Joyce Dias - Academia.edu (original) (raw)

Papers by Joyce Dias

Semina: Ciências Agrárias, 2009

Este experimento foi realizado em um vinhedo localizado na região Centro -Sul do Estado Paraná, c... more Este experimento foi realizado em um vinhedo localizado na região Centro -Sul do Estado Paraná, com o objetivo de avaliar diferentes tipos de poda na cultura da videira cv. Bordô na safra 2007/08. Foram utilizadas plantas com 6 anos de idade, conduzidas no sistema latada e espaçadas 3,0 x 1,0 m. As videiras foram submetidas aos tratamentos de poda esporonada (esporões com duas a três gemas), poda longa (varas de cinco a seis gemas) e poda mista (esporões e varas). As variáveis avaliadas foram: número de cachos por planta, produção por planta e massa média dos cachos. Observou-se que em relação ao número de cachos por planta houve diferenças significativas somente para poda longa em relação às demais, assim como para massa média dos cachos. Em relação à produção por planta houve diferença significativa entre todos os tratamentos sendo que a poda longa apresentou maior produção por planta, chegando a ser aproximadamente três vezes maior que a produção da poda esporonada.

Growth Hormone & IGF Research, 2010

Growth hormone isoforms 20 kDa-hGH 22 kDa-hGH Octreotide LAR a b s t r a c t Background: Human gr... more Growth hormone isoforms 20 kDa-hGH 22 kDa-hGH Octreotide LAR a b s t r a c t Background: Human growth hormone (hGH) circulates as a mixture of different isoforms. It has been previously reported that the ratio of 20 kDa to 20 kDa plus 22 kDa (%20 kDa-hGH) is increased in patients with active acromegaly. Objectives: To evaluate the GH isoforms (20 kDa-and 22 kDa-hGH) in acromegalic patients before and after six months of treatment with octreotide LAR, and to compare the results with those in healthy controls. In addition, the relationships between the %20 kDa-hGH, tumor size and biochemical measurements were also investigated. Design: Random serum samples from 23 acromegalic patients evaluated before and after six months of treatment with octreotide LAR and from 23 matched healthy controls were studied. Growth hormone, IGF-I and prolactin (PRL) were measured by chemiluminescence immunometric assay and the 20 kDaand 22 kDa-hGH isoforms were measured by specific time-resolved fluorescence immunoassays. Results: In acromegalic patients before treatment, there was a significantly higher median %20 Da-hGH in comparison to healthy controls (14.31% vs. 9.59%, p < 0.001). After six months of treatment, the median %20 kDa-hGH was similar to the baseline values. Patients with GH < 2.5 ng/mL after six months of treatment had already lower GH and %20 kDa-hGH at baseline (p < 0.01). The IGF-I (SD-scores) was positively correlated to total GH levels in acromegalic patients after treatment. There was no correlation between the %20 kDa-hGH and PRL levels or tumor size. Conclusions: Our study confirmed that acromegalic patients have an increased proportion of circulating 20 kDa-hGH isoform. Consequently, the use of a 22 kDa-hGH specific assay may underestimate the tumor production of total GH. Although octreotide LAR promoted a significant decrease in the GH and IGF-I levels, it did not normalize the GH isoforms composition and suggests that the secretion of GH isoforms is equally inhibited by somatostatin analogues and that it is the disease control that normalizes the GH isoforms composition in acromegaly.

Bju International, 2008

Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intr... more Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic caused by urolithiasis.Patients and methods The study included 61 patients randomized into three different groups; group A received desmopressin (40 µg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale (a 10-cm horizontal scale ranging from ‘no pain’ to ‘unbearable pain’) at baseline, 10, 20 and 30 min after administering the treatments.Results On admission, the pain level was the same in all three groups. At 10 min the pain decreased in all groups to a level that was not significantly different. At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0. At 30 min, groups B and C scored 2–3, and group A 5.6. All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.Conclusions Desmopressin has several advantages, e.g. ease of administration, simplicity of delivery and apparent lack of side-effects, which makes it suitable for ambulatory use. Desmopressin acts rapidly and seems to be effective in both single and combined therapy with diclofenac; it decreases the need for a second treatment and increases the analgesic effect of diclofenac. Some patients responded well to desmopressin, with rapid and complete pain relief. These results indicate that desmopressin may be used to treat renal colic either alone or combined, increasing the analgesic effect of other drugs. More studies are needed to validate and confirm the results; it would also be useful to determine factors that may identify the subgroup of patients who respond quickly and with almost complete pain relief.

Bju International, 2008

Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intr... more Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic caused by urolithiasis.Patients and methods The study included 61 patients randomized into three different groups; group A received desmopressin (40 µg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale (a 10-cm horizontal scale ranging from ‘no pain’ to ‘unbearable pain’) at baseline, 10, 20 and 30 min after administering the treatments.Results On admission, the pain level was the same in all three groups. At 10 min the pain decreased in all groups to a level that was not significantly different. At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0. At 30 min, groups B and C scored 2–3, and group A 5.6. All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.Conclusions Desmopressin has several advantages, e.g. ease of administration, simplicity of delivery and apparent lack of side-effects, which makes it suitable for ambulatory use. Desmopressin acts rapidly and seems to be effective in both single and combined therapy with diclofenac; it decreases the need for a second treatment and increases the analgesic effect of diclofenac. Some patients responded well to desmopressin, with rapid and complete pain relief. These results indicate that desmopressin may be used to treat renal colic either alone or combined, increasing the analgesic effect of other drugs. More studies are needed to validate and confirm the results; it would also be useful to determine factors that may identify the subgroup of patients who respond quickly and with almost complete pain relief.

