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Papers by Juan Angel Lara Gonzalez

PLoS genetics, 2012

Most individuals throughout the Americas are admixed descendants of Native American, European, an... more Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R 2 .0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.

Revista Española de …, 2010

Introduction and objectives.The presence of peripheral arterial disease in patients with coronary... more Introduction and objectives.The presence of peripheral arterial disease in patients with coronary artery disease is associated with a poor cardiovascular outcome. However, the majority of affected patients are asymptomatic and the condition is underdiagnosed. The ankle-brachial index (ABI) provides a simple method of diagnosis. The aim of this study was to assess the usefulness of an abnormal ABI for identifying multivessel coronary artery disease in patients with acute coronary syndrome (ACS).

Encontros …, 2004

El sustantivo crecimiento del número de tesauros no ha servido para responder a la necesidad de t... more El sustantivo crecimiento del número de tesauros no ha servido para responder a la necesidad de trabajar en entornos multidisciplinares. Para responder a esta situación, se fomentó, en un primer momento, la fusión de tesauros con objeto de adaptar los preexistentes a las necesidades planteadas por los nuevos dominios. Más tarde, en el afán de atender precisamente a un mundo de información cambiante y en crecimiento, se empezó a trabajar en los mapas conceptuales de navegación. Hasta desembocar en los Topic maps surgidos de la necesidad de fusionar índices para incorporar así la utilidad de los hiperenlaces. Su éxito se plasmó en la norma ISO/ICE 13250:1999, que motivó la hipótesis de su uso en la elaboración de tesauros, proceso en el que se manifestaron las contradicciones entre ambos sistemas. Por lo que se analizan los elementos conceptuales esenciales en la arquitectura de los topics maps para hallar su correlato en los tesauros. Este estudio comparativo permite señalar como límites de los topics maps, su indefinición conceptual, sus innumerables relaciones y su ambigüedad, lo que no oculta sus ventajas como una mayor riqueza semántica, la consecución de un nuevo marco conceptual para dominios fusionados, las asociaciones determinadas por verbos y la capacidad de organizar recursos informativos de distinto tipo.

Physics Letters B, 2013

Angular correlations between charged trigger and associated particles are measured by the ALICE d... more Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < p T,assoc < p T,trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in highmultiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p T bins, and the widths show no significant evolution with event multiplicity or p T . These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge.

Astronomical …, 2003

During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for... more During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes-imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. After the GTC Commissioning we also ...

The EMBO …, 1998

complexes. Immunofluorescence analysis demonstrated that HBx induces the nuclear translocation of... more complexes. Immunofluorescence analysis demonstrated that HBx induces the nuclear translocation of NF-AT, which can be blocked by the immunosuppressive drug cyclosporin A. Furthermore, immunoblot analysis showed that the HBxinduced activation and translocation of NF-AT are associated with its dephosphorylation. Thus, HBx may play a relevant role in the intrahepatic inflammatory processes by inducing locally the expression of cytokines that are regulated by NF-AT.

Brain research, 2002

This work examines the age-related changes of the NO pathway in the central nervous system (CNS),... more This work examines the age-related changes of the NO pathway in the central nervous system (CNS), analyzing nitric oxide synthase (NOS) isoform expression, the level of nitrotyrosine-modified proteins, and the NOS activity in the cerebral cortex, decorticated brain (basal ganglia, thalamus, hypothalamus, tegtum and tegmentum) and cerebellum of young, adult and aged rats. Our data demonstrate that the different NOS isoforms are not uniformly expressed across the CNS. In this sense, the nNOS and eNOS isoenzymes are expressed mainly in the cerebellum and decorticated brain, respectively, while the iNOS isoenzyme shows the highest level in cerebellum. Concerning age, in the cerebral cortex nNOS significantly increased its expression only in adult animals; meanwhile, in the cerebellum the eNOS expression decreased whereas iNOS increased in adult and aged rats. No age-related changes in any isoform were found in decorticated brain. NOS activity, determined by nitrate plus nitrite quantification, registered the highest levels in the cerebellum, where the significant increase detected with aging was probably related to iNOS activity. The number of nitrotyrosine-modified immunoreactive bands differed among regions; thus, the highest number was detected in the decorticated brain while the cerebellum showed the least number of bands. Finally, bulk protein nitration increased in cerebral cortex only in adult animal. No changes were found in the decorticated brain, and the decrease detected in the cerebellum of aged animals was not significant. According to these results, the NO pathway is differently modified with age in the three CNS regions analyzed.

Journal of High Energy …, 2012

A bstract The ALICE experiment at the LHC has studied J/ψ production at mid-rapidity in pp collis... more A bstract The ALICE experiment at the LHC has studied J/ψ production at mid-rapidity in pp collisions at sqrts=7\ sqrt {s}= 7sqrts=7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L int= 5. 6 nb− 1. The fraction of J/ψ from the decay of long-lived beauty hadrons was determined for J/ψ candidates with transverse momentum pt&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 1. 3 GeV/c and rapidity| y|&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0. 9. The cross section for prompt J/ψ mesons, ie directly produced J/ψ and prompt decays of heavier charmonium states such as the ψ (2S) ...

