Joseph Sidaoui - Academia.edu (original) (raw)
Papers by Joseph Sidaoui
Journal of Craniofacial Surgery, 2014
Background and Purpose: Since 2009, a synthetic material known as kryptonite has become increasin... more Background and Purpose: Since 2009, a synthetic material known as kryptonite has become increasingly utilized during cranioplasty to repair bony defects. It provides bone-like strength and adhesive properties that make it a suitable replacement for bone. However, applications have been observed in the immediate postoperative period that demonstrates an increase in its original volume, giving rise to irregularities in the cranial surface. Methods: Ten kryptonite samples were reconstituted and allowed to polymerize according to the manufacturer's directions. The kryptonite samples were molded into a cylindrical shape, and they were immersed in 10 graduated cylinders filled with normal saline. Measurements of the rise in saline relative to baseline were taken at 0, 10, 20, 30, 40, 50, and 60 minutes, and then hourly through 5 hours, with the final measurement recorded at 24 hours. Results: The mean expansion of kryptonite was approximately 49% with an SD of 22%. The bulk of the expansion occurred within the first 2 hours, after which the rate tended to plateau for the remaining 22 hours. Conclusions: Kryptonite has been touted as an excellent alternative for repairing contour abnormalities manifested in cranioplasty. Given the unpredictability of its expansile properties, the surgeon must take this variability into careful consideration when planning the desired surgical outcome. The results of the current study were communicated with the manufacture. Immediately thereafter, the manufacturer withdrew the product from the US market and is no longer Food and Drug Administration approved for cranioplasty.
AbstractMuenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 ne... more AbstractMuenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis. Anomalies in patients with Muenke syndrome include craniosynostosis, hypertelorism, sensorineural hearing loss, and developmental delay, among others. Most craniosynostoses in patients with Muenke syndrome involve bicoronal suture fusion. This article reports, for the first time, the existence of squamosal craniosynostosis in patients with Muenke syndrome.
Body: OBJECTIVES: Dialysis patients with peripheral vascular disease (PVD) are at high risk for c... more Body: OBJECTIVES: Dialysis patients with peripheral vascular disease (PVD) are at high risk for complications following surgical bypass, and it is not clear if endovascular interventions have affected survival and limb salvage in this patient population. We sought to characterize the outcomes of endovascular and open revascularization in dialysis patients treated for claudication or critical limb ischemia (CLI). METHODS: The United States Renal Data System (USRDS) was utilized to review all patients undergoing LER in dialysis patients in the United States between 2005-2008. Diagnoses and procedures were identified by ICD-9 and CPT codes respectively. Primary outcomes were mortality and limb salvage. Bivariate associations were tested using the chi-squared test, and predictors were identified using Cox regression models. RESULTS: A total of 12,029 incident dialysis patients underwent LER (24% endo,76% open). CLI was the indication in 79.9% of endo LER, and 72.8% of open LER. Major am...
Journal of Craniofacial Surgery, 2014
Muenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns a... more Muenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis. Anomalies in patients with Muenke syndrome include craniosynostosis, hypertelorism, sensorineural hearing loss, and developmental delay, among others. Most craniosynostoses in patients with Muenke syndrome involve bicoronal suture fusion. This article reports, for the first time, the existence of squamosal craniosynostosis in patients with Muenke syndrome.
Acta chirurgica Belgica
ABSTRACT
European cytokine network
tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steato... more tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high TNF-α plasma protein levels in patients with NASH compared to healthy volunteers. We herein aimed to revisit these findings using other molecular techniques. a cross-sectional evaluation of patients newly diagnosed with NASH. A quantitative assay for the measurement of TNF-α messenger ribonucleic acid (mRNA) was performed for NASH patients and controls using real-time reverse transcription polymerase chain reaction (RT-PCR). in 39 patients with NASH (mean age 38.6 ± 9.4 years, range 28-60 years; 79% males), the mean TNF-α mRNA level was significantly higher than that found for controls (137.6 ± 102.3 ng/mL versus 83.5 ± 43.8 ng/mL, respectively; P = 0.012). A TNF-α mRNA cut-off of 100 ng/mL predicted NASH most optimally (AUC 0.685 ± 0.066, P = 0.01; with 66.7% sensitivity and 74.1% specificity). Serum TNF-α and soluble TNF-α receptor II...
