne zue la, No viem bre 2005. Page 2. ... LACárdenas y et al. / Cien cia Vol. 15, Nº 3 (2007) 380 - 385 381 Page 3. ...
Revista Chilena De Enfermedades Respiratorias, 2008
Gastroenterol Latinoam, 2004
Resumo: Introducción: Los tumores primarios de intestino delgado (TID) son de baja frecuencia y s... more Resumo: Introducción: Los tumores primarios de intestino delgado (TID) son de baja frecuencia y su diagnóstico habitualmente es tardío, debido a su relativa inaccesibilidad a métodos diagnósticos. Objetivo: Precisar las formas de presentación, métodos ...
Acta Andin, 1995
AActa Andina 1995; 4 (1): 53 - 64. CRECIMIENTO Y DESARROLLO DE NIÑOS Y ADOLESCENTES A DIVERSAS AL... more AActa Andina 1995; 4 (1): 53 - 64. CRECIMIENTO Y DESARROLLO DE NIÑOS Y ADOLESCENTES A DIVERSAS ALTURAS SOBRE EL NIVEL DEL MAR. Isaac Crespo*., José Valera*., Gustavo F. Gonzales** y Roger Guerra-García**. RESUMEN. ...
Revista Medica De Chile, Sep 1, 2004
We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pa... more We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pain, mild jaundice, hepatomegaly and ascites. Magnetic resonance imaging study and liver biopsy were compatible with veno-occlusive disease. Incidentally, an ulcerative colitis and portal vein thrombosis were diagnosed. Anticoagulant treatment was started, with good clinical and radiological response. Veno-occlusive disease of the liver must be suspected In cases of liver failure and ascites associated to procoagulant conditions.
Gastroenterologia Y Hepatologia, 2008
Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other ... more Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases (CLD), such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC).AIM: To study the frequency of serological markers of CD in patients with NAFLD and CLD and their correlation with duodenal biopsy.PATIENTS AND METHODS: In patients with NAFLD, PBC, AIH and PSC, we studied anti-endomysium (AE) IgA by indirect immunofluorescence and anti-gliadin IgA-IgG (AG) and human anti-tissue transglutaminase (tTG) IgA antibodies by an ELISA technique. Patients with positive serology for at least one marker underwent endoscopy with duodenal biopsies.RESULTS: Positive CD markers were found in 9 of 101 patients (8.9%): 7 patients were positive for tTG alone, 1 for AE and AG, and 1 patient for 3 antibodies. Positivity was as follows: 3/38 (7.9%) in NAFLD, 3/44 (6.8%) in PBC, 2/16 (12.5%) in AIH and 1/3 in PSC. Endoscopy was performed in 8 patients, with normal duodenal biopsy in 7 and 1 patient with Marsh stage 1 CD with NAFLD, positive AE and AG. The only patient with 3 positive markers died during the study without undergoing endoscopy. None of the patients had symptoms suggestive of CD.CONCLUSION: A high prevalence of positive tTG was found in patients with CLD and NAFLD. However, duodenal biopsy should be performed in these patients, given that the results of this procedure were normal in most patients in this study.
Gastroenterología y hepatología, 2008
Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other ... more Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases (CLD), such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). To study the frequency of serological markers of CD in patients with NAFLD and CLD and their correlation with duodenal biopsy. In patients with NAFLD, PBC, AIH and PSC, we studied anti-endomysium (AE) IgA by indirect immunofluorescence and anti-gliadin IgA-IgG (AG) and human anti-tissue transglutaminase (tTG) IgA antibodies by an ELISA technique. Patients with positive serology for at least one marker underwent endoscopy with duodenal biopsies. Positive CD markers were found in 9 of 101 patients (8.9%): 7 patients were positive for tTG alone, 1 for AE and AG, and 1 patient for 3 antibodies. Positivity was as follows: 3/38 (7.9%) in NAFLD, 3/44 (6.8%) in PBC, 2/16 (12.5%) in AIH and 1/3 in PSC. Endoscopy was performed in 8 patients, with normal duoden...
Revista chilena de enfermedades respiratorias, 2008
Revista médica de Chile, 2004
We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pa... more We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pain, mild jaundice, hepatomegaly and ascites. Magnetic resonance imaging study and liver biopsy were compatible with veno-occlusive disease. Incidentally, an ulcerative colitis and portal vein thrombosis were diagnosed. Anticoagulant treatment was started, with good clinical and radiological response. Veno-occlusive disease of the liver must be suspected In cases of liver failure and ascites associated to procoagulant conditions.
