Joseph Joseph - Academia.edu (original) (raw)
Papers by Joseph Joseph
RETINAL Cases & Brief Reports
Australian Journal of General Practice
COMMON WARTS (Verruca vulgaris), plantar warts (Verruca plantaris) and flat/plane warts (Verruca ... more COMMON WARTS (Verruca vulgaris), plantar warts (Verruca plantaris) and flat/plane warts (Verruca plana), collectively known as cutaneous warts, are benign growths of the skin caused by the human papillomavirus (HPV). In Australia, up to 24% of children and 5% of adults are affected. 1 A break in the epidermal barrier of the skin allows entry of HPV and subsequent infection of basal epithelial cells. HPV replicates alongside the natural lifecycle of epithelial cells, and is eventually released from desquamated keratinocytes on the surface of warts, potentially infecting other sites via direct contact or through fomites. 2 Cutaneous warts generally self-resolve. Up to two-thirds of immunocompetent children experience spontaneous clearance of their cutaneous warts by two years of age. 3 Adults tend to take longer. Patients might request treatment for their warts when they cause discomfort, functional impairment, social ostracism, are numerous, grow large or raise concerns regarding transmission. 4 Treatment for cutaneous warts can be painful, scar, cause pigmentary disturbances and might not be effective. 5 Therefore, clinicians should be wary of the evidence behind the efficacy of cutaneous wart treatment. This review summarises high-quality studies investigating the efficacy of chemical and physical destructive wart therapies. Methods We performed a literature review (up to June 2021) of published articles for wart management from the MEDLINE and Embase databases. No language restrictions were applied. We considered systematic reviews, randomised controlled trials (RCTs), cohort studies and case series. Case reports were excluded. For MEDLINE, we used the Boolean operation to combine MeSH terms 'warts' AND 'therapeutics'. For Embase, we used the Boolean operation to combine MeSH terms 'Verruca vulgaris' AND 'therapy'. We included studies that investigated chemical or physical destructive therapies.
Asia-Pacific Journal of Clinical Oncology
INTRODUCTION Epidermal growth factor receptor (EGFR) inhibitors are established therapies for adv... more INTRODUCTION Epidermal growth factor receptor (EGFR) inhibitors are established therapies for advanced lung, colorectal, and head and neck cancers. They commonly cause acneiform eruptions that affect patient quality of life and may lead to discontinuation of therapy. METHODS A systematic review and meta-analysis was undertaken to assess strategies for the prevention and reactive management of acneiform rash associated with EGFR inhibitor therapy for advanced lung, colorectal, and head and neck cancers. A systematic Medline, Embase, and EBM Reviews database search was conducted on the 2nd of January 2021. The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed and the studies were critically appraised. Studies were selected if they focused on preventing or treating acneiform eruptions in adults being treated for advanced lung cancer, colorectal cancer, and head and neck cancers with EGFR inhibitors. RESULTS Oral antibiotics had the greatest efficacy in preventing grade 2 or higher acneiform eruptions with a relative risk reduction of 40% (RR = .6, 95% CI .46-.79, p < .01). Other treatment modalities did not have statistically significant results. Topical antibiotics had a total relative risk reduction of 19% (RR = .81, 95% CI .45-1.48, p = .5). Vitamin K1 cream did not reduce the relative risk (RR = 1.08, 95% CI .45-1.48, p = .50). Sunscreen had a total relative risk reduction of 25% (RR = .75, 95% CI .49-1.14, p = .18). CONCLUSIONS The results of this meta-analysis reinforce the fact that oral tetracycline antibiotics are the most efficacious prophylactic option for acneiform eruptions in EGFR inhibitors. They should be offered to suitable patients commencing treatment and used with a general skin-care routine involving emollients and avoidance of irritants.