European cytokine network
tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steato... more tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high TNF-α plasma protein levels in patients with NASH compared to healthy volunteers. We herein aimed to revisit these findings using other molecular techniques. a cross-sectional evaluation of patients newly diagnosed with NASH. A quantitative assay for the measurement of TNF-α messenger ribonucleic acid (mRNA) was performed for NASH patients and controls using real-time reverse transcription polymerase chain reaction (RT-PCR). in 39 patients with NASH (mean age 38.6 ± 9.4 years, range 28-60 years; 79% males), the mean TNF-α mRNA level was significantly higher than that found for controls (137.6 ± 102.3 ng/mL versus 83.5 ± 43.8 ng/mL, respectively; P = 0.012). A TNF-α mRNA cut-off of 100 ng/mL predicted NASH most optimally (AUC 0.685 ± 0.066, P = 0.01; with 66.7% sensitivity and 74.1% specificity). Serum TNF-α and soluble TNF-α receptor II...
Journal of Vascular Surgery, 2014
treatment was delayed by uncertainty regarding the source. In all three, initial aneurysm dilatat... more treatment was delayed by uncertainty regarding the source. In all three, initial aneurysm dilatation was followed by shrinkage. The failed treatment of a type I endoleak in a case of aortoiliac dissection resulted in the only rupture in the entire series. Type II endoleaks were not treated.
Aesthetic Surgery Journal, 2015
Background: To date, no standardized minimally invasive approach for the treatment of excessive g... more Background: To date, no standardized minimally invasive approach for the treatment of excessive gingival display exists. Objectives: This systematic review aims to assess the evidence in the literature regarding the role of botulinum toxin injection in the management of gummy smile. Methods: All publications through December 2014 and pertaining to the subject were electronically searched in PubMed, Embase, Scopus, and Web of Science, and the bibliographies of retrieved articles were manually screened. Results: Out of 33 articles, 29 were discarded based on exclusion criteria. Although all 4 selected articles were in line with a role for botulinum toxin injection in the treatment of gummy smiles and the importance of targeting the levator labii superioris alaeque nasi muscle, studies differed in the type and the dose of toxin administered and the technique adopted. Conclusions: Injection with botulinum toxin is a novel, safe, and cosmetically effective treatment for gummy smile when performed by experienced practitioners. However, further randomized controlled trials are warranted.
BioMed Research International, 2015
Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompani... more Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with ...
Journal of vascular surgery, 2014
Elective abdominal aortic aneurysm (AAA) repair in suitable candidates is a standard modality. Th... more Elective abdominal aortic aneurysm (AAA) repair in suitable candidates is a standard modality. The outcomes of AAA repair in patients with end-stage renal disease on dialysis are not well characterized, and there is questionable survival advantage in such patients with limited life expectancy. We sought to describe outcomes after AAA repair in U.S. dialysis patients. The United States Renal Data System was used to collect data on intact asymptomatic AAA repair procedures in dialysis patients in the United States between 2005 and 2008. Endovascular AAA repair (EVAR) and open aortic repair (OAR) were identified by Current Procedural Terminology codes. Primary outcomes were perioperative (30-day) mortality and long-term survival. Predictors of mortality were identified by multivariate regression models. A total of 1557 patients were identified who had undergone elective AAA repair: 261 OAR and 1296 EVAR. The 30-day mortality was 11.3% (EVAR, 10.3%; OAR, 16.1%; P = .010), with increased...
Journal of Vascular Surgery, 2013
Journal of Vascular Surgery, 2013
Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifu... more Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifurcations can be complicated by inability to access the contralateral gate, iliac limb compression, or aortic disruption. This study analyzes outcomes of EVAR using bifurcated stent grafts or aortouniiliac converters in patients with narrow distal aortic bifurcation.
Journal of Vascular Surgery, 2013
Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifu... more Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifurcations can be complicated by inability to access the contralateral gate, iliac limb compression, or aortic disruption. This study analyzes outcomes of EVAR using bifurcated stent grafts or aortouniiliac converters in patients with narrow distal aortic bifurcation.
