Jovanka Filipović - Academia.edu (original) (raw)

Papers by Jovanka Filipović

Research paper thumbnail of Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels

Chemical Engineering Journal, 2010

Research paper thumbnail of Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hydrogel Hybrids

Acta Physica Polonica A

A simple and fast approach to the design and production of new hybrid polymeric biomaterials with... more A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing "green" agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 • C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogel's composition and the type of microbes

Research paper thumbnail of Removal of Pb2+ ions from aqueous solution by P(HEA/IA) hydrogels

Hemijska industrija, 2016

A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different H... more A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ ions from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+ ions. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) ...

Research paper thumbnail of Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation

Radiation Physics and Chemistry, 2007

The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) ... more The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the ...

Research paper thumbnail of Hydrogels Based on 2-Hydroxyethyl Methacrylate Obtained by Gamma Irradiation

Materials Science Forum, 2005

Research paper thumbnail of pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

Macromolecular Research, 2014

Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different pol... more Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.

Research paper thumbnail of Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver

Hemijska industrija, 2010

In this work new hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl met... more In this work new hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver particles. FTIR spectroscopy has confirmed binding of silver particels in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive ...

Research paper thumbnail of Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application

Materials and Manufacturing Processes, 2009

Research paper thumbnail of Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid

Journal of Hazardous Materials, 2011

Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied a... more Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied as adsorbents for the removal of Zn(2+) ions from aqueous solution. In batch tests, the influence of solution pH, contact time, initial metal ion concentration and temperature was examined. The sorption was found pH dependent, pH 5.5 being the optimum value. The adsorption process was well described by the pseudo-second order kinetic. The hydrogels were characterized by spectral (Fourier transform infrared-FTIR) and structural (SEM/EDX and atomic force microscopy-AFM) analyses. The surface topography changes were observed by atomic force microscopy, while the changes in surface composition were detected using phase imaging AFM. The negative values of free energy and enthalpy indicated that the adsorption is spontaneous and exothermic one. The best fitting isotherms were Langmuir and Redlich-Peterson and it was found that both linear and nonlinear methods were appropriate for obtaining the isotherm parameters. However, the increase of temperature leads to higher adsorption capacity, since swelling degree increased with temperature.

Research paper thumbnail of Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels

Polymer Bulletin, 2013

New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical cr... more New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 °C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.

Research paper thumbnail of Release and Diffusion Studies of Hydrogels Based on Itaconic Acid

Materials Science …, 2007

Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and genta... more Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.

Research paper thumbnail of Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid

Research paper thumbnail of Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin

Research paper thumbnail of Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation

Radiation Physics and Chemistry, 2007

ABSTRACT The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid ... more ABSTRACT The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 °C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 °C, the P(HEMA/IA) hydrogel containing 5 mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25–42 °C, in order to evaluate their potential for medical applications.

Research paper thumbnail of Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization

Research paper thumbnail of Dilute solution properties and unperturbed dimensions of poly(di-ni-alkyl itaconate)s

ABSTRACT The diesters of itaconic acid (methylenesuccinic acid) with higher C12 – C20 unbranched,... more ABSTRACT The diesters of itaconic acid (methylenesuccinic acid) with higher C12 – C20 unbranched, saturated, aliphatic alcohols were prepared, purified, and polymerized in bulk or in solution with 2,2′-azoisobutyronitrile as initiator. The transparent to waxy polymers obtained were fractionated and all fractions characterized by viscosity and light scattering measurements. The Kuhn-Mark-Houwink-Sakurada relations were established and then extrapolated to thetaconditions, in order to calculate the unperturbed dimensions. High values of the steric factor σ, and the characteristic ratio C∞ were obtained. The results correlate well with those obtained previously for poly(di-n-alkyl itaconate)s from the corresponding lower C1 – C11 alcohols.

Research paper thumbnail of Solubilities and polymer-solvent-nonsolvent θ-compositions of poly (di-n-alkyl itaconates)