Cureus, 2021
The causes of osteoporosis in Crohn's disease (CD) are multifactorial; cytokines, steroids, and v... more The causes of osteoporosis in Crohn's disease (CD) are multifactorial; cytokines, steroids, and vitamin deficiency all have an essential role. It is imperative to distinguish the factors that contribute to bone resorption, potentially increasing the risk of low bone mineral density (BMD), osteoporosis, and fracture. However, the pathogenicity of osteoporosis associated with CD remains unclear. Although osteoporosis treatment may vary between bisphosphonate and corticosteroid, infliximab's efficacy, when combined with immune modulators, suppresses both CD symptoms and osteoporosis progression. In this review, we aim to understand the present pathogenicity of osteoporosis, including the factors pro-inflammatory cytokines, chronic steroid use, and malnutrition, developing osteoporosis in a different pathological way, and to assist the treatment lines implying a positive outcome of osteoporosis in CD patients. Osteoporosis is considered to be one of the early complications of CD where early detection can prevent osteoporosis progression. This can be done by utilizing dual-energy X-ray-absorptiometry (DEXA) to evaluate the Z-score and treat the existing factors that have a role in the progression of osteoporosis in CD patients.
Australian Journal of General Practice, 2022
The New Eastern Mediterranean Transformed, 2021
The discovery of significant oil and gas deposits in the exclusive economic zones (EEZ) of Israel... more The discovery of significant oil and gas deposits in the exclusive economic zones (EEZ) of Israel, Egypt, and Cyprus, and the alleged deposits in Greece, could potentially provide the European Union with an additional energy source that will contribute to the diversification, security, and resilience of Europe's energy supplies. Yet energy developments in the region have raised a number of legal and geopolitical challenges, mirroring the antagonistic and often turbulent relations amongst states in the region. This chapter provides an overview of the hydrocarbon discoveries in the Eastern Mediterranean with the aim to explore the conditions under which countries have shaped their energy policies in the broader context of their national strategies and account for the EU's strategic involvement in the region. The analysis highlights the legal, geopolitical as well as security concerns preoccupying stakeholders in the region and examines the prospects and limitations of the Eastern Mediterranean energy resources reaching Europe.
The Infravec2 infrastructure project provides insect vector resources and facility access to rese... more The Infravec2 infrastructure project provides insect vector resources and facility access to researchers worldwide at no cost. The project is funded by the European Commission Horizon 2020 Research Infrastructure Program (INFRAIA). The 24 Infravec2 partners operate major European biosecure insectaries for experimental infection and containment of insect vectors and other key insect vector technology platforms including front-line field sites in Africa, the Pacific, and the Americas. Researchers can shop online and request resources from an extensive product catalog (www.infravec2.eu). Infravec2 is also developing innovative new research tools, providing training courses, and is networking the community with activities such as common experimental standards and protocols to obtain reproducible vector infection results across different facilities. Infravec2 is a source of EU research support for vector researchers. The Infravec2 goal is to accelerate European innovation in basic and tr...
2007 37th annual frontiers in education conference - global engineering: knowledge without borders, opportunities without passports, 2007
The Oregon Institute of Technology [OIT] is the only public institute of technology in the Pacifi... more The Oregon Institute of Technology [OIT] is the only public institute of technology in the Pacific Northwest. OIT offers degree programs in engineering, management, communications, health technology, and applied science. OIT's Computer Systems Engineering Technology [CSET] Department uses a sequence of three quarter-length senior project classes to meet ABET-TAC capstone design requirements. Due to a lack of student preparation for this senior project class sequence, an additional set of three quarter-length prerequisite classes, junior project, was added. Both of these classes feature complex programmable digital logic circuit designs based on current VLSI technology. The junior project class is based on team projects and the success or failure of the students is influenced by both the quality of the faculty proctor's direction and the excellence of the social dynamics of the students' teamwork. This paper presents a paradigm for a conflict resolution scheme based on allowing the team members to fire a non-performing colleague in certain circumstances.
Australian Journal of General Practice, 2021
International Journal of Dermatology, 2021
Dermatology consultation has been shown to have a significant beneficial impact on admitted hospi... more Dermatology consultation has been shown to have a significant beneficial impact on admitted hospital patients with concurrent or newly diagnosed skin conditions. This study aimed to determine the change in diagnosis and management after dermatology consultation in a tertiary Australian referral hospital.
Australian Journal of General Practice, 2021
CommIT (Communication and Information Technology) Journal, 2020
The problem that currently happens in the decision process of the nutritional status for toddlers... more The problem that currently happens in the decision process of the nutritional status for toddlers is often based on manual calculation. However, the manual calculation is prone to data duplication, insufficient data, and a lack of availability of the data itself, which can hinder the monitoring status and the report. Therefore, to ease the determination and calculation process of the nutritional status of toddlers, the researchers conduct a study using the Simple Additive Weighting (SAW) method. The SAW method is selected because it defines the best alternative and some other alternatives based on specified or preferred criteria. This research is conducted by finding the weight value of each attribute and rating the data to determine the nutritional status of toddlers. For the result, the researchers find there are no toddlers with malnutrition in Pemberdayaan Kesejahteraan Keluarga, Program Kerja Kelompok Kerja IV (PKK POKJA IV) of Depok.