Journal of Craniofacial Surgery, 2014
Background and Purpose: Since 2009, a synthetic material known as kryptonite has become increasin... more Background and Purpose: Since 2009, a synthetic material known as kryptonite has become increasingly utilized during cranioplasty to repair bony defects. It provides bone-like strength and adhesive properties that make it a suitable replacement for bone. However, applications have been observed in the immediate postoperative period that demonstrates an increase in its original volume, giving rise to irregularities in the cranial surface. Methods: Ten kryptonite samples were reconstituted and allowed to polymerize according to the manufacturer's directions. The kryptonite samples were molded into a cylindrical shape, and they were immersed in 10 graduated cylinders filled with normal saline. Measurements of the rise in saline relative to baseline were taken at 0, 10, 20, 30, 40, 50, and 60 minutes, and then hourly through 5 hours, with the final measurement recorded at 24 hours. Results: The mean expansion of kryptonite was approximately 49% with an SD of 22%. The bulk of the expansion occurred within the first 2 hours, after which the rate tended to plateau for the remaining 22 hours. Conclusions: Kryptonite has been touted as an excellent alternative for repairing contour abnormalities manifested in cranioplasty. Given the unpredictability of its expansile properties, the surgeon must take this variability into careful consideration when planning the desired surgical outcome. The results of the current study were communicated with the manufacture. Immediately thereafter, the manufacturer withdrew the product from the US market and is no longer Food and Drug Administration approved for cranioplasty.
AbstractMuenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 ne... more AbstractMuenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis. Anomalies in patients with Muenke syndrome include craniosynostosis, hypertelorism, sensorineural hearing loss, and developmental delay, among others. Most craniosynostoses in patients with Muenke syndrome involve bicoronal suture fusion. This article reports, for the first time, the existence of squamosal craniosynostosis in patients with Muenke syndrome.
Body: OBJECTIVES: Dialysis patients with peripheral vascular disease (PVD) are at high risk for c... more Body: OBJECTIVES: Dialysis patients with peripheral vascular disease (PVD) are at high risk for complications following surgical bypass, and it is not clear if endovascular interventions have affected survival and limb salvage in this patient population. We sought to characterize the outcomes of endovascular and open revascularization in dialysis patients treated for claudication or critical limb ischemia (CLI). METHODS: The United States Renal Data System (USRDS) was utilized to review all patients undergoing LER in dialysis patients in the United States between 2005-2008. Diagnoses and procedures were identified by ICD-9 and CPT codes respectively. Primary outcomes were mortality and limb salvage. Bivariate associations were tested using the chi-squared test, and predictors were identified using Cox regression models. RESULTS: A total of 12,029 incident dialysis patients underwent LER (24% endo,76% open). CLI was the indication in 79.9% of endo LER, and 72.8% of open LER. Major am...
Journal of Craniofacial Surgery, 2014
Muenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns a... more Muenke syndrome caused by point mutation (C749G) in the FGFR3 gene affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis. Anomalies in patients with Muenke syndrome include craniosynostosis, hypertelorism, sensorineural hearing loss, and developmental delay, among others. Most craniosynostoses in patients with Muenke syndrome involve bicoronal suture fusion. This article reports, for the first time, the existence of squamosal craniosynostosis in patients with Muenke syndrome.
Acta chirurgica Belgica
ABSTRACT
European cytokine network
tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steato... more tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high TNF-α plasma protein levels in patients with NASH compared to healthy volunteers. We herein aimed to revisit these findings using other molecular techniques. a cross-sectional evaluation of patients newly diagnosed with NASH. A quantitative assay for the measurement of TNF-α messenger ribonucleic acid (mRNA) was performed for NASH patients and controls using real-time reverse transcription polymerase chain reaction (RT-PCR). in 39 patients with NASH (mean age 38.6 ± 9.4 years, range 28-60 years; 79% males), the mean TNF-α mRNA level was significantly higher than that found for controls (137.6 ± 102.3 ng/mL versus 83.5 ± 43.8 ng/mL, respectively; P = 0.012). A TNF-α mRNA cut-off of 100 ng/mL predicted NASH most optimally (AUC 0.685 ± 0.066, P = 0.01; with 66.7% sensitivity and 74.1% specificity). Serum TNF-α and soluble TNF-α receptor II...