Revista médica de Chile, 2004
The diagnosis of hepatocellular carcinoma in cirrhotic patients has increased, mainly due to earl... more The diagnosis of hepatocellular carcinoma in cirrhotic patients has increased, mainly due to early detection using newer imaging techniques. The therapeutic approach depends on the tumor staging and the liver function. Cardiac involvement has a very bad prognosis. We report three males aged 59, 75 and 76 years and two females, aged 64 and 79 years. All had cirrhosis of diverse aetiologies with hepatocellular carcinoma and tumoral invasion of the inferior vena cava and right atrium. Three patients died during hospital stay and two were discharged for conservative management at home. This rare complication has to be considered in cirrhosis.
Gastroenterología y Hepatología, 2011
Recibido el 12 de julio de 2010; aceptado el 13 de octubre de 2010 Disponible en Internet el 30 d... more Recibido el 12 de julio de 2010; aceptado el 13 de octubre de 2010 Disponible en Internet el 30 de diciembre de 2010 PALABRAS CLAVE Fibrosis hepática; Hepatitis autoinmune; Cirrosis; Corticoides; Inmunosupresores
Gastroenterología y Hepatología, 2008
RESUMEN La enfermedad celíaca (EC) se ha asociado con hígado graso no alcohólico (HGNA) y hepatop... more RESUMEN La enfermedad celíaca (EC) se ha asociado con hígado graso no alcohólico (HGNA) y hepatopatías crónicas, como cirrosis biliar primaria (CBP), hepatitis autoinmune (HAI) y colangitis esclerosante primaria (CEP). OBJETIVO: Estudiar la frecuencia de ...
Determination of Trace Concentrations of Co(II) in Electrolyte for Electrowinning of Zn by Differ... more Determination of Trace Concentrations of Co(II) in Electrolyte for Electrowinning of Zn by Differential Pulse Voltammetry. [ECS Transactions 29, 409 (2010)]. Jose Adolfo Valera, Roumen Zlatev, Margarita Stoytcheva, Benjamin Valdez. Abstract. ...
C29. CONTROL OF VENTILATION: FROM BENCH TO BEDSIDE, 2010
Respiratory Patophysiology, Cava dei Tirreni, Italy, Pneumology, Messina, Italy, Hospital Son Dur... more Respiratory Patophysiology, Cava dei Tirreni, Italy, Pneumology, Messina, Italy, Hospital Son Dureta, Pneumology, Palma de Mallorca, 1 ... : Respiratory failure by muscle weakness is the major cause of death in patients affected by Amyotrophic Lateral Sclerosis Background ...
Books Abroad, 1959
Ensayo en el que su autor propone exponer y explicar el movimiento de autonomía cultural que impl... more Ensayo en el que su autor propone exponer y explicar el movimiento de autonomía cultural que implicó el resurgimiento de la literatura gallega en el siglo XIX, luego de tres siglos durante los que este idioma había desaparecido casi por completo en la expresión escrita, si bien ...
Simultaneous Species Determination in Industrial Solutions by Differential Alternative Pulse Volt... more Simultaneous Species Determination in Industrial Solutions by Differential Alternative Pulse Voltammetry (DAPV). [ECS Transactions 28, 99 (2010)]. Jose Adolfo Valera, Roumen K. Zlatev, Margarita Stoytcheva, Benjamin Valdez, Monica Carrillo. Abstract. ...
HIV Medicine, 2013
Pulmonary abnormalities are often present in patients infected with the human immunodeficiency vi... more Pulmonary abnormalities are often present in patients infected with the human immunodeficiency virus (HIV). The aim of the study was to determine the prevalence and characteristics of, and risk factors for, pulmonary abnormalities in HIV-positive patients. A total of 275 HIV-positive patients [mean (± standard deviation) age 48.5 ± 6.6 years] were included in the study, of whom 95.6% had been receiving highly active antiretroviral therapy (HAART) for a mean (± standard deviation) duration of 11.9 ± 5.4 years. The median (interquartile range) CD4 lymphocyte count was 541 (392-813) cells/μL, and 92% of the patients had an undetectable viral load. We determined: (1) spirometry, static lung volumes, lung diffusing capacity, pulmonary gas exchange and exercise tolerance, and (2) the amount of emphysema via a computed tomography (CT) scan. Chronic cough and expectoration (47%) and breathlessness during exercise (33.9%) were commonly reported. Airflow limitation (AL) was present in 17.2%, low pulmonary diffusing capacity in 52.2% and emphysema in 10.5-37.7% of patients, depending on the method used for quantification. Most of these abnormalities had not been diagnosed or treated previously. Smoking exposure and previous tuberculosis were the main risk factors for AL, whereas smoking exposure and several variables related to HIV infection appeared to contribute to the risk of emphysema and low diffusing capacity. Despite HAART, pulmonary structural and functional abnormalities are frequent in HIV-positive patients. They are probably attributable to both environmental (smoking and tuberculosis) and HIV-related factors. Most of these abnormalities remain unnoticed and untreated. Given the relatively young age of these patients, these results anticipate a significant health problem in the next few years as, thanks to the efficacy of HAART, patients survive longer and experience the effects of aging.
