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Theeffects ofamrinone, dobutamine, anda combination ofthetwodrugs on peak positive left ventricul... more Theeffects ofamrinone, dobutamine, anda combination ofthetwodrugs on peak positive left ventricular dP/dt andleft ventricular performance were evaluated in11patients with chronic congestive heart failure. Whenadministered alone, bothdobutamine (10.9gg/kg/min) and intravenous amrinone (1.9 mg/kg/min) significantly increased left ventricular dP/dt andperformance. Whencompared withdobutamine alone, theaddition ofamrinone resulted infurther increases inleft ventricular dP/dt andcardiac index (to1319 ± 419from1202 ± 376mm Hg/sec, p < .002, andto 3.56 ± 0.78from3.04 ± 0.67liters/min/m2, p < .01, respectively). Thecombination also induced a further reduction inleft ventricular end-diastolic pressure(to15.3 ± 11.3from18.2 ± 10.3 mm Hg, p < .05) whencompared withamrinone alone. Thecombination ofdobutamine andamrinone in- creased heart rateslightly whencompared witheither drugalone, butdidnotfurther reduce systemic arterial pressurewhencompared withamrinone alone. Thedose-response cu...

Circulation, 1986

The effects of amrinone, dobutamine, and a combination of the two drugs on peak positive left ven... more The effects of amrinone, dobutamine, and a combination of the two drugs on peak positive left ventricular dP/dt and left ventricular performance were evaluated in 11 patients with chronic congestive heart failure. When administered alone, both dobutamine (10.9 micrograms/kg/min) and intravenous amrinone (1.9 mg/kg/min) significantly increased left ventricular dP/dt and performance. When compared with dobutamine alone, the addition of amrinone resulted in further increases in left ventricular dP/dt and cardiac index (to 1319 +/- 419 from 1202 +/- 376 mm Hg/sec, p less than .002, and to 3.56 +/- 0.78 from 3.04 +/- 0.67 liters/min/m2, p less than .01, respectively). The combination also induced a further reduction in left ventricular end-diastolic pressure (to 15.3 +/- 11.3 from 18.2 +/- 10.3 mm Hg, p less than .05) when compared with amrinone alone. The combination of dobutamine and amrinone increased heart rate slightly when compared with either drug alone, but did not further reduce...

The American Journal of Medicine, 1986