Semina: Ciências Agrárias, 2009

Este experimento foi realizado em um vinhedo localizado na região Centro -Sul do Estado Paraná, c... more Este experimento foi realizado em um vinhedo localizado na região Centro -Sul do Estado Paraná, com o objetivo de avaliar diferentes tipos de poda na cultura da videira cv. Bordô na safra 2007/08. Foram utilizadas plantas com 6 anos de idade, conduzidas no sistema latada e espaçadas 3,0 x 1,0 m. As videiras foram submetidas aos tratamentos de poda esporonada (esporões com duas a três gemas), poda longa (varas de cinco a seis gemas) e poda mista (esporões e varas). As variáveis avaliadas foram: número de cachos por planta, produção por planta e massa média dos cachos. Observou-se que em relação ao número de cachos por planta houve diferenças significativas somente para poda longa em relação às demais, assim como para massa média dos cachos. Em relação à produção por planta houve diferença significativa entre todos os tratamentos sendo que a poda longa apresentou maior produção por planta, chegando a ser aproximadamente três vezes maior que a produção da poda esporonada.

Growth Hormone & IGF Research, 2010

Growth hormone isoforms 20 kDa-hGH 22 kDa-hGH Octreotide LAR a b s t r a c t Background: Human gr... more Growth hormone isoforms 20 kDa-hGH 22 kDa-hGH Octreotide LAR a b s t r a c t Background: Human growth hormone (hGH) circulates as a mixture of different isoforms. It has been previously reported that the ratio of 20 kDa to 20 kDa plus 22 kDa (%20 kDa-hGH) is increased in patients with active acromegaly. Objectives: To evaluate the GH isoforms (20 kDa-and 22 kDa-hGH) in acromegalic patients before and after six months of treatment with octreotide LAR, and to compare the results with those in healthy controls. In addition, the relationships between the %20 kDa-hGH, tumor size and biochemical measurements were also investigated. Design: Random serum samples from 23 acromegalic patients evaluated before and after six months of treatment with octreotide LAR and from 23 matched healthy controls were studied. Growth hormone, IGF-I and prolactin (PRL) were measured by chemiluminescence immunometric assay and the 20 kDaand 22 kDa-hGH isoforms were measured by specific time-resolved fluorescence immunoassays. Results: In acromegalic patients before treatment, there was a significantly higher median %20 Da-hGH in comparison to healthy controls (14.31% vs. 9.59%, p < 0.001). After six months of treatment, the median %20 kDa-hGH was similar to the baseline values. Patients with GH < 2.5 ng/mL after six months of treatment had already lower GH and %20 kDa-hGH at baseline (p < 0.01). The IGF-I (SD-scores) was positively correlated to total GH levels in acromegalic patients after treatment. There was no correlation between the %20 kDa-hGH and PRL levels or tumor size. Conclusions: Our study confirmed that acromegalic patients have an increased proportion of circulating 20 kDa-hGH isoform. Consequently, the use of a 22 kDa-hGH specific assay may underestimate the tumor production of total GH. Although octreotide LAR promoted a significant decrease in the GH and IGF-I levels, it did not normalize the GH isoforms composition and suggests that the secretion of GH isoforms is equally inhibited by somatostatin analogues and that it is the disease control that normalizes the GH isoforms composition in acromegaly.

Bju International, 2008

Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intr... more Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic caused by urolithiasis.Patients and methods The study included 61 patients randomized into three different groups; group A received desmopressin (40 µg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale (a 10-cm horizontal scale ranging from ‘no pain’ to ‘unbearable pain’) at baseline, 10, 20 and 30 min after administering the treatments.Results On admission, the pain level was the same in all three groups. At 10 min the pain decreased in all groups to a level that was not significantly different. At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0. At 30 min, groups B and C scored 2–3, and group A 5.6. All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.Conclusions Desmopressin has several advantages, e.g. ease of administration, simplicity of delivery and apparent lack of side-effects, which makes it suitable for ambulatory use. Desmopressin acts rapidly and seems to be effective in both single and combined therapy with diclofenac; it decreases the need for a second treatment and increases the analgesic effect of diclofenac. Some patients responded well to desmopressin, with rapid and complete pain relief. These results indicate that desmopressin may be used to treat renal colic either alone or combined, increasing the analgesic effect of other drugs. More studies are needed to validate and confirm the results; it would also be useful to determine factors that may identify the subgroup of patients who respond quickly and with almost complete pain relief.

Bju International, 2008

Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intr... more Objectives To assess the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic caused by urolithiasis.Patients and methods The study included 61 patients randomized into three different groups; group A received desmopressin (40 µg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale (a 10-cm horizontal scale ranging from ‘no pain’ to ‘unbearable pain’) at baseline, 10, 20 and 30 min after administering the treatments.Results On admission, the pain level was the same in all three groups. At 10 min the pain decreased in all groups to a level that was not significantly different. At 20 min groups B and C had similar mean pain levels (3.7), whereas in group A it was 5.0. At 30 min, groups B and C scored 2–3, and group A 5.6. All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A.Conclusions Desmopressin has several advantages, e.g. ease of administration, simplicity of delivery and apparent lack of side-effects, which makes it suitable for ambulatory use. Desmopressin acts rapidly and seems to be effective in both single and combined therapy with diclofenac; it decreases the need for a second treatment and increases the analgesic effect of diclofenac. Some patients responded well to desmopressin, with rapid and complete pain relief. These results indicate that desmopressin may be used to treat renal colic either alone or combined, increasing the analgesic effect of other drugs. More studies are needed to validate and confirm the results; it would also be useful to determine factors that may identify the subgroup of patients who respond quickly and with almost complete pain relief.