ABSTRACT In order to establish the prerequisites for the examination of solution properties of po... more ABSTRACT In order to establish the prerequisites for the examination of solution properties of poly(di-n-alkyl itaconates), the solubilities of the first 11 members of this polymer homologous series were determined in 70 solvents, and the results correlated with the lengths of the ester substituents of the polymer chain, the solvent solubility parameters and the solvent hydrogen bonding capacities. The relation between solvent strength and the lengths of ester substituents of the monomer units was established quantitatively for several solvents in terms of φ2 crit., the nonsolvent volume fraction in ternary polymer-solvent-nonsolvent θ-mixtures, and evaluated according to a turbidometric titration method proposed by ELIAS1. Both groups of results are a guideline for the probable existance of θ-conditions for particular polymer-solvent pairs and permit the prediction of solubilities of still higher members of the series.Um die nötigen Voraussetzungen für Untersuchungen über Lösungseigenschaften von Poly(di-n-alkylitakonaten) festzustellen, wurde die Löslichkeit der 11 ersten Glieder dieser polymerhomologen Reihe in 70 Lösungsmitteln untersucht und die Ergebnisse mit der Länge der Estersubstituenten, den Lösungsparametern der Lösungsmittel und deren Wasserstoffbrückenbildungsvermögen in Zusammenhang gebracht. Das Verhältnis zwischen der Güte einiger Lösungsmittel und der Länge der Estersubstituenten der Monomeren wurde quantitativ durch φ2 crit., das Fällungsmittelvolumen in Polymer-Lösungsmittel-Fällungsmittel-θ-Mischungen, ausgedrückt, welches turbidometrisch nach ELIAS1 bestimmt wurde. Die Ergebnisse dienen auch als Hinweis für das wahrscheinliche Vorkommen von θ-Temperaturen für bestimmte Polymere/Lösungsmittel-Paare und erlauben Voraussagen über die Löslichkeit noch höherer Glieder der Polymerenreihe.

Research paper thumbnail of Refractive index increments of di-n-alkylitaconate polymers and copolymers

ABSTRACT Refractive index increments of 11 poly(di-n-alkylitaconate) polymers were determined sys... more ABSTRACT Refractive index increments of 11 poly(di-n-alkylitaconate) polymers were determined systematically in seven organic solvents, expected to be suitable for light scattering and other solution property measurements. Of 13 solvents tried, poly(dimethylitaconate) was soluble only in 6, however higher members of the polymer series exhibit better solubility. The measured dn/dc values in butanone and ethyl-and amylacetate are practically independent of an increase of the number of carbon atoms in the ester substituents of the monomer, however a decrease of the values for solvents with higher refractive indices can be observed. For statistical poly(styrene-co-di-n-alkylitaconate) samples the additive character of dn/dc in butanone and toluene was observed and verified from copolymer compositions determined by UV and elemental analysis.Brechungsinkremnte von elf verschieden Di-n-alkylitakonat-Polymeren wurden systematisch in sieben organischen Lösungsmitteln bestimmt, um eine günstige Auswahl für Lichtstreuungs- und andere Lösungseigenschaftsmessungen zu ermöglichen. Polydimethylitakonat war in sechs von 13 untersuchten Lösungsmitteln lölich, während höhere Glieder der Polymerenreihe bedeutend bedeutend bessere Löslichketiten aufwiesen. Die ermittelten dn/de Werte in Butanon, Äthyl- und Amylacetat hängen praktisch von einer Zunahme der Zahl der Kohlenstoffatome in den Estersubstituenten nicht ab; bei Lösungsmitteln mit höheren Brechungsindizes ist aber eine sinkende Tendenz der Werte bemerkbar. Bei statistischen Copolymeren aus Styrol und Di--alkylitakonat wird der additive Charakter von dn/dc in Butanon und Toluol bemerkbar, welcher durch Bestimmung der chemischen Zusammensetzung mittels UV und Kohlenstoffgehalt bestätigt werden konnte.

Research paper thumbnail of Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution

Applied Surface Science, 2015

Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA... more Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd 2+ removal from aqueous solution. The hydrogels before and after Cd 2+ adsorption were characterized using FTIR, DSC, SEM/EDX, AFM and DMA analysis. The swelling results showed that these hydrogels are pH and temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd 2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd 2+ removal.

Research paper thumbnail of Smart hydrogels based on itaconic acid for biomedical application

Hemijska industrija, 2009

pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic ... more pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; t...

Research paper thumbnail of Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels

Chemical Engineering Journal, 2010

Research paper thumbnail of Swelling, Mechanical and Antimicrobial Studies of Ag/P(HEMA/IA)/PVP Semi-IPN Hydrogel Hybrids

Acta Physica Polonica A

A simple and fast approach to the design and production of new hybrid polymeric biomaterials with... more A simple and fast approach to the design and production of new hybrid polymeric biomaterials with silver particles is presented in this work. Silver/semi-interpenetrating network hybrid hydrogels (Ag/semi-IPNHHs) were prepared through an optimized solution crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA), in the presence of PVP, a silver salt and a reducing "green" agent (Ag/P(HEMA/IA)/PVP). PVP was chosen due to its protective, reduction, and nucleation properties in the production of metal particles. The structure of the Ag/semi-IPNHH was characterized by Fourier transform infrared spectroscopy (FTIR). The presence of silver and PVP in the network was confirmed by FTIR spectra. The results obtained by dynamic mechanical analysis (DMA) showed good mechanical properties for all samples. The swelling studies of Ag/P(HEMA/IA)/PVP were conducted in the temperature range of 25-55 • C, in the buffer of pH 7.40. The Ag/semi-IPNHH showed temperature-sensitive swelling properties, with the lower critical solution temperature (LCST) values in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus and C. albicans pathogens. It was concluded that the antimicrobial potential depends on the hydrogel's composition and the type of microbes

Research paper thumbnail of Removal of Pb2+ ions from aqueous solution by P(HEA/IA) hydrogels

Hemijska industrija, 2016

A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different H... more A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ ions from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+ ions. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) ...