Journal of Clinical Nursing, 2020
Gut, Jun 11, 2017
Patients with long-standing UC have an increased risk for the development of colonic neoplastic l... more Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. To compare the performance of CE to VC for the detection of neoplastic lesions in patients with long-standing UC. A multicentre prospective randomised controlled trial. 131 patients with long-standing UC were randomised between CE with methylene blue 0.1% (n=66) or VC with narrow band imaging (NBI) (n=65). Biopsies were taken from visible lesions and surrounding mucosa. No random biopsies were performed. The primary outcome was the difference in total number of neoplastic lesions detected in each group. There was no significant difference between NBI and CE for neoplasia detection. Mean number of neoplastic lesions per colonoscopy was 0.47 for CE and 0.32 for NBI (p=0.992). The neoplasia detection rate was not different between CE (21.2%) and ...
International journal of medical informatics, Nov 1, 2016
Since the UN Human Rights Council's recognition on the subject in 2011, the right to access t... more Since the UN Human Rights Council's recognition on the subject in 2011, the right to access the Internet and information is now considered one of the most basic human rights of global citizens [1,2]. Despite this, an information gap between developed and resource-limited countries remains, and there is scant research on actual information needs of workers themselves. The Republic of Botswana represents a fertile ground to address existing gaps in research, policy, and practice, due to its demonstrated gap in access to information and specialists among rural health care workers (HCWs), burgeoning mHealth capacity, and a timely offer from Orange Telecommunications to access Wikipedia for free on mobile platforms for Botswana subscribers. In this study, we sought to identify clinical information needs of HCWs of Botswana and their perception of Wikipedia as a clinical tool. Twenty-eight facilitated focus groups, consisting of 113 HCWs of various cadres based at district hospitals, ...
RETINAL Cases & Brief Reports
Australian Journal of General Practice
COMMON WARTS (Verruca vulgaris), plantar warts (Verruca plantaris) and flat/plane warts (Verruca ... more COMMON WARTS (Verruca vulgaris), plantar warts (Verruca plantaris) and flat/plane warts (Verruca plana), collectively known as cutaneous warts, are benign growths of the skin caused by the human papillomavirus (HPV). In Australia, up to 24% of children and 5% of adults are affected. 1 A break in the epidermal barrier of the skin allows entry of HPV and subsequent infection of basal epithelial cells. HPV replicates alongside the natural lifecycle of epithelial cells, and is eventually released from desquamated keratinocytes on the surface of warts, potentially infecting other sites via direct contact or through fomites. 2 Cutaneous warts generally self-resolve. Up to two-thirds of immunocompetent children experience spontaneous clearance of their cutaneous warts by two years of age. 3 Adults tend to take longer. Patients might request treatment for their warts when they cause discomfort, functional impairment, social ostracism, are numerous, grow large or raise concerns regarding transmission. 4 Treatment for cutaneous warts can be painful, scar, cause pigmentary disturbances and might not be effective. 5 Therefore, clinicians should be wary of the evidence behind the efficacy of cutaneous wart treatment. This review summarises high-quality studies investigating the efficacy of chemical and physical destructive wart therapies. Methods We performed a literature review (up to June 2021) of published articles for wart management from the MEDLINE and Embase databases. No language restrictions were applied. We considered systematic reviews, randomised controlled trials (RCTs), cohort studies and case series. Case reports were excluded. For MEDLINE, we used the Boolean operation to combine MeSH terms 'warts' AND 'therapeutics'. For Embase, we used the Boolean operation to combine MeSH terms 'Verruca vulgaris' AND 'therapy'. We included studies that investigated chemical or physical destructive therapies.
