Joseph Reo - Academia.edu (original) (raw)

Papers by Joseph Reo

The expression pharmaceutical composition is provided - available quickly to stimulate sexual des... more The expression pharmaceutical composition is provided - available quickly to stimulate sexual desire and improve the attention and perform the treatment, sexual activity in male and female sexual dysfunction. The composition (a) a therapeutically or sexual-stimulating effective total amount, if 250 having the following molecular weights of, effective at least one of a medicament for the treatment of sexual dysfunction, except for the counter ion, and (b) allow the at least one pharmaceutical a formulation containing the excipient is adapted for delivery to a route of administration that entails interaction with the gustatory system having acceptable water-soluble sense. Exemplary useful drug in the formulation of the present invention is a salt thereof and a pharmaceutically acceptable compound having the formula I, is In this equation, X is O or S.

International Journal of Pharmaceutics, 2009

A taste sensor instrument (electronic tongue) was evaluated to determine its utility in developin... more A taste sensor instrument (electronic tongue) was evaluated to determine its utility in developing a tasteenhanced liquid formulation. To train the electronic tongue, human sensory panel data were collected for two prototype formulations, a solution of the drug in water and several marketed products. Studies using the electronic tongue were conducted to determine taste-masking effectiveness of formulations compared to a matching placebo, to establish correlation with human sensory data, and to evaluate unknown formulations and predict their bitterness scores. In the first experiment, the effectiveness of a proposed taste-masking strategy was determined by comparing formulation prototypes containing a bitter active pharmaceutical ingredient (API) against corresponding placebos (i.e. formulations without an active ingredient) using electronic tongue data. The analysis of the electronic tongue data was based on the assumption that the drug was well taste masked if the placebo matched the formulation with API. In a second set of experiments, electronic tongue data were compared to existing data from a human taste panel for several marketed products and prototype formulations. A good correlation (r 2 = 0.99) was achieved from this comparison, and the relative taste of prototype formulations not tasted by humans was predicted.

Abstract. The objective of this study was to investigate the properties of granules and tablets w... more Abstract. The objective of this study was to investigate the properties of granules and tablets with carbamazepine which were prepared employing a fluidized hot-melt granulation (FHMG) technique. The FHMG process was carried out at 65°C. Macrogol 6000 (PEG 6000) was used as a binder at the content 10 % (w/w) of the granulated mass. Granules containing up to 70 % (w/w) of the drug and 20–90 % (w/w) of a filler (lactose, mannitol, calcium hydrogen phosphate (Di-Cafos), pregelatinized starch, and microcrystalline cellulose (MCC)) were produced. When the drug content was 30 % (w/w), the yield of the process was satisfying (>95%) and flowability of the granules was better than placebo granules or drug-loaded granules prepared by wet granulation. Type of a filler had strong impact on physical properties of granules, and size distribution of the particles was the most homogenous when lactose or Di-Cafos were used. The FHMG technique enabled preparation of granules with better compressab...

SON HECHAS TABLETAS DE MEDICAMENTOS MASTICABLES DE ROTOGRANULOS CUBIERTOS DE UN MEDICAMENTO, EN D... more SON HECHAS TABLETAS DE MEDICAMENTOS MASTICABLES DE ROTOGRANULOS CUBIERTOS DE UN MEDICAMENTO, EN DONDE LOS ROTOGRANULOS SON FORMADOS DE UNA MEZCLA DE GRANULACION DE MEDICAMENTO, POR EJEMPLO IBUPROFEN, POIVINILPIRROLIDONE Y SULFATO LAURIL DE SODIO, Y LOS ROTOGRANULOS SON CUBIERTOS CON CELULOSA HIDROXIETIL O UNA MEZCLA DE CELULOSA HIDROXIETIL Y METILCELULOSA HIDROXIPROPIL; Y UN PROCESO PARA HACER TALES TABLETAS, Y UN METODO DE PROVEER EL SABOR QUE ENMASCARA LOS MEDICAMENTOS UTILIZANDO TALES ROTOGRANULOS CUBIERTOS EN UNA TABLETA.

"VALDECOXIB compositions that disintegrate INTRA-ORAL PREPARED BY granulation process FLUIDI... more "VALDECOXIB compositions that disintegrate INTRA-ORAL PREPARED BY granulation process FLUIDIZED BED." The present invention relates to rapidly dissolving valdecoxib orally disintegrating tablets and processes for preparing these dosage forms. The compositions are useful in the treatment and prophylaxis of conditions and disorders mediated by cyclooxygenase-2.

La presente invention concerne des compositions pharmaceutiques comprenant de la phenylephrine ou... more La presente invention concerne des compositions pharmaceutiques comprenant de la phenylephrine ou un sel pharmaceutiquement acceptable de celle-ci. L'invention porte egalement sur des procedes d'administration desdites compositions pharmaceutiques, ces compositions etant formulees pour permettre l'absorption systemique de phenylephrine, ce qui evite le metabolisme de premier passage hepatique. Les compositions de la presente invention sont formulees pour etre appliquees a la muqueuse orale d'un animal, en vue de permettre l'amelioration de l'administration systemique de la forme de phenylephrine therapeutiquement active.

International Journal of Pharmaceutics, 2009