Research paper thumbnail of Swelling and drug release behavior of poly(2-hydroxyethyl methacrylate/itaconic acid) copolymeric hydrogels obtained by gamma irradiation

Radiation Physics and Chemistry, 2007

The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) ... more The new copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were prepared by gamma irradiation, in order to examine the potential use of these hydrogels in controlled drug release systems. The influence of IA content in the gel on the ...

Research paper thumbnail of Hydrogels Based on 2-Hydroxyethyl Methacrylate Obtained by Gamma Irradiation

Materials Science Forum, 2005

Research paper thumbnail of pH-sensitive hydrogels based on (meth)acrylates and itaconic acid

Macromolecular Research, 2014

Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different pol... more Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.

Research paper thumbnail of Antimicrobial activity of hybrid hydrogels based on poly(vinylpyrrolidone) containing silver

Hemijska industrija, 2010

In this work new hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl met... more In this work new hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver particles. FTIR spectroscopy has confirmed binding of silver particels in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive ...

Research paper thumbnail of Preparation of Silver(I) Complexes with Itaconic Acid-Based Hydrogels for Biomedical Application

Materials and Manufacturing Processes, 2009

Research paper thumbnail of Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid

Journal of Hazardous Materials, 2011

Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied a... more Novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid were applied as adsorbents for the removal of Zn(2+) ions from aqueous solution. In batch tests, the influence of solution pH, contact time, initial metal ion concentration and temperature was examined. The sorption was found pH dependent, pH 5.5 being the optimum value. The adsorption process was well described by the pseudo-second order kinetic. The hydrogels were characterized by spectral (Fourier transform infrared-FTIR) and structural (SEM/EDX and atomic force microscopy-AFM) analyses. The surface topography changes were observed by atomic force microscopy, while the changes in surface composition were detected using phase imaging AFM. The negative values of free energy and enthalpy indicated that the adsorption is spontaneous and exothermic one. The best fitting isotherms were Langmuir and Redlich-Peterson and it was found that both linear and nonlinear methods were appropriate for obtaining the isotherm parameters. However, the increase of temperature leads to higher adsorption capacity, since swelling degree increased with temperature.

Research paper thumbnail of Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels

Polymer Bulletin, 2013

New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical cr... more New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 °C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.

Research paper thumbnail of Release and Diffusion Studies of Hydrogels Based on Itaconic Acid

Materials Science …, 2007

Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and genta... more Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.

Research paper thumbnail of Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid

Research paper thumbnail of Evaluation of novel antiproliferative controlled drug delivery system based on poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels and nickel complex with Oxaprozin

Research paper thumbnail of Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation

Radiation Physics and Chemistry, 2007

ABSTRACT The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid ... more ABSTRACT The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization. Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2, 3.5 and 5 mol%) were studied in a wide pH and temperature range. Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior. Special attention was devoted to temperature investigations around physiological temperature (37 °C), where small changes in temperature significantly influence swelling and drug release of these hydrogels. Due to maximum swelling of hydrogels around 40 °C, the P(HEMA/IA) hydrogel containing 5 mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25–42 °C, in order to evaluate their potential for medical applications.

Research paper thumbnail of Synthesis, characterization and application of poly(N-isopropylacrylamide-co-itaconic acid) hydrogels as supports for lipase immobilization

Research paper thumbnail of Dilute solution properties and unperturbed dimensions of poly(di-ni-alkyl itaconate)s

ABSTRACT The diesters of itaconic acid (methylenesuccinic acid) with higher C12 – C20 unbranched,... more ABSTRACT The diesters of itaconic acid (methylenesuccinic acid) with higher C12 – C20 unbranched, saturated, aliphatic alcohols were prepared, purified, and polymerized in bulk or in solution with 2,2′-azoisobutyronitrile as initiator. The transparent to waxy polymers obtained were fractionated and all fractions characterized by viscosity and light scattering measurements. The Kuhn-Mark-Houwink-Sakurada relations were established and then extrapolated to thetaconditions, in order to calculate the unperturbed dimensions. High values of the steric factor σ, and the characteristic ratio C∞ were obtained. The results correlate well with those obtained previously for poly(di-n-alkyl itaconate)s from the corresponding lower C1 – C11 alcohols.

