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Papers by Joseph Nagyvary

Naturwissenschaften, Oct 1, 1988

... Considering the exalted and controversial role of the antique var-nish in the excellence of t... more ... Considering the exalted and controversial role of the antique var-nish in the excellence of the violins from the same period [1], it is ... that ap-peared in the unreviewed section of Nature (332, 313, 1988) suggested that pozzolana ash may constitute the lowest layer of Stra-divari's ...

Journal of Molecular Evolution, Dec 1, 1974

It is proposed that inorganic thiophosphate was a versatile and highly reactive constituent of th... more It is proposed that inorganic thiophosphate was a versatile and highly reactive constituent of the primitive earth. Some of the ramifications of this assumption with regard to prebiotic chemistry stein from the dual nature of thiophosphate as the most superior nucleophilic agent and an energy rich phosphate. The Michael addition of thiophosphate to acrylonitrile yields S-cyanoethylphosphorothioate in high yield. This compound in turn can be used to phosphorylate 2'-deoxythymidine in organic solvents and in the solid state. A mixture of 5' and 3'-dTMP were identified via chromatography, elementary analysis and NMR spectroscopy.

Journal of Organic Chemistry, Nov 1, 1980

... Synthesis and Properties of 2'-Deoxy-2'-thiocytidin... more ... Synthesis and Properties of 2'-Deoxy-2'-thiocytidine Arvind D. Patel, Wayne H. Schrier, and Joseph Nagyvary* ... Only one ana-logue, 2'-deoxy-2'-thiouridine was chemically character-i~ed,~JO but it was not investigated biochemically or bio-...

Chemischer Informationsdienst, Sep 10, 1974

ChemInform Abstract Die Trinucleosid-monophosphate (Ia)-(Ic) werden in ihrer Herstellung sowie' i... more ChemInform Abstract Die Trinucleosid-monophosphate (Ia)-(Ic) werden in ihrer Herstellung sowie' in ihrem pharmakologischen Verhalten diskutiert. (UV-, NMR-Spektren).

Tetrahedron, 1961

ABSTRACT

Chemischer Informationsdienst, Apr 7, 1981

Aus dem Anhydro‐nucleosid (I) erhält man mit Phosphorpentasulfid über (II) die Verbindungen (III)... more Aus dem Anhydro‐nucleosid (I) erhält man mit Phosphorpentasulfid über (II) die Verbindungen (III) und (IV).

Biochemical Education, 1985

Angewandte Chemie, Aug 17, 2021

Angewandte Chemie, Jun 27, 2021

Nucleosides and Nucleotides, 1983

Abstract This communication describes the synthesis of 5′-deoxy-5′-chloro-3′-(2-thio-1,3,2-dioxap... more Abstract This communication describes the synthesis of 5′-deoxy-5′-chloro-3′-(2-thio-1,3,2-dioxaphosphorinanyl)thymidine, N4,2′,3′-triacetyl-5′-(2-thio-1,3,2-dioxaphosphorinanyl)-1-β-D-arabinosyl-cytosine and N4-acetyl-5′-(2-thio-1,3,2-dioxaphosphorinanyl)-1-β-D-arabinosylcytosine.

Chemischer Informationsdienst. Organische Chemie, 1971

Journal of Organic Chemistry, Jul 23, 1980

Biochemical and Biophysical Research Communications, 1968

Science, 1972

Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the ... more Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.

Angewandte Chemie, Aug 17, 2021

Precambrian Research, 1976

Naturwissenschaften, Oct 1, 1988

... Considering the exalted and controversial role of the antique var-nish in the excellence of t... more ... Considering the exalted and controversial role of the antique var-nish in the excellence of the violins from the same period [1], it is ... that ap-peared in the unreviewed section of Nature (332, 313, 1988) suggested that pozzolana ash may constitute the lowest layer of Stra-divari's ...

Journal of Molecular Evolution, Dec 1, 1974

It is proposed that inorganic thiophosphate was a versatile and highly reactive constituent of th... more It is proposed that inorganic thiophosphate was a versatile and highly reactive constituent of the primitive earth. Some of the ramifications of this assumption with regard to prebiotic chemistry stein from the dual nature of thiophosphate as the most superior nucleophilic agent and an energy rich phosphate. The Michael addition of thiophosphate to acrylonitrile yields S-cyanoethylphosphorothioate in high yield. This compound in turn can be used to phosphorylate 2'-deoxythymidine in organic solvents and in the solid state. A mixture of 5' and 3'-dTMP were identified via chromatography, elementary analysis and NMR spectroscopy.

Journal of Organic Chemistry, Nov 1, 1980

... Synthesis and Properties of 2'-Deoxy-2'-thiocytidin... more ... Synthesis and Properties of 2'-Deoxy-2'-thiocytidine Arvind D. Patel, Wayne H. Schrier, and Joseph Nagyvary* ... Only one ana-logue, 2'-deoxy-2'-thiouridine was chemically character-i~ed,~JO but it was not investigated biochemically or bio-...

Chemischer Informationsdienst, Sep 10, 1974

ChemInform Abstract Die Trinucleosid-monophosphate (Ia)-(Ic) werden in ihrer Herstellung sowie' i... more ChemInform Abstract Die Trinucleosid-monophosphate (Ia)-(Ic) werden in ihrer Herstellung sowie' in ihrem pharmakologischen Verhalten diskutiert. (UV-, NMR-Spektren).

Tetrahedron, 1961

ABSTRACT

Chemischer Informationsdienst, Apr 7, 1981

Aus dem Anhydro‐nucleosid (I) erhält man mit Phosphorpentasulfid über (II) die Verbindungen (III)... more Aus dem Anhydro‐nucleosid (I) erhält man mit Phosphorpentasulfid über (II) die Verbindungen (III) und (IV).

Biochemical Education, 1985

Angewandte Chemie, Aug 17, 2021

Angewandte Chemie, Jun 27, 2021

Nucleosides and Nucleotides, 1983

Abstract This communication describes the synthesis of 5′-deoxy-5′-chloro-3′-(2-thio-1,3,2-dioxap... more Abstract This communication describes the synthesis of 5′-deoxy-5′-chloro-3′-(2-thio-1,3,2-dioxaphosphorinanyl)thymidine, N4,2′,3′-triacetyl-5′-(2-thio-1,3,2-dioxaphosphorinanyl)-1-β-D-arabinosyl-cytosine and N4-acetyl-5′-(2-thio-1,3,2-dioxaphosphorinanyl)-1-β-D-arabinosylcytosine.

Chemischer Informationsdienst. Organische Chemie, 1971

Journal of Organic Chemistry, Jul 23, 1980

Biochemical and Biophysical Research Communications, 1968

Science, 1972

Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the ... more Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.

Angewandte Chemie, Aug 17, 2021

Precambrian Research, 1976