Asia-Pacific Journal of Clinical Oncology
INTRODUCTION Epidermal growth factor receptor (EGFR) inhibitors are established therapies for adv... more INTRODUCTION Epidermal growth factor receptor (EGFR) inhibitors are established therapies for advanced lung, colorectal, and head and neck cancers. They commonly cause acneiform eruptions that affect patient quality of life and may lead to discontinuation of therapy. METHODS A systematic review and meta-analysis was undertaken to assess strategies for the prevention and reactive management of acneiform rash associated with EGFR inhibitor therapy for advanced lung, colorectal, and head and neck cancers. A systematic Medline, Embase, and EBM Reviews database search was conducted on the 2nd of January 2021. The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed and the studies were critically appraised. Studies were selected if they focused on preventing or treating acneiform eruptions in adults being treated for advanced lung cancer, colorectal cancer, and head and neck cancers with EGFR inhibitors. RESULTS Oral antibiotics had the greatest efficacy in preventing grade 2 or higher acneiform eruptions with a relative risk reduction of 40% (RR = .6, 95% CI .46-.79, p < .01). Other treatment modalities did not have statistically significant results. Topical antibiotics had a total relative risk reduction of 19% (RR = .81, 95% CI .45-1.48, p = .5). Vitamin K1 cream did not reduce the relative risk (RR = 1.08, 95% CI .45-1.48, p = .50). Sunscreen had a total relative risk reduction of 25% (RR = .75, 95% CI .49-1.14, p = .18). CONCLUSIONS The results of this meta-analysis reinforce the fact that oral tetracycline antibiotics are the most efficacious prophylactic option for acneiform eruptions in EGFR inhibitors. They should be offered to suitable patients commencing treatment and used with a general skin-care routine involving emollients and avoidance of irritants.
Cureus, 2021
The causes of osteoporosis in Crohn's disease (CD) are multifactorial; cytokines, steroids, and v... more The causes of osteoporosis in Crohn's disease (CD) are multifactorial; cytokines, steroids, and vitamin deficiency all have an essential role. It is imperative to distinguish the factors that contribute to bone resorption, potentially increasing the risk of low bone mineral density (BMD), osteoporosis, and fracture. However, the pathogenicity of osteoporosis associated with CD remains unclear. Although osteoporosis treatment may vary between bisphosphonate and corticosteroid, infliximab's efficacy, when combined with immune modulators, suppresses both CD symptoms and osteoporosis progression. In this review, we aim to understand the present pathogenicity of osteoporosis, including the factors pro-inflammatory cytokines, chronic steroid use, and malnutrition, developing osteoporosis in a different pathological way, and to assist the treatment lines implying a positive outcome of osteoporosis in CD patients. Osteoporosis is considered to be one of the early complications of CD where early detection can prevent osteoporosis progression. This can be done by utilizing dual-energy X-ray-absorptiometry (DEXA) to evaluate the Z-score and treat the existing factors that have a role in the progression of osteoporosis in CD patients.
Australian Journal of General Practice, 2022
The New Eastern Mediterranean Transformed, 2021
The discovery of significant oil and gas deposits in the exclusive economic zones (EEZ) of Israel... more The discovery of significant oil and gas deposits in the exclusive economic zones (EEZ) of Israel, Egypt, and Cyprus, and the alleged deposits in Greece, could potentially provide the European Union with an additional energy source that will contribute to the diversification, security, and resilience of Europe's energy supplies. Yet energy developments in the region have raised a number of legal and geopolitical challenges, mirroring the antagonistic and often turbulent relations amongst states in the region. This chapter provides an overview of the hydrocarbon discoveries in the Eastern Mediterranean with the aim to explore the conditions under which countries have shaped their energy policies in the broader context of their national strategies and account for the EU's strategic involvement in the region. The analysis highlights the legal, geopolitical as well as security concerns preoccupying stakeholders in the region and examines the prospects and limitations of the Eastern Mediterranean energy resources reaching Europe.
The Infravec2 infrastructure project provides insect vector resources and facility access to rese... more The Infravec2 infrastructure project provides insect vector resources and facility access to researchers worldwide at no cost. The project is funded by the European Commission Horizon 2020 Research Infrastructure Program (INFRAIA). The 24 Infravec2 partners operate major European biosecure insectaries for experimental infection and containment of insect vectors and other key insect vector technology platforms including front-line field sites in Africa, the Pacific, and the Americas. Researchers can shop online and request resources from an extensive product catalog (www.infravec2.eu). Infravec2 is also developing innovative new research tools, providing training courses, and is networking the community with activities such as common experimental standards and protocols to obtain reproducible vector infection results across different facilities. Infravec2 is a source of EU research support for vector researchers. The Infravec2 goal is to accelerate European innovation in basic and tr...