European cytokine network
tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steato... more tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high TNF-α plasma protein levels in patients with NASH compared to healthy volunteers. We herein aimed to revisit these findings using other molecular techniques. a cross-sectional evaluation of patients newly diagnosed with NASH. A quantitative assay for the measurement of TNF-α messenger ribonucleic acid (mRNA) was performed for NASH patients and controls using real-time reverse transcription polymerase chain reaction (RT-PCR). in 39 patients with NASH (mean age 38.6 ± 9.4 years, range 28-60 years; 79% males), the mean TNF-α mRNA level was significantly higher than that found for controls (137.6 ± 102.3 ng/mL versus 83.5 ± 43.8 ng/mL, respectively; P = 0.012). A TNF-α mRNA cut-off of 100 ng/mL predicted NASH most optimally (AUC 0.685 ± 0.066, P = 0.01; with 66.7% sensitivity and 74.1% specificity). Serum TNF-α and soluble TNF-α receptor II...
Journal of Vascular Surgery, 2014
treatment was delayed by uncertainty regarding the source. In all three, initial aneurysm dilatat... more treatment was delayed by uncertainty regarding the source. In all three, initial aneurysm dilatation was followed by shrinkage. The failed treatment of a type I endoleak in a case of aortoiliac dissection resulted in the only rupture in the entire series. Type II endoleaks were not treated.
Aesthetic Surgery Journal, 2015
Background: To date, no standardized minimally invasive approach for the treatment of excessive g... more Background: To date, no standardized minimally invasive approach for the treatment of excessive gingival display exists. Objectives: This systematic review aims to assess the evidence in the literature regarding the role of botulinum toxin injection in the management of gummy smile. Methods: All publications through December 2014 and pertaining to the subject were electronically searched in PubMed, Embase, Scopus, and Web of Science, and the bibliographies of retrieved articles were manually screened. Results: Out of 33 articles, 29 were discarded based on exclusion criteria. Although all 4 selected articles were in line with a role for botulinum toxin injection in the treatment of gummy smiles and the importance of targeting the levator labii superioris alaeque nasi muscle, studies differed in the type and the dose of toxin administered and the technique adopted. Conclusions: Injection with botulinum toxin is a novel, safe, and cosmetically effective treatment for gummy smile when performed by experienced practitioners. However, further randomized controlled trials are warranted.
BioMed Research International, 2015
Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompani... more Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with ...
Journal of vascular surgery, 2014
Elective abdominal aortic aneurysm (AAA) repair in suitable candidates is a standard modality. Th... more Elective abdominal aortic aneurysm (AAA) repair in suitable candidates is a standard modality. The outcomes of AAA repair in patients with end-stage renal disease on dialysis are not well characterized, and there is questionable survival advantage in such patients with limited life expectancy. We sought to describe outcomes after AAA repair in U.S. dialysis patients. The United States Renal Data System was used to collect data on intact asymptomatic AAA repair procedures in dialysis patients in the United States between 2005 and 2008. Endovascular AAA repair (EVAR) and open aortic repair (OAR) were identified by Current Procedural Terminology codes. Primary outcomes were perioperative (30-day) mortality and long-term survival. Predictors of mortality were identified by multivariate regression models. A total of 1557 patients were identified who had undergone elective AAA repair: 261 OAR and 1296 EVAR. The 30-day mortality was 11.3% (EVAR, 10.3%; OAR, 16.1%; P = .010), with increased...
Journal of Vascular Surgery, 2013
Journal of Vascular Surgery, 2013
Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifu... more Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifurcations can be complicated by inability to access the contralateral gate, iliac limb compression, or aortic disruption. This study analyzes outcomes of EVAR using bifurcated stent grafts or aortouniiliac converters in patients with narrow distal aortic bifurcation.
Journal of Vascular Surgery, 2013
Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifu... more Objectives: Endovascular aortic aneurysm repair (EVAR) in patients with narrow distal aortic bifurcations can be complicated by inability to access the contralateral gate, iliac limb compression, or aortic disruption. This study analyzes outcomes of EVAR using bifurcated stent grafts or aortouniiliac converters in patients with narrow distal aortic bifurcation.