PLoS genetics, 2012

Most individuals throughout the Americas are admixed descendants of Native American, European, an... more Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R 2 .0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.

Revista Española de …, 2010

Introduction and objectives.The presence of peripheral arterial disease in patients with coronary... more Introduction and objectives.The presence of peripheral arterial disease in patients with coronary artery disease is associated with a poor cardiovascular outcome. However, the majority of affected patients are asymptomatic and the condition is underdiagnosed. The ankle-brachial index (ABI) provides a simple method of diagnosis. The aim of this study was to assess the usefulness of an abnormal ABI for identifying multivessel coronary artery disease in patients with acute coronary syndrome (ACS).

Encontros …, 2004

El sustantivo crecimiento del número de tesauros no ha servido para responder a la necesidad de t... more El sustantivo crecimiento del número de tesauros no ha servido para responder a la necesidad de trabajar en entornos multidisciplinares. Para responder a esta situación, se fomentó, en un primer momento, la fusión de tesauros con objeto de adaptar los preexistentes a las necesidades planteadas por los nuevos dominios. Más tarde, en el afán de atender precisamente a un mundo de información cambiante y en crecimiento, se empezó a trabajar en los mapas conceptuales de navegación. Hasta desembocar en los Topic maps surgidos de la necesidad de fusionar índices para incorporar así la utilidad de los hiperenlaces. Su éxito se plasmó en la norma ISO/ICE 13250:1999, que motivó la hipótesis de su uso en la elaboración de tesauros, proceso en el que se manifestaron las contradicciones entre ambos sistemas. Por lo que se analizan los elementos conceptuales esenciales en la arquitectura de los topics maps para hallar su correlato en los tesauros. Este estudio comparativo permite señalar como límites de los topics maps, su indefinición conceptual, sus innumerables relaciones y su ambigüedad, lo que no oculta sus ventajas como una mayor riqueza semántica, la consecución de un nuevo marco conceptual para dominios fusionados, las asociaciones determinadas por verbos y la capacidad de organizar recursos informativos de distinto tipo.

Physics Letters B, 2013

Angular correlations between charged trigger and associated particles are measured by the ALICE d... more Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < p T,assoc < p T,trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in highmultiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p T bins, and the widths show no significant evolution with event multiplicity or p T . These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge.

Astronomical …, 2003

During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for... more During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes-imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. After the GTC Commissioning we also ...

The EMBO …, 1998

complexes. Immunofluorescence analysis demonstrated that HBx induces the nuclear translocation of... more complexes. Immunofluorescence analysis demonstrated that HBx induces the nuclear translocation of NF-AT, which can be blocked by the immunosuppressive drug cyclosporin A. Furthermore, immunoblot analysis showed that the HBxinduced activation and translocation of NF-AT are associated with its dephosphorylation. Thus, HBx may play a relevant role in the intrahepatic inflammatory processes by inducing locally the expression of cytokines that are regulated by NF-AT.

Brain research, 2002

This work examines the age-related changes of the NO pathway in the central nervous system (CNS),... more This work examines the age-related changes of the NO pathway in the central nervous system (CNS), analyzing nitric oxide synthase (NOS) isoform expression, the level of nitrotyrosine-modified proteins, and the NOS activity in the cerebral cortex, decorticated brain (basal ganglia, thalamus, hypothalamus, tegtum and tegmentum) and cerebellum of young, adult and aged rats. Our data demonstrate that the different NOS isoforms are not uniformly expressed across the CNS. In this sense, the nNOS and eNOS isoenzymes are expressed mainly in the cerebellum and decorticated brain, respectively, while the iNOS isoenzyme shows the highest level in cerebellum. Concerning age, in the cerebral cortex nNOS significantly increased its expression only in adult animals; meanwhile, in the cerebellum the eNOS expression decreased whereas iNOS increased in adult and aged rats. No age-related changes in any isoform were found in decorticated brain. NOS activity, determined by nitrate plus nitrite quantification, registered the highest levels in the cerebellum, where the significant increase detected with aging was probably related to iNOS activity. The number of nitrotyrosine-modified immunoreactive bands differed among regions; thus, the highest number was detected in the decorticated brain while the cerebellum showed the least number of bands. Finally, bulk protein nitration increased in cerebral cortex only in adult animal. No changes were found in the decorticated brain, and the decrease detected in the cerebellum of aged animals was not significant. According to these results, the NO pathway is differently modified with age in the three CNS regions analyzed.

Journal of High Energy …, 2012

A bstract The ALICE experiment at the LHC has studied J/ψ production at mid-rapidity in pp collis... more A bstract The ALICE experiment at the LHC has studied J/ψ production at mid-rapidity in pp collisions at sqrts=7\ sqrt {s}= 7sqrts=7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L int= 5. 6 nb− 1. The fraction of J/ψ from the decay of long-lived beauty hadrons was determined for J/ψ candidates with transverse momentum pt&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 1. 3 GeV/c and rapidity| y|&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0. 9. The cross section for prompt J/ψ mesons, ie directly produced J/ψ and prompt decays of heavier charmonium states such as the ψ (2S) ...