European Respiratory Journal, Sep 1, 2012
Number: 2219 Publication Number: P3471 Abstract Group: 1.12. Clinical Problems -COPD
Ciencia, Sep 1, 2007
... Tra ba jo pre sen ta do en el V Con gre so de la So cie dad Ve ne zo la na de Fí si ca, Uni v... more ... Tra ba jo pre sen ta do en el V Con gre so de la So cie dad Ve ne zo la na de Fí si ca, Uni ver si dad del Zu lia. Nu cleo Pun to Fijo - Edo. Fal cón, Ve ne zue la, No viem bre 2005. Page 2. ... LACárdenas y et al. / Cien cia Vol. 15, Nº 3 (2007) 380 - 385 381 Page 3. ...
Revista Chilena De Enfermedades Respiratorias, 2008
Gastroenterol Latinoam, 2004
Resumo: Introducción: Los tumores primarios de intestino delgado (TID) son de baja frecuencia y s... more Resumo: Introducción: Los tumores primarios de intestino delgado (TID) son de baja frecuencia y su diagnóstico habitualmente es tardío, debido a su relativa inaccesibilidad a métodos diagnósticos. Objetivo: Precisar las formas de presentación, métodos ...
Acta Andin, 1995
AActa Andina 1995; 4 (1): 53 - 64. CRECIMIENTO Y DESARROLLO DE NIÑOS Y ADOLESCENTES A DIVERSAS AL... more AActa Andina 1995; 4 (1): 53 - 64. CRECIMIENTO Y DESARROLLO DE NIÑOS Y ADOLESCENTES A DIVERSAS ALTURAS SOBRE EL NIVEL DEL MAR. Isaac Crespo*., José Valera*., Gustavo F. Gonzales** y Roger Guerra-García**. RESUMEN. ...
Revista Medica De Chile, Sep 1, 2004
We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pa... more We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pain, mild jaundice, hepatomegaly and ascites. Magnetic resonance imaging study and liver biopsy were compatible with veno-occlusive disease. Incidentally, an ulcerative colitis and portal vein thrombosis were diagnosed. Anticoagulant treatment was started, with good clinical and radiological response. Veno-occlusive disease of the liver must be suspected In cases of liver failure and ascites associated to procoagulant conditions.
Gastroenterologia Y Hepatologia, 2008
Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other ... more Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases (CLD), such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC).AIM: To study the frequency of serological markers of CD in patients with NAFLD and CLD and their correlation with duodenal biopsy.PATIENTS AND METHODS: In patients with NAFLD, PBC, AIH and PSC, we studied anti-endomysium (AE) IgA by indirect immunofluorescence and anti-gliadin IgA-IgG (AG) and human anti-tissue transglutaminase (tTG) IgA antibodies by an ELISA technique. Patients with positive serology for at least one marker underwent endoscopy with duodenal biopsies.RESULTS: Positive CD markers were found in 9 of 101 patients (8.9%): 7 patients were positive for tTG alone, 1 for AE and AG, and 1 patient for 3 antibodies. Positivity was as follows: 3/38 (7.9%) in NAFLD, 3/44 (6.8%) in PBC, 2/16 (12.5%) in AIH and 1/3 in PSC. Endoscopy was performed in 8 patients, with normal duodenal biopsy in 7 and 1 patient with Marsh stage 1 CD with NAFLD, positive AE and AG. The only patient with 3 positive markers died during the study without undergoing endoscopy. None of the patients had symptoms suggestive of CD.CONCLUSION: A high prevalence of positive tTG was found in patients with CLD and NAFLD. However, duodenal biopsy should be performed in these patients, given that the results of this procedure were normal in most patients in this study.
Gastroenterología y hepatología, 2008
Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other ... more Celiac disease (CD) has been associated with non-alcoholic fatty liver disease (NAFLD) and other chronic liver diseases (CLD), such as primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). To study the frequency of serological markers of CD in patients with NAFLD and CLD and their correlation with duodenal biopsy. In patients with NAFLD, PBC, AIH and PSC, we studied anti-endomysium (AE) IgA by indirect immunofluorescence and anti-gliadin IgA-IgG (AG) and human anti-tissue transglutaminase (tTG) IgA antibodies by an ELISA technique. Patients with positive serology for at least one marker underwent endoscopy with duodenal biopsies. Positive CD markers were found in 9 of 101 patients (8.9%): 7 patients were positive for tTG alone, 1 for AE and AG, and 1 patient for 3 antibodies. Positivity was as follows: 3/38 (7.9%) in NAFLD, 3/44 (6.8%) in PBC, 2/16 (12.5%) in AIH and 1/3 in PSC. Endoscopy was performed in 8 patients, with normal duoden...
Revista chilena de enfermedades respiratorias, 2008
Revista médica de Chile, 2004
We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pa... more We report a previously healthy 29 years old man, presenting with a sudden episode of abdominal pain, mild jaundice, hepatomegaly and ascites. Magnetic resonance imaging study and liver biopsy were compatible with veno-occlusive disease. Incidentally, an ulcerative colitis and portal vein thrombosis were diagnosed. Anticoagulant treatment was started, with good clinical and radiological response. Veno-occlusive disease of the liver must be suspected In cases of liver failure and ascites associated to procoagulant conditions.
Revista médica de Chile, 2004
The diagnosis of hepatocellular carcinoma in cirrhotic patients has increased, mainly due to earl... more The diagnosis of hepatocellular carcinoma in cirrhotic patients has increased, mainly due to early detection using newer imaging techniques. The therapeutic approach depends on the tumor staging and the liver function. Cardiac involvement has a very bad prognosis. We report three males aged 59, 75 and 76 years and two females, aged 64 and 79 years. All had cirrhosis of diverse aetiologies with hepatocellular carcinoma and tumoral invasion of the inferior vena cava and right atrium. Three patients died during hospital stay and two were discharged for conservative management at home. This rare complication has to be considered in cirrhosis.
Gastroenterología y Hepatología, 2011
Recibido el 12 de julio de 2010; aceptado el 13 de octubre de 2010 Disponible en Internet el 30 d... more Recibido el 12 de julio de 2010; aceptado el 13 de octubre de 2010 Disponible en Internet el 30 de diciembre de 2010 PALABRAS CLAVE Fibrosis hepática; Hepatitis autoinmune; Cirrosis; Corticoides; Inmunosupresores
Gastroenterología y Hepatología, 2008
RESUMEN La enfermedad celíaca (EC) se ha asociado con hígado graso no alcohólico (HGNA) y hepatop... more RESUMEN La enfermedad celíaca (EC) se ha asociado con hígado graso no alcohólico (HGNA) y hepatopatías crónicas, como cirrosis biliar primaria (CBP), hepatitis autoinmune (HAI) y colangitis esclerosante primaria (CEP). OBJETIVO: Estudiar la frecuencia de ...
Determination of Trace Concentrations of Co(II) in Electrolyte for Electrowinning of Zn by Differ... more Determination of Trace Concentrations of Co(II) in Electrolyte for Electrowinning of Zn by Differential Pulse Voltammetry. [ECS Transactions 29, 409 (2010)]. Jose Adolfo Valera, Roumen Zlatev, Margarita Stoytcheva, Benjamin Valdez. Abstract. ...
C29. CONTROL OF VENTILATION: FROM BENCH TO BEDSIDE, 2010
Respiratory Patophysiology, Cava dei Tirreni, Italy, Pneumology, Messina, Italy, Hospital Son Dur... more Respiratory Patophysiology, Cava dei Tirreni, Italy, Pneumology, Messina, Italy, Hospital Son Dureta, Pneumology, Palma de Mallorca, 1 ... : Respiratory failure by muscle weakness is the major cause of death in patients affected by Amyotrophic Lateral Sclerosis Background ...
Books Abroad, 1959
Ensayo en el que su autor propone exponer y explicar el movimiento de autonomía cultural que impl... more Ensayo en el que su autor propone exponer y explicar el movimiento de autonomía cultural que implicó el resurgimiento de la literatura gallega en el siglo XIX, luego de tres siglos durante los que este idioma había desaparecido casi por completo en la expresión escrita, si bien ...
Simultaneous Species Determination in Industrial Solutions by Differential Alternative Pulse Volt... more Simultaneous Species Determination in Industrial Solutions by Differential Alternative Pulse Voltammetry (DAPV). [ECS Transactions 28, 99 (2010)]. Jose Adolfo Valera, Roumen K. Zlatev, Margarita Stoytcheva, Benjamin Valdez, Monica Carrillo. Abstract. ...