Research paper thumbnail of Solubilities and polymer-solvent-nonsolvent θ-compositions of poly (di-n-alkyl itaconates)

ABSTRACT In order to establish the prerequisites for the examination of solution properties of po... more ABSTRACT In order to establish the prerequisites for the examination of solution properties of poly(di-n-alkyl itaconates), the solubilities of the first 11 members of this polymer homologous series were determined in 70 solvents, and the results correlated with the lengths of the ester substituents of the polymer chain, the solvent solubility parameters and the solvent hydrogen bonding capacities. The relation between solvent strength and the lengths of ester substituents of the monomer units was established quantitatively for several solvents in terms of φ2 crit., the nonsolvent volume fraction in ternary polymer-solvent-nonsolvent θ-mixtures, and evaluated according to a turbidometric titration method proposed by ELIAS1. Both groups of results are a guideline for the probable existance of θ-conditions for particular polymer-solvent pairs and permit the prediction of solubilities of still higher members of the series.Um die nötigen Voraussetzungen für Untersuchungen über Lösungseigenschaften von Poly(di-n-alkylitakonaten) festzustellen, wurde die Löslichkeit der 11 ersten Glieder dieser polymerhomologen Reihe in 70 Lösungsmitteln untersucht und die Ergebnisse mit der Länge der Estersubstituenten, den Lösungsparametern der Lösungsmittel und deren Wasserstoffbrückenbildungsvermögen in Zusammenhang gebracht. Das Verhältnis zwischen der Güte einiger Lösungsmittel und der Länge der Estersubstituenten der Monomeren wurde quantitativ durch φ2 crit., das Fällungsmittelvolumen in Polymer-Lösungsmittel-Fällungsmittel-θ-Mischungen, ausgedrückt, welches turbidometrisch nach ELIAS1 bestimmt wurde. Die Ergebnisse dienen auch als Hinweis für das wahrscheinliche Vorkommen von θ-Temperaturen für bestimmte Polymere/Lösungsmittel-Paare und erlauben Voraussagen über die Löslichkeit noch höherer Glieder der Polymerenreihe.

Research paper thumbnail of Refractive index increments of di-n-alkylitaconate polymers and copolymers

ABSTRACT Refractive index increments of 11 poly(di-n-alkylitaconate) polymers were determined sys... more ABSTRACT Refractive index increments of 11 poly(di-n-alkylitaconate) polymers were determined systematically in seven organic solvents, expected to be suitable for light scattering and other solution property measurements. Of 13 solvents tried, poly(dimethylitaconate) was soluble only in 6, however higher members of the polymer series exhibit better solubility. The measured dn/dc values in butanone and ethyl-and amylacetate are practically independent of an increase of the number of carbon atoms in the ester substituents of the monomer, however a decrease of the values for solvents with higher refractive indices can be observed. For statistical poly(styrene-co-di-n-alkylitaconate) samples the additive character of dn/dc in butanone and toluene was observed and verified from copolymer compositions determined by UV and elemental analysis.Brechungsinkremnte von elf verschieden Di-n-alkylitakonat-Polymeren wurden systematisch in sieben organischen Lösungsmitteln bestimmt, um eine günstige Auswahl für Lichtstreuungs- und andere Lösungseigenschaftsmessungen zu ermöglichen. Polydimethylitakonat war in sechs von 13 untersuchten Lösungsmitteln lölich, während höhere Glieder der Polymerenreihe bedeutend bedeutend bessere Löslichketiten aufwiesen. Die ermittelten dn/de Werte in Butanon, Äthyl- und Amylacetat hängen praktisch von einer Zunahme der Zahl der Kohlenstoffatome in den Estersubstituenten nicht ab; bei Lösungsmitteln mit höheren Brechungsindizes ist aber eine sinkende Tendenz der Werte bemerkbar. Bei statistischen Copolymeren aus Styrol und Di--alkylitakonat wird der additive Charakter von dn/dc in Butanon und Toluol bemerkbar, welcher durch Bestimmung der chemischen Zusammensetzung mittels UV und Kohlenstoffgehalt bestätigt werden konnte.

Research paper thumbnail of Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution

Applied Surface Science, 2015

Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA... more Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd 2+ removal from aqueous solution. The hydrogels before and after Cd 2+ adsorption were characterized using FTIR, DSC, SEM/EDX, AFM and DMA analysis. The swelling results showed that these hydrogels are pH and temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd 2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd 2+ removal.

Research paper thumbnail of Smart hydrogels based on itaconic acid for biomedical application

Hemijska industrija, 2009

pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic ... more pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; t...