Joseph Baxter - Academia.edu (original) (raw)

Papers by Joseph Baxter

Two major issues in the design of multi-robot systems are those of communication and coordination... more Two major issues in the design of multi-robot systems are those of communication and coordination. Communication within real world environments cannot always be guaranteed. A multi-robot system must, therefore, be able to continue with its task in the absence of communication between team members. Coordination of multiple robots to perform a specific task involves team members being able to make decisions as a single entity and as a member of a team. The coordination needs to be robust enough to handle failures within the system and unknown phenomena within the I would like to take this opportunity to thank my academic supervisors, Dr. Jonathan Garibaldi and Prof. Edmund Burke, for their support and guidance throughout my study. I would also like to thank my industrial supervisor, Dr. Mark Norman from Merlin Systems, for the opportunity to use the Miabot Pro. Special thanks to Patrick Peglar and Simon Norman at Merlin Systems, for their technical support. I would also like to express my thanks to Phil Birkin from the University of Nottingham for his input throughout my research. This work was supported by an EPSRC industrial CASE award, made available through the Knowledge Training Network (KTN), and so many thanks go to Melvin Brown and all those at the Smith Institute. iii iv Contents Contents iv List of Figures x List of Tables xiv LIST OF FIGURES xiii 6.10 Plot of differences between ranks for the pessimistic system.. .. . .

Annals of Oncology, Jun 1, 2022

Molecular Oncology, Jun 5, 2022

The DNA damage response (DDR) represents a complex network of proteins which detect and repair DN... more The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faults in the DDR are a known driver and hallmark of cancer. Furthermore, inhibition of DDR enzymes can be used to treat the disease. This is exemplified by PARP inhibitors (PARPi) used to treat cancers with defects in the homologous recombination DDR pathway. A series of novel DDR targets are now also under pre‐clinical or clinical investigation, including inhibitors of ATR kinase, WRN helicase or the DNA polymerase/helicase Polθ (Pol‐Theta). Drug resistance is a common phenomenon that impairs the overall effectiveness of cancer treatments and there is already some understanding of how resistance to PARPi occurs. Here, we discuss how an understanding of PARPi resistance could inform how resistance to new drugs targeting the DDR emerges. We also discuss potential strategies that could limit the impact of these therapy resistance mechanisms in cancer.

This study examined faculty perceptions of accessibility and quality of graduate programs offered... more This study examined faculty perceptions of accessibility and quality of graduate programs offered via the Internet. A total of 25 faculty (38 percent return rate) with experience teaching graduate courses via the Internet completed an e-mailed survey. It was found that half of the respondents had less than one year of experience teaching graduate courses using the Internet, and that nearly all also taught college courses in a traditional classroom setting. The largest groups of respondents taught graduate courses in education (32 percent), communications (20 percent), and the liberal arts or humanities (16 percent). Over two-thirds of the respondents reported that they were satisfied with their preparation time and efforts in teaching via the Internet. Respondents indicated that course or program administration was the most important environmental factor when considering course quality and accessibility. A high level of satisfaction was reported by most of the respondents in regard to the quality of the courses taught via the Internet. Data tables show results of the survey. (Contains 10 references.) (MDM)

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington headquarters Services, Directorate for Information Operations and Reports,

bioRxiv (Cold Spring Harbor Laboratory), Aug 26, 2022

The PSMC3IP-MND1 heterodimer promotes RAD51 and DMC1-dependent D-loop formation during meiosis in... more The PSMC3IP-MND1 heterodimer promotes RAD51 and DMC1-dependent D-loop formation during meiosis in yeast and mammalian organisms. For this purpose, it catalyzes the DNA strand exchange activities of the recombinases. Interestingly, in a panel of genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, we found that depletion of either PSMC3IP or MND1 caused sensitivity to clinical Poly (ADP-Ribose) Polymerase inhibitors (PARPi). A retroviral mutagenesis screen in mitotic cells also identified PSMC3IP and MND1 as genetic determinants of ionizing radiation sensitivity. The role PSMC3IP and MND1 play in preventing PARPi sensitivity in mitotic cells appears to be independent of a previously described role in alternative lengthening of telomeres (ALT). PSMC3IP or MND1 depleted cells accumulate toxic RAD51 foci in response to DNA damage, show impaired homology-directed DNA repair, and become PARPi sensitive, even in cells lacking both BRCA1 and TP53BP1. Although replication fork reversal is also affected, the epistatic relationship between PSMC3IP-MND1 and BRCA1/BRCA2 suggests that the abrogated D-loop formation is the major cause of PARPi sensitivity. This is corroborated by the fact that a PSMC3IP p.Glu201del D-loop formation mutant associated with ovarian dysgenesis fails to reverse PARPi sensitivity. These observations suggest that meiotic proteins such as MND1 and PSMC3IP could have a greater role in mitotic cells in determining the response to therapeutic DNA damage.

Bulletin of the National Association of Secondary-School Principals, Mar 1, 1962

Reginald L. Jones is Research Assistant Professor, Miami University, Oxford, Ohio, and Joseph R. ... more Reginald L. Jones is Research Assistant Professor, Miami University, Oxford, Ohio, and Joseph R. Baxter is associated with the Cincinnati Public School System, Cincinnati, Ohio. THERE has been little systematic assessment of parent attitudes about acceleration of able high-school youth. 1 However, such assessment has value, for it gives us some ideas about the climate of opinion surrounding the able high-school student in general, and the forces shaping his own educational philosophy in particular. This study2 has focused on the opinions about a specific program of acceleration (See Baxter and Jones,3 for a description of the program) of two groups of parents of &dquo;superior high-school students.&dquo; One group of University School parents (USP) had children who qualified for, and enrolled in, one or more college courses

European Journal of Cancer

Molecular Oncology