2007 37th annual frontiers in education conference - global engineering: knowledge without borders, opportunities without passports, 2007
The Oregon Institute of Technology [OIT] is the only public institute of technology in the Pacifi... more The Oregon Institute of Technology [OIT] is the only public institute of technology in the Pacific Northwest. OIT offers degree programs in engineering, management, communications, health technology, and applied science. OIT's Computer Systems Engineering Technology [CSET] Department uses a sequence of three quarter-length senior project classes to meet ABET-TAC capstone design requirements. Due to a lack of student preparation for this senior project class sequence, an additional set of three quarter-length prerequisite classes, junior project, was added. Both of these classes feature complex programmable digital logic circuit designs based on current VLSI technology. The junior project class is based on team projects and the success or failure of the students is influenced by both the quality of the faculty proctor's direction and the excellence of the social dynamics of the students' teamwork. This paper presents a paradigm for a conflict resolution scheme based on allowing the team members to fire a non-performing colleague in certain circumstances.
Australian Journal of General Practice, 2021
International Journal of Dermatology, 2021
Dermatology consultation has been shown to have a significant beneficial impact on admitted hospi... more Dermatology consultation has been shown to have a significant beneficial impact on admitted hospital patients with concurrent or newly diagnosed skin conditions. This study aimed to determine the change in diagnosis and management after dermatology consultation in a tertiary Australian referral hospital.
Australian Journal of General Practice, 2021
CommIT (Communication and Information Technology) Journal, 2020
The problem that currently happens in the decision process of the nutritional status for toddlers... more The problem that currently happens in the decision process of the nutritional status for toddlers is often based on manual calculation. However, the manual calculation is prone to data duplication, insufficient data, and a lack of availability of the data itself, which can hinder the monitoring status and the report. Therefore, to ease the determination and calculation process of the nutritional status of toddlers, the researchers conduct a study using the Simple Additive Weighting (SAW) method. The SAW method is selected because it defines the best alternative and some other alternatives based on specified or preferred criteria. This research is conducted by finding the weight value of each attribute and rating the data to determine the nutritional status of toddlers. For the result, the researchers find there are no toddlers with malnutrition in Pemberdayaan Kesejahteraan Keluarga, Program Kerja Kelompok Kerja IV (PKK POKJA IV) of Depok.
Journal of Clinical Nursing, 2020
Gut, Jun 11, 2017
Patients with long-standing UC have an increased risk for the development of colonic neoplastic l... more Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. To compare the performance of CE to VC for the detection of neoplastic lesions in patients with long-standing UC. A multicentre prospective randomised controlled trial. 131 patients with long-standing UC were randomised between CE with methylene blue 0.1% (n=66) or VC with narrow band imaging (NBI) (n=65). Biopsies were taken from visible lesions and surrounding mucosa. No random biopsies were performed. The primary outcome was the difference in total number of neoplastic lesions detected in each group. There was no significant difference between NBI and CE for neoplasia detection. Mean number of neoplastic lesions per colonoscopy was 0.47 for CE and 0.32 for NBI (p=0.992). The neoplasia detection rate was not different between CE (21.2%) and ...
International journal of medical informatics, Nov 1, 2016
Since the UN Human Rights Council's recognition on the subject in 2011, the right to access t... more Since the UN Human Rights Council's recognition on the subject in 2011, the right to access the Internet and information is now considered one of the most basic human rights of global citizens [1,2]. Despite this, an information gap between developed and resource-limited countries remains, and there is scant research on actual information needs of workers themselves. The Republic of Botswana represents a fertile ground to address existing gaps in research, policy, and practice, due to its demonstrated gap in access to information and specialists among rural health care workers (HCWs), burgeoning mHealth capacity, and a timely offer from Orange Telecommunications to access Wikipedia for free on mobile platforms for Botswana subscribers. In this study, we sought to identify clinical information needs of HCWs of Botswana and their perception of Wikipedia as a clinical tool. Twenty-eight facilitated focus groups, consisting of 113 HCWs of various cadres based at